-
1
-
-
0025367497
-
Auxilin, a newly identified clathrin-associated protein in coated vesicles from bovine brain
-
Ahle S., Ungewickell E. Auxilin, a newly identified clathrin-associated protein in coated vesicles from bovine brain. J. Cell Biol. 1990, 111:19-29.
-
(1990)
J. Cell Biol.
, vol.111
, pp. 19-29
-
-
Ahle, S.1
Ungewickell, E.2
-
2
-
-
80355139374
-
Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration
-
Ali Y.O., Escala W., Ruan K., Zhai R.G. Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration. J. Vis. Exp. 2011, 1-5. 10.3791/2504.
-
(2011)
J. Vis. Exp.
-
-
Ali, Y.O.1
Escala, W.2
Ruan, K.3
Zhai, R.G.4
-
3
-
-
84900520403
-
Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation
-
Ambroso M.R., Hegde B.G., Langen R. Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:6982-6987. 10.1073/pnas.1402233111.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 6982-6987
-
-
Ambroso, M.R.1
Hegde, B.G.2
Langen, R.3
-
4
-
-
84961311181
-
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
-
Arranz A.M., Delbroek L., Van Kolen K., Guimarães M.R., Mandemakers W., Daneels G., Matta S., Calafate S., Shaban H., Baatsen P., De Bock P.-J., Gevaert K., Vanden Berghe P., Verstreken P., De Strooper B., Moechars D. LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism. J. Cell Sci. 2014, 10.1242/jcs.158196.
-
(2014)
J. Cell Sci.
-
-
Arranz, A.M.1
Delbroek, L.2
Van Kolen, K.3
Guimarães, M.R.4
Mandemakers, W.5
Daneels, G.6
Matta, S.7
Calafate, S.8
Shaban, H.9
Baatsen, P.10
De Bock, P.-J.11
Gevaert, K.12
Vanden Berghe, P.13
Verstreken, P.14
De Strooper, B.15
Moechars, D.16
-
5
-
-
70350335328
-
Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance
-
Arthur C.R., Morton S.L., Dunham L.D., Keeney P.M., Bennett J.P. Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance. Mol. Neurodegener. 2009, 4(37). 10.1186/1750-1326-4-37.
-
(2009)
Mol. Neurodegener.
, vol.4
, Issue.37
-
-
Arthur, C.R.1
Morton, S.L.2
Dunham, L.D.3
Keeney, P.M.4
Bennett, J.P.5
-
6
-
-
84906861963
-
Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
-
Ashrafi G., Schlehe J.S., LaVoie M.J., Schwarz T.L. Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. J. Cell Biol. 2014, 206:655-670. 10.1083/jcb.201401070.
-
(2014)
J. Cell Biol.
, vol.206
, pp. 655-670
-
-
Ashrafi, G.1
Schlehe, J.S.2
LaVoie, M.J.3
Schwarz, T.L.4
-
7
-
-
84924042444
-
The ongoing pursuit of neuroprotective therapies in Parkinson disease
-
Athauda D., Foltynie T. The ongoing pursuit of neuroprotective therapies in Parkinson disease. Nat. Rev. Neurol. 2014, 10.1038/nrneurol.2014.226.
-
(2014)
Nat. Rev. Neurol.
-
-
Athauda, D.1
Foltynie, T.2
-
8
-
-
84892437994
-
Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system
-
Bassett A.R., Tibbit C., Ponting C.P., Liu J.-L. Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep. 2013, 4:220-228. 10.1016/j.celrep.2013.06.020.
-
(2013)
Cell Rep.
, vol.4
, pp. 220-228
-
-
Bassett, A.R.1
Tibbit, C.2
Ponting, C.P.3
Liu, J.-L.4
-
9
-
-
37749040775
-
The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network
-
Belenkaya T.Y., Wu Y., Tang X., Zhou B., Cheng L., Sharma Y.V., Yan D., Selva E.M., Lin X. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev. Cell 2008, 14:120-131. 10.1016/j.devcel.2007.12.003.
-
(2008)
Dev. Cell
, vol.14
, pp. 120-131
-
-
Belenkaya, T.Y.1
Wu, Y.2
Tang, X.3
Zhou, B.4
Cheng, L.5
Sharma, Y.V.6
Yan, D.7
Selva, E.M.8
Lin, X.9
-
10
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 2000, 3:1301-1306. 10.1038/81834.
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
MacKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
Greenamyre, J.T.6
-
11
-
-
10644276290
-
Drosophila, the golden bug, emerges as a tool for human genetics
-
Bier E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat. Rev. Genet. 2005, 6:9-23. 10.1038/nrg1503.
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 9-23
-
-
Bier, E.1
-
12
-
-
84859108554
-
Animal models of Parkinson's disease
-
Blandini F., Armentero M.-T. Animal models of Parkinson's disease. FEBS J. 2012, 279:1156-1166. 10.1111/j.1742-4658.2012.08491.x.
-
(2012)
FEBS J.
, vol.279
, pp. 1156-1166
-
-
Blandini, F.1
Armentero, M.-T.2
-
13
-
-
0037428241
-
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
-
Bonifati V., Rizzu P., van Baren M.J., Schaap O., Breedveld G.J., Krieger E., Dekker M.C.J., Squitieri F., Ibanez P., Joosse M., van Dongen J.W., Vanacore N., van Swieten J.C., Brice A., Meco G., van Duijn C.M., Oostra B.a, Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 2003, 299:256-259. 10.1126/science.1077209.
-
(2003)
Science
, vol.299
, pp. 256-259
-
-
Bonifati, V.1
Rizzu, P.2
van Baren, M.J.3
Schaap, O.4
Breedveld, G.J.5
Krieger, E.6
Dekker, M.C.J.7
Squitieri, F.8
Ibanez, P.9
Joosse, M.10
van Dongen, J.W.11
Vanacore, N.12
van Swieten, J.C.13
Brice, A.14
Meco, G.15
van Duijn, C.M.16
Oostra, B.A.17
Heutink, P.18
-
14
-
-
84860615324
-
Neurotoxin-based models of Parkinson's disease
-
Bové J., Perier C. Neurotoxin-based models of Parkinson's disease. Neuroscience 2012, 211:51-76. 10.1016/j.neuroscience.2011.10.057.
-
(2012)
Neuroscience
, vol.211
, pp. 51-76
-
-
Bové, J.1
Perier, C.2
-
15
-
-
0027160708
-
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
-
Brand A.H., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415.
-
(1993)
Development
, vol.118
, pp. 401-415
-
-
Brand, A.H.1
Perrimon, N.2
-
16
-
-
78049529676
-
Vps35 mediates vesicle transport between the mitochondria and peroxisomes
-
Braschi E., Goyon V., Zunino R., Mohanty A., Xu L., McBride H.M. Vps35 mediates vesicle transport between the mitochondria and peroxisomes. Curr. Biol. 2010, 20:1310-1315. 10.1016/j.cub.2010.05.066.
-
(2010)
Curr. Biol.
, vol.20
, pp. 1310-1315
-
-
Braschi, E.1
Goyon, V.2
Zunino, R.3
Mohanty, A.4
Xu, L.5
McBride, H.M.6
-
17
-
-
84883462430
-
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
-
Burchell V.S., Nelson D.E., Sanchez-Martinez A., Delgado-Camprubi M., Ivatt R.M., Pogson J.H., Randle S.J., Wray S., Lewis P.a, Houlden H., Abramov A.Y., Hardy J., Wood N.W., Whitworth A.J., Laman H., Plun-Favreau H. The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat. Neurosci. 2013, 16:1257-1265. 10.1038/nn.3489.
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 1257-1265
-
-
Burchell, V.S.1
Nelson, D.E.2
Sanchez-Martinez, A.3
Delgado-Camprubi, M.4
Ivatt, R.M.5
Pogson, J.H.6
Randle, S.J.7
Wray, S.8
Lewis, P.A.9
Houlden, H.10
Abramov, A.Y.11
Hardy, J.12
Wood, N.W.13
Whitworth, A.J.14
Laman, H.15
Plun-Favreau, H.16
-
18
-
-
84859169870
-
The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity
-
Butler E.K., Voigt A., Lutz A.K., Toegel J.P., Gerhardt E., Karsten P., Falkenburger B., Reinartz A., Winklhofer K.F., Schulz J.B. The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity. PLoS Genet. 2012, 8:e1002488. 10.1371/journal.pgen.1002488.
-
(2012)
PLoS Genet.
, vol.8
, pp. e1002488
-
-
Butler, E.K.1
Voigt, A.2
Lutz, A.K.3
Toegel, J.P.4
Gerhardt, E.5
Karsten, P.6
Falkenburger, B.7
Reinartz, A.8
Winklhofer, K.F.9
Schulz, J.B.10
-
19
-
-
84882838081
-
Genetically targeted optical electrophysiology in intact neural circuits
-
Cao G., Platisa J., Pieribone V.a, Raccuglia D., Kunst M., Nitabach M.N. Genetically targeted optical electrophysiology in intact neural circuits. Cell 2013, 154:904-913. 10.1016/j.cell.2013.07.027.
-
(2013)
Cell
, vol.154
, pp. 904-913
-
-
Cao, G.1
Platisa, J.2
Pieribone, V.A.3
Raccuglia, D.4
Kunst, M.5
Nitabach, M.N.6
-
20
-
-
84914680340
-
Upregulation of parkin in endophilin mutant mice
-
Cao M., Milosevic I., Giovedi S., De Camilli P. Upregulation of parkin in endophilin mutant mice. J. Neurosci. 2014, 34:16544-16549. 10.1523/JNEUROSCI. 1710-14.2014.
-
(2014)
J. Neurosci.
, vol.34
, pp. 16544-16549
-
-
Cao, M.1
Milosevic, I.2
Giovedi, S.3
De Camilli, P.4
-
21
-
-
22544458436
-
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila
-
Cha G.-H., Kim S., Park J., Lee E., Kim M., Lee S.B., Kim J.M., Chung J., Cho K.S. Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:10345-10350. 10.1073/pnas.0500346102.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 10345-10350
-
-
Cha, G.-H.1
Kim, S.2
Park, J.3
Lee, E.4
Kim, M.5
Lee, S.B.6
Kim, J.M.7
Chung, J.8
Cho, K.S.9
-
22
-
-
84894075304
-
Genetic insights into sporadic Parkinson's disease pathogenesis
-
Chai C., Lim K. Genetic insights into sporadic Parkinson's disease pathogenesis. Curr. Genomics 2013, 14:486-501. 10.2174/1389202914666131210195808.
-
(2013)
Curr. Genomics
, vol.14
, pp. 486-501
-
-
Chai, C.1
Lim, K.2
-
23
-
-
17844406856
-
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
Chen L., Feany M.B. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat. Neurosci. 2005, 8:657-663. 10.1038/nn1443.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
-
24
-
-
70449347241
-
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation
-
Chen L., Periquet M., Wang X., Negro A., McLean P.J., Hyman B.T., Feany M.B. Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. J. Clin. Invest. 2009, 119:3257-3265. 10.1172/JCI39088.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3257-3265
-
-
Chen, L.1
Periquet, M.2
Wang, X.3
Negro, A.4
McLean, P.J.5
Hyman, B.T.6
Feany, M.B.7
-
25
-
-
84901669528
-
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
-
Cirnaru M.D., Marte A., Belluzzi E., Russo I., Gabrielli M., Longo F., Arcuri L., Murru L., Bubacco L., Matteoli M., Fedele E., Sala C., Passafaro M., Morari M., Greggio E., Onofri F., Piccoli G. LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex. Front. Mol. Neurosci. 2014, 7:49. 10.3389/fnmol.2014.00049.
-
(2014)
Front. Mol. Neurosci.
, vol.7
, pp. 49
-
-
Cirnaru, M.D.1
Marte, A.2
Belluzzi, E.3
Russo, I.4
Gabrielli, M.5
Longo, F.6
Arcuri, L.7
Murru, L.8
Bubacco, L.9
Matteoli, M.10
Fedele, E.11
Sala, C.12
Passafaro, M.13
Morari, M.14
Greggio, E.15
Onofri, F.16
Piccoli, G.17
-
26
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark I.E., Dodson M.W., Jiang C., Cao J.H., Huh J.R., Seol J.H., Yoo S.J., Hay B.a, Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006, 441:1162-1166. 10.1038/nature04779.
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
Cao, J.H.4
Huh, J.R.5
Seol, J.H.6
Yoo, S.J.7
Hay, B.A.8
Guo, M.9
-
27
-
-
84878533362
-
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease
-
Costa A.C., Loh S.H.Y., Martins L.M. Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. Cell Death Dis. 2013, 4:e467. 10.1038/cddis.2012.205.
-
(2013)
Cell Death Dis.
, vol.4
, pp. e467
-
-
Costa, A.C.1
Loh, S.H.Y.2
Martins, L.M.3
-
28
-
-
0032736675
-
Essential role of phosphoinositide metabolism in synaptic vesicle recycling
-
Cremona O., Di Paolo G., Wenk M.R., Lüthi A., Kim W.T., Takei K., Daniell L., Nemoto Y., Shears S.B., Flavell R.a, McCormick D.a, De Camilli P. Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell 1999, 99:179-188.
-
(1999)
Cell
, vol.99
, pp. 179-188
-
-
Cremona, O.1
Di Paolo, G.2
Wenk, M.R.3
Lüthi, A.4
Kim, W.T.5
Takei, K.6
Daniell, L.7
Nemoto, Y.8
Shears, S.B.9
Flavell, R.A.10
McCormick, D.A.11
De Camilli, P.12
-
29
-
-
79551545935
-
Expression of PINK1 in the brain, eye and ear of mouse during embryonic development
-
d'Amora M., Angelini C., Marcoli M., Cervetto C., Kitada T., Vallarino M. Expression of PINK1 in the brain, eye and ear of mouse during embryonic development. J. Chem. Neuroanat. 2011, 41:73-85. 10.1016/j.jchemneu.2010.11.004.
-
(2011)
J. Chem. Neuroanat.
, vol.41
, pp. 73-85
-
-
d'Amora, M.1
Angelini, C.2
Marcoli, M.3
Cervetto, C.4
Kitada, T.5
Vallarino, M.6
-
30
-
-
84909630198
-
Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice
-
Dai Y., Clark J., Zheng K., Kujoth G.C., Prolla T.a, Simon D.K. Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice. Neurotoxicol. Teratol. 2014, 46C:62-67. 10.1016/j.ntt.2014.10.004.
-
(2014)
Neurotoxicol. Teratol.
, vol.46 C
, pp. 62-67
-
-
Dai, Y.1
Clark, J.2
Zheng, K.3
Kujoth, G.C.4
Prolla, T.A.5
Simon, D.K.6
-
31
-
-
44949138796
-
A review of Parkinson's disease
-
Davie C.a A review of Parkinson's disease. Br. Med. Bull. 2008, 86:109-127. 10.1093/bmb/ldn013.
-
(2008)
Br. Med. Bull.
, vol.86
, pp. 109-127
-
-
Davie, C.A.1
-
32
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng H., Dodson M.W., Huang H., Guo M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:14503-14508. 10.1073/pnas.0803998105.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
33
-
-
33644994992
-
Altered synaptic development and active zone spacing in endocytosis mutants
-
Dickman D.K., Lu Z., Meinertzhagen I.a, Schwarz T.L. Altered synaptic development and active zone spacing in endocytosis mutants. Curr. Biol. 2006, 16:591-598. 10.1016/j.cub.2006.02.058.
-
(2006)
Curr. Biol.
, vol.16
, pp. 591-598
-
-
Dickman, D.K.1
Lu, Z.2
Meinertzhagen, I.A.3
Schwarz, T.L.4
-
34
-
-
84863241584
-
Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
-
Dodson M.W., Zhang T., Jiang C., Chen S., Guo M. Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Hum. Mol. Genet. 2012, 21:1350-1363. 10.1093/hmg/ddr573.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 1350-1363
-
-
Dodson, M.W.1
Zhang, T.2
Jiang, C.3
Chen, S.4
Guo, M.5
-
35
-
-
84919674911
-
Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo
-
Dodson M.W., Leung L.K., Lone M., Lizzio M.a, Guo M. Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo. Dis. Model. Mech. 2014, 7:1351-1363. 10.1242/dmm.017020.
-
(2014)
Dis. Model. Mech.
, vol.7
, pp. 1351-1363
-
-
Dodson, M.W.1
Leung, L.K.2
Lone, M.3
Lizzio, M.A.4
Guo, M.5
-
36
-
-
77951249562
-
Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153
-
Doxakis E. Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153. J. Biol. Chem. 2010, 285:12726-12734. 10.1074/jbc.M109.086827.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 12726-12734
-
-
Doxakis, E.1
-
37
-
-
84860487766
-
A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism
-
Edvardson S., Cinnamon Y., Ta-Shma A., Shaag A., Yim Y.-I., Zenvirt S., Jalas C., Lesage S., Brice A., Taraboulos A., Kaestner K.H., Greene L.E., Elpeleg O. A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism. PLoS One 2012, 7:e36458. 10.1371/journal.pone.0036458.
-
(2012)
PLoS One
, vol.7
, pp. e36458
-
-
Edvardson, S.1
Cinnamon, Y.2
Ta-Shma, A.3
Shaag, A.4
Yim, Y.-I.5
Zenvirt, S.6
Jalas, C.7
Lesage, S.8
Brice, A.9
Taraboulos, A.10
Kaestner, K.H.11
Greene, L.E.12
Elpeleg, O.13
-
38
-
-
66049134102
-
The neuromuscular junction
-
Engel A.G. The neuromuscular junction. Handb. Clin. Neurol. 2008, 91:103-148. 10.1016/S0072-9752(07)01503-5.
-
(2008)
Handb. Clin. Neurol.
, vol.91
, pp. 103-148
-
-
Engel, A.G.1
-
39
-
-
83455225173
-
Synaptic vesicle trafficking and Parkinson's disease
-
Esposito G., Ana Clara F., Verstreken P. Synaptic vesicle trafficking and Parkinson's disease. Dev. Neurobiol. 2012, 72:134-144. 10.1002/dneu.20916.
-
(2012)
Dev. Neurobiol.
, vol.72
, pp. 134-144
-
-
Esposito, G.1
Ana Clara, F.2
Verstreken, P.3
-
40
-
-
84876841576
-
Aconitase causes iron toxicity in Drosophila pink1 mutants
-
Esposito G., Vos M., Vilain S., Swerts J., De Sousa Valadas J., Van Meensel S., Schaap O., Verstreken P. Aconitase causes iron toxicity in Drosophila pink1 mutants. PLoS Genet. 2013, 9:e1003478. 10.1371/journal.pgen.1003478.
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003478
-
-
Esposito, G.1
Vos, M.2
Vilain, S.3
Swerts, J.4
De Sousa Valadas, J.5
Van Meensel, S.6
Schaap, O.7
Verstreken, P.8
-
41
-
-
34249098322
-
Identification of genes that interact with Drosophila liquid facets
-
Eun S.H., Lea K., Overstreet E., Stevens S., Lee J.-H., Fischer J.a Identification of genes that interact with Drosophila liquid facets. Genetics 2007, 175:1163-1174. 10.1534/genetics.106.067959.
-
(2007)
Genetics
, vol.175
, pp. 1163-1174
-
-
Eun, S.H.1
Lea, K.2
Overstreet, E.3
Stevens, S.4
Lee, J.-H.5
Fischer, J.A.6
-
42
-
-
42549118559
-
Auxilin is essential for Delta signaling
-
Eun S.H., Banks S.M.L., Fischer J.a Auxilin is essential for Delta signaling. Development 2008, 135:1089-1095. 10.1242/dev.009530.
-
(2008)
Development
, vol.135
, pp. 1089-1095
-
-
Eun, S.H.1
Banks, S.M.L.2
Fischer, J.A.3
-
43
-
-
0034704752
-
A Drosophila model of Parkinson's disease
-
Feany M.B., Bender W.W. A Drosophila model of Parkinson's disease. Nature 2000, 404:394-398. 10.1038/35006074.
-
(2000)
Nature
, vol.404
, pp. 394-398
-
-
Feany, M.B.1
Bender, W.W.2
-
44
-
-
79955106109
-
Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila
-
Fernandes C., Rao Y. Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila. Mol. Brain 2011, 4:17. 10.1186/1756-6606-4-17.
-
(2011)
Mol. Brain
, vol.4
, pp. 17
-
-
Fernandes, C.1
Rao, Y.2
-
45
-
-
38849106101
-
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex
-
Franch-Marro X., Wendler F., Guidato S., Griffith J., Baena-Lopez A., Itasaki N., Maurice M.M., Vincent J.-P. Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex. Nat. Cell Biol. 2008, 10:170-177. 10.1038/ncb1678.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 170-177
-
-
Franch-Marro, X.1
Wendler, F.2
Guidato, S.3
Griffith, J.4
Baena-Lopez, A.5
Itasaki, N.6
Maurice, M.M.7
Vincent, J.-P.8
-
46
-
-
49649097747
-
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
-
Gautier C.a, Kitada T., Shen J. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:11364-11369. 10.1073/pnas.0802076105.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 11364-11369
-
-
Gautier, C.A.1
Kitada, T.2
Shen, J.3
-
47
-
-
84897852467
-
The protein-vesicle network of autophagy
-
Ge L., Baskaran S., Schekman R., Hurley J.H. The protein-vesicle network of autophagy. Curr. Opin. Cell Biol. 2014, 29:18-24. 10.1016/j.ceb.2014.02.005.
-
(2014)
Curr. Opin. Cell Biol.
, vol.29
, pp. 18-24
-
-
Ge, L.1
Baskaran, S.2
Schekman, R.3
Hurley, J.H.4
-
48
-
-
77955152366
-
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
-
Gehrke S., Imai Y., Sokol N., Lu B. Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 2010, 466:637-641. 10.1038/nature09191.
-
(2010)
Nature
, vol.466
, pp. 637-641
-
-
Gehrke, S.1
Imai, Y.2
Sokol, N.3
Lu, B.4
-
49
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler S., Holmström K.M., Skujat D., Fiesel F.C., Rothfuss O.C., Kahle P.J., Springer W. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 2010, 12:119-131. 10.1038/ncb2012.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmström, K.M.2
Skujat, D.3
Fiesel, F.C.4
Rothfuss, O.C.5
Kahle, P.J.6
Springer, W.7
-
50
-
-
38349160161
-
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
-
Gitler A.D., Bevis B.J., Shorter J., Strathearn K.E., Hamamichi S., Su L.J., Caldwell K.A., Caldwell G.A., Rochet J.-C., McCaffery J.M., Barlowe C., Lindquist S. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:145-150. 10.1073/pnas.0710685105.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 145-150
-
-
Gitler, A.D.1
Bevis, B.J.2
Shorter, J.3
Strathearn, K.E.4
Hamamichi, S.5
Su, L.J.6
Caldwell, K.A.7
Caldwell, G.A.8
Rochet, J.-C.9
McCaffery, J.M.10
Barlowe, C.11
Lindquist, S.12
-
51
-
-
84880088705
-
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease
-
Gratz S.J., Cummings A.M., Nguyen J.N., Hamm D.C., Donohue L.K., Harrison M.M., Wildonger J., O'Connor-Giles K.M. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics 2013, 194:1029-1035. 10.1534/genetics.113.152710.
-
(2013)
Genetics
, vol.194
, pp. 1029-1035
-
-
Gratz, S.J.1
Cummings, A.M.2
Nguyen, J.N.3
Hamm, D.C.4
Donohue, L.K.5
Harrison, M.M.6
Wildonger, J.7
O'Connor-Giles, K.M.8
-
52
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
Greene J.C., Whitworth A.J., Kuo I., Andrews L.a, Feany M.B., Pallanck L.J. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:4078-4083. 10.1073/pnas.0737556100.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 4078-4083
-
-
Greene, J.C.1
Whitworth, A.J.2
Kuo, I.3
Andrews, L.A.4
Feany, M.B.5
Pallanck, L.J.6
-
53
-
-
0033532062
-
SAC1-like Domains of Yeast SAC1, INP52, and INP53 and of Human Synaptojanin Encode Polyphosphoinositide Phosphatases
-
Guo S., Stolz L.E., Lemrow S.M., York J.D. SAC1-like Domains of Yeast SAC1, INP52, and INP53 and of Human Synaptojanin Encode Polyphosphoinositide Phosphatases. J. Biol. Chem. 1999, 274:12990-12995. 10.1074/jbc.274.19.12990.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12990-12995
-
-
Guo, S.1
Stolz, L.E.2
Lemrow, S.M.3
York, J.D.4
-
54
-
-
80053496448
-
Cost of disorders of the brain in Europe 2010
-
Gustavsson A., Svensson M., Jacobi F., Allgulander C., Alonso J., Beghi E., Dodel R., Ekman M., Faravelli C., Fratiglioni L., Gannon B., Jones D.H., Jennum P., Jordanova A., Jönsson L., Karampampa K., Knapp M., Kobelt G., Kurth T., Lieb R., Linde M., Ljungcrantz C., Maercker A., Melin B., Moscarelli M., Musayev A., Norwood F., Preisig M., Pugliatti M., Rehm J., Salvador-Carulla L., Schlehofer B., Simon R., Steinhausen H.-C., Stovner L.J., Vallat J.-M., Van den Bergh P., van Os J., Vos P., Xu W., Wittchen H.-U., Jönsson B., Olesen J. Cost of disorders of the brain in Europe 2010. Eur. Neuropsychopharmacol. 2011, 21:718-779. 10.1016/j.euroneuro.2011.08.008.
-
(2011)
Eur. Neuropsychopharmacol.
, vol.21
, pp. 718-779
-
-
Gustavsson, A.1
Svensson, M.2
Jacobi, F.3
Allgulander, C.4
Alonso, J.5
Beghi, E.6
Dodel, R.7
Ekman, M.8
Faravelli, C.9
Fratiglioni, L.10
Gannon, B.11
Jones, D.H.12
Jennum, P.13
Jordanova, A.14
Jönsson, L.15
Karampampa, K.16
Knapp, M.17
Kobelt, G.18
Kurth, T.19
Lieb, R.20
Linde, M.21
Ljungcrantz, C.22
Maercker, A.23
Melin, B.24
Moscarelli, M.25
Musayev, A.26
Norwood, F.27
Preisig, M.28
Pugliatti, M.29
Rehm, J.30
Salvador-Carulla, L.31
Schlehofer, B.32
Simon, R.33
Steinhausen, H.-C.34
Stovner, L.J.35
Vallat, J.-M.36
Van den Bergh, P.37
van Os, J.38
Vos, P.39
Xu, W.40
Wittchen, H.-U.41
Jönsson, B.42
Olesen, J.43
more..
-
55
-
-
84880807019
-
Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy
-
Haddad D.M., Vilain S., Vos M., Esposito G., Matta S., Kalscheuer V.M., Craessaerts K., Leyssen M., Nascimento R.M.P., Vianna-Morgante A.M., De Strooper B., Van Esch H., Morais V.a, Verstreken P. Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy. Mol. Cell 2013, 50:831-843. 10.1016/j.molcel.2013.04.012.
-
(2013)
Mol. Cell
, vol.50
, pp. 831-843
-
-
Haddad, D.M.1
Vilain, S.2
Vos, M.3
Esposito, G.4
Matta, S.5
Kalscheuer, V.M.6
Craessaerts, K.7
Leyssen, M.8
Nascimento, R.M.P.9
Vianna-Morgante, A.M.10
De Strooper, B.11
Van Esch, H.12
Morais, V.A.13
Verstreken, P.14
-
56
-
-
33646425317
-
Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway
-
Hagedorn E.J., Bayraktar J.L., Kandachar V.R., Bai T., Englert D.M., Chang H.C. Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway. J. Cell Biol. 2006, 173:443-452. 10.1083/jcb.200602054.
-
(2006)
J. Cell Biol.
, vol.173
, pp. 443-452
-
-
Hagedorn, E.J.1
Bayraktar, J.L.2
Kandachar, V.R.3
Bai, T.4
Englert, D.M.5
Chang, H.C.6
-
57
-
-
77953084081
-
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
-
Hao L.-Y., Giasson B.I., Bonini N.M. DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:9747-9752. 10.1073/pnas.0911175107.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 9747-9752
-
-
Hao, L.-Y.1
Giasson, B.I.2
Bonini, N.M.3
-
58
-
-
0034617998
-
Mutations in synaptojanin disrupt synaptic vesicle recycling
-
Harris T.W., Hartwieg E., Horvitz H.R., Jorgensen E.M. Mutations in synaptojanin disrupt synaptic vesicle recycling. J. Cell Biol. 2000, 150:589-600.
-
(2000)
J. Cell Biol.
, vol.150
, pp. 589-600
-
-
Harris, T.W.1
Hartwieg, E.2
Horvitz, H.R.3
Jorgensen, E.M.4
-
59
-
-
2642516493
-
Parkin counteracts symptoms in a Drosophila model of Parkinson's disease
-
Haywood A.F.M., Staveley B.E. Parkin counteracts symptoms in a Drosophila model of Parkinson's disease. BMC Neurosci. 2004, 5:14. 10.1186/1471-2202-5-14.
-
(2004)
BMC Neurosci.
, vol.5
, pp. 14
-
-
Haywood, A.F.M.1
Staveley, B.E.2
-
60
-
-
0023740954
-
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
-
Hirsch E., Graybiel A.M., Agid Y.A. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 1988, 334:345-348. 10.1038/334345a0.
-
(1988)
Nature
, vol.334
, pp. 345-348
-
-
Hirsch, E.1
Graybiel, A.M.2
Agid, Y.A.3
-
61
-
-
47649109936
-
Auxilin depletion causes self-assembly of clathrin into membraneless cages in vivo
-
Hirst J., Sahlender D.a, Li S., Lubben N.B., Borner G.H.H., Robinson M.S. Auxilin depletion causes self-assembly of clathrin into membraneless cages in vivo. Traffic 2008, 9:1354-1371. 10.1111/j.1600-0854.2008.00764.x.
-
(2008)
Traffic
, vol.9
, pp. 1354-1371
-
-
Hirst, J.1
Sahlender, D.A.2
Li, S.3
Lubben, N.B.4
Borner, G.H.H.5
Robinson, M.S.6
-
62
-
-
84861749376
-
Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila
-
Humphrey D.M., Parsons R.B., Ludlow Z.N., Riemensperger T., Esposito G., Verstreken P., Jacobs H.T., Birman S., Hirth F. Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. Hum. Mol. Genet. 2012, 21:2698-2712. 10.1093/hmg/dds096.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 2698-2712
-
-
Humphrey, D.M.1
Parsons, R.B.2
Ludlow, Z.N.3
Riemensperger, T.4
Esposito, G.5
Verstreken, P.6
Jacobs, H.T.7
Birman, S.8
Hirth, F.9
-
63
-
-
34047135028
-
Evolution of mitochondrial cell death pathway: proapoptotic role of HtrA2/Omi in Drosophila
-
Igaki T., Suzuki Y., Tokushige N., Aonuma H., Takahashi R., Miura M. Evolution of mitochondrial cell death pathway: proapoptotic role of HtrA2/Omi in Drosophila. Biochem. Biophys. Res. Commun. 2007, 356:993-997. 10.1016/j.bbrc.2007.03.079.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.356
, pp. 993-997
-
-
Igaki, T.1
Suzuki, Y.2
Tokushige, N.3
Aonuma, H.4
Takahashi, R.5
Miura, M.6
-
64
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
Imai Y., Gehrke S., Wang H.-Q., Takahashi R., Hasegawa K., Oota E., Lu B. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 2008, 27:2432-2443. 10.1038/emboj.2008.163.
-
(2008)
EMBO J.
, vol.27
, pp. 2432-2443
-
-
Imai, Y.1
Gehrke, S.2
Wang, H.-Q.3
Takahashi, R.4
Hasegawa, K.5
Oota, E.6
Lu, B.7
-
65
-
-
77956522541
-
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
-
Irrcher I., Aleyasin H., Seifert E.L., Hewitt S.J., Chhabra S., Phillips M., Lutz a K., Rousseaux M.W.C., Bevilacqua L., Jahani-Asl A., Callaghan S., MacLaurin J.G., Winklhofer K.F., Rizzu P., Rippstein P., Kim R.H., Chen C.X., Fon E.a, Slack R.S., Harper M.E., McBride H.M., Mak T.W., Park D.S. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum. Mol. Genet. 2010, 19:3734-3746. 10.1093/hmg/ddq288.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3734-3746
-
-
Irrcher, I.1
Aleyasin, H.2
Seifert, E.L.3
Hewitt, S.J.4
Chhabra, S.5
Phillips, M.6
Lutz, A.K.7
Rousseaux, M.W.C.8
Bevilacqua, L.9
Jahani-Asl, A.10
Callaghan, S.11
MacLaurin, J.G.12
Winklhofer, K.F.13
Rizzu, P.14
Rippstein, P.15
Kim, R.H.16
Chen, C.X.17
Fon, E.A.18
Slack, R.S.19
Harper, M.E.20
McBride, H.M.21
Mak, T.W.22
Park, D.S.23
more..
-
66
-
-
0032585530
-
Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation
-
Jost M., Simpson F., Kavran J.M., Lemmon M.a, Schmid S.L. Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Curr. Biol. 1998, 8:1399-1402. 10.1016/S0960-9822(98)00022-0.
-
(1998)
Curr. Biol.
, vol.8
, pp. 1399-1402
-
-
Jost, M.1
Simpson, F.2
Kavran, J.M.3
Lemmon, M.A.4
Schmid, S.L.5
-
67
-
-
69149102628
-
Repression of alpha-synuclein expression and toxicity by microRNA-7
-
Junn E., Lee K.-W., Jeong B.S., Chan T.W., Im J.-Y., Mouradian M.M. Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:13052-13057. 10.1073/pnas.0906277106.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 13052-13057
-
-
Junn, E.1
Lee, K.-W.2
Jeong, B.S.3
Chan, T.W.4
Im, J.-Y.5
Mouradian, M.M.6
-
68
-
-
44249100959
-
The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis
-
Kandachar V., Bai T., Chang H.C. The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis. BMC Dev. Biol. 2008, 8:50. 10.1186/1471-213X-8-50.
-
(2008)
BMC Dev. Biol.
, vol.8
, pp. 50
-
-
Kandachar, V.1
Bai, T.2
Chang, H.C.3
-
69
-
-
84899539731
-
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
-
Kane L.a, Lazarou M., Fogel A.I., Li Y., Yamano K., Sarraf S.a, Banerjee S., Youle R.J. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J. Cell Biol. 2014, 205:143-153. 10.1083/jcb.201402104.
-
(2014)
J. Cell Biol.
, vol.205
, pp. 143-153
-
-
Kane, L.A.1
Lazarou, M.2
Fogel, A.I.3
Li, Y.4
Yamano, K.5
Sarraf, S.A.6
Banerjee, S.7
Youle, R.J.8
-
70
-
-
70350338222
-
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models
-
Karpinar D.P., Balija M.B.G., Kügler S., Opazo F., Rezaei-Ghaleh N., Wender N., Kim H.-Y., Taschenberger G., Falkenburger B.H., Heise H., Kumar A., Riedel D., Fichtner L., Voigt A., Braus G.H., Giller K., Becker S., Herzig A., Baldus M., Jäckle H., Eimer S., Schulz J.B., Griesinger C., Zweckstetter M. Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J. 2009, 28:3256-3268. 10.1038/emboj.2009.257.
-
(2009)
EMBO J.
, vol.28
, pp. 3256-3268
-
-
Karpinar, D.P.1
Balija, M.B.G.2
Kügler, S.3
Opazo, F.4
Rezaei-Ghaleh, N.5
Wender, N.6
Kim, H.-Y.7
Taschenberger, G.8
Falkenburger, B.H.9
Heise, H.10
Kumar, A.11
Riedel, D.12
Fichtner, L.13
Voigt, A.14
Braus, G.H.15
Giller, K.16
Becker, S.17
Herzig, A.18
Baldus, M.19
Jäckle, H.20
Eimer, S.21
Schulz, J.B.22
Griesinger, C.23
Zweckstetter, M.24
more..
-
71
-
-
77950371695
-
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
-
Kawajiri S., Saiki S., Sato S., Sato F., Hatano T., Eguchi H., Hattori N. PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett. 2010, 584:1073-1079. 10.1016/j.febslet.2010.02.016.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1073-1079
-
-
Kawajiri, S.1
Saiki, S.2
Sato, S.3
Sato, F.4
Hatano, T.5
Eguchi, H.6
Hattori, N.7
-
72
-
-
84899421556
-
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
-
Kazlauskaite A., Kondapalli C., Gourlay R., Campbell D.G., Ritorto M.S., Hofmann K., Alessi D.R., Knebel A., Trost M., Muqit M.M.K. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. Biochem. J. 2014, 460:127-139. 10.1042/BJ20140334.
-
(2014)
Biochem. J.
, vol.460
, pp. 127-139
-
-
Kazlauskaite, A.1
Kondapalli, C.2
Gourlay, R.3
Campbell, D.G.4
Ritorto, M.S.5
Hofmann, K.6
Alessi, D.R.7
Knebel, A.8
Trost, M.9
Muqit, M.M.K.10
-
73
-
-
33646948530
-
Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
-
Keeney P.M., Xie J., Capaldi R.a, Bennett J.P. Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J. Neurosci. 2006, 26:5256-5264. 10.1523/JNEUROSCI.0984-06.2006.
-
(2006)
J. Neurosci.
, vol.26
, pp. 5256-5264
-
-
Keeney, P.M.1
Xie, J.2
Capaldi, R.A.3
Bennett, J.P.4
-
74
-
-
44049089302
-
The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila
-
Khan F.S., Fujioka M., Datta P., Fernandes-Alnemri T., Jaynes J.B., Alnemri E.S. The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila. Cell Death Differ. 2008, 15:1073-1083. 10.1038/cdd.2008.19.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 1073-1083
-
-
Khan, F.S.1
Fujioka, M.2
Datta, P.3
Fernandes-Alnemri, T.4
Jaynes, J.B.5
Alnemri, E.S.6
-
75
-
-
84881557256
-
Glutathione S-transferase omega suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila
-
Kim K., Yim J. Glutathione S-transferase omega suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila. Biochem. Biophys. Res. Commun. 2013, 437:615-619. 10.1016/j.bbrc.2013.07.011.
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.437
, pp. 615-619
-
-
Kim, K.1
Yim, J.2
-
76
-
-
20244365801
-
DJ-1, a novel regulator of the tumor suppressor PTEN
-
Kim R.H., Peters M., Jang Y., Shi W., Pintilie M., Fletcher G.C., DeLuca C., Liepa J., Zhou L., Snow B., Binari R.C., Manoukian A.S., Bray M.R., Liu F.-F., Tsao M.-S., Mak T.W. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 2005, 7:263-273. 10.1016/j.ccr.2005.02.010.
-
(2005)
Cancer Cell
, vol.7
, pp. 263-273
-
-
Kim, R.H.1
Peters, M.2
Jang, Y.3
Shi, W.4
Pintilie, M.5
Fletcher, G.C.6
DeLuca, C.7
Liepa, J.8
Zhou, L.9
Snow, B.10
Binari, R.C.11
Manoukian, A.S.12
Bray, M.R.13
Liu, F.-F.14
Tsao, M.-S.15
Mak, T.W.16
-
77
-
-
56049091236
-
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
-
Kim Y., Park J., Kim S., Song S., Kwon S.-K., Lee S.-H., Kitada T., Kim J.-M., Chung J. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 2008, 377:975-980. 10.1016/j.bbrc.2008.10.104.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 975-980
-
-
Kim, Y.1
Park, J.2
Kim, S.3
Song, S.4
Kwon, S.-K.5
Lee, S.-H.6
Kitada, T.7
Kim, J.-M.8
Chung, J.9
-
78
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y., Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998, 392:605-608. 10.1038/33416.
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
79
-
-
84897895717
-
Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
-
Klein P., Müller-Rischart A.K., Motori E., Schönbauer C., Schnorrer F., Winklhofer K.F., Klein R. Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J. 2014, 33:341-355. 10.1002/embj.201284290.
-
(2014)
EMBO J.
, vol.33
, pp. 341-355
-
-
Klein, P.1
Müller-Rischart, A.K.2
Motori, E.3
Schönbauer, C.4
Schnorrer, F.5
Winklhofer, K.F.6
Klein, R.7
-
81
-
-
33749583553
-
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
-
Kontopoulos E., Parvin J.D., Feany M.B. Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum. Mol. Genet. 2006, 15:3012-3023. 10.1093/hmg/ddl243.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 3012-3023
-
-
Kontopoulos, E.1
Parvin, J.D.2
Feany, M.B.3
-
82
-
-
37749033461
-
Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation
-
Korolchuk V.I., Schütz M.M., Gómez-Llorente C., Rocha J., Lansu N.R., Collins S.M., Wairkar Y.P., Robinson I.M., O'Kane C.J. Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation. J. Cell Sci. 2007, 120:4367-4376. 10.1242/jcs.012336.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 4367-4376
-
-
Korolchuk, V.I.1
Schütz, M.M.2
Gómez-Llorente, C.3
Rocha, J.4
Lansu, N.R.5
Collins, S.M.6
Wairkar, Y.P.7
Robinson, I.M.8
O'Kane, C.J.9
-
83
-
-
84875543467
-
The current and projected economic burden of Parkinson's disease in the United States
-
Kowal S.L., Dall T.M., Chakrabarti R., Storm M.V., Jain A. The current and projected economic burden of Parkinson's disease in the United States. Mov. Disord. 2013, 28:311-318. 10.1002/mds.25292.
-
(2013)
Mov. Disord.
, vol.28
, pp. 311-318
-
-
Kowal, S.L.1
Dall, T.M.2
Chakrabarti, R.3
Storm, M.V.4
Jain, A.5
-
84
-
-
84901751574
-
Ubiquitin is phosphorylated by PINK1 to activate parkin
-
Koyano F., Okatsu K., Kosako H., Tamura Y., Go E., Kimura M., Kimura Y., Tsuchiya H., Yoshihara H., Hirokawa T., Endo T., Fon E.a, Trempe J.-F., Saeki Y., Tanaka K., Matsuda N. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 2014, 510:162-166. 10.1038/nature13392.
-
(2014)
Nature
, vol.510
, pp. 162-166
-
-
Koyano, F.1
Okatsu, K.2
Kosako, H.3
Tamura, Y.4
Go, E.5
Kimura, M.6
Kimura, Y.7
Tsuchiya, H.8
Yoshihara, H.9
Hirokawa, T.10
Endo, T.11
Fon, E.A.12
Trempe, J.-F.13
Saeki, Y.14
Tanaka, K.15
Matsuda, N.16
-
85
-
-
84881610810
-
The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures
-
Krebs C.E., Karkheiran S., Powell J.C., Cao M., Makarov V., Darvish H., Di Paolo G., Walker R.H., Shahidi G.A., Buxbaum J.D., De Camilli P., Yue Z., Paisán-Ruiz C. The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures. Hum. Mutat. 2013, 34:1200-1207. 10.1002/humu.22372.
-
(2013)
Hum. Mutat.
, vol.34
, pp. 1200-1207
-
-
Krebs, C.E.1
Karkheiran, S.2
Powell, J.C.3
Cao, M.4
Makarov, V.5
Darvish, H.6
Di Paolo, G.7
Walker, R.H.8
Shahidi, G.A.9
Buxbaum, J.D.10
De Camilli, P.11
Yue, Z.12
Paisán-Ruiz, C.13
-
86
-
-
17144459368
-
Parkin expression in the developing mouse
-
Kühn K., Zhu X.-R., Lübbert H., Stichel C.C. Parkin expression in the developing mouse. Brain Res. Dev. Brain Res. 2004, 149:131-142. 10.1016/j.devbrainres.2004.02.001.
-
(2004)
Brain Res. Dev. Brain Res.
, vol.149
, pp. 131-142
-
-
Kühn, K.1
Zhu, X.-R.2
Lübbert, H.3
Stichel, C.C.4
-
87
-
-
0020680904
-
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
-
Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983, 219:979-980.
-
(1983)
Science
, vol.219
, pp. 979-980
-
-
Langston, J.W.1
Ballard, P.2
Tetrud, J.W.3
Irwin, I.4
-
88
-
-
34548021452
-
Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits
-
Lavara-Culebras E., Paricio N. Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits. Gene 2007, 400:158-165. 10.1016/j.gene.2007.06.013.
-
(2007)
Gene
, vol.400
, pp. 158-165
-
-
Lavara-Culebras, E.1
Paricio, N.2
-
89
-
-
77955846610
-
The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons
-
Lawal H.O., Chang H.-Y., Terrell A.N., Brooks E.S., Pulido D., Simon A.F., Krantz D.E. The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons. Neurobiol. Dis. 2010, 40:102-112. 10.1016/j.nbd.2010.05.008.
-
(2010)
Neurobiol. Dis.
, vol.40
, pp. 102-112
-
-
Lawal, H.O.1
Chang, H.-Y.2
Terrell, A.N.3
Brooks, E.S.4
Pulido, D.5
Simon, A.F.6
Krantz, D.E.7
-
90
-
-
34248574535
-
Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
-
Lee S.B., Kim W., Lee S., Chung J. Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila. Biochem. Biophys. Res. Commun. 2007, 358:534-539. 10.1016/j.bbrc.2007.04.156.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.358
, pp. 534-539
-
-
Lee, S.B.1
Kim, W.2
Lee, S.3
Chung, J.4
-
91
-
-
84858693790
-
Role of mendelian genes in "sporadic" Parkinson's disease
-
Lesage S., Brice A. Role of mendelian genes in "sporadic" Parkinson's disease. Parkinsonism Relat. Disord. 2012, 18(Suppl. 1):S66-S70. 10.1016/S1353-8020(11)70022-0.
-
(2012)
Parkinsonism Relat. Disord.
, vol.18
, pp. S66-S70
-
-
Lesage, S.1
Brice, A.2
-
92
-
-
77957377567
-
LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß
-
Lin C.-H., Tsai P.-I., Wu R.-M., Chien C.-T. LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß. J. Neurosci. 2010, 30:13138-13149. 10.1523/JNEUROSCI. 1737-10.2010.
-
(2010)
J. Neurosci.
, vol.30
, pp. 13138-13149
-
-
Lin, C.-H.1
Tsai, P.-I.2
Wu, R.-M.3
Chien, C.-T.4
-
93
-
-
84906573100
-
Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2)
-
Linhart R., Wong S.A., Cao J., Tran M., Huynh A., Ardrey C., Park J.M., Hsu C., Taha S., Peterson R., Shea S., Kurian J., Venderova K. Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2). Mol. Neurodegener. 2014, 9:23. 10.1186/1750-1326-9-23.
-
(2014)
Mol. Neurodegener.
, vol.9
, pp. 23
-
-
Linhart, R.1
Wong, S.A.2
Cao, J.3
Tran, M.4
Huynh, A.5
Ardrey, C.6
Park, J.M.7
Hsu, C.8
Taha, S.9
Peterson, R.10
Shea, S.11
Kurian, J.12
Venderova, K.13
-
94
-
-
77954563918
-
A genomic response to the yeast transcription factor GAL4 in Drosophila
-
Liu Y., Lehmann M. A genomic response to the yeast transcription factor GAL4 in Drosophila. Fly (Austin) 2008, 2:92-98.
-
(2008)
Fly (Austin)
, vol.2
, pp. 92-98
-
-
Liu, Y.1
Lehmann, M.2
-
95
-
-
79961233786
-
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
-
Liu W., Acín-Peréz R., Geghman K.D., Manfredi G., Lu B., Li C. Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:12920-12924. 10.1073/pnas.1107332108.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 12920-12924
-
-
Liu, W.1
Acín-Peréz, R.2
Geghman, K.D.3
Manfredi, G.4
Lu, B.5
Li, C.6
-
96
-
-
84861348512
-
Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy
-
Liu J., Li C., Yu Z., Huang P., Wu H., Wei C., Zhu N., Shen Y., Chen Y., Zhang B., Deng W.-M., Jiao R. Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy. J. Genet. Genomics 2012, 39:209-215. 10.1016/j.jgg.2012.04.003.
-
(2012)
J. Genet. Genomics
, vol.39
, pp. 209-215
-
-
Liu, J.1
Li, C.2
Yu, Z.3
Huang, P.4
Wu, H.5
Wei, C.6
Zhu, N.7
Shen, Y.8
Chen, Y.9
Zhang, B.10
Deng, W.-M.11
Jiao, R.12
-
97
-
-
84859237566
-
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria
-
Liu S., Sawada T., Lee S., Yu W., Silverio G., Alapatt P., Millan I., Shen A., Saxton W., Kanao T., Takahashi R., Hattori N., Imai Y., Lu B. Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet. 2012, 8:e1002537. 10.1371/journal.pgen.1002537.
-
(2012)
PLoS Genet.
, vol.8
, pp. e1002537
-
-
Liu, S.1
Sawada, T.2
Lee, S.3
Yu, W.4
Silverio, G.5
Alapatt, P.6
Millan, I.7
Shen, A.8
Saxton, W.9
Kanao, T.10
Takahashi, R.11
Hattori, N.12
Imai, Y.13
Lu, B.14
-
98
-
-
84929503196
-
TALEN-mediated Drosophila genome editing: protocols and applications
-
Liu J., Chen Y., Jiao R. TALEN-mediated Drosophila genome editing: protocols and applications. Methods 2014, 69:22-31. 10.1016/j.ymeth.2014.04.010.
-
(2014)
Methods
, vol.69
, pp. 22-31
-
-
Liu, J.1
Chen, Y.2
Jiao, R.3
-
99
-
-
0042415580
-
How much phenotypic variation can be attributed to parkin genotype?
-
Lohmann E., Periquet M., Bonifati V., Wood N.W., De Michele G., Bonnet A., Fraix V., Broussolle E., Horstink M.W.I.M., Vidailhet M., Verpillat P., Gasser T., Nicholl D., Teive H., Raskin S., Rascol O., Destée A., Ruberg M., Gasparini F., Meco G., Agid Y., Durr A., Brice A. How much phenotypic variation can be attributed to parkin genotype?. Ann. Neurol. 2003, 54:176-185. 10.1002/ana.10613.
-
(2003)
Ann. Neurol.
, vol.54
, pp. 176-185
-
-
Lohmann, E.1
Periquet, M.2
Bonifati, V.3
Wood, N.W.4
De Michele, G.5
Bonnet, A.6
Fraix, V.7
Broussolle, E.8
Horstink, M.W.I.M.9
Vidailhet, M.10
Verpillat, P.11
Gasser, T.12
Nicholl, D.13
Teive, H.14
Raskin, S.15
Rascol, O.16
Destée, A.17
Ruberg, M.18
Gasparini, F.19
Meco, G.20
Agid, Y.21
Durr, A.22
Brice, A.23
more..
-
100
-
-
0034624017
-
The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity.
-
Lotharius J., O'Malley K.L. The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity. J. Biol. Chem. 2000, 275:38581-38588. 10.1074/jbc.M005385200.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 38581-38588
-
-
Lotharius, J.1
O'Malley, K.L.2
-
101
-
-
84885049621
-
Advances with microRNAs in Parkinson's disease research
-
Ma L., Wei L., Wu F., Hu Z., Liu Z., Yuan W. Advances with microRNAs in Parkinson's disease research. Drug Des. Devel. Ther. 2013, 7:1103-1113. 10.2147/DDDT.S48500.
-
(2013)
Drug Des. Devel. Ther.
, vol.7
, pp. 1103-1113
-
-
Ma, L.1
Wei, L.2
Wu, F.3
Hu, Z.4
Liu, Z.5
Yuan, W.6
-
102
-
-
84873281274
-
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
-
MacLeod D.A., Rhinn H., Kuwahara T., Zolin A., Di Paolo G., McCabe B.D., MacCabe B.D., Marder K.S., Honig L.S., Clark L.N., Small S.A., Abeliovich A. RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 2013, 77:425-439. 10.1016/j.neuron.2012.11.033.
-
(2013)
Neuron
, vol.77
, pp. 425-439
-
-
MacLeod, D.A.1
Rhinn, H.2
Kuwahara, T.3
Zolin, A.4
Di Paolo, G.5
McCabe, B.D.6
MacCabe, B.D.7
Marder, K.S.8
Honig, L.S.9
Clark, L.N.10
Small, S.A.11
Abeliovich, A.12
-
103
-
-
60549086949
-
Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome
-
Malhotra A., Edelman-Novemsky I., Xu Y., Plesken H., Ma J., Schlame M., Ren M. Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2337-2341. 10.1073/pnas.0811224106.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2337-2341
-
-
Malhotra, A.1
Edelman-Novemsky, I.2
Xu, Y.3
Plesken, H.4
Ma, J.5
Schlame, M.6
Ren, M.7
-
104
-
-
84865560576
-
LRRK2 expression is enriched in the striosomal compartment of mouse striatum
-
Mandemakers W., Snellinx A., O'Neill M.J., de Strooper B. LRRK2 expression is enriched in the striosomal compartment of mouse striatum. Neurobiol. Dis. 2012, 48:582-593. 10.1016/j.nbd.2012.07.017.
-
(2012)
Neurobiol. Dis.
, vol.48
, pp. 582-593
-
-
Mandemakers, W.1
Snellinx, A.2
O'Neill, M.J.3
de Strooper, B.4
-
105
-
-
84860811822
-
Fixing the broken system of genetic locus symbols: Parkinson disease and dystonia as examples
-
Marras C., Lohmann K., Lang A., Klein C. Fixing the broken system of genetic locus symbols: Parkinson disease and dystonia as examples. Neurology 2012, 78:1016-1024. 10.1212/WNL.0b013e31824d58ab.
-
(2012)
Neurology
, vol.78
, pp. 1016-1024
-
-
Marras, C.1
Lohmann, K.2
Lang, A.3
Klein, C.4
-
106
-
-
84898622052
-
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
-
Martin I., Kim J.W., Lee B.D., Kang H.C., Xu J.-C., Jia H., Stankowski J., Kim M.-S., Zhong J., Kumar M., Andrabi S.a, Xiong Y., Dickson D.W., Wszolek Z.K., Pandey A., Dawson T.M., Dawson V.L. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell 2014, 157:472-485. 10.1016/j.cell.2014.01.064.
-
(2014)
Cell
, vol.157
, pp. 472-485
-
-
Martin, I.1
Kim, J.W.2
Lee, B.D.3
Kang, H.C.4
Xu, J.-C.5
Jia, H.6
Stankowski, J.7
Kim, M.-S.8
Zhong, J.9
Kumar, M.10
Andrabi, S.A.11
Xiong, Y.12
Dickson, D.W.13
Wszolek, Z.K.14
Pandey, A.15
Dawson, T.M.16
Dawson, V.L.17
-
107
-
-
84866510734
-
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis
-
Matta S., Van Kolen K., da Cunha R., van den Bogaart G., Mandemakers W., Miskiewicz K., De Bock P.-J., Morais V.a, Vilain S., Haddad D., Delbroek L., Swerts J., Chávez-Gutiérrez L., Esposito G., Daneels G., Karran E., Holt M., Gevaert K., Moechars D.W., De Strooper B., Verstreken P. LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron 2012, 75:1008-1021. 10.1016/j.neuron.2012.08.022.
-
(2012)
Neuron
, vol.75
, pp. 1008-1021
-
-
Matta, S.1
Van Kolen, K.2
da Cunha, R.3
van den Bogaart, G.4
Mandemakers, W.5
Miskiewicz, K.6
De Bock, P.-J.7
Morais, V.A.8
Vilain, S.9
Haddad, D.10
Delbroek, L.11
Swerts, J.12
Chávez-Gutiérrez, L.13
Esposito, G.14
Daneels, G.15
Karran, E.16
Holt, M.17
Gevaert, K.18
Moechars, D.W.19
De Strooper, B.20
Verstreken, P.21
more..
-
108
-
-
0034708767
-
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.
-
McLean P.J., Kawamata H., Ribich S., Hyman B.T. Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations. J. Biol. Chem. 2000, 275:8812-8816. 10.1074/jbc.275.12.8812.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8812-8816
-
-
McLean, P.J.1
Kawamata, H.2
Ribich, S.3
Hyman, B.T.4
-
109
-
-
2642622186
-
A presynaptic inositol-5-phosphatase
-
McPherson P.S., Garcia E.P., Slepnev V.I., David C., Zhang X., Grabs D., Sossin W.S., Bauerfeind R., Nemoto Y., De Camilli P. A presynaptic inositol-5-phosphatase. Nature 1996, 379:353-357. 10.1038/379353a0.
-
(1996)
Nature
, vol.379
, pp. 353-357
-
-
McPherson, P.S.1
Garcia, E.P.2
Slepnev, V.I.3
David, C.4
Zhang, X.5
Grabs, D.6
Sossin, W.S.7
Bauerfeind, R.8
Nemoto, Y.9
De Camilli, P.10
-
110
-
-
24044506249
-
Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress
-
Menzies F.M., Yenisetti S.C., Min K.-T. Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr. Biol. 2005, 15:1578-1582. 10.1016/j.cub.2005.07.036.
-
(2005)
Curr. Biol.
, vol.15
, pp. 1578-1582
-
-
Menzies, F.M.1
Yenisetti, S.C.2
Min, K.-T.3
-
111
-
-
24044472010
-
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
-
Meulener M., Whitworth A.J., Armstrong-Gold C.E., Rizzu P., Heutink P., Wes P.D., Pallanck L.J., Bonini N.M. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr. Biol. 2005, 15:1572-1577. 10.1016/j.cub.2005.07.064.
-
(2005)
Curr. Biol.
, vol.15
, pp. 1572-1577
-
-
Meulener, M.1
Whitworth, A.J.2
Armstrong-Gold, C.E.3
Rizzu, P.4
Heutink, P.5
Wes, P.D.6
Pallanck, L.J.7
Bonini, N.M.8
-
112
-
-
79960135400
-
MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
-
Miñones-Moyano E., Porta S., Escaramís G., Rabionet R., Iraola S., Kagerbauer B., Espinosa-Parrilla Y., Ferrer I., Estivill X., Martí E. MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. Hum. Mol. Genet. 2011, 20:3067-3078. 10.1093/hmg/ddr210.
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 3067-3078
-
-
Miñones-Moyano, E.1
Porta, S.2
Escaramís, G.3
Rabionet, R.4
Iraola, S.5
Kagerbauer, B.6
Espinosa-Parrilla, Y.7
Ferrer, I.8
Estivill, X.9
Martí, E.10
-
113
-
-
84906503242
-
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
-
Miura E., Hasegawa T., Konno M., Suzuki M., Sugeno N., Fujikake N., Geisler S., Tabuchi M., Oshima R., Kikuchi A., Baba T., Wada K., Nagai Y., Takeda A., Aoki M. VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease. Neurobiol. Dis. 2014, 71:1-13. 10.1016/j.nbd.2014.07.014.
-
(2014)
Neurobiol. Dis.
, vol.71
, pp. 1-13
-
-
Miura, E.1
Hasegawa, T.2
Konno, M.3
Suzuki, M.4
Sugeno, N.5
Fujikake, N.6
Geisler, S.7
Tabuchi, M.8
Oshima, R.9
Kikuchi, A.10
Baba, T.11
Wada, K.12
Nagai, Y.13
Takeda, A.14
Aoki, M.15
-
114
-
-
77953666757
-
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
-
Morais V.a, Verstreken P., Roethig A., Smet J., Snellinx A., Vanbrabant M., Haddad D., Frezza C., Mandemakers W., Vogt-Weisenhorn D., Van Coster R., Wurst W., Scorrano L., De Strooper B. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol. Med. 2009, 1:99-111. 10.1002/emmm.200900006.
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 99-111
-
-
Morais, V.A.1
Verstreken, P.2
Roethig, A.3
Smet, J.4
Snellinx, A.5
Vanbrabant, M.6
Haddad, D.7
Frezza, C.8
Mandemakers, W.9
Vogt-Weisenhorn, D.10
Van Coster, R.11
Wurst, W.12
Scorrano, L.13
De Strooper, B.14
-
115
-
-
84898023373
-
PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling
-
Morais V.A., Haddad D., Craessaerts K., De Bock P.-J., Swerts J., Vilain S., Aerts L., Overbergh L., Grünewald A., Seibler P., Klein C., Gevaert K., Verstreken P., De Strooper B. PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science 2014, 344:203-207. 10.1126/science.1249161.
-
(2014)
Science
, vol.344
, pp. 203-207
-
-
Morais, V.A.1
Haddad, D.2
Craessaerts, K.3
De Bock, P.-J.4
Swerts, J.5
Vilain, S.6
Aerts, L.7
Overbergh, L.8
Grünewald, A.9
Seibler, P.10
Klein, C.11
Gevaert, K.12
Verstreken, P.13
De Strooper, B.14
-
116
-
-
84859500773
-
MicroRNAs in Parkinson's disease
-
Mouradian M.M. MicroRNAs in Parkinson's disease. Neurobiol. Dis. 2012, 46:279-284. 10.1016/j.nbd.2011.12.046.
-
(2012)
Neurobiol. Dis.
, vol.46
, pp. 279-284
-
-
Mouradian, M.M.1
-
117
-
-
36248991758
-
Overexpression of Septin 4, the Drosophila homologue of human CDCrel-1, is toxic for dopaminergic neurons
-
Muñoz-Soriano V., Paricio N. Overexpression of Septin 4, the Drosophila homologue of human CDCrel-1, is toxic for dopaminergic neurons. Eur. J. Neurosci. 2007, 26:3150-3158. 10.1111/j.1460-9568.2007.05937.x.
-
(2007)
Eur. J. Neurosci.
, vol.26
, pp. 3150-3158
-
-
Muñoz-Soriano, V.1
Paricio, N.2
-
118
-
-
67650243261
-
Parkin-induced mitophagy in the pathogenesis of Parkinson disease
-
Narendra D., Tanaka A., Suen D.-F., Youle R.J. Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy 2009, 5:706-708. 10.4161/auto.5.5.8505.
-
(2009)
Autophagy
, vol.5
, pp. 706-708
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.-F.3
Youle, R.J.4
-
119
-
-
78649300971
-
P62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
-
Narendra D., Kane L.a, Hauser D.N., Fearnley I.M., Youle R.J. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010, 6:1090-1106. 10.4161/auto.6.8.13426.
-
(2010)
Autophagy
, vol.6
, pp. 1090-1106
-
-
Narendra, D.1
Kane, L.A.2
Hauser, D.N.3
Fearnley, I.M.4
Youle, R.J.5
-
120
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
Narendra D.P., Jin S.M., Tanaka A., Suen D.-F., Gautier C.a, Shen J., Cookson M.R., Youle R.J. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 2010, 8:e1000298. 10.1371/journal.pbio.1000298.
-
(2010)
PLoS Biol.
, vol.8
, pp. e1000298
-
-
Narendra, D.P.1
Jin, S.M.2
Tanaka, A.3
Suen, D.-F.4
Gautier, C.A.5
Shen, J.6
Cookson, M.R.7
Youle, R.J.8
-
121
-
-
78149414741
-
Mitochondrial abnormalities in the putamen in Parkinson's disease dyskinesia
-
Naydenov A.V., Vassoler F., Luksik A.S., Kaczmarska J., Konradi C. Mitochondrial abnormalities in the putamen in Parkinson's disease dyskinesia. Acta Neuropathol. 2010, 120:623-631. 10.1007/s00401-010-0740-8.
-
(2010)
Acta Neuropathol.
, vol.120
, pp. 623-631
-
-
Naydenov, A.V.1
Vassoler, F.2
Luksik, A.S.3
Kaczmarska, J.4
Konradi, C.5
-
122
-
-
70349103837
-
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila
-
Ng C.-H., Mok S.Z.S., Koh C., Ouyang X., Fivaz M.L., Tan E.-K., Dawson V.L., Dawson T.M., Yu F., Lim K.-L. Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. J. Neurosci. 2009, 29:11257-11262. 10.1523/JNEUROSCI. 2375-09.2009.
-
(2009)
J. Neurosci.
, vol.29
, pp. 11257-11262
-
-
Ng, C.-H.1
Mok, S.Z.S.2
Koh, C.3
Ouyang, X.4
Fivaz, M.L.5
Tan, E.-K.6
Dawson, V.L.7
Dawson, T.M.8
Yu, F.9
Lim, K.-L.10
-
123
-
-
79955894792
-
POLG1-related and other "mitochondrial Parkinsonisms": an overview
-
Orsucci D., Caldarazzo Ienco E., Mancuso M., Siciliano G. POLG1-related and other "mitochondrial Parkinsonisms": an overview. J. Mol. Neurosci. 2011, 44:17-24. 10.1007/s12031-010-9488-9.
-
(2011)
J. Mol. Neurosci.
, vol.44
, pp. 17-24
-
-
Orsucci, D.1
Caldarazzo Ienco, E.2
Mancuso, M.3
Siciliano, G.4
-
124
-
-
84918556447
-
Treatment strategies in early and advanced Parkinson disease
-
Ossig C., Reichmann H. Treatment strategies in early and advanced Parkinson disease. Neurol. Clin. 2015, 33:19-37. 10.1016/j.ncl.2014.09.009.
-
(2015)
Neurol. Clin.
, vol.33
, pp. 19-37
-
-
Ossig, C.1
Reichmann, H.2
-
125
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
Paisán-Ruíz C., Jain S., Evans E.W., Gilks W.P., Simón J., van der Brug M., López de Munain A., Aparicio S., Gil A.M., Khan N., Johnson J., Martinez J.R., Nicholl D., Carrera I.M., Pena A.S., de Silva R., Lees A., Martí-Massó J.F., Pérez-Tur J., Wood N.W., Singleton A.B. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004, 44:595-600. 10.1016/j.neuron.2004.10.023.
-
(2004)
Neuron
, vol.44
, pp. 595-600
-
-
Paisán-Ruíz, C.1
Jain, S.2
Evans, E.W.3
Gilks, W.P.4
Simón, J.5
van der Brug, M.6
López de Munain, A.7
Aparicio, S.8
Gil, A.M.9
Khan, N.10
Johnson, J.11
Martinez, J.R.12
Nicholl, D.13
Carrera, I.M.14
Pena, A.S.15
de Silva, R.16
Lees, A.17
Martí-Massó, J.F.18
Pérez-Tur, J.19
Wood, N.W.20
Singleton, A.B.21
more..
-
126
-
-
60849121924
-
Characterization of PLA2G6 as a locus for dystonia-parkinsonism
-
Paisan-Ruiz C., Bhatia K.P., Li A., Hernandez D., Davis M., Wood N.W., Hardy J., Houlden H., Singleton A., Schneider S.a Characterization of PLA2G6 as a locus for dystonia-parkinsonism. Ann. Neurol. 2009, 65:19-23. 10.1002/ana.21415.
-
(2009)
Ann. Neurol.
, vol.65
, pp. 19-23
-
-
Paisan-Ruiz, C.1
Bhatia, K.P.2
Li, A.3
Hernandez, D.4
Davis, M.5
Wood, N.W.6
Hardy, J.7
Houlden, H.8
Singleton, A.9
Schneider, S.A.10
-
127
-
-
27144519984
-
Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
-
Park J., Kim S.Y., Cha G.-H., Lee S.B., Kim S., Chung J. Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene 2005, 361:133-139. 10.1016/j.gene.2005.06.040.
-
(2005)
Gene
, vol.361
, pp. 133-139
-
-
Park, J.1
Kim, S.Y.2
Cha, G.-H.3
Lee, S.B.4
Kim, S.5
Chung, J.6
-
128
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park J., Lee S.B., Lee S., Kim Y., Song S., Kim S., Bae E., Kim J., Shong M., Kim J.-M., Chung J. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 2006, 441:1157-1161. 10.1038/nature04788.
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
Kim, Y.4
Song, S.5
Kim, S.6
Bae, E.7
Kim, J.8
Shong, M.9
Kim, J.-M.10
Chung, J.11
-
129
-
-
2542560342
-
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
-
Pesah Y., Pham T., Burgess H., Middlebrooks B., Verstreken P., Zhou Y., Harding M., Bellen H., Mardon G. Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development 2004, 131:2183-2194. 10.1242/dev.01095.
-
(2004)
Development
, vol.131
, pp. 2183-2194
-
-
Pesah, Y.1
Pham, T.2
Burgess, H.3
Middlebrooks, B.4
Verstreken, P.5
Zhou, Y.6
Harding, M.7
Bellen, H.8
Mardon, G.9
-
130
-
-
79951534656
-
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
-
Piccoli G., Condliffe S.B., Bauer M., Giesert F., Boldt K., De Astis S., Meixner A., Sarioglu H., Vogt-Weisenhorn D.M., Wurst W., Gloeckner C.J., Matteoli M., Sala C., Ueffing M. LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J. Neurosci. 2011, 31:2225-2237. 10.1523/JNEUROSCI. 3730-10.2011.
-
(2011)
J. Neurosci.
, vol.31
, pp. 2225-2237
-
-
Piccoli, G.1
Condliffe, S.B.2
Bauer, M.3
Giesert, F.4
Boldt, K.5
De Astis, S.6
Meixner, A.7
Sarioglu, H.8
Vogt-Weisenhorn, D.M.9
Wurst, W.10
Gloeckner, C.J.11
Matteoli, M.12
Sala, C.13
Ueffing, M.14
-
131
-
-
84912124648
-
The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy
-
Pogson J.H., Ivatt R.M., Sanchez-Martinez A., Tufi R., Wilson E., Mortiboys H., Whitworth A.J. The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. PLoS Genet. 2014, 10:e1004815. 10.1371/journal.pgen.1004815.
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004815
-
-
Pogson, J.H.1
Ivatt, R.M.2
Sanchez-Martinez, A.3
Tufi, R.4
Wilson, E.5
Mortiboys, H.6
Whitworth, A.J.7
-
132
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
133
-
-
39449088321
-
The PINK1/Parkin pathway regulates mitochondrial morphology
-
Poole A.C., Thomas R.E., Andrews L.a, McBride H.M., Whitworth A.J., Pallanck L.J. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:1638-1643. 10.1073/pnas.0709336105.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 1638-1643
-
-
Poole, A.C.1
Thomas, R.E.2
Andrews, L.A.3
McBride, H.M.4
Whitworth, A.J.5
Pallanck, L.J.6
-
134
-
-
77955844260
-
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway
-
Poole A.C., Thomas R.E., Yu S., Vincow E.S., Pallanck L. The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS One 2010, 5:e10054. 10.1371/journal.pone.0010054.
-
(2010)
PLoS One
, vol.5
, pp. e10054
-
-
Poole, A.C.1
Thomas, R.E.2
Yu, S.3
Vincow, E.S.4
Pallanck, L.5
-
135
-
-
38849134055
-
Wingless secretion promotes and requires retromer-dependent cycling of Wntless
-
Port F., Kuster M., Herr P., Furger E., Bänziger C., Hausmann G., Basler K. Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat. Cell Biol. 2008, 10:178-185. 10.1038/ncb1687.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 178-185
-
-
Port, F.1
Kuster, M.2
Herr, P.3
Furger, E.4
Bänziger, C.5
Hausmann, G.6
Basler, K.7
-
136
-
-
34547127902
-
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
-
Pridgeon J.W., Olzmann J.a, Chin L.-S., Li L. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 2007, 5:e172. 10.1371/journal.pbio.0050172.
-
(2007)
PLoS Biol.
, vol.5
, pp. e172
-
-
Pridgeon, J.W.1
Olzmann, J.A.2
Chin, L.-S.3
Li, L.4
-
137
-
-
84881612311
-
Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism
-
Quadri M., Fang M., Picillo M., Olgiati S., Breedveld G.J., Graafland J., Wu B., Xu F., Erro R., Amboni M., Pappatà S., Quarantelli M., Annesi G., Quattrone A., Chien H.F., Barbosa E.R., Oostra B.a, Barone P., Wang J., Bonifati V. Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism. Hum. Mutat. 2013, 34:1208-1215. 10.1002/humu.22373.
-
(2013)
Hum. Mutat.
, vol.34
, pp. 1208-1215
-
-
Quadri, M.1
Fang, M.2
Picillo, M.3
Olgiati, S.4
Breedveld, G.J.5
Graafland, J.6
Wu, B.7
Xu, F.8
Erro, R.9
Amboni, M.10
Pappatà, S.11
Quarantelli, M.12
Annesi, G.13
Quattrone, A.14
Chien, H.F.15
Barbosa, E.R.16
Oostra, B.A.17
Barone, P.18
Wang, J.19
Bonifati, V.20
more..
-
138
-
-
77956288664
-
Electron microscopy of Drosophila larval neuromuscular junctions
-
(pdb.prot5474)
-
Ramachandran P., Budnik V. Electron microscopy of Drosophila larval neuromuscular junctions. Cold Spring Harb. Protoc. 2010, 5(8). (pdb.prot5474).
-
(2010)
Cold Spring Harb. Protoc.
, vol.5
, Issue.8
-
-
Ramachandran, P.1
Budnik, V.2
-
139
-
-
33749133430
-
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
-
Ramirez A., Heimbach A., Gründemann J., Stiller B., Hampshire D., Cid L.P., Goebel I., Mubaidin A.F., Wriekat A.-L., Roeper J., Al-Din A., Hillmer A.M., Karsak M., Liss B., Woods C.G., Behrens M.I., Kubisch C. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat. Genet. 2006, 38:1184-1191. 10.1038/ng1884.
-
(2006)
Nat. Genet.
, vol.38
, pp. 1184-1191
-
-
Ramirez, A.1
Heimbach, A.2
Gründemann, J.3
Stiller, B.4
Hampshire, D.5
Cid, L.P.6
Goebel, I.7
Mubaidin, A.F.8
Wriekat, A.-L.9
Roeper, J.10
Al-Din, A.11
Hillmer, A.M.12
Karsak, M.13
Liss, B.14
Woods, C.G.15
Behrens, M.I.16
Kubisch, C.17
-
140
-
-
84919762182
-
Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila
-
Ren X., Yang Z., Xu J., Sun J., Mao D., Hu Y., Yang S.-J., Qiao H.-H., Wang X., Hu Q., Deng P., Liu L.-P., Ji J.-Y., Li J.B., Ni J.-Q. Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila. Cell Rep. 2014, 9:1151-1162. 10.1016/j.celrep.2014.09.044.
-
(2014)
Cell Rep.
, vol.9
, pp. 1151-1162
-
-
Ren, X.1
Yang, Z.2
Xu, J.3
Sun, J.4
Mao, D.5
Hu, Y.6
Yang, S.-J.7
Qiao, H.-H.8
Wang, X.9
Hu, Q.10
Deng, P.11
Liu, L.-P.12
Ji, J.-Y.13
Li, J.B.14
Ni, J.-Q.15
-
141
-
-
0030739938
-
The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain
-
Ringstad N., Nemoto Y., De Camilli P. The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:8569-8574.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 8569-8574
-
-
Ringstad, N.1
Nemoto, Y.2
De Camilli, P.3
-
142
-
-
84866728707
-
Endoplasmic reticulum-mitochondria contacts: function of the junction
-
Rowland A.a, Voeltz G.K. Endoplasmic reticulum-mitochondria contacts: function of the junction. Nat. Rev. Mol. Cell Biol. 2012, 13:607-625. 10.1038/nrm3440.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 607-625
-
-
Rowland, A.A.1
Voeltz, G.K.2
-
143
-
-
0035965299
-
Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex
-
Scheele U., Kalthoff C., Ungewickell E. Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex. J. Biol. Chem. 2001, 276:36131-36138. 10.1074/jbc.M106511200.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 36131-36138
-
-
Scheele, U.1
Kalthoff, C.2
Ungewickell, E.3
-
144
-
-
84876984956
-
Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components
-
Schertel C., Huang D., Björklund M., Bischof J., Yin D., Li R., Wu Y., Zeng R., Wu J., Taipale J., Song H., Basler K. Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components. Dev. Cell 2013, 25:207-219. 10.1016/j.devcel.2013.02.019.
-
(2013)
Dev. Cell
, vol.25
, pp. 207-219
-
-
Schertel, C.1
Huang, D.2
Björklund, M.3
Bischof, J.4
Yin, D.5
Li, R.6
Wu, Y.7
Zeng, R.8
Wu, J.9
Taipale, J.10
Song, H.11
Basler, K.12
-
145
-
-
84941114061
-
Clinical and pathological features of Parkinson's disease
-
Schneider S.A., Obeso J.A. Clinical and pathological features of Parkinson's disease. Curr. Top. Behav. Neurosci. 2014, 10.1007/7854_2014_317.
-
(2014)
Curr. Top. Behav. Neurosci.
-
-
Schneider, S.A.1
Obeso, J.A.2
-
146
-
-
84871891737
-
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
-
Shiba-Fukushima K., Imai Y., Yoshida S., Ishihama Y., Kanao T., Sato S., Hattori N. PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci. Rep. 2012, 2:1002. 10.1038/srep01002.
-
(2012)
Sci. Rep.
, vol.2
, pp. 1002
-
-
Shiba-Fukushima, K.1
Imai, Y.2
Yoshida, S.3
Ishihama, Y.4
Kanao, T.5
Sato, S.6
Hattori, N.7
-
147
-
-
84919629959
-
Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes parkin mitochondrial tethering
-
Shiba-Fukushima K., Arano T., Matsumoto G., Inoshita T., Yoshida S., Ishihama Y., Ryu K.-Y., Nukina N., Hattori N., Imai Y. Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes parkin mitochondrial tethering. PLoS Genet. 2014, 10:e1004861. 10.1371/journal.pgen.1004861.
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004861
-
-
Shiba-Fukushima, K.1
Arano, T.2
Matsumoto, G.3
Inoshita, T.4
Yoshida, S.5
Ishihama, Y.6
Ryu, K.-Y.7
Nukina, N.8
Hattori, N.9
Imai, Y.10
-
148
-
-
44449112128
-
Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500K SNP arrays
-
Shojaee S., Sina F., Banihosseini S.S., Kazemi M.H., Kalhor R., Shahidi G.-A., Fakhrai-Rad H., Ronaghi M., Elahi E. Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500K SNP arrays. Am. J. Hum. Genet. 2008, 82:1375-1384. 10.1016/j.ajhg.2008.05.005.
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 1375-1384
-
-
Shojaee, S.1
Sina, F.2
Banihosseini, S.S.3
Kazemi, M.H.4
Kalhor, R.5
Shahidi, G.-A.6
Fakhrai-Rad, H.7
Ronaghi, M.8
Elahi, E.9
-
149
-
-
79751509762
-
Parkinson's disease: genetics and pathogenesis
-
Shulman J.M., De Jager P.L., Feany M.B. Parkinson's disease: genetics and pathogenesis. Annu. Rev. Pathol. 2011, 6:193-222. 10.1146/annurev-pathol-011110-130242.
-
(2011)
Annu. Rev. Pathol.
, vol.6
, pp. 193-222
-
-
Shulman, J.M.1
De Jager, P.L.2
Feany, M.B.3
-
150
-
-
0242300619
-
Alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., Gwinn-Hardy K. alpha-Synuclein locus triplication causes Parkinson's disease. Science 2003, 302:841. 10.1126/science.1090278.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
151
-
-
84874322054
-
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila
-
Song S., Jang S., Park J., Bang S., Choi S., Kwon K.-Y., Zhuang X., Kim E., Chung J. Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. J. Biol. Chem. 2013, 288:5660-5672. 10.1074/jbc.M112.430801.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 5660-5672
-
-
Song, S.1
Jang, S.2
Park, J.3
Bang, S.4
Choi, S.5
Kwon, K.-Y.6
Zhuang, X.7
Kim, E.8
Chung, J.9
-
152
-
-
79953846844
-
Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis
-
Soper J.H., Kehm V., Burd C.G., Bankaitis V.a, Lee V.M.-Y. Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis. J. Mol. Neurosci. 2011, 43:391-405. 10.1007/s12031-010-9455-5.
-
(2011)
J. Mol. Neurosci.
, vol.43
, pp. 391-405
-
-
Soper, J.H.1
Kehm, V.2
Burd, C.G.3
Bankaitis, V.A.4
Lee, V.M.-Y.5
-
153
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997, 388:839-840. 10.1038/42166.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
154
-
-
67650718212
-
Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin
-
Tain L.S., Chowdhury R.B., Tao R.N., Plun-Favreau H., Moisoi N., Martins L.M., Downward J., Whitworth a J., Tapon N. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death Differ. 2009, 16:1118-1125. 10.1038/cdd.2009.23.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1118-1125
-
-
Tain, L.S.1
Chowdhury, R.B.2
Tao, R.N.3
Plun-Favreau, H.4
Moisoi, N.5
Martins, L.M.6
Downward, J.7
Whitworth, A.J.8
Tapon, N.9
-
155
-
-
84866341645
-
Overexpression of ubiquitin carboxyl terminal hydrolase impairs multiple pathways during eye development in Drosophila melanogaster
-
Thao D.T.P., An P.N.T., Yamaguchi M., LinhThuoc T. Overexpression of ubiquitin carboxyl terminal hydrolase impairs multiple pathways during eye development in Drosophila melanogaster. Cell Tissue Res. 2012, 348:453-463. 10.1007/s00441-012-1404-x.
-
(2012)
Cell Tissue Res.
, vol.348
, pp. 453-463
-
-
Thao, D.T.P.1
An, P.N.T.2
Yamaguchi, M.3
LinhThuoc, T.4
-
156
-
-
84901615924
-
PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix
-
Thomas R.E., Andrews L.a, Burman J.L., Lin W.-Y., Pallanck L.J. PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix. PLoS Genet. 2014, 10:e1004279. 10.1371/journal.pgen.1004279.
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004279
-
-
Thomas, R.E.1
Andrews, L.A.2
Burman, J.L.3
Lin, W.-Y.4
Pallanck, L.J.5
-
157
-
-
57149110259
-
Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease
-
Todd A.M., Staveley B.E. Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease. Genome 2008, 51:1040-1046. 10.1139/G08-085.
-
(2008)
Genome
, vol.51
, pp. 1040-1046
-
-
Todd, A.M.1
Staveley, B.E.2
-
158
-
-
84887351302
-
Production of polyclonal anti-dUCH (Drosophila ubiquitin carboxyl-terminal hydrolase) antibodies
-
Tram N.T.Q., Trang N.T.T., Thao D.T.P., Thuoc T.L. Production of polyclonal anti-dUCH (Drosophila ubiquitin carboxyl-terminal hydrolase) antibodies. Monoclon. Antib. Immunodiagn. Immunother. 2013, 32:105-112. 10.1089/mab.2012.0109.
-
(2013)
Monoclon. Antib. Immunodiagn. Immunother.
, vol.32
, pp. 105-112
-
-
Tram, N.T.Q.1
Trang, N.T.T.2
Thao, D.T.P.3
Thuoc, T.L.4
-
159
-
-
72149095496
-
SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination
-
Trempe J.-F., Chen C.X.-Q., Grenier K., Camacho E.M., Kozlov G., McPherson P.S., Gehring K., Fon E.a SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol. Cel 2009, 36:1034-1047. 10.1016/j.molcel.2009.11.021.
-
(2009)
Mol. Cel
, vol.36
, pp. 1034-1047
-
-
Trempe, J.-F.1
Chen, C.X.-Q.2
Grenier, K.3
Camacho, E.M.4
Kozlov, G.5
McPherson, P.S.6
Gehring, K.7
Fon, E.A.8
-
160
-
-
38349014710
-
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease
-
Trinh K., Moore K., Wes P.D., Muchowski P.J., Dey J., Andrews L., Pallanck L.J. Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. J. Neurosci. 2008, 28:465-472. 10.1523/JNEUROSCI. 4778-07.2008.
-
(2008)
J. Neurosci.
, vol.28
, pp. 465-472
-
-
Trinh, K.1
Moore, K.2
Wes, P.D.3
Muchowski, P.J.4
Dey, J.5
Andrews, L.6
Pallanck, L.J.7
-
161
-
-
84928757484
-
PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila
-
Tsai P.-I., Course M.M., Lovas J.R., Hsieh C.-H., Babic M., Zinsmaier K.E., Wang X. PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila. Sci. Rep. 2014, 4:6962. 10.1038/srep06962.
-
(2014)
Sci. Rep.
, vol.4
, pp. 6962
-
-
Tsai, P.-I.1
Course, M.M.2
Lovas, J.R.3
Hsieh, C.-H.4
Babic, M.5
Zinsmaier, K.E.6
Wang, X.7
-
162
-
-
84895904175
-
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease
-
Tufi R., Gandhi S., de Castro I.P., Lehmann S., Angelova P.R., Dinsdale D., Deas E., Plun-Favreau H., Nicotera P., Abramov A.Y., Willis A.E., Mallucci G.R., Loh S.H.Y., Martins L.M. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat. Cell Biol. 2014, 16:157-166. 10.1038/ncb2901.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 157-166
-
-
Tufi, R.1
Gandhi, S.2
de Castro, I.P.3
Lehmann, S.4
Angelova, P.R.5
Dinsdale, D.6
Deas, E.7
Plun-Favreau, H.8
Nicotera, P.9
Abramov, A.Y.10
Willis, A.E.11
Mallucci, G.R.12
Loh, S.H.Y.13
Martins, L.M.14
-
163
-
-
0028808230
-
Role of auxilin in uncoating clathrin-coated vesicles
-
Ungewickell E., Ungewickell H., Holstein S.E., Lindner R., Prasad K., Barouch W., Martin B., Greene L.E., Eisenberg E. Role of auxilin in uncoating clathrin-coated vesicles. Nature 1995, 378:632-635. 10.1038/378632a0.
-
(1995)
Nature
, vol.378
, pp. 632-635
-
-
Ungewickell, E.1
Ungewickell, H.2
Holstein, S.E.3
Lindner, R.4
Prasad, K.5
Barouch, W.6
Martin, B.7
Greene, L.E.8
Eisenberg, E.9
-
164
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente E.M., Abou-Sleiman P.M., Caputo V., Muqit M.M.K., Harvey K., Gispert S., Ali Z., Del Turco D., Bentivoglio A.R., Healy D.G., Albanese A., Nussbaum R., González-Maldonado R., Deller T., Salvi S., Cortelli P., Gilks W.P., Latchman D.S., Harvey R.J., Dallapiccola B., Auburger G., Wood N.W. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004, 304:1158-1160. 10.1126/science.1096284.
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
Muqit, M.M.K.4
Harvey, K.5
Gispert, S.6
Ali, Z.7
Del Turco, D.8
Bentivoglio, A.R.9
Healy, D.G.10
Albanese, A.11
Nussbaum, R.12
González-Maldonado, R.13
Deller, T.14
Salvi, S.15
Cortelli, P.16
Gilks, W.P.17
Latchman, D.S.18
Harvey, R.J.19
Dallapiccola, B.20
Auburger, G.21
Wood, N.W.22
more..
-
165
-
-
5444268144
-
The zebrafish nrc mutant reveals a role for the polyphosphoinositide phosphatase synaptojanin 1 in cone photoreceptor ribbon anchoring
-
Van Epps H.A., Hayashi M., Lucast L., Stearns G.W., Hurley J.B., De Camilli P., Brockerhoff S.E. The zebrafish nrc mutant reveals a role for the polyphosphoinositide phosphatase synaptojanin 1 in cone photoreceptor ribbon anchoring. J. Neurosci. 2004, 24:8641-8650. 10.1523/JNEUROSCI.2892-04.2004.
-
(2004)
J. Neurosci.
, vol.24
, pp. 8641-8650
-
-
Van Epps, H.A.1
Hayashi, M.2
Lucast, L.3
Stearns, G.W.4
Hurley, J.B.5
De Camilli, P.6
Brockerhoff, S.E.7
-
166
-
-
84904006504
-
Synucleins regulate the kinetics of synaptic vesicle endocytosis
-
Vargas K.J., Makani S., Davis T., Westphal C.H., Castillo P.E., Chandra S.S. Synucleins regulate the kinetics of synaptic vesicle endocytosis. J. Neurosci. 2014, 34:9364-9376. 10.1523/JNEUROSCI. 4787-13.2014.
-
(2014)
J. Neurosci.
, vol.34
, pp. 9364-9376
-
-
Vargas, K.J.1
Makani, S.2
Davis, T.3
Westphal, C.H.4
Castillo, P.E.5
Chandra, S.S.6
-
167
-
-
70350683754
-
Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease
-
Venderova K., Kabbach G., Abdel-Messih E., Zhang Y., Parks R.J., Imai Y., Gehrke S., Ngsee J., Lavoie M.J., Slack R.S., Rao Y., Zhang Z., Lu B., Haque M.E., Park D.S. Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum. Mol. Genet. 2009, 18:4390-4404. 10.1093/hmg/ddp394.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4390-4404
-
-
Venderova, K.1
Kabbach, G.2
Abdel-Messih, E.3
Zhang, Y.4
Parks, R.J.5
Imai, Y.6
Gehrke, S.7
Ngsee, J.8
Lavoie, M.J.9
Slack, R.S.10
Rao, Y.11
Zhang, Z.12
Lu, B.13
Haque, M.E.14
Park, D.S.15
-
168
-
-
51649083468
-
Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation
-
Venken K.J.T., Kasprowicz J., Kuenen S., Yan J., Hassan B.a, Verstreken P. Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation. Nucleic Acids Res. 2008, 36:e114. 10.1093/nar/gkn486.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. e114
-
-
Venken, K.J.T.1
Kasprowicz, J.2
Kuenen, S.3
Yan, J.4
Hassan, B.A.5
Verstreken, P.6
-
169
-
-
80052287311
-
MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes
-
Venken K., Schulze K., Haelterman N. MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nature 2011, 8:737-743.
-
(2011)
Nature
, vol.8
, pp. 737-743
-
-
Venken, K.1
Schulze, K.2
Haelterman, N.3
-
170
-
-
0037023566
-
Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release
-
Verstreken P., Kjaerulff O., Lloyd T.E., Atkinson R., Zhou Y., Meinertzhagen I.a, Bellen H.J. Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell 2002, 109:101-112.
-
(2002)
Cell
, vol.109
, pp. 101-112
-
-
Verstreken, P.1
Kjaerulff, O.2
Lloyd, T.E.3
Atkinson, R.4
Zhou, Y.5
Meinertzhagen, I.A.6
Bellen, H.J.7
-
171
-
-
10744226845
-
Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating
-
Verstreken P., Koh T.-W., Schulze K.L., Zhai R.G., Hiesinger P.R., Zhou Y., Mehta S.Q., Cao Y., Roos J., Bellen H.J. Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron 2003, 40:733-748.
-
(2003)
Neuron
, vol.40
, pp. 733-748
-
-
Verstreken, P.1
Koh, T.-W.2
Schulze, K.L.3
Zhai, R.G.4
Hiesinger, P.R.5
Zhou, Y.6
Mehta, S.Q.7
Cao, Y.8
Roos, J.9
Bellen, H.J.10
-
172
-
-
84857462488
-
The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants
-
Vilain S., Esposito G., Haddad D., Schaap O., Dobreva M.P., Vos M., Van Meensel S., Morais V.a, De Strooper B., Verstreken P. The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. PLoS Genet. 2012, 8:e1002456. 10.1371/journal.pgen.1002456.
-
(2012)
PLoS Genet.
, vol.8
, pp. e1002456
-
-
Vilain, S.1
Esposito, G.2
Haddad, D.3
Schaap, O.4
Dobreva, M.P.5
Vos, M.6
Van Meensel, S.7
Morais, V.A.8
De Strooper, B.9
Verstreken, P.10
-
173
-
-
84916935483
-
Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposons
-
Vilain S., Vanhauwaert R., Maes I., Schoovaerts N., Zhou L., Soukup S., da Cunha R., Lauwers E., Fiers M., Verstreken P. Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposons. G3 (Bethesda) 2014, 4:2381-2387. 10.1534/g3.114.014803.
-
(2014)
G3 (Bethesda)
, vol.4
, pp. 2381-2387
-
-
Vilain, S.1
Vanhauwaert, R.2
Maes, I.3
Schoovaerts, N.4
Zhou, L.5
Soukup, S.6
da Cunha, R.7
Lauwers, E.8
Fiers, M.9
Verstreken, P.10
-
174
-
-
84876213313
-
The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
-
Vincow E.S., Merrihew G., Thomas R.E., Shulman N.J., Beyer R.P., MacCoss M.J., Pallanck L.J. The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:6400-6405. 10.1073/pnas.1221132110.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 6400-6405
-
-
Vincow, E.S.1
Merrihew, G.2
Thomas, R.E.3
Shulman, N.J.4
Beyer, R.P.5
MacCoss, M.J.6
Pallanck, L.J.7
-
175
-
-
21744443838
-
Prevalence and incidence of Parkinson's disease in Europe
-
Von Campenhausen S., Bornschein B., Wick R., Bötzel K., Sampaio C., Poewe W., Oertel W., Siebert U., Berger K., Dodel R. Prevalence and incidence of Parkinson's disease in Europe. Eur. Neuropsychopharmacol. 2005, 15:473-490. 10.1016/j.euroneuro.2005.04.007.
-
(2005)
Eur. Neuropsychopharmacol.
, vol.15
, pp. 473-490
-
-
Von Campenhausen, S.1
Bornschein, B.2
Wick, R.3
Bötzel, K.4
Sampaio, C.5
Poewe, W.6
Oertel, W.7
Siebert, U.8
Berger, K.9
Dodel, R.10
-
176
-
-
84861983560
-
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency
-
Vos M., Esposito G., Edirisinghe J.N., Vilain S., Haddad D.M., Slabbaert J.R., Van Meensel S., Schaap O., De Strooper B., Meganathan R., Morais V.a, Verstreken P. Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science 2012, 336:1306-1310. 10.1126/science.1218632.
-
(2012)
Science
, vol.336
, pp. 1306-1310
-
-
Vos, M.1
Esposito, G.2
Edirisinghe, J.N.3
Vilain, S.4
Haddad, D.M.5
Slabbaert, J.R.6
Van Meensel, S.7
Schaap, O.8
De Strooper, B.9
Meganathan, R.10
Morais, V.A.11
Verstreken, P.12
-
177
-
-
84892941561
-
Near-infrared 808nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model
-
Vos M., Lovisa B., Geens A., Morais V.a, Wagnières G., van den Bergh H., Ginggen A., De Strooper B., Tardy Y., Verstreken P. Near-infrared 808nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model. PLoS One 2013, 8:e78562. 10.1371/journal.pone.0078562.
-
(2013)
PLoS One
, vol.8
, pp. e78562
-
-
Vos, M.1
Lovisa, B.2
Geens, A.3
Morais, V.A.4
Wagnières, G.5
van den Bergh, H.6
Ginggen, A.7
De Strooper, B.8
Tardy, Y.9
Verstreken, P.10
-
178
-
-
33748600694
-
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila
-
Wang D., Qian L., Xiong H., Liu J., Neckameyer W.S., Oldham S., Xia K., Wang J., Bodmer R., Zhang Z. Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:13520-13525. 10.1073/pnas.0604661103.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 13520-13525
-
-
Wang, D.1
Qian, L.2
Xiong, H.3
Liu, J.4
Neckameyer, W.S.5
Oldham, S.6
Xia, K.7
Wang, J.8
Bodmer, R.9
Zhang, Z.10
-
179
-
-
34547885021
-
Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities
-
Wang C., Lu R., Ouyang X., Ho M.W.L., Chia W., Yu F., Lim K.-L. Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities. J. Neurosci. 2007, 27:8563-8570. 10.1523/JNEUROSCI. 0218-07.2007.
-
(2007)
J. Neurosci.
, vol.27
, pp. 8563-8570
-
-
Wang, C.1
Lu, R.2
Ouyang, X.3
Ho, M.W.L.4
Chia, W.5
Yu, F.6
Lim, K.-L.7
-
180
-
-
41549124987
-
Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
-
Wang D., Tang B., Zhao G., Pan Q., Xia K., Bodmer R., Zhang Z. Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol. Neurodegener. 2008, 3:3. 10.1186/1750-1326-3-3.
-
(2008)
Mol. Neurodegener.
, vol.3
, pp. 3
-
-
Wang, D.1
Tang, B.2
Zhao, G.3
Pan, Q.4
Xia, K.5
Bodmer, R.6
Zhang, Z.7
-
181
-
-
81055140895
-
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
-
Wang X., Winter D., Ashrafi G., Schlehe J., Wong Y.L., Selkoe D., Rice S., Steen J., LaVoie M.J., Schwarz T.L. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 2011, 147:893-906. 10.1016/j.cell.2011.10.018.
-
(2011)
Cell
, vol.147
, pp. 893-906
-
-
Wang, X.1
Winter, D.2
Ashrafi, G.3
Schlehe, J.4
Wong, Y.L.5
Selkoe, D.6
Rice, S.7
Steen, J.8
LaVoie, M.J.9
Schwarz, T.L.10
-
182
-
-
84907983816
-
In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila
-
Wang H.-S., Toh J., Ho P., Tio M., Zhao Y., Tan E.-K. In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila. Mol. Brain 2014, 7:73. 10.1186/s13041-014-0073-y.
-
(2014)
Mol. Brain
, vol.7
, pp. 73
-
-
Wang, H.-S.1
Toh, J.2
Ho, P.3
Tio, M.4
Zhao, Y.5
Tan, E.-K.6
-
183
-
-
84900388752
-
The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration
-
Wang S., Tan K.L., Agosto M.a, Xiong B., Yamamoto S., Sandoval H., Jaiswal M., Bayat V., Zhang K., Charng W.-L., David G., Duraine L., Venkatachalam K., Wensel T.G., Bellen H.J. The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2014, 12:e1001847. 10.1371/journal.pbio.1001847.
-
(2014)
PLoS Biol.
, vol.12
, pp. e1001847
-
-
Wang, S.1
Tan, K.L.2
Agosto, M.A.3
Xiong, B.4
Yamamoto, S.5
Sandoval, H.6
Jaiswal, M.7
Bayat, V.8
Zhang, K.9
Charng, W.-L.10
David, G.11
Duraine, L.12
Venkatachalam, K.13
Wensel, T.G.14
Bellen, H.J.15
-
184
-
-
84891730000
-
The dopaminergic system in the aging brain of Drosophila
-
White K.E., Humphrey D.M., Hirth F. The dopaminergic system in the aging brain of Drosophila. Front. Neurosci. 2010, 4:205. 10.3389/fnins.2010.00205.
-
(2010)
Front. Neurosci.
, vol.4
, pp. 205
-
-
White, K.E.1
Humphrey, D.M.2
Hirth, F.3
-
185
-
-
20344369560
-
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
-
Whitworth A.J., Theodore D.a, Greene J.C., Benes H., Wes P.D., Pallanck L.J. Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:8024-8029. 10.1073/pnas.0501078102.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 8024-8029
-
-
Whitworth, A.J.1
Theodore, D.A.2
Greene, J.C.3
Benes, H.4
Wes, P.D.5
Pallanck, L.J.6
-
186
-
-
58149397651
-
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
-
discussion 173
-
Whitworth A.J., Lee J.R., Ho V.M.-W., Flick R., Chowdhury R., McQuibban G.A. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Dis. Model. Mech. 2008, 1:168-174. discussion 173. 10.1242/dmm.000109.
-
(2008)
Dis. Model. Mech.
, vol.1
, pp. 168-174
-
-
Whitworth, A.J.1
Lee, J.R.2
Ho, V.M.-W.3
Flick, R.4
Chowdhury, R.5
McQuibban, G.A.6
-
187
-
-
0035882344
-
Expression of α-synuclein in the human brain: relation to Lewy body disease
-
Wirdefeldt K., Bogdanovic N. Expression of α-synuclein in the human brain: relation to Lewy body disease. Mol. brain 2001, 92:58-65.
-
(2001)
Mol. brain
, vol.92
, pp. 58-65
-
-
Wirdefeldt, K.1
Bogdanovic, N.2
-
188
-
-
84873028465
-
Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance
-
Wu Z., Sawada T., Shiba K., Liu S., Kanao T., Takahashi R., Hattori N., Imai Y., Lu B. Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance. Genes Dev. 2013, 27:157-162. 10.1101/gad.203406.112.
-
(2013)
Genes Dev.
, vol.27
, pp. 157-162
-
-
Wu, Z.1
Sawada, T.2
Shiba, K.3
Liu, S.4
Kanao, T.5
Takahashi, R.6
Hattori, N.7
Imai, Y.8
Lu, B.9
-
189
-
-
84876414704
-
Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart
-
Yacobi-Sharon K., Namdar Y., Arama E. Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart. Dev. Cell 2013, 25:29-42. 10.1016/j.devcel.2013.02.002.
-
(2013)
Dev. Cell
, vol.25
, pp. 29-42
-
-
Yacobi-Sharon, K.1
Namdar, Y.2
Arama, E.3
-
190
-
-
13544266179
-
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity
-
Yamamoto A., Friedlein A., Imai Y., Takahashi R., Kahle P.J., Haass C. Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. J. Biol. Chem. 2005, 280:3390-3399. 10.1074/jbc.M407724200.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 3390-3399
-
-
Yamamoto, A.1
Friedlein, A.2
Imai, Y.3
Takahashi, R.4
Kahle, P.J.5
Haass, C.6
-
191
-
-
84864991509
-
Atg9 vesicles are an important membrane source during early steps of autophagosome formation
-
Yamamoto H., Kakuta S., Watanabe T.M., Kitamura A., Sekito T., Kondo-Kakuta C., Ichikawa R., Kinjo M., Ohsumi Y. Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J. Cell Biol. 2012, 198:219-233. 10.1083/jcb.201202061.
-
(2012)
J. Cell Biol.
, vol.198
, pp. 219-233
-
-
Yamamoto, H.1
Kakuta, S.2
Watanabe, T.M.3
Kitamura, A.4
Sekito, T.5
Kondo-Kakuta, C.6
Ichikawa, R.7
Kinjo, M.8
Ohsumi, Y.9
-
192
-
-
26444489693
-
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
-
Yang Y., Gehrke S., Haque M.E., Imai Y., Kosek J., Yang L., Beal M.F., Nishimura I., Wakamatsu K., Ito S., Takahashi R., Lu B. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:13670-13675. 10.1073/pnas.0504610102.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 13670-13675
-
-
Yang, Y.1
Gehrke, S.2
Haque, M.E.3
Imai, Y.4
Kosek, J.5
Yang, L.6
Beal, M.F.7
Nishimura, I.8
Wakamatsu, K.9
Ito, S.10
Takahashi, R.11
Lu, B.12
-
193
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
-
Yang Y., Gehrke S., Imai Y., Huang Z., Ouyang Y., Wang J.-W., Yang L., Beal M.F., Vogel H., Lu B. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:10793-10798. 10.1073/pnas.0602493103.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 10793-10798
-
-
Yang, Y.1
Gehrke, S.2
Imai, Y.3
Huang, Z.4
Ouyang, Y.5
Wang, J.-W.6
Yang, L.7
Beal, M.F.8
Vogel, H.9
Lu, B.10
-
194
-
-
44349195101
-
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
-
Yang Y., Ouyang Y., Yang L., Beal M.F., McQuibban A., Vogel H., Lu B. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:7070-7075. 10.1073/pnas.0711845105.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 7070-7075
-
-
Yang, Y.1
Ouyang, Y.2
Yang, L.3
Beal, M.F.4
McQuibban, A.5
Vogel, H.6
Lu, B.7
-
195
-
-
77749292142
-
Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice
-
Yim Y.-I., Sun T., Wu L.-G., Raimondi A., De Camilli P., Eisenberg E., Greene L.E. Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:4412-4417. 10.1073/pnas.1000738107.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 4412-4417
-
-
Yim, Y.-I.1
Sun, T.2
Wu, L.-G.3
Raimondi, A.4
De Camilli, P.5
Eisenberg, E.6
Greene, L.E.7
-
196
-
-
58149375389
-
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo
-
Yun J., Cao J.H., Dodson M.W., Clark I.E., Kapahi P., Chowdhury R.B., Guo M. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J. Neurosci. 2008, 28:14500-14510. 10.1523/JNEUROSCI. 5141-08.2008.
-
(2008)
J. Neurosci.
, vol.28
, pp. 14500-14510
-
-
Yun, J.1
Cao, J.H.2
Dodson, M.W.3
Clark, I.E.4
Kapahi, P.5
Chowdhury, R.B.6
Guo, M.7
-
197
-
-
84883034462
-
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
-
Yun H.J., Park J., Ho D.H., Kim H., Kim C.-H., Oh H., Ga I., Seo H., Chang S., Son I., Seol W. LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Exp. Mol. Med. 2013, 45:e36. 10.1038/emm.2013.68.
-
(2013)
Exp. Mol. Med.
, vol.45
, pp. e36
-
-
Yun, H.J.1
Park, J.2
Ho, D.H.3
Kim, H.4
Kim, C.-H.5
Oh, H.6
Ga, I.7
Seo, H.8
Chang, S.9
Son, I.10
Seol, W.11
-
198
-
-
0028284411
-
Purification and characterization of eukaryotic polypeptide chain initiation factor 4F from Drosophila melanogaster embryos
-
Zapata J.M., Martínez M.A., Sierra J.M. Purification and characterization of eukaryotic polypeptide chain initiation factor 4F from Drosophila melanogaster embryos. J. Biol. Chem. 1994, 269:18047-18052.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 18047-18052
-
-
Zapata, J.M.1
Martínez, M.A.2
Sierra, J.M.3
-
199
-
-
77958100823
-
Electrophysiological recording from Drosophila larval body-wall muscles
-
(pdb.prot5487-pdb.prot5487)
-
Zhang B., Stewart B. Electrophysiological recording from Drosophila larval body-wall muscles. Cold Spring Harb. Protoc. 2010, (pdb.prot5487-pdb.prot5487). 10.1101/pdb.prot5487.
-
(2010)
Cold Spring Harb. Protoc.
-
-
Zhang, B.1
Stewart, B.2
-
200
-
-
84878529485
-
TRAP1 rescues PINK1 loss-of-function phenotypes
-
Zhang L., Karsten P., Hamm S., Pogson J.H., Müller-Rischart a K., Exner N., Haass C., Whitworth A.J., Winklhofer K.F., Schulz J.B., Voigt A. TRAP1 rescues PINK1 loss-of-function phenotypes. Hum. Mol. Genet. 2013, 22:2829-2841. 10.1093/hmg/ddt132.
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 2829-2841
-
-
Zhang, L.1
Karsten, P.2
Hamm, S.3
Pogson, J.H.4
Müller-Rischart, A.K.5
Exner, N.6
Haass, C.7
Whitworth, A.J.8
Winklhofer, K.F.9
Schulz, J.B.10
Voigt, A.11
-
201
-
-
77950384477
-
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
-
Ziviani E., Tao R.N., Whitworth A.J. Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:5018-5023. 10.1073/pnas.0913485107.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 5018-5023
-
-
Ziviani, E.1
Tao, R.N.2
Whitworth, A.J.3
|