Characterization and in-vivo ocular absorption of liposome-encapsulated acyclovir

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 5, 1999, Pages 565-576

  Fresta, Massimo ^a   Panico, Anna Maria ^a   Bucolo, Claudio ^b   Giannavola, Claudia ^a   Puglisi, Giovanni ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b Fidia Oftal Research Laboratories   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPOSOME;

ANIMAL EXPERIMENT; AQUEOUS HUMOR; CONFERENCE PAPER; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; ENCAPSULATION; HYDROGEN BOND; LIPID MEMBRANE; MALE; MEMBRANE VESICLE; NONHUMAN; RABBIT; SUBCONJUNCTIVAL DRUG ADMINISTRATION;

ABSORPTION; ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CORNEA; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; LIPOSOMES; MALE; OCULAR PHYSIOLOGY; RABBITS;

EID: 0033020812     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772664     Document Type: Conference Paper

References (43)

1. Abrams, S. B., Yager, P. (1993) Perturbation of the chain melting transition of DPPC by galactose, agarose and Laurdan as determined by differential scanning calorimetry. Biochim. Biophys. Acta 1146: 127-135
2. Bartlett, G. R. (1959) Phosphorous assay in column chromatography. J. Biol. Chem. 234: 466-468
3. Benita, S., Poly, P. A., Puisieux, F., Delattre, J. (1984) Radiopaque liposomes: effect of formulation conditions on encapsulation efficiency. J. Pharm. Sci. 73: 1751-1754
4. Berleur, F., Roman, V., Jaskierowicz, D., Daveloose, D., Leterrier, F., Ter-Minassian-Saraga, L., Madelmont, G. (1985) Interaction of vinblastine sulfate with artificial phospholipid membranes. A study by differential scanning calorimetry and spin labeling. Biochem. Pharmacol. 34: 3081-3086
5. Berne, B., Pecora, R. (1976) Dynamic Light Scattering. John Wiley and Sons, New York
6. Canaves, J. M., Ferragut, J. A., Gonzalez-Ros, J. M. (1991) Verapamil prevents the effects of daunomycin on the thermotropic phase transition of model lipid bilayers. Biochem. J. 279: 413-418
7. Chapman, D., Williams, R. M., Ladbrooke, B. D. (1967) Physical studies of phospholipids. VI. Thermotropic and lyotropic mesomorphism of some 1,2-diacylphosphatidylcholines (lecithins). Chem. Phys. Lipids 1: 445-475
8. Chu, B. (1974) Laser Light Scattering. Academic Press, New York
9. Davies, N. M., Kellaway, I. W., Greaves, J. L., Wilson, C. G. (1993) Advanced corneal delivery systems: liposomes. In: Mitra, A. K. (ed.) Ophthalmic Drug Delivery Systems. Marcel Dekker Inc., New York, pp 289-306
10. Deliconstantonos, G., Kopeikina-Tsiboukidou, L., Villiotou, V. (1987) Evaluation of membrane fluidity effects and enzyme activity alterations in adriamycin neurotoxicity. Biochem. Pharmacol. 36: 1153-1161
11. Elion, G. B. (1982) Mechanism of action and sensitivity of acyclovir. Am. J. Med. 73 (1A): 7-13
12. Fisher, P. H., Prusoff, W. H. (1984) Chemotherapy of ocular viral infections and tumors. In: Sears, M. L. (ed.) Pharmacology of the Eye. Springer-Verlag, Berlin, pp. 553-570
13. Fitzgerald, P., Hadgraft, J., Kreuter, J., Wilson, C. G. (1987a) A γ-scintigraphic evaluation of microparticulate ophthalmic delivery systems: liposomes and nanoparticles. Int. J. Pharm. 40: 81-84
14. Fitzgerald, P., Hadgraft, J., Wilson, C. G. (1987b) A γ-scintigraphic evaluation of the precorneal residence of liposomal formulations in the rabbit. J. Pharm. Pharmacol. 39: 487-490
15. Fletcher, C., Bean, B. (1985) Evaluation of oral acyclovir therapy. Drug Intel. Clin. Pharm. 19: 518-524
16. Fresta, M., Puglisi, G., Di Giacomo, C., Russo, A. (1994) Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischemic reperfusion. J. Pharm. Pharmacol. 46: 974-981
17. Fresta, M., Spadaro, A., Cerniglia, G., Ropero, I. M., Puglisi, G., Furneri, P. M. (1995a) Intracellular accumulation of ofloxacin-loaded liposomes in human synovial fibroblasts. Antimicrob. Agents Chemother. 39: 1372-1375
18. Fresta, M., Wehrli, E., Puglisi, G. (1995b) Neutrase entrapment in stable multilamellar and large unilamellar vesicles for the acceleration of cheese ripening. J. Microencapsulation 12: 307-325
19. M1 containing small liposomes as demonstrated in a rat ischemia model. Pharm. Res. 12: 1769-1774
20. Fresta, M., Furneri, P. M., Mezzasalma, E., Nicolosi, V. M., Puglisi, G. (1996) Correlation of trimethoprim and brodimoprim physicochemical and lipid membrane interaction properties with their accumulation in human neutrophils. Antimicrob. Agents Chemother. 40: 2865-2873
21. Gregoriadis, G., da Silva, H., Florence, A. T. (1990) A procedure for the efficient entrapment of drugs in dehydration-rehydration liposomes (DRVs). Int. J. Pharm. 65: 235-242
22. Hayden, F. G. (1996) Antiviral agents. In: Hardman, J. G., Limbird, L. E., Molinoff, P. B., Ruddon, R. W., Gilman, A.G. (eds) The Pharmacological Basis of Therapeutics, 9th edn, McGraw-Hill, New York, pp 1191-1223
23. Hughes, P. M., Mitra, A. K. (1993) Effect of acylation on the ocular disposition of acyclovir. II: corneal permeability and anti-HSV 1 activity of 2′-esters in rabbit epithelial keratitis. J. Ocular Pharm. 9 (4): 299-309
24. Jain, M. K. (1988) Order and dynamics in bilayers and solute in bilayers. In Jain, M. K. (ed.) Introduction to Biological Membranes. John Wiley & Sons Inc., New York, pp 122-146
25. Janknecht, R., De Marie, S., Bakker-Woudenberg, I. A. J. M., Crommelin, D. J. A. (1992) Liposomal and lipid formulations of amphotericin B. Clin. Pharmacokin. 23: 279-291
26. Laskin, O. L., Langstreth, J. A., Sral, R., Demiranda, P., Keeney R., Lietman, P. S. (1982) Pharmacokinetics and tolerance of acyclovir, a new antiherpes virus agent, in humans. Antimicrob. Agents Chemother. 21: 393-398
27. Lee, V. H. L., Robinson, J. R. (1986) Topical drug delivery: recent developments and challenges. J. Ocular Pharmacol. 2: 67-108
28. Magallanes, M., Dijkstra, J., Fierer, J. (1993) Liposome-incorporated ciprofloxacin in treatment of murine salmonellosis. Antimicrob. Agents Chemother. 37: 2293-2297
29. Mauger, T. F. (1994) Antiviral drugs. In: Mauger, T. F., Craig, E. L. (eds) Ocular Pharmacology. 6th edn, Mosby, St Louis, pp 297-313
30. McDonald, T. O., Shedduck, J. A. (1977) Eye irritation. In: Marzulli, F. M., Maibach, H. I. (eds) Advances in Modern Toxicology. Vol. 4, John Wiley & Sons, New York, pp139-191
31. Meisner, D., Pringle, J., Mezei, M. (1989) Liposomal ophthalmic drug delivery 3. Pharmacodynamic and biodisposition studies of atropine. Int. J. Pharm. 55: 105-113
32. Müller, M., Meister, C., Moor, H. (1980) Freezing in a propane jet and its application in freeze-fracturing. Mikroskopie (Wien) 36: 129-140
33. Naito, T., Shiota, H., Mimura, Y. (1987) Side effects in the treatment of herpetic keratitis. Curr. Eye Res. 6: 237-239
34. New, R. R. C., Black, C. D. V., Parker, R. J., Pun, A., Schephof, G. L. (1990) Liposomes in biological systems. In: New, R. R. C (ed.) Liposomes. IRL Press at Oxford University, Oxford, England, pp 221-237
35. Pavan-Langston, D. (1994) Herpetic infections. In: Smolin, G., Thoft, R. A. (eds) The Cornea. 3rd edn, Little, Brown, Boston, pp 183-214
36. Puglisi, G., Fresta, M., Mazzone, G., Furneri, P. M., Tempera, G. (1995) Formulation parameters of fluoroquinolones-loaded liposomes and in vitro antimicrobial activity. Int. J. Pharm. 118: 65-76
37. Puglisi, G., Fresta, M., Ventura, C. A. (1996) Interaction of natural and modified β-cyclodextrins with a biological membrane model of dipalmitoylphosphatidylcholine. J. Colloid Interface Sci. 180: 542-547
38. Schaeffer, H. E., Krohn, D. L. (1982) Liposomes in topical drug delivery. Invest. Ophthalmol. Vis. Sci. 22: 220-227
39. Singh, K., Mezei, M. (1984) Liposomal ophthalmic drug delivery system II. Dihydrostreptomycin sulfate. Int. J. Pharm. 19: 263-269
40. Smolin, G., Okumoto, M., Feiler, S., Condon, D. (1981) Idoxuridine-liposome therapy for HS keratitis. Am. J. Ophthalmol. 91: 220-225
41. Stewart, J. C. M. (1980) Colorimetric determination of phospholipids with ferrothiocyanate. Anal. Biochem. 104: 10-14
42. Stratford, R. E. J., Yang, D. C., Redell, M. A., Lee, V. H. L. (1983) Effects of topically applied liposomes on disposition of epinephrine and inulin in the albino rabbit eye. Int. J. Pharm. 13: 263-272
43. Van Bloois, L., Dekker, D. D., Crommelin, D. J. A. (1987) Solubilization of lipophilic drugs by amphiphiles: Improvement of the apparent solubility of almitrine bismesylate by liposomes, mixed micelles and O/W emulsions. Acta Pharm. Technol. 33: 136-139