Studies on in situ hydrogel: A smart way for safe and sustained ocular drug delivery

Journal of Young Pharmacists

Volumn 2, Issue 2, 2010, Pages 116-120

  Shastri, D H ^a   Patel, L D ^b   Parikh, R K ^c  

^a K B INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

^b Faculty of Pharmacy and Research   (India)

^c L M COLLEGE OF PHARMACY   (India)

Author keywords

Carbopol 940; cromolyn sodium; in situ gelation; ophthalmic delivery; Pluronic F 127

Indexed keywords

ALGINIC ACID; CARBOPOL 940; CROMOGLYCATE DISODIUM; HYDROXYPROPYLMETHYLCELLULOSE; POLOXAMER; XANTHAN;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FLOW KINETICS; GELATION; HYDROGEL; IN VITRO STUDY; PH; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; VISCOSITY;

EID: 78049390868     PISSN: 09751483     EISSN: 09751505     Source Type: Journal    
DOI: 10.4103/0975-1483.63144     Document Type: Article

References (14)

1. Wood RW, Li VH, Kreuter J, Robinson JR. Ocular disposition of poly-hexyl-2-cyanol[3-14C]acrylate nanoparticles in the albino rabbit. Int J Pharm 1985;23:175-83.
2. Wagh VD. Inamdar B. Samanta MK. Polymers used in ocular dosage form and drug delivery systems. Asian J Pharm 2008;2:12-7.
3. Lee VH, Robinson JR. Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits. J Pharm Sci 1979;68:673-84.
4. Ching HS, Park H, Kelly P, Robinson JR. Bioadhesive polymers as platforms for oral controlled drug delivery II: Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J Pharm Sci 1985;74:399-405.
5. Lee VH. Topical ocular drug delivery: Recent advances and future prospective. Int J Pharm 1985;6:135-8.
6. Lee VHL. Robinson JR. Topical ocular drug delivery: recent developments and future challenges. J Ocular Pharmacol 1986;2:67-108.
7. Miller SC, Donovan MD. Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. Int J Pharm 1982;12:147-52.
8. Haslam JL, Higuchi T, Mlodozeniec AR. Drug delivery system utilizing thermosetting gels. US Patent 1984;4:474-752.
9. Lindell K, Engstrom S. In-vitro release of timolol maleate from an in-situ gelling polymer system. Int J Pharm 1993;95:219-28.
10. Gurny R, Boye T, Ibrahim H. Ocular therapy with nanoparticulate systems for controlled drug delivery. J Control Release 1985;2:353-61.
11. Rozier A, Mazuel C, Grove J, Plazonnet B. Gelrite: A novel ion-activated, in-situ gelling polymer for ophthalmic vehicles. Int J Pharm 1989;57:163-8.
12. Tabbara KF. Tear tryptase in vernal kerato-conjunctivitis. Arch Ophthalmol 2001;119:338-42.
13. Lin HR, Sung KC. Carbopol/Pluronic phase change solutions for ophthalmic drug delivery. J Control Rel 2000;69:379-88.
14. United States Pharmacopoeia (USP-23), 1995. p. 774-5, 2227.