In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate

International Journal of Pharmaceutics

Volumn 241, Issue 1, 2002, Pages 47-55

  El Kamel, A H ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Additives; Ocular bioavailability; Pluronic F127; Rheological behavior; Timolol maleate

Indexed keywords

METHYLCELLULOSE; POLOXAMER; TIMOLOL MALEATE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DELAYED DRUG RELEASE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GEL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; SLOW DRUG RELEASE; VISCOSITY;

ADRENERGIC BETA-ANTAGONISTS; ALGORITHMS; ANIMALS; AQUEOUS HUMOR; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; EXCIPIENTS; ISOTONIC SOLUTIONS; OPHTHALMIC SOLUTIONS; POLOXAMER; RABBITS; SPECTROPHOTOMETRY, ULTRAVIOLET; TIMOLOL; VISCOSITY;

EID: 0037043105     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00234-X     Document Type: Article

References (29)

1. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: Thermodynamic, structure, dynamic and modeling
2. Formulation influence on conjunctival penetration of four beta blockers in the pigmented rabbit: A comparison with corneal penetration
3. Controlled release delivery system for the α-MSH analog melanotan-1 using poloxamer 407
4. Ophthalmic drug delivery systems - Recent advance
5. Study of the gelation process of polyethylene oxide-polypropylene oxide-poly-ethylene oxide copolymer (poloxamer 407) aqueous solutions
6. Rheology
7. In vitro release of lidocaine from Pluronic F127 gels
8. In vitro evaluation of Pluronic F127-based controlled-release ocular delivery systems for pilocarpine
9. Recent developments in ophthalmic drug delivery
10. Rheological study of a thermoreversible morphine gel
11. Corneal collagen shields for ocular drug delivery
12. Micellar structure of an ethylene oxide-propylene oxide block copolymer: A small-angle neutron scattering study
13. Precorneal, corneal and postcorneal factors
14. Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits
15. Carbopol/Pluronic phase change solutions for ophthalmic drug delivery
16. Comparative evaluation of Butea frondosa and flurbiprofen for ocular anti-inflammatory activity in rabbits
17. Rheological properties of poloxamer vehicles
18. Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels
19. Loss of gelation ability of Pluronic®F127 in presence of some salts
20. Ocular drug delivery. Mechanism of corneal drug transport and mucoadhesive delivery systems
21. Gelrite®: A novel, ion-activated, in situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol
22. Artificial skin. Preparation and properties of Pluronic F127 gels for the treatment of burns
23. Effect of inorganic additives on solutions of non-ionic surfactants III. Cmc's and surface properties
24. Gels and jellies
25. Controlled drug delivery devices for experimental ocular studies with timolol 1. In vitro release studies
26. Thermodynamic studies on the gel-sol transition of some Pluronic polyols