Ophthalmic drug delivery systems - Recent advances

Progress in Retinal and Eye Research

Volumn 17, Issue 1, 1998, Pages 33-58

  Le Bourlais, Chrystèle ^a   Acar, Liliane ^a   Zia, Hosein ^b   Sado, Pierre A ^a   Needham, Thomas ^b   Leverge, Roger ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; AGENTS ACTING ON THE EYE; AMIKACIN; BETAXOLOL; CARBONATE DEHYDRATASE INHIBITOR; CLINDAMYCIN; COLLAGEN; CYCLODEXTRIN; CYCLOSPORIN; EYE DROPS; FLURBIPROFEN; FUSIDIC ACID; GANCICLOVIR; GENTAMICIN; HYDROCORTISONE; LIPOSOME; METHYLPREDNISOLONE; NANOPARTICLE; PENICILLIN G; PILOCARPINE; TIMOLOL;

COLLOID; CORNEA PERMEABILITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RESEARCH; DRUG SOLUBILITY; DRUG TOLERANCE; GEL; HUMAN; HYDROGEL; INTRAOCULAR DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SUBCONJUNCTIVAL DRUG ADMINISTRATION; SUSTAINED RELEASE PREPARATION; TOPICAL DRUG ADMINISTRATION; VISUAL IMPAIRMENT;

ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL DRESSINGS; COLLAGEN; COLLOIDS; CYCLODEXTRINS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EYE; GELS; HUMANS; OPHTHALMIC SOLUTIONS;

EID: 0031965225     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1350-9462(97)00002-5     Document Type: Review

References (175)

1. Ahmed, I. and Patton, T. F. (1985) Importance of the noncorneal absorption route in topical ophthalmic drug delivery. Invest. Ophthalmol. Vis. Sci. 26: 584-587.
2. Ahmed, I. and Patton, T. F. (1987) Disposition of timolol and inulin in the rabbit eye following corneal versus non-corneal absorption. Int. J. Pharm. 38: 9-21.
3. Albertsson, A. C., Carlfors, J. and Sturesson, C. (1996) Preparation and characterization of poly(adipic anhydride) microspheres for ocular drug delivery. J. Appl. Polymer Science 62, 4: 695-705.
4. Alghadyan, A. A., Peyman, G. A., Khoobehi, B., Milner, S. and Liu, K. R. (1988) Liposome-bound cyclosporine: aqueous and vitreous level after subconjunctival injection. Int. Ophthalmol. 12: 101-104.
5. Allen, R. C., Boys-Smith, J. and Campbell, D. (1984) A one-year multicenter clinical trial of pilocarpine gel. Am. J. Ophthalmol. 97: 723-729.
6. al Mansouri, S., Tabbara, K. F. and Rask-Pedersen, E. (1994) Lubrithal (Leo viscous eye gel), precorneal residence time in normal and dry eyes. Doc. Ophthalmol. 88(2): 187-194.
7. Alonso, M. J., Calvo, P., Vila-Jato, J. L., Lopez, M. I., Llorente, J. and Pastor, J. C. (1995) Increased ocular corneal uptake of drugs using poly-ε-caprolactone nanocapsules and nanoemulsions, 22nd international Symposium Controlled Release Bioactive Materials, 30th July-4th August 1995, Seattle, USA.
8. Andermann, G., De Burlet, G. and Cannet, C. (1982) Etude comparative de l'activité antiglaucomateuse de Glauplex 2 et du nitrate de pilocarpine sur le glaucome expérimental à l'alpha-chymotrypsine. J. Fr. Ophtalmol. 5(8-9): 499-504.
9. Ayers, D., Cuthbertson, J. M., Schroyer, K. and Sullivan, S. M. (1996) Polyacrylic acid mediated ocular of ribozymes. J. Contr. Release 38: 167-175.
10. Barza, M., Baum, J. and Szoka, F. (1984) Pharmacokinetics of subconjunctival liposome-encapsulated gentamicin in normal rabbit eyes. Invest. Ophthalmol. Vis. Sci. 25: 486-490.
11. Benedetti, L. M., Topp, E. M. and Stella, V. J. (1990) Microspheres of hyaluronic acid esters fabrication methods and in vitro hydrocortisone release. J. Contr. Release 13: 33-41.
12. Bernatchez, S. F., Tabatabay, C. and Gurny, R. (1993) Sodium hyaluronate 0.25% used as vehicle increases the bioavailability of topically administered gentamicin. Graefes Arch. Clin. Exp. Ophthalmol. 231: 157-171.
13. Bloomfield, S. E., Miyata, T., Dunn, M. W., Bueser, N., Stenzel, K. H. and Rubin, A. L. (1978) Soluble gentamicin ophthalmic inserts as a drug delivery system. Arch. Ophthalmol. 96: 885-887.
14. Brechu, W. F. and Maren, T. H. (1993) pH and drug ionization affects ocular pressure lowering of topical carbonic anhydrase inhibitors. Invest. Ophthalmol. Vis. Sci. 34: 2581-2587.
15. Calvo, P., Thomas, C., Alonso, M. J., Vila-Jato, J. and Robinson, J. R. (1994) Study of the mechanism of interaction of poly(ε-caprolactone) nanocapsules with the cornea by confocal laser scanning microscopy. Int. J. Pharm. 103: 283-291.
16. Calvo, P., Vila-Lato, J. L. and Alonso, M. J. (1996a) Comparative in vitro evaluation of several colloidal systems, nanoparticles, nanocapsules, and nanoemulsions, as ocular drug carriers. J. Pharm. Sci. 85(5): 530-536.
17. Calvo, P., Sanchez, A., Martinez, J., Lopez, M. I., Calonge, M., Pastor, J. C. and Alonso, M. J. (1996b) Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A. Pharm. Res. 13(2): 311-315.
18. Chang, S. C., Chien, D. S., Bundgaard, H. and Lee, V. H. L. (1988) Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp. Eye Res. 46: 59-69.
19. Chang, S. C. and Lee, V. H. L. (1987) Nasal and conjunctival contributions to the systemic absorption of topical timolol in the pigmented rabbits: implications in the design of strategies to maximize the ratio of ocular to systemic absorption. J. Ocul. Pharmacol. 3: 159-169.
20. Cheeks, L., Kaswan, R. L. and Green, K. (1992) Influence of vehicle and anterior chamber protein concentration on cyclosporin penetration through the isolated rabbit cornea. Curr. Eye Res. 11(7): 641-649.
21. Chen, Y. F., Gebhardt, B. M., Reidy, J. J. and Kaufman, H. E. (1990) Cyclosporine-containing collagen shields suppress corneal allograft rejection. Am. J. Ophthalmol. 109: 132-137.
22. Das, S. K., Tucker, I. G., Hill, D. J. and Ganguly, N. (1995) Evaluation of poly(isobutylcyanoacrylate) nanoparticles for mucoadhesive ocular drug delivery. I. Effect of formulation variables on physicochemical characteristics of nanoparticles, Pharm. Res. 12(4): 534-540.
23. Davies, N. M., Farr, S. J., Hadgraft, J. and Kellaway, I. W. (1991) Evaluation of mucoadhesive polymers in ocular drug delivery. 1. Viscous solutions. Pharm. Res. 8(8): 1039-1043.
24. Davies, N. M., Farr, S. J., Hadgraft, J. and Kellaway, I. W. (1992) Evaluation of mucoadhesive polymers in ocular drug delivery. II. Polymer-coated vesicles. Pharm. Res. 9(9): 1137-1144.
25. Diaz-Llopis, M. and Menezo, J. L. (1989) Penetration of 2% cyclosporin eye-drops into human aqueous humor. Br. J. Ophthalmol. 73: 600-603.
26. Diaz-Llopis, M., Martos, M. J., Espana, E., Cervera, M., Vila, A. O., Navea, A., Molina, F. J. and Romero, F. J. (1992) Liposomally-entrapped ganciclovir for the treatment of cytomegalovirus retinitis in AIDS patients. Doc. Ophthalmol. 82: 297-305.
27. Dickstein, K. and Aarsland, T. (1996) Comparison of the effects of aqueous and gellan ophthalmic timolol on peak exercise performance in middle-age men. Am. J. Ophthalmol. 121(4): 367-371.
28. Diepold, R., Kreuter, J., Himber, J., Gurny, R., Lee, V. H. L., Robinson, J. R., Saettone, M. F. and Schnaudigel, O. E. (1989) Comparison of different models for the testing of pilocarpine eye-drops using conventional eye-drops and a novel depot formulation (nanoparticles). Graefes Arch. Clin. Exp. Ophthalmol. 227: 188-193.
29. Dimitriu, S., Popa, M., Vancea, D. and Costin, D. (1988) Polycomponent ophthalmic inserts with polysaccharide support. J. Bioactive Compatible Polymers 3: 370-383.
30. Dittgen, M., Oestereich, S. and Eckhardt, D. (1992) Influence of bioadhesion on the elimination of drugs from the eye and on their penetration ability across the pig cornea. S.T.P. Pharm. Sci. 2(1): 93-97.
31. Duchêne, D., Touchard, F. and Peppas, N. A. (1988) Pharmaceutical and medical aspects of bioadhesive systems of drug administration. Drug dev. Indust. Pharmacy 14(2-3): 283-318.
32. Dudinski, O., Finnin, B. C. and Reed, B. L. (1983) Acceptability of thickened eye-drops to human subjects. Curr. Eye Res. 33: 322-337.
33. Durrani, A. M., Davies, N. M., Thomas, M. and Kellaway, I. W. (1992) Pilocarpine bioavailability from a mucoadhesive liposomal ophthalmic drug delivery system. Int. J. Pharm. 88: 409-415.
34. Durrani, A. M., Farr, S. J. and Kellaway, I. W. (1995) Influence of molecular weight and formulation pH on the precorneal clearance rate of hyaluronic acid in rabbit eye. Int. J. Pharm. 118(2): 243-250.
35. Fessi, H., Puisieux, F., Devissaguet, J. P., Ammoury, N. and Benitas, S. (1989) Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int. J. Pharm. 55: R1-R4.
36. Fiscella, R., Peyman, G. A. and Fishman, P. H. (1987) Duration of therapeutic levels of intravitreally-injected liposome-encapsulated clindamicin in the rabbit. Can. J. Ophthalmol. 22: 307-309.
37. Fishman, P. H., Peyman, G. A. and Lesar, T. (1986) Intravitreal liposome-encapsulated gentamicin in a rabbit model. Invest. Ophthalmol. Vis. Sci. 27: 1103-1106.
38. Fitzgerald, P., Hadgraft, J., Kreuter, J. and Wilson, C. G. (1987) A gamma scintigraphic evaluation of microparticulate ophthalmic delivery systems: liposomes and nanoparticles. Int. J. Pharm. 40: 81-84.
39. Fitzgerald, P. and Wilson, C. G. (1994) Polymeric systems for ophthalmic drug delivery. In: Polymeric Biomaterials (S. Dimitriu, ed.) pp. 373-398. Marcel Dekker, New York.
40. Freedman, K. A., Klein, J. W. and Crosson, C. E. (1993) Beta-cyclodextrins enhance bioavailability of pilocarpine. Curr. Eye Res. 12: 641-647.
41. Gilbert, J. C., Hadgraft, J., Bye, A. and Brookes, L. G. (1986) Drug release from Pluronic F-127 gels. Int. J. Pharm. 32: 223-228.
42. Grass, G. M. and Robinson, J. R. (1988) Mechanisms of corneal drug penetration II: Ultrastructural analysis of potential pathways for drug movement. J. Pharm. Sci. 77: 15-23.
43. Greaves, J. L., Olejnik, O. and Wilson, C. G. (1992) Polymers and the precorneal tear film. S.T.P. Pharm. Sci. 2(1): 13-33.
44. Greaves, J. L., Wilson, C. G., Rozier, A., Grove, J. and Plazonnet, B. (1990) Scintigraphic assessment of an ophthalmic gelling vehicle in man and rabbit. Curr. Eye Res. 9(5): 415-420.
45. Gunning, F. P., Greve, E. L., Bron, A. M., Bosc, J. M., Royer, J. G., George, J. L., Lesure, P. and Sirbat, D. (1993) Two topical carbonic anhydrase inhibitors sezolamide and dorzolamide in Gelrite vehicle: a multiple-dose efficacy study. Graefes Arch. Clin. Exp. Ophthalmol. 231: 384-388.
46. Gurny, R. (1981) Preliminary study of prolonged acting drug delivery system for the treatment of glaucoma. Pharm. Acta Helvetica 56(4-5): 130132.
47. Gurny, R., Boye, T. and Ibrahim, H. (1985) Ocular therapy with nanoparticulate systems for controlled drug delivery. J. Contr. Rel. 2: 353-361.
48. Gurny, R., Ibrahim, H., Aebi, A., Buri, P., Wilson, C. G., Washington, N., Edman, P. and Camber, O. (1987) Design and evaluation of controlled release systems for the eye. J. Contr. Rel. 6: 367-373.
49. Gurny, R., Ibrahim, H. and Buri, P. (1993) The development and use of in situ formed gels triggered by pH. In: Biopharmaceutics of Ocular Drug Delivery (P. Edman, ed.) pp. 81-90. CRC Press, Boca Raton, Florida.
50. Gurny, R., Ryser, J. E., Tabatabay, C., Martenet, M., Edman, P. and Camber, O. (1990) Precorneal residence time in humans of sodium hyaluronate as measured by gamma scintigraphy. Graefe's Arch. Clin. Ophthalmol. 228: 510-512.
51. Gurtler, F. and Gurny, R. (1995) Patent literature review of ophthalmic inserts. Drug Dev. Indust. Pharmacy. 21(1): 1-18.
52. Harmia, T., Speiser, P., Kreuter, J., Boye, T., Gurny, R. and Kubis, A. (1986) Enhancement of the miotic response of rabbits with pilocarpine-loaded poly-butylcyanoacrylate nanoparticles. Int. J. Pharm. 33: 187-193.
53. Huffman, A., Chen, G., Kaang, S. and Priebe, D. T. (1995) New bioadhesive polymer compositions for prolonged drug release in the eye. Proc. Int. Symp. Control. Rel. Bioact. Mater., 22, CRS.
54. Horven, I. (1993) Acute conjunctivitis. A comparison of fusidic acid viscous eye-drops and chloramphenicol. Acta Ophthalmol. Copenh. 71(2): 165-168.
55. Huang, A. J. W., Tseng, S. C. G. and Kenyon, K. R. (1989) Paracellular permeability of corneal and conjunctival epithelia. Invest. Ophthalmol. Vis. Sci. 30: 684-689.
56. Jani, R., Can, O., Ali, Y., Rodstrom, R. and Hancock, S. (1994) Ion exchange resins for ophthalmic delivery. J. Ocul. Pharmacol. 10(1): 57-67.
57. Jansen, T., Xhonneux, B., Mesens, J. and Borgers, M. (1990) Beta-cyclodextrins as vehicles in eye-drop formulations: an evaluation of their effects on rabbit corneal epithelium. Lens Eye Toxicity Res. 7: 459-468.
58. Jarho, P., Järvinen, K., Urtti, A., Stella, V. J. and Järvinen, T. (1996) Modified β-cyclodextrin (SBE7-β-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits. J. Pharm. Pharmacol. 48: 263-269.
59. Järvinen, K., Järvinen, T., Thompson, D. O. and Stella, V. (1994) The effect of a modified β-cyclodextrin, SBE-β-CD, on the aqueous stability and ocular absorption of pilocarpine. Curr. Eye Res. 13(12): 897-905.
60. Järvinen, K., Järvinen, T. and Urtti, A. (1995) Ocular absorption following topical delivery. Adv. Drug Delivery Rev. 16: 3-19.
61. Järvinen, K., Vartiainen, E. and Urtti, A. (1992) Optimizing the systemic and ocular absorption of timolol from eye-drops. S.T.P. Pharm. Sci. 2(1): 105-110.
62. Kanai, A., Alba, R. M., Takano, T., Kobayashi, C., Nakajima, A., Kurihara, K., Yokoyama, T. and Fukami, M. (1989) The effect on the cornea of alpha cyclodextrin vehicle for cyclosporin eye-drops. Transplant. Proc. 21(1): 3150-3152.
63. Kaufman, H. E., Steinemann, T. L., Lehman, E., Thompson, H. W., Varnell, E. D., Jacob-Labarre, J. T. and Gebhardt, B. M. (1994) Collagen-based drug delivery and artificial tears. J. Ocul. Pharmacol. 10(1): 17-27.
64. Kelly, J., Molyneux, P. D., Smith, S. A. and Smith, S. E. (1989) Relative bioavailability of pilocarpine from a novel ophthalmic delivery system and conventional eyedrop formulations. Br. J. Ophthalmol. 7: 360-362.
65. Koller, C. and Buri, P. (1987) Propriétés et intérêt pharmaceutique des gels thermoréversibles à base de poloxamers et poloxamines. S.T.P. Pharm. Sci. 3: 115-124.
66. Kreuter, J. (1990) Nanoparticles as bioadhesive ocular drug delivery systems. In: Bioadhesive Drug Delivery Systems (V. Lenaerts and R. Gurny, eds), Chapter 11, pp. 203-212. CRC Press, Boca Raton, Florida.
67. Kreuter, J. and Speiser, P. P. (1976) In vitro studies of poly(methyl methacrylate) adjuvents. J. Pharm. Sci. 65: 1624-1627.
68. Kristinsson, J. K., Fridriksdottir, H., Thorisdottir, S., Sigurdardottir, A. M., Stefansson, E. and Loftsson, T. (1996) Dexamethasone-cyclodextrin-polymer cocomplexes in aqueous eye-drops. Aqueous humor pharmacokinetics in humans. Invest. Ophthalmol. Vis. Sci. 37(6): 1199-1203.
69. Kumar, S., Haglund, B. O. and Himmelstein, K. J. (1995) In situ-forming gels for ophthalmic drug delivery. J. Ocul. Pharmacol. 10(1): 47-56.
70. Kumar, S. and Himmelstein, K. J. (1995) Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose. J. Pharm. Sci. 84(3): 344-348.
71. Kyyrönen, K., Hume, L., Benedetti, L., Urtti, A., Topp, E. and Stella, V. (1992) Methylprednisolone esters of hyaluronic acid in ophthalmic drug delivery: in vitro and in vivo release studies. Int. J. Pharm. 80: 161-169.
72. Kyyrönen, K. and Urtti, A. (1990) Improved ocular: systemic absorption ratio of timolol by viscous vehicle and phenylephrine. Invest. Ophthalmol. Vis. Sci. 31(9): 1827-1833.
73. Lang, J. C. (1995) Ocular drug delivery conventional ocular formulations. Adv. Drug Delivery Rev. 16: 39-43.
74. Le Bourlais, C., Chevanne, F., Ropert, P., Bretagne, G., Acar, L., Zia, H., Sado, P. A., Needham, T. E. and Leverge, R. (1996) Release kinetics of liposome-encapsulated ganciclovir after intravitreal injection in rabbits. J. Microencapsulation 13(4): 473-480.
75. Le Bourlais, C., Chevanne, F., Turlin, B., Acar, L., Zia, H., Sado, P. A., Needham, T. E. and Leverge, R. (1997) Effect of cyclosporine A formulations on bovine corneal absorption: ex-vivo study. J. Microencapsulation, 14(4): 457-467.
76. Lee, V. H. L. (1990) Review: New Directions in the optimization of ocular drug delivery. J. Ocul. Pharmacol. 6(2): 157-164.
77. Lee, V. H. L. (1993) Application of liposomes in ocular drug delivery. In: Liposomes in Ophthalmology and Dermatology, (U. Pleyer, K. Schmidt and H. J. Thiel, eds) pp. 53-59. Hippokrates, Stuttgart.
78. Lee, B. L., Matoba, A. Y., Osato, M. S. and Robinson, N. M. (1992) The solubility of antibiotic and corticosteroid combinations. Am. J. Ophthalmol. 114: 212-215.
79. Lee, V. H. L. and Robinson, J. R. (1979) Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits. J. Pharm. Sci. 68(6): 673-684.
80. Lee, V. H. L., Urrea, P. T., Smith, R. E. and Schanzlin, D. J. (1985) Ocular drug bioavailability from topically applied liposomes. Surv. Ophthalmol. 29(5): 335-348.
81. Lehr, C. M., Yong, H. L. and Lee, V. H. L. (1994) Improved ocular penetration of gentamicin by mucoadhesive polymer polycarbophil in the pigmented rabbit. Invest. Ophthalmol. Vis. Sci. 35(6): 2809-2814.
82. Li, V. H. K., Wood, R. W., Kreuter, J., Harmia, T. and Robinson, J. R. (1986) Ocular drug delivery of progesterone using nanoparticles. J. Microencapsulation 3(3): 213-218.
83. Liaw, J. and Robinson, J. R. (1992) The effect of polyethylene glycol molecular weight on corneal transport and the related influence of penetration enhancers. Int. J. Pharm. 88: 125-140.
84. Liaw, J., Rojanasakul, Y. and Robinson, J. R. (1992) The effect of drug charge type and charge density on corneal transport. Int. J. Pharm. 88: 111-124.
85. Liesang, T. J. (1990) Viscoelastic substances in ophthalmology. Surv. Ophthalmol. 34(4): 268-293.
86. Liu, K. R., Peyman, G. A., She, S. C., Niesman, M. R. and Khoobehi, B. (1989) Efficacy of liposome-bound amphotericin B for the treatment of experimental fungal endophtalmitis in rabbits. Invest. Ophthalmol. Vis. Sci. 30(7): 1527-1534.
87. Llaroche, L., Arrata, M., Brasseur, G., Lagoutte, F., Le Mer, Y., Lumbrooso, P. and Mercante, M. (1991) Treatment of dry eye syndrome with lacrimal gel: a randomized multicenter study. J. Fr. Ophthalmol. 14(5): 3321-3326.
88. Losa, C., Alonso, M. J., Vila-Jato, J. L., Orallo, F., Martinez, J., Saavedra, J. A. and Pastor, J. C. (1992) Reduction of cardiovascular side effects associated with ocular administration of metipranolol by inclusion in polymeric nanocapsules. J. Ocul. Pharmacol. 8(3): 191-198.
89. Losa, C., Calvo, P., Castro, E., Vila-Jato, J. L. and Alonso, M. J. (1991) Improvement of ocular penetration of amikacin sulphate by association to poly(butylcyanoacrylate) nanoparticles. J. Pharm. Pharmacol. 43: 548-552.
90. Losa, C., Marchal-Heussler, L., Orallo, F., Vila-Jato, J. L. and Alonso, M. J. (1993) Design of new formulations for topical ocular administration: polymeric nanocapsules containing metipranolol. Pharm. Res. 10(1): 80-87.
91. Ludwig, A. and Van Ooteghem, M. (1988) Influence of the viscosity and the surface tension of ophthalmic vehicles on the precorneal area of human eyes. Drug dev. Ind. Pharmacy 14: 2267-2284.
92. Ludwig, A. and van Ooteghem, M. (1992) Influence of viscoslysers on the residence of ophthalmic solutions evaluated by slip lamp fluorophotometry. S.T.P. Pharm Sci. 2(1): 81-87.
93. Mahlberg, K., Uusitalo, R. J., Gebhart, B. and Kaufman, H. E. (1991) Prevention of experimental corneal allograft rejection in rabbits using cyclosporin-collagen shields. Graefes Arch. Ophthalmol. 229: 69-74.
94. Maincent P., Marchal-Heussler, L., Thouvenot, P., Sirbat, D., Hoffman, M., Vallet, J. A. and Bergamini, M. (1995) Ocular distribution of indium oxine following topical administration of poly(epsilon caprolactone) nanocapsules. 22nd International Symposium Controlled Release Bioactive Materials, 30 July-4 August 1995, Seattle, USA.
95. Marchal-Heussler, L., Fessi, H., Devissaguet, J. P., Hoffman, M. and Maincent, P. (1992) Colloidal drug delivery systems for the eye: a comparison of the efficacy of three different polymers: polyisobutylcyanoacrylate polylactic-co-glycolic acid, poly-ε-caprolactone. S.T.P. Pharm. Sci. 2(1): 98-104.
96. Marchal-Heussler, L., Maincent, P., Hoffman, M., Spittler, J. and Couvreur, P. (1990) Antiglaucomatous activity of betaxolol chlorhydrate sorbed onto different isobutylcyanoacrylate nanoparticles preparations. Int. J. Pharm. 58: 115-122.
97. Marchal-Heussler, L., Sirbat, D., Hoffman, M. and Maincent, P. (1993) Poly(ε-caprolactone) nanocapsules in carteolol ophthalmic delivery. Pharm. Res. 10(3): 386-390.
98. Maren, T. H. and Jankowska, L. (1985) Ocular pharmacology of sulfonamides: the cornea as barrier and depot. Curr. Eye Res. 4: 399-408.
99. Marriott, C. and Gregory, N. P. (1990) Mucus physiology and pathology. In: Bioadhesive Drug Delivery Systems (V. Lenearts and R. Gurny, eds) pp. 2-24. CRC Press, Boca Raton, Florida.
100. Maurice, D. M. and Srinivas, S. P. (1992) Use of fluorimetry in assessing the efficacy of a cation-sensitive gel as an ophthalmic vehicle: comparison with scintigraphy. J. Pharm. Sci. 81: 615-619.
101. Mayer, H. and Von der Ohe, N. (1996) Efficacy of a novel hydrogel formulation in human volunteers. Ophthalmologica 210(2): 101-103.
102. Meisner, D. and Mezei, M. (1995) Liposome ocular delivery systems. Adv. Drug Delivery Rev. 16: 75-93.
103. Mengi, S. and Deshpande, S. G. (1992) Development and evaluation of flurbiprofen hydrogels on the breakdown of the blood/aqueous humor barrier. S.T.P. Pharm. Sci. 2(1): 118-124.
104. Meseguer, G., Gurny, R. and Buri, P. (1994) In vivo evaluation of dosage forms: application of gamma scintigraphy to non-enteral routes of administration. J. Drug Targeting 2: 269-288.
105. Mezei, M. and Gulasekharam, V. (1982) Liposomes-A selective drug delivery system for the topical route of administration: gel dosage form. J. Pharm. Pharmacol. 34: 473-474.
106. Middleton, D. L., Leung, S. S. and Robinson, J. R. (1990) Ocular bioadhesive delivery systems. In Bioadhesive Drug Delivery Systems (V. Lenaerts and R. Gurny, eds) pp. 180-199. CRC Press, Boca Raton, Florida.
107. Middleton, D. L. and Robinson, J. R. (1991) Design and evaluation of an ocular bioadhesive delivery system. S.T.P. Pharm. Sci. 1(3): 200-206.
108. Milani, J. K., Pleyer, U., Dukes, A., Chou, J., Lutz, S., Rückert, D., Schmidt, K. and Mondino, B. J. (1993) Prolongation of corneal allograft survival with liposome-encapsulated cyclosporine in the rat eye. Ophthalmology 100(6): 890-896.
109. Miller, S. C. and Donovan, M. D. (1982) Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. Int. J. Pharm. 12: 147-152.
110. Minguez, E., Tiestos, M. T., Cristobal, J. A., Castillo, J., Dapena, M. P. and Palomar, A. (1992) Absorption intra-oculaire du collyre de cyclosporineA. J. Fr. Ophthalmol. 15(4): 263-267.
111. Mishima, S. (1981) Clinical pharmacokinetics of the eye -Proctor lecture. Invest. Ophthalmol. Vis. Sci. 21(4): 504-541.
112. Moorhouse, R., Colegrove, G. T., Sandford, P. A., Baird, J. K. and Kan, K. S. (1981) PS-60: a new gel-forming polysaccharide. In: Solution Properties of Polysaccharides (D. A. Brandt, ed.) pp. 111-124. Washington, D.C.
113. Muchtar, S., Almog, S., Torraca, M. T., Saettone, M. F. and Benita, S. (1992) A submicron emulsion as ocular vehicle for delta-8-tetrahydrocannabinol: effect on intraocular pressure in rabbits. Ophthalmic Res. 24: 142-149.
114. Nagasubramamian, S., Stewart, R. and Hitchings, R. (1994) Long-term effects of glaucoma therapy with 4% pilocarpine gel on corneal clarity and endothelial cell density. Int. Ophthalmol. 18: 5-8.
115. Naveh, N., Muchtar, S. and Benita, S. (1994) Pilocarpine incorporated into a submicron emulsion vehicle causes an unexpectedly prolonged ocular hypotensive effect in rabbits. J. Ocul. Pharmacol. 10(3): 509-520.
116. O'Brien, T. P., Sawusch, M. R., Dick, J. D., Hamburg, T. R. and Gottsch, J. D. (1988) Use of collagen shields versus soft contact lenses to enhance penetration of topical tobramycin. J. Cataract Refract. Surg. 14: 505-507.
117. Park, H. and Robinson, J. R. (1985) Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion. J. Contr. Rel. 2: 47-57.
118. Park, H. and Robinson, J. R. (1987) Mechanisms of mucoadhesion of poly(acrylic acid) and hydrogels. Pharm. Res. 4(6): 457-464.
119. Peyman, G. A., Khoobehi, B., Tawakol, M. E., Schulman, J. A., Mortada, H. A., Alkan, H. and Fiscella, R. (1987) Intravitreal liposome-encapsulated ganciclovir in a rabbit model. Retina 7: 227-229.
120. Pleyer, U., Elkins, B., Rückert, D., Lutz, S., Grammer, J., Chou, J., Schmidt, K. H. and Mondino, B. J. (1994) Ocular absorption of cyclosporine A from liposomes incorporated into collagen shields. Curr. Eye Res. 13: 177-181.
121. Ponchel, G., Touchard, F., duchêne, D. and Peppas, N. A. (1987) Bioadhesive analysis of controlled-release systems. I. Fracture and interpenetration analysis in poly(acrylic acid)-containing systems. J. Contr. Rel. 5: 129-141.
122. Reer, O., Bock, T. K. and Muller, B. W. (1994) In vitro corneal permeability of diclofenac sodium in formulations containing cyclodextrins compared to the commercial product voltaren ophta. J. Pharm. Sci. 83(9): 1345-1349.
123. Reidy, J. J., Gebhardt, B. M. and Kaufman, H. E. (1990) The collagen shield: a new vehicle for delivery of cyclosporine to the eye. Cornea 9(3): 196-199.
124. Robinson, J. R. (1989) Ocular drug delivery mechanism(s) of corneal drug transport and mucoadhesive delivery systems. S.T.P. Pharm. Sci. 5(12): 839-846.
125. Robinson, J. R. and Mlynek, G. M. (1995) Bioadhesive and phase-change polymers for ocular drug delivery. Adv. Drug Delivery Rev. 16: 45-50.
126. Rojanasakul, Y., Wang, L. Y., Bhat, M., Glover, D. D., Malanga, C. J. and Ma, J. K. H. (1992) The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit. Pharm. Res. 9: 1029-1034.
127. Rolland, A., Gibassier, D., Sado, P. A. and Leverge, R. (1986) Méthodologie de préparation de vecteurs nanoparticulaires à base de polymères acryliques. J. Pharm. Belg. 41(2): 83-93.
128. Rollot, J. M., Couvreur, P., Roblot-Treupel, L., Devissaguet, J. P. and Puisieux, F. (1986) Physico-chemical and morphological characterization of polyisobutylcyanoacrylate nanocapsules. J. Pharm. Sci. 75: 361-364.
129. Romanelli, L., Valeri, P., Morrone, L. A., Pimpinella, G., Graziani, G. and Tita, B. (1994) Ocular absorption and distribution of bendazac after topical administration to rabbits with different vehicles. Life Sci. 54(13): 877-885.
130. R: a novel, ion-activated, in situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol. Int. J. Pharm. 57: 163-168.
131. Saettone, M. F., Chetoni, P., Torraca, M. T., Burgalassi, S. and Giannaccini, B. (1989) Evaluation of mucoadhesive properties and in vivo activity of ophthalmic vehicles based on hyaluronic acid. Int. J. Pharm. 51: 203-212.
132. Saettone, M. F., Giannaccini, B., Guiducci, A. and Savigni, P. (1986) Semi-solid ophthalmic vehicles. III. An evaluation of four organic hydrogels containing pilocarpine. Int. J. Pharm. 31: 261-270.
133. Saettone, M. F., Teneggi, A., Savigni, P. and Tellini, N. (1982) Vehicle effects on ophthalmic bioavailability. The influence of different polymers. J. Pharm. Pharmacol. 34: 464-466.
134. Sanzgiri, Y. D., Maschi, S., Crescenzi, V., Callegaro, L., Topp, E. M. and Stella, V. J. (1993) Gellan-based systems for ophthalmic sustained delivery of methylprednisolone. J. Contr. Release 26: 195-201.
135. Sasamoto, Y., Hirose, S., Ohno, S., Onoé, K. and Matsuda, H. (1991) Topical application of ciclosporin ophthalmic solution containing alpha-cyclodextrin in experimental uveitis. Ophthalmologica 203: 118-125.
136. Sawusch, M. R., O'Brien, T. P., Dick, J. D. and Ottsch, J. D. (1988) Use of collagen corneal shields in the treatment of bacterial keratitis. Am. J. Ophthalmol. 106: 279-281.
137. Sawusch, M. R., O'Brien, T. P. and Updegraff, S. (1989) Collagen corneal shields enhance penetration of prednisolone acetate. J. Cataract Refract. Surg. 15: 625-628.
138. Schaeffer, H. E. and Krohn, D. L. (1982) Liposomes in topical drug delivery. Invest. Ophthalmol. Vis. Sci. 22: 220-227.
139. Schoenwald, R. D. (1990) Ocular drug delivery - pharmacokinetic considerations. Clin. Pharmacokinetics 18(4): 255-269.
140. Schoenwald, R. D. and Huang, H. S. (1983) Corneal penetration behaviour of β-blocking agents I: physicochemical factors. J. Pharm. Sci. 72: 1266-1272.
141. Schoenwald, R. D. and Ward, R. (1978) Relationship between steroid permeability across excised rabbit cornea and octanol-water partition coefficients. J. Pharm. Sci. 67: 786-788.
142. Schwartz, S. D., Harrison, S. A., Engstrom, R. E., Bawden, R. E., Lee, D. A. and Mondino, B. J. (1990) Collagen shield delivery of Amphotericin B. Am. J. Ophthalmol. 109: 701-704.
143. Shek, P. N. and Barber, R. F. (1987) Liposomes are effective carriers for the ocular delivery of prophylactics. Biochim. Biophys. Acta 902: 229-236.
144. Shell, J. W. (1982) Ocular drug delivery systems - a review. J. Toxicol. 1(1): 49-63.
145. Shell, J. W. (1985) Ophthalmic drug delivery systems. Drug Dev. Res. 6: 245-261.
146. Sieg, J. W. and Robinson, J. R. (1977) Vehicle effects on ocular drug bioavailability II: Evaluation of pilocarpine. J. Pharm. Sci. 66: 1222-1228.
147. Singh, K. and Mezei, M. (1983) Liposomal ophthalmic drug delivery system. I. Triamcinolone acetonide. Int. J. Pharm. 16: 339-344.
148. Singh, K. and Mezei, M. (1984) Liposomal ophthalmic drug delivery system. II. Dihydrostreptomycin sulfate. Int. J. Pharm. 19: 263-269.
149. Slovin, E. M. and Robinson, J. R. (1993) Bioadhesives in ocular drug delivery. In: Biopharmaceutics of Ocular Drug Delivery (P. Edman, ed.) pp. 145-157. CRC Press, Boca Raton, Florida.
150. Snibson, G. R., Greaves, J. L., Soper, N. D. W., Prydal, J. I., Wilson, C. G. and Bron, A. J. (1990) Precorneal residence time of sodium hyaluronate solutions studied by gamma scintigraphy. Eye 4: 594-602.
151. Suhonen, P., Järvinen, T., Lehmussaari, K., Reunamäki, T. and Urtti, A. (1995) Ocular absorption and irritation of pilocarpine prodrug is modified with buffer, polymer, and cyclodextrin in the eyedrop. Pharm. Res. 12(4): 529-533.
152. Szejtli, L. (1994) Medicinal applications of cyclodextrins. Med. Res. Rev. 14(3): 353-386.
153. Szulc, J., Woyczikowski, B. and De Laval, W. (1988) Effect of pilocarpine hydrochloride liposomes on the intraocular pressure of the rabbit eye pupil. Farm. Pol. 44: 462-465.
154. Taniguchi, K., Yamamoto, Y., Itakura, K., Miichi, H. and Hayashi, S. (1988) Assessment of ocular irritability of liposome preparation. J. Pharmacobiodyn. 11: 607-611.
155. Thermes, F., Rozier, A., Plazonnet, B. and Grove, J. (1992a) Bioadhesion: the effect of polyacrylic acid on the ocular bioavailability of timolol. Int. J. Pharm. 8(1): 59-65.
156. Thermes, F., Grove, J., Chastaing, G., Rozier, A., Soper, K. and Plazonnet, B. (1992b) Effect of the mucolytic agent, acetylcysteine, on bioadhesion and ocular penetration. S.T.P. Pharm. Sci. 2(1): 88-92.
157. Ticho, U., Blumenthal, M., Zonis, S., Gal, A., Blank, I. and Mazor, Z. W. (1979) A clinical trial with Piloplex a new long-acting pilocarpine compound: preliminary report. Ann. Ophthalmol. 4: 555-561.
158. Tous, S. S. and El Nasser, K. A. (1992) Acetazolamide topical formulation and ocular effect. S.T.P. Pharma. Sci. 2(1): 125-131.
159. Unterman, S. R., Rootman, D. S., Hill, J. M., Parelman, J. J., Thompson, H. W. and Kaufman, H. E. (1988) Collagen shield drug delivery: therapeutic concentrations of tobramycin in the rabbit cornea and aqueous humor. J. Cataract Refract. Surg. 14: 500-504.
160. Urtti, A., Rouhiainen, H., Kaila, T. and Saano, V. (1994) Controlled ocular timolol delivery: systemic absorption and intraocular pressure effects in humans. Pharm. Res. 11: 1278-1282.
161. Usayapant, A., Karara, A. H. and Narurkar, M. M. (1991) Effect of 2-hydroxypropyl-β-cyclodextrin on the ocular absorption of dexamethasone and dexamethasone acetate. Pharm. Res. 8(12): 1495-1499.
162. Vadnere, M., Amidon, G., Lindenbaum, S. and Haslam, J. L. (1984) Thermodynamic studies on the gel-sol transition of some pluronic polyols. Int. J. Pharm. 22: 207-218.
163. Van Ooteghem, M. (1995) In: Préparations Ophtalmiques, ed. Galenica, Technique and documentation. Lavoisier, Paris.
164. Vasantha, R., Sehgal, P. K. and Panduranga Rao, K. (1988) Collagen ophthalmic inserts for pilocarpine drug delivery system. Int. J. Pharm. 47: 95-102.
165. Verschueren, E., Van Santvliet, L. and Ludwig, A. (1996) Evaluation of various carrageenans as ophthalmic viscolysers. S.T.P. Pharm. Sci. 6(3): 203-210.
166. Vogel, R., Kulaga, S. F., Laurence, J. K., Gross, R. L., Haik, B. G., Karp, D., Koby, M. and Zimmerman, T. J. (1990) The effect of a Gelrite (G) vehicle on the efficacy of low concentrations of timolol (T). Invest. Ophthalmol. Vis. Sci. 31: 404.
167. Vyas, S. P., Ramchandraiach, S., Jain, C. P. and Jain, S. K. (1992) Polymeric pseudolatices bearing pilocarpine for controlled ocular delivery. J. Microencapsulation 9(3): 347-355.
168. Weinreb, R. N. and Jani, R. (1992) A novel formulation of an ophthalmic β-adrenoreceptor antagonist. J. Parenteral. Sci. Tech. 46(2): 51-53.
169. Wiederholdt, M., Kossendrup, D., Schulz, W. and Hoffman, F. (1986) Pharmacokinetics of topical cyclosporin A in the rabbit eye. Invest. Ophthalmol. Vis. Sci. 27: 519-524.
170. Wood, R. W., Li, V. H., Kreuter, J. and Robinson, J. R. (1985) Ocular disposition of poly-hexyl-2-cyano-[3-14C]-acrylate nanoparticles in the albino rabbit. Int. J. Pharm. 23: 175-183.
171. Zignani, M., Tabatabay, C. and Gurny, R. (1995) Topical semi-solid drug delivery: kinetics and tolerance of ophthalmic hydrogels. Adv. Drug Delivery Rev. 16: 51-60.
172. Zimmer, A. K., Kreuter, J. and Robinson, J. R. (1991) Studies on the transport pathway of PBCA nanoparticles in ocular tissues. J. Microencapsulation 8(4): 497-504.
173. Zimmer, A. K., Zerbe, H. and Kreuter, J. (1994) Evaluation of pilocarpine-loaded albumin particles as drug delivery systems for controlled delivery in the eye. I. In vitro and in vivo characterization. J. Contr. Rel. 32: 57-70.
174. Zimmer, A. K., Chetoni, P., Saettone, M. F., Zerbe, H. and Kreuter, J. (1995) Evaluation of pilocarpine-loaded albumin particles as controlled drug delivery systems for the eye. II. Co-administration with bioadhesive and viscous polymers. J. Contr. Rel. 33: 31-46.
175. Zimmer, A. K. and Kreuter, J. (1995) Microspheres and nanoparticles used in ocular delivery systems. Adv. Drug Delivery Rev. 16: 61-73.