Thermoresponsive polymers: Insights into decisive hydrogel characteristics, mechanisms of gelation, and promising biomedical applications

International Journal of Pharmaceutics

Volumn 472, Issue 1-2, 2014, Pages 262-275

  Matanović, Maja Radivojša ^a   Kristl, Julijana ^a   Grabnar, Pegi Ahlin ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Controlled release; In situ forming systems; Nanocarriers; Protein delivery; Thermosensitive hydrogels; Tissue regeneration

Indexed keywords

ASCORBIC ACID; CELLULOSE DERIVATIVE; CHITOSAN; COPOLYMER; DEXAMETHASONE; GELATIN; GONADORELIN; HUMAN INSULIN; HYDROXYPROPYLMETHYLCELLULOSE; LEVOTHYROXINE; MACROGOL; METHYLCELLULOSE; NANOCARRIER; NANOPARTICLE; PACLITAXEL; POLOXAMER; POLY(N ISOPROPYLACRYLAMIDE); POLYCAPROLACTONE; POLYGLACTIN; POLYMER; POLYPEPTIDE; POLYSACCHARIDE; PROTEIN; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG; XYLOGLUCAN; DRUG CARRIER; HYDROGEL; PEPTIDE;

AQUEOUS SOLUTION; BIOCOMPATIBILITY; BIODEGRADABILITY; CELL ENCAPSULATION; CHEMICAL COMPOSITION; CHEMICAL PHENOMENA; CONTROLLED DRUG RELEASE; CRITICAL MICELLE CONCENTRATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; FLOW KINETICS; GELATION; HEAT SENSITIVITY; HUMAN; HYDROGEL; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NONHUMAN; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SOLUBILIZATION; TISSUE REGENERATION; TRANSITION TEMPERATURE; ADMINISTRATION AND DOSAGE; ANIMAL; CHEMISTRY; TEMPERATURE;

ANIMALS; DRUG CARRIERS; HUMANS; HYDROGELS; PEPTIDES; POLYMERS; TEMPERATURE;

EID: 84903714320     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.06.029     Document Type: Review

References (122)

1. P. Ahlin Grabnar, and J. Kristl The manufacturing techniques of drug-loaded polymeric nanoparticles from preformed polymers J. Microencapsulation 28 2011 323 335
2. P. Alexandridis, and T. Alan Hatton Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling Colloid Surf. A-Physicochem. Eng. Aspects 96 1995 1 46
3. A.F. Azarbayjani, J.R. Venugopal, S. Ramakrishna, P.F. Lim, Y.W. Chan, and S.Y. Chan Smart polymeric nanofibers for topical delivery of levothyroxine J. Pharm. Pharm. Sci. 13 2010 400 410
4. A.K. Bajpai, S.K. Shukla, S. Bhanu, and S. Kankane Responsive polymers in controlled drug delivery Prog. Polym. Sci. 33 2008 1088 1118
5. J.M. Barichello, M. Morishita, K. Takayama, and T. Nagai Absorption of insulin from Pluronic F-127 gels following subcutaneous administration in rats Int. J. Pharm. 184 1999 189 198 (Pubitemid 29317652)
6. N. Bhattarai, F.A. Matsen, and M. Zhang PEG-grafted chitosan as an injectable thermoreversible hydrogel Macromol. Biosci. 5 2005 107 111 (Pubitemid 40803835)
7. N. Bhattarai, H.R. Ramay, J. Gunn, F.A. Matsen, and M. Zhang PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release J. Control. Rel. 103 2005 609 624 (Pubitemid 40471019)
8. L. Bromberg Novel family of thermogelling materials via CC bonding between poly(acrylic acid) and poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) J. Phys. Chem. B 102 1998 1956 1963 (Pubitemid 128586648)
9. L. Bromberg Properties of aqueous solutions and gels of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-g-poly(acrylic acid) J. Phys. Chem. B 102 1998 10736 10744 (Pubitemid 128716586)
10. L.E. Bromberg, T.H.E. Mendum, M.J. Orkisz, M.E. Schiller, E.C. Lupton, and E.S. Ron Polyoxyethylene-b-polyoxypropylene-b-polyoxyethylene-g-poly(acrylic acid) polymers (smart hydrogel™) as a carrier in controlled delivery of proteins and peptides Am. Chem. Soc. Polym. Prepr. Div. Polym. Chem. 38 1997 602 603 (Pubitemid 127545557)
11. L.E. Bromberg, and E.S. Ron Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery Adv. Drug Deliv. Rev. 31 1998 197 221 (Pubitemid 28191866)
12. A.K. Burkoth, and K.S. Anseth A review of photocrosslinked polyanhydrides: in situ forming degradable networks Biomaterials 21 2000 2395 2404
13. A. Cabana, A. Aït-Kadi, and J. Juhász Study of the gelation process of polyethylene oxide(a)-polypropylene oxide(b)-polyethylene oxide, copolymer (poloxamer 407) aqueous solutions J. Colloid Interf. Sci. 190 1997 307 312 (Pubitemid 27470860)
14. M.T. Calejo, A. Kjøniksena, A. Pinazoc, L. Pérezc, A.M.S. Cardosod, M.C. Pedroso de Limad, A.S. Juradod, S.A. Sandea, and B. Nyström Thermoresponsive hydrogels with low toxicity from mixtures of ethyl(hydroxyethyl) cellulose and arginine-based surfactants Int. J. Pharm. 436 2012 454 462
15. S.Y. Chae, S.W. Kim, and Y.H. Bae Bioactive polymers for biohybrid artificial pancreas J. Drug Target. 9 2001 473 484 (Pubitemid 34071721)
16. D. Chen, P. Guo, S. Chen, Y. Cao, W. Ji, X. Lei, L. Liu, P. Zhao, R. Wang, C. Qi, Y. Liu, and H. He Properties of xyloglucan hydrogel as the biomedical sustained-release carriers J. Mater. Sci. Mater. Med. 23 2012 955 962
17. Chen, G., Hoffman, A.S., York, B.M., 1995. Block and graft copolymers and methods relating thereto. US Patent 6486213.
18. Y. Cheng, C. He, J. Ding, C. Xiao, X. Zhuang, and X. Chen Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs Biomaterials 34 2013 10338 10347
19. A. Chenite, M. Buschmann, D. Wang, C. Chaput, and N. Kandani Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions Carbohydr. Polym. 46 2001 39 47 (Pubitemid 32487087)
20. A. Chenite, C. Chaput, D. Wang, C. Combes, M.D. Buschmann, C.D. Hoemann, J.C. Leroux, B.L. Atkinson, F. Binette, and A. Selmani Novel injectable neutral solutions of chitosan form biodegradable gels in situ Biomaterials 21 2000 2155 2161 (Pubitemid 30612386)
21. D.A. Chiappetta, and A. Sosnik Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: improved hydrosolubility, stability and bioavailability of drugs Eur. J. Pharm. Biopharm. 66 2007 303 317 (Pubitemid 46756232)
22. J.H. Cho, S.-H. Kim, K.D. Park, M.C. Jung, W.I. Yang, S.W. Han, J.Y. Noh, and J.W. Lee Chondrogenic differentiation of human mesenchymal stem cells using a thermosensitive poly(N-isopropylacrylamide) and water-soluble chitosan copolymer Biomaterials 25 2004 5743 5751 (Pubitemid 38624454)
23. J.E. Chung, M. Yokoyama, M. Yamato, T. Aoyagi, Y. Sakurai, and T. Okano Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate) J. Control. Rel. 62 1999 115 127 (Pubitemid 29486490)
24. D.C. Coughlan, F.P. Quilty, and O.I. Corrigan Effect of drug physicochemical properties on swelling/deswelling kinetics and pulsatile drug release from thermoresponsive poly(N-isopropylacrylamide) hydrogels J. Control. Rel. 98 2004 97 114 (Pubitemid 38881611)
25. K.E. Crompton, J.D. Goud, R.V. Bellamkonda, T.R. Gengenbach, D.I. Finkelstein, M.K. Horne, and J.S. Forsythe Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering Biomaterials 28 2007 441 449 (Pubitemid 44740107)
26. S. Drotleff, U. Lungwitz, M. Breunig, A. Dennis, T. Blunk, J. Tessmar, and A. Göpferich Biomimetic polymers in pharmaceutical and biomedical sciences Eur. J. Pharm. Biopharm. 58 2004 385 407 (Pubitemid 39037243)
27. A. El-Kamel, and M. El-Khatib Thermally reversible in situ gelling carbamazepine liquid suppository Drug Deliv. 13 2006 143 148 (Pubitemid 43162311)
28. J.J. Escobar-Chavez, M. Lopez-Cervantes, A. Naik, Y.N. Kalia, D. Quintanar-Guerrero, and A. Ganem-Quintanar Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations J. Pharm. Pharm. Sci. 9 2006 339 358 (Pubitemid 46655458)
29. J.C. Garbern, A.S. Hoffman, and P.S. Stayton Injectable pH- and temperature-responsive poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for delivery of angiogenic growth factors Biomacromolecules 11 2010 1833 1839
30. H. Geng, H. Song, J. Qi, and D. Cui Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix Nanoscale Res. Lett. 6 2011 1 8
31. J.R. Gillmor, R.W. Connelly, R.H. Colby, and J.S. Tan Effect of sodium poly(styrene sulfonate) on thermoreversible gelation of gelatin J. Polym. Sci. B: Polym. Phys. 37 1999 2287 2295
32. C.-Y. Gong, S. Shi, X.-Y. Peng, B. Kan, L. Yang, M.-J. Huang, F. Luo, X. Zhao, Y.-Q. Wei, and Z.-Y. Qian Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity Growth Factors 27 2009 377 383
33. C. Gong, S. Shi, L. Wu, M. Gou, Q. Yin, Q. Guo, P. Dong, F. Zhang, F. Luo, X. Zhao, Y. Wei, and Z. Qian Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: sol-gel-sol transition and drug delivery behavior Acta Biomater. 5 2009 3358 3370
34. C.Y. Gong, S. Shi, P.W. Dong, B. Yang, X.R. Qi, G. Guo, Y.C. Gu, X. Zhao, Y.Q. Wei, and Z.Y. Qian Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel: Part 1 - synthesis, characterization, and acute toxicity evaluation J. Pharm. Sci. 98 2009 4684 4694
35. M. Gou, X. Li, M. Dai, C. Gong, X. Wang, Y. Xie, H. Deng, L. Chen, X. Zhao, Z. Qian, and Y. Wei A novel injectable local hydrophobic drug delivery system: biodegradable nanoparticles in thermo-sensitive hydrogel Int. J. Pharm. 359 2008 228 233
36. M. Gou, X. Zheng, K. Men, J. Zhang, L. Zheng, X. Wang, F. Luo, Y. Zhao, X. Zhao, Y. Wei, and Z. Qian Poly(μ-caprolactone)/poly(ethylene glycol)/poly(μ-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery J. Phys. Chem. B 113 2009 12928 12933
37. M. Hamidi, A. Azadi, and P. Rafiei Hydrogel nanoparticles in drug delivery Adv. Drug Deliv. Rev. 60 2008 1638 1649
38. H. Hatakeyama, A. Kikuchi, M. Yamato, and T. Okano Bio-functionalized thermoresponsive interfaces facilitating cell adhesion and proliferation Biomaterials 27 2006 5069 5078 (Pubitemid 43928122)
39. C. He, S.W. Kim, and D.S. Lee In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery J. Control. Release 127 2008 189 207
40. W.E. Hennink, and C.F. van Nostrum Novel crosslinking methods to design hydrogels Adv. Drug Deliv. Rev. 64 2012 223 236
41. A. Higuchi, N. Aoki, T. Yamamoto, Y. Gomei, S. Egashira, Y. Matsuoka, T. Miyazaki, H. Fukushima, S. Jyujyoji, and S.H. Natori Bioinert surface of pluronic-immobilized flask for preservation of hematopoietic stem cells Biomacromolecules 7 2006 1083 1089 (Pubitemid 43675329)
42. T.R. Hoare, and D.S. Kohane Hydrogels in drug delivery: progress and challenges Polymer 49 2008 1993 2007
43. B. Janković, J. Pelipenko, M. Škarabot, I. Muševič, and J. Kristl The design trend in tissue-engineering scaffolds based on nanomechanical properties of individual electrospun nanofibers Int. J. Pharm. 455 2013 338 347
44. B. Jeong, Y.H. Bae, and S.W. Kim In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof J. Biomed. Mater. Res. 50 2000 171 177
45. B. Jeong, Y.K. Choi, Y.H. Bae, G. Zentner, and S.W. Kim New biodegradable polymers for injectable drug delivery systems J. Control. Rel. 62 1999 109 114 (Pubitemid 29486489)
46. C. Joly-Duhamel, D. Hellio, and M. Djabourov All gelatin networks: 1. Biodiversity and physical chemistry† Langmuir 18 2002 7208 7217 (Pubitemid 35383219)
47. A. Kabanov, J. Zhu, and V. Alakhov Pluronic block copolymers for gene delivery Adv. Genet. 53 2005 231 261 (Pubitemid 43696280)
48. M. Katakam, W.R. Ravis, and A.K. Banga Controlled release of human growth hormone in rats following parenteral administration of poloxamer gels J. Control. Rel. 49 1997 21 26 (Pubitemid 27417897)
49. S. Kempe, H. Metz, M. Bastrop, A. Hvilsom, R.V. Contri, and K. Mäder Characterization of thermosensitive chitosan-based hydrogels by rheology and electron paramagnetic resonance spectroscopy Eur. J. Pharm. Biopharm. 68 2008 26 33 (Pubitemid 350181415)
50. E. Khodaverdi, A. Golmohammadian, S.A. Mohajeri, G. Zohuri, F.S. Mirzazadeh Tekie, and F. Hadizadeh Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive poly(epsilon-caprolactone)- poly(ethylene glycol)-poly(epsilon-caprolactone) hydrogel ISRN Pharm. 27 2012 7
51. E.-Y. Kim, Z.-G. Gao, J.-S. Park, H. Li, and K. Han rhEGF/HP-β-CD complex in poloxamer gel for ophthalmic delivery Int. J. Pharm. 233 2002 159 167 (Pubitemid 34230428)
52. I.-S. Kim, Y.-I. Jeong, C.-S. Cho, and S.-H. Kim Thermo-responsive self-assembled polymeric micelles for drug delivery in vitro Int. J. Pharm. 205 2000 165 172
53. J. Kim, Y.-W. Won, K. Lim, and Y.-H. Kim Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery Pharm. Res. 29 2012 525 534
54. S. Kim, J.-H. Kim, O. Jeon, I.C. Kwon, and K. Park Engineered polymers for advanced drug delivery Eur. J. Pharm. Biopharm. 71 2009 420 430
55. Y. Kim, S. Choi, J. Koh, M. Lee, K. Ko, and S. Kim Controlled release of insulin from injectable biodegradable triblock copolymer Pharm. Res. 18 2001 548 550 (Pubitemid 32592590)
56. L. Klouda, and A.G. Mikos Thermoresponsive hydrogels in biomedical applications Eur. J. Pharm. Biopharm. 68 2008 34 45 (Pubitemid 350181413)
57. J. Kristl, S. Pečar, J. Šmid-Korbar, and M. Schara Molecular motion of drugs in hydrocolloids measured by electron paramagnetic resonance Pharm. Res. 8 1991 505 507
58. J. Kristl, J. Šmid-Korbar, E. Štruc, M. Schara, and H. Rupprecht Hydrocolloids and gels of chitosan as drug carriers Int. J. Pharm. 99 1993 13 19 (Pubitemid 23276357)
59. S.S. Kulkarni, and N.H. Aloorkar Smart polymers in drug delivery: an overview J. Pharm. Res. 3 2010 100 108
60. C.K. Kuo, and P.X. Ma Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties Biomaterials 22 2001 511 521 (Pubitemid 32015873)
61. K.-W. Kwon, M.J. Park, Y.H. Bae, H.D. Kim, and K. Char Gelation behavior of PEO-PLGA-PEO triblock copolymers in water Polymer 43 2002 3353 3358 (Pubitemid 34292932)
62. P.-L. Lai, D.-W. Hong, K.-L. Ku, Z.-T. Lai, and I.M. Chu Novel thermosensitive hydrogels based on methoxy polyethylene glycol-co-poly(lactic acid-co-aromatic anhydride) for cefazolin delivery Nanomed.: Nanotechnol. Biol. Med. 10 2014 553 560
63. G. Li, S. Song, L. Guo, and S. Ma Self-assembly of thermo- and pH-responsive poly(acrylic acid)-b-poly(N-isopropylacrylamide) micelles for drug delivery J. Polym. Sci. Part A: Polym. Chem. 46 2008 5028 5035
64. H. Li, G.-E. Yu, C. Price, C. Booth, E. Hecht, and H. Hoffmann Concentrated aqueous micellar solutions of diblock copoly(oxyethylene/ oxybutylene) e41b8: a study of phase behavior Macromolecules 30 1997 1347 1354 (Pubitemid 127574428)
65. Y. Li, S. Pan, W. Zhang, and Z. Du Novel thermo-sensitive core-shell nanoparticles for targeted paclitaxel delivery Nanotechnology 20 2009 0957 4484
66. M. Licciardi, G. Amatoa, A. Cappellic, M. Paolinoc, G. Giulianic, B. Belmonted, C. Guarnottad, G. Pitarresi, and G. Giammona Evaluation of thermoresponsive properties and biocompatibility of polybenzofulvene aggregates for leuprolide delivery Int. J. Pharm. 438 2012 279 286
67. Y.-H. Lien, J.-H. Wu, J.-W. Liao, and T.-M. Wu In vitro evaluation of the thermosensitive and magnetic nanoparticles for the controlled drug delivery of vitamin D3 Macromol. Res. 21 2013 511 518
68. Y.-H. Lien, and T.-M. Wu Preparation and characterization of thermosensitive polymers grafted onto silica-coated iron oxide nanoparticles J. Colloid Interf. Sci. 326 2008 517 521
69. Y.-H. Lien, T.-M. Wu, J.-H. Wu, and J.-W. Liao Cytotoxicity and drug release behavior of PNIPAM grafted on silica-coated iron oxide nanoparticles J. Nanopart. Res. 13 2011 5065 5075
70. H.-H. Lin, and Y.-L. Cheng In-situ thermoreversible gelation of block and star copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) of varying architectures Macromolecules 34 2001 3710 3715 (Pubitemid 34216911)
71. B. Liu, M. Yang, R. Li, Y. Ding, X. Qian, L. Yu, and X. Jiang The antitumor effect of novel docetaxel-loaded thermosensitive micelles Eur. J. Pharm. Biopharm. 69 2008 527 534
72. S.-Q. Liu, N. Wiradharma, S.-J. Gao, Y.W. Tong, and Y.-Y. Yang Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs Biomaterials 28 2007 1423 1433 (Pubitemid 46001461)
73. W. Liu, B. Zhang, W.W. Lu, X. Li, D. Zhu, Y. De, K. Wang, Q. Zhao, and C. Wang A rapid temperature-responsive sol-reversible poly(N-isopropylacrylamide)- g-methylcellulose copolymer hydrogel Biomaterials 25 2004 3005 3012 (Pubitemid 38210193)
74. X.-M. Liu, L.-S. Wang, L. Wang, J. Huang, and C. He The effect of salt and pH on the phase-transition behaviors of temperature-sensitive copolymers based on N-isopropylacrylamide Biomaterials 25 2004 5659 5666 (Pubitemid 38680494)
75. Y.-Y. Liu, Y.-H. Shao, and J. Lü Preparation, properties and controlled release behaviors of pH-induced thermosensitive amphiphilic gels Biomaterials 27 2006 4016 4024 (Pubitemid 44316594)
76. R. Majithiya, P. Ghosh, M. Umrethia, and R.R. Murthy Thermoreversible- mucoadhesive gel for nasal delivery of sumatriptan AAPS Pharm. Sci. Tech. 7 2006 E80 E86
77. S. Miyazaki, F. Suisha, N. Kawasaki, M. Shirakawa, K. Yamatoya, and D. Attwood Thermally reversible xyloglucan gels as vehicles for rectal drug delivery J. Control. Rel. 56 1998 75 83 (Pubitemid 28511128)
78. K. Mortensen, and J.S. Pedersen Structural study on the micelle formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer in aqueous solution Macromolecules 26 1993 805 812
79. K. Na, S.W. Kim, B.K. Sun, D.G. Woo, H.N. Yang, H.M. Chung, and K.H. Park Osteogenic differentiation of rabbit mesenchymal stem cells in thermo-reversible hydrogel constructs containing hydroxyapatite and bone morphogenic protein-2 (BMP-2) Biomaterials 28 2007 2631 2637 (Pubitemid 46389528)
80. K. Na, J.H. Park, S.W. Kim, B.K. Sun, D.G. Woo, H.-M. Chung, and K.-H. Park Delivery of dexamethasone, ascorbate, and growth factor (TGF β-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes Biomaterials 27 2006 5951 5957 (Pubitemid 44349006)
81. M. Nakayama, T. Okano, T. Miyazaki, F. Kohori, K. Sakai, and M. Yokoyama Molecular design of biodegradable polymeric micelles for temperature-responsive drug release J. Control. Rel. 115 2006 46 56 (Pubitemid 44419528)
82. M. Nakayama, N. Yamada, Y. Kumashiro, H. Kanazawa, M. Yamato, and T. Okano Thermoresponsive poly(N-isopropylacrylamide)-based block copolymer coating for optimizing cell sheet fabrication Macromol. Biosci. 12 2012 751 760
83. D.R. Nisbet, K.E. Crompton, S.D. Hamilton, S. Shirakawa, R.J. Prankerd, D.I. Finkelstein, M.K. Horne, and J.S. Forsythe Morphology and gelation of thermosensitive xyloglucan hydrogels Biophys. Chem. 121 2006 14 20
84. S. Ohya, and T. Matsuda Poly(N-isopropylacrylamide) (PNIPAM)-grafted gelatin as thermoresponsive three-dimensional artificial extracellular matrix: molecular and formulation parameters vs. cell proliferation potential J. Biomater. Sci. Polym. Ed. 16 2005 809 827 (Pubitemid 40973995)
85. D.A. Ossipov, and J. Hilborn Poly(vinyl alcohol)-based hydrogels formed by "click chemistry" Macromolecules 39 2006 1709 1718
86. A. Paavola, J. Yliruusi, and P. Rosenberg Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels J. Control. Rel. 52 1998 169 178 (Pubitemid 28123184)
87. Q. Peng, X. Sun, T. Gong, C.Y. Wu, T. Zhang, J. Tan, and Z.R. Zhang Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin Acta Biomater. 9 2013 5063 5069
88. N.A. Peppas, P. Bures, W. Leobandung, and H. Ichikawa Hydrogels in pharmaceutical formulations Eur. J. Pharm. Biopharm. 50 2000 27 46 (Pubitemid 30326687)
89. O. Pillai, and R. Panchagnula Transdermal delivery of insulin from poloxamer gel: ex vivo and in vivo skin permeation studies in rat using iontophoresis and chemical enhancers J. Control. Rel. 89 2003 127 140 (Pubitemid 36412117)
90. Y. Qiu, and K. Park Environment-sensitive hydrogels for drug delivery Adv. Drug Deliv. Rev. 53 2001 321 339 (Pubitemid 34024913)
91. M. Radivojša, I. Grabnar, and P. Ahlin Grabnar Thermoreversible in situ gelling poloxamer-based systems with chitosan nanocomplexes for prolonged subcutaneous delivery of heparin: design and in vitro evaluation Eur. J. Pharm. Sci. 50 2013 93 101
92. S.J.T. Rezaei, M.R. Nabida, H. Niknejadb, and A.A. Entezami Folate-decorated thermoresponsive micelles based on star-shaped amphiphilic block copolymers for efficient intracellular release of anticancer drugs Int. J. Pharm. 437 2012 70 79
93. E.J. Ricci, M.V.L.B. Bentley, M. Farah, R.E.S. Bretas, and J.M. Marchetti Rheological characterization of Poloxamer 407 lidocaine hydrochloride gels Eur. J. Pharm. Sci. 17 2002 161 167 (Pubitemid 35248270)
94. E.J. Ricci, L.O. Lunardi, D.M.A. Nanclares, and J.M. Marchetti Sustained release of lidocaine from Poloxamer 407 gels Int. J. Pharm. 288 2005 235 244 (Pubitemid 40038576)
95. D. Roy, W.L.A. Brooks, and B.S. Sumerlin New directions in thermoresponsive polymers Chem. Soc. Rev. 42 2013 7214 7243
96. E. Ruel-Gariépy, and J.-C. Leroux In situ-forming hydrogels - review of temperature-sensitive systems Eur. J. Pharm. Biopharm. 58 2004 409 426 (Pubitemid 39037244)
97. E. Ruel-Gariépy, M. Shive, A. Bichara, M. Berrada, D. Le Garrec, A. Chenite, and J.-C. Leroux A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel Eur. J. Pharm. Biopharm. 57 2004 53 63 (Pubitemid 38058803)
98. N. Sarkar Thermal gelation properties of methyl and hydroxypropyl methylcellulose J. Appl. Polym. Sci. 24 1979 1073 1087 (Pubitemid 9475816)
99. H.G. Schild Poly(N-isopropylacrylamide): experiment, theory and application Prog. Polym. Sci. 17 1992 163 249
100. K. Schillén, O. Glatter, and W. Brown Characterization of a PEO-PPO-PEO block copolymer system P. Laggner, O. Glatter, Trends in Colloid and Interface Science VII 1993 Steinkopff 66 71
101. S.-C. Shin, C.-W. Cho, and I.-J. Oh Effects of non-ionic surfactants as permeation enhancers towards piroxicam from the poloxamer gel through rat skins Int. J. Pharm. 222 2001 199 203 (Pubitemid 32568363)
102. A. Sousa, D. Maria, R. Sousa, and E. Sousa Synthesis and characterization of mesoporous silica/poly(N-isopropylacrylamide) functional hybrid useful for drug delivery J. Mater. Sci. 45 2010 1478 1486
103. S.E. Stabenfeldt, A.J. García, and M.C. LaPlaca Thermoreversible laminin-functionalized hydrogel for neural tissue engineering J. Biomed. Mater. Res. Part A 77A 2006 718 725 (Pubitemid 47233553)
104. T. Ta, and T.M. Porter Thermosensitive liposomes for localized delivery and triggered release of chemotherapy J. Control. Rel. 169 2013 112 125
105. M. Talelli, and W.E. Hennink Thermosensitive polymeric micelles for targeted drug delivery Nanomedicine 6 2011 1245 1255
106. B. Vernon, S.W. Kim, and Y.H. Bae Insulin release from islets of Langerhans entrapped in a poly(N-isopropylacrylamide-co-acrylic acid) polymer gel J. Biomater. Sci. Polym. Ed. 10 1999 183 198 (Pubitemid 29097165)
107. P.-L. Wang, and T.P. Johnston Sustained-release interleukin-2 following intramuscular injection in rats Int. J. Pharm. 113 1995 73 81 (Pubitemid 24323036)
108. W. Wang, P. Zhang, W. Shan, J. Gao, and W. Liang A novel chitosan-based thermosensitive hydrogel containing doxorubicin liposomes for topical cancer therapy J. Biomater. Sci. Polym. Ed. 24 2013 1649 1659
109. X. Wang, S. Li, Z. Wan, Z. Quan, and Q. Tan Investigation of thermo-sensitive amphiphilic micelles as drug carriers for chemotherapy in cholangiocarcinoma in vitro and in vivo Int. J. Pharm. 463 2014 81 88
110. G. Wanka, H. Hoffmann, and W. Ulbricht The aggregation behavior of poly-(oxyethylene)-poly-(oxypropylene)-poly-(oxyethylene)-block-copolymers in aqueous solution Colloid Polym. Sci. 268 1990 101 117 (Pubitemid 20682391)
111. M.A. Ward, and T.K. Georgiou Thermoresponsive polymers for biomedical applications Polymers 3 2011 1215 1242
112. H. Wei, X.-Z. Zhang, Y. Zhou, S.-X. Cheng, and R.-X. Zhuo Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate) Biomaterials 27 2006 2028 2034 (Pubitemid 41759496)
113. Q.J. Wu, X.C. Zhu, X. Xiao, P. Wang, D.k. Xiong, C.Y. Gong, Y.S. Wang, L. Yang, and Y.Q. Wei A novel vaccine delivery system: biodegradable nanoparticles in thermosensitive hydrogel Growth Factors 29 2011 290 297
114. J.-J. Xuan, P. Balakrishnan, D.H. Oh, W.H. Yeo, S.M. Park, C.S. Yong, and H.-G. Choi Rheological characterization and in vivo evaluation of thermosensitive poloxamer-based hydrogel for intramuscular injection of piroxicam Int. J. Pharm. 395 2010 317 323
115. J. Yan, L. Yang, G. Wang, Y. Xiao, B. Zhang, and N. Qi Biocompatibility evaluation of chitosan-based injectable hydrogels for the culturing mice mesenchymal stem cells in vitro J. Biomater. Appl. 24 2010 625 637
116. H. Yang, and W. Kao Thermoresponsive gelatin/monomethoxy poly(ethylene glycol)-poly(d,l-lactide) hydrogels: formulation, characterization, and antibacterial drug delivery Pharm. Res. 23 2006 205 214 (Pubitemid 43214677)
117. X. Yin, A.S. Hoffman, and P.S. Stayton Poly(N-isopropylacrylamide-co- propylacrylic acid) copolymers that respond sharply to temperature and pH Biomacromolecules 7 2006 1381 1385 (Pubitemid 43811191)
118. J. Yun Chang, Y.-K. Oh, H. SooKong, E. JungKim, D. DeukJang, K. TaekNam, and C.-K. Kim Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis J. Controlled Release 82 2002 39 50 (Pubitemid 34775046)
119. G.M. Zentner, R. Rathi, C. Shih, J.C. McRea, M.H. Seo, H. Oh, B.G. Rhee, J. Mestecky, Z. Moldoveanu, M. Morgan, and S. Weitman Biodegradable block copolymers for delivery of proteins and water-insoluble drugs J. Control. Rel. 72 2001 203 215 (Pubitemid 32522358)
120. J.X. Zhang, L.Y. Qiu, Y. Jin, and K.J. Zhu Thermally responsive polymeric micelles self-assembled by amphiphilic polyphosphazene with poly(N-isopropylacrylamide) and ethyl glycinate as side groups: polymer synthesis, characterization, and in vitro drug release study J. Biomed. Mater. Res. A 76 2006 773 780 (Pubitemid 47233486)
121. S. Zhou, X. Deng, and H. Yang Biodegradable poly(μ-caprolactone)- poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system Biomaterials 24 2003 3563 3570 (Pubitemid 36703130)
122. Z. Zhou, and B. Chu Light-scattering study on the association behavior of triblock polymers of ethylene oxide and propylene oxide in aqueous solution J. Colloid Interf. Sci. 126 1988 171 180