In vitro and in vivo evaluation of the Gelrite® gellan gum-based ocular delivery system for indomethacin

Acta Pharmaceutica

Volumn 53, Issue 4, 2003, Pages 251-261

  Balasubramaniam, Jagdish ^a   Kant, Shri ^b   Pandit, Jayanta Kumar ^a  

^a BANARAS HINDU UNIVERSITY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Gellan; Indomethacin; Ocular delivery

Indexed keywords

DIVALENT CATION; DRUG VEHICLE; EYE DROPS; GELLAN; GELLING AGENT; GELRITE; INDOMETACIN; ION; MONOVALENT CATION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG FORMULATION; DRUG INSTILLATION; EYE; GELATION; IN VITRO STUDY; IN VIVO STUDY; LACRIMAL FLUID; NONHUMAN; PHASE TRANSITION; RABBIT; SUSTAINED DRUG RELEASE; UVEITIS;

EID: 0345827826     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. D. M. Maurice, Kinetics of Topically Applied Drugs, in Ophthalmic Drug Delivery, Biopharmaceutical, Technological and Clinical Aspects, Vol 11, Fidia Research Series (Eds. M. S. Saettone, P. Bucci and P. Speiser), Liviana Press, Padova 1987, pp. 19-26.
2. C. L. Bourlais, L. Acar, H. Zia, P. A. Sado, T. Needham and R. Leverge, Ophthalmic drug delivery systems - recent advance, Prog. Retinal Eye Res. 17 (1998) 33-58.
3. S. Ding, Recent developments in ophthalmic drug delivery, Pharm. Sci. Technol. Today 1 (1998) 328-335.
4. J. M. Hill, R. J. O'Callaghan, J. A. Hobden and E. Kaufman, Controlled Collagen Shields for Ocular Delivery, in Ophthalmic Drug Delivery Systems (Ed. A. K. Mitra), Marcel Dekker, New York 1993, pp. 261-275.
5. A. H. El-Kamel, In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate, Int. J. Pharm. 241 (2002) 47-55.
6. R. Gurny, Preliminary study of prolonged acting drug delivery system for the treatment of glaucoma, Pharm. Acta Helv. 56 (1981) 130-132.
7. R. Gurny, T. Boye and H. Ibrahim, Ocular therapy with nanoparticulate systems for controlled drug delivery, J. Contr. Rel. 2 (1985) 353-361.
8. B. Srividya, R. M. Cardoza and P. D. Amin, Sustained ophthalmic delivery of ofloxacin from a pH-triggered in situ gelling system, J. Contr. Rel. 73 (2001) 205-211.
9. S. C. Miller and M. D. Donovan, Effect of polaxomer 407 gel in the miotic activity of pilocarpine nitrate in rabbits, Int. J. Pharm. 12 (1982) 147-152.
10. S. D. Desai and J. Blanchard, In vitro evaluation of pluronic F127 based controlled release ocular delivery systems for pilocarpine, J. Pharm. Sci. 87 (1998) 226-230.
11. M. Vadnere, G. Amidon, S. Lendenbaum and J. L. Haslam, Thermodynamic studies on the gelsol transition of some pluronic polyols, Int. J. Pharm. 22 (1984) 207-218.
12. C. W. Spancake, A. K. Mitra and D. O. Klidsig, Kinetics of aspirin hydrolysis in aqueous solutions and gels of poloxamines (tetronic 1508). Influence of microenvironment, Int. J. Pharm. 57 (1989) 163-168.
13. A. Rozier, C. Manuel, J. Groove and B. Plazonet, Gelrite: A novel ion activated in situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol, Int. J. Pharm. 57 (1989) 163-168.
14. Y. D. Sanzgiri, S. Maschi, V. Crescenzi, L. Calligaro, E. M. Topp and V. J. Stella, Gellan-based systems for ophthalmic sustained delivery of methyl prednisolone, J. Contr. Rel. 26 (1993) 195-201.
15. J. Balasubramaniam, M. Thilek Kumar, J. K. Pandit and S. Kant, In vitro and in vivo characterization of scleral implants of indomethacin, Pharmazie 56 (2001) 793-799.
16. J. Balasubramaniam and J. K. Pandit, In vitro characterizaton of non-degradable scleral implants of indomethacin for prolonged ocular delivery, Acta Pharm. 52 (2002) 181-188.
17. N. J. Van Haeringen, Clinical biochemistry of tears, Surv. Ophthalmol. 26 (1981) 84-95.
18. H. Lin and K. C. Sung, Carbopol/pluronic phase change solutions for ophthalmic drug delivery, J. Contr. Rel. 69 (2000) 379-388.
19. M. M. Van Ooteghem, in Biopharmaceutics of Ocular Drug Delivery (Ed. P. Edman), CRC Press, Boca Raton 1993, pp. 27-41.
20. H. Bothner, T. Waaler and O. Wik, Rheological characterization of tear substitutes, Drug Dev. Ind. Pharm. 16 (1990) 755-768.
21. S. Cohen, E. Lobel, A. Trevgoda and Y. Peled, A novel in situ forming ophthalmic drug delivery system from alginates undergoing gelation in the eye, J. Contr. Rel. 44 (1997) 201-208.