Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability

International Journal of Pharmaceutics

Volumn 396, Issue 1-2, 2010, Pages 179-187

  Gan, Li ^a   Han, Shun ^a   Shen, Jinqiu ^b   Zhu, Jiabi ^b   Zhu, Chunliu ^a   Zhang, Xinxin ^a   Gan, Yong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cubosome; Dexamethasone; Ocular bioavailability; Ophthalmic delivery; Preocular retention

Indexed keywords

CARBOMER; CUBOSOME; DEXAMETHASONE; EYE DROPS; GLYCEROL OLEATE; NANOPARTICLE; PENETRATION ENHANCING AGENT; POLOXAMER; SODIUM DIHYDROGEN PHOSPHATE; UNCLASSIFIED DRUG; WATER; ACYLGLYCEROL; DRUG CARRIER; EXCIPIENT; GLUCOCORTICOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; BIOCOMPATIBILITY; CORNEA; CRYOELECTRON MICROSCOPY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG INSTILLATION; DRUG PENETRATION; DRUG RETENTION; DRUG STRUCTURE; DRUG TOLERABILITY; EXPERIMENTAL RABBIT; GEL; HISTOLOGY; LIQUID CRYSTAL; MALE; MAXIMUM PLASMA CONCENTRATION; MICELLE; MICRODIALYSIS; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; COMPARATIVE STUDY; EYE; MEDICINAL CHEMISTRY; METABOLISM; NANOTECHNOLOGY; PERMEABILITY; PHARMACEUTICS; PROCEDURES; RABBIT; SMALL ANGLE SCATTERING; TOPICAL DRUG ADMINISTRATION; VISCOSITY; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, TOPICAL; ANIMALS; AQUEOUS HUMOR; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CORNEA; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; DEXAMETHASONE; DRUG CARRIERS; DRUG COMPOUNDING; EXCIPIENTS; EYE; GLUCOCORTICOIDS; GLYCERIDES; LIQUID CRYSTALS; MALE; MICRODIALYSIS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NANOTECHNOLOGY; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; PERMEABILITY; POLOXAMER; RABBITS; SCATTERING, SMALL ANGLE; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY; WATER;

EID: 77955049646     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.06.015     Document Type: Article

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