DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 21, 2010, Pages 9747-9752

  Hao, Ling Yang ^a   Giasson, Benoit I ^b   Bonini, Nancy M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Drosophila; Oxidative stress; Parkin; Parkinson's disease

Indexed keywords

ADENOSINE TRIPHOSPHATE; DJ 1 PROTEIN; MITOCHONDRIAL PROTEIN; PARKIN; PROTEIN PINK1; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; DROSOPHILA; LOSS OF FUNCTION MUTATION; MITOCHONDRIAL RESPIRATION; MITOCHONDRION FUNCTION; NONHUMAN; PRIORITY JOURNAL; SPERMATOGENESIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE DELETION; MALE; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; MUTATION; NERVE TISSUE PROTEINS; ONCOGENE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SPERMATOGENESIS; UP-REGULATION;

EID: 77953084081     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911175107     Document Type: Article

References (40)

1. Gelb DJ, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinson disease. Arch Neurol 56:33-39.
2. Forman MS, Lee VM, Trojanowski JQ (2005) Nosology of Parkinson's disease: Looking for the way out of a quagmire. Neuron 47:479-482.
3. Pakkenberg B, Møller A, Gundersen HJ, Mouritzen Dam A, Pakkenberg H (1991) The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J Neurol Neurosurg Psychiatry 54:30-33.
4. Damier P, Hirsch EC, Agid Y, Graybiel AM (1999) The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 122:1437-1448.
5. Warner TT, Schapira AH (2003) Genetic and environmental factors in the cause of Parkinson's disease. Ann Neurol 53 (Suppl 3):S16-S23; discussion S23-S15.
6. Bonifati V, et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299:256-259. (Pubitemid 36131051)
7. Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol 2:e362.
8. Meulener MC, et al. (2006) Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc Natl Acad Sci USA 103: 12517-12522.
9. Goldberg MS, et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45:489-496.
10. Kim RH, et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci USA 102: 5215-5220.
11. Park J, et al. (2005) Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene 361:133-139.
12. Meulener M, et al. (2005) Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr Biol 15:1572-1577.
13. Shimura H, et al. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25:302-305.
14. Narendra D, Tanaka A, Suen DF, Youle RJ (2009) Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy 5:706-708.
15. Valente EM, et al. (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304:1158-1160.
16. Greene JC, et al. (2003) Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci USA 100:4078-4083.
17. Clark IE, et al. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441:1162-1166.
18. Park J, et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441:1157-1161.
19. Moore DJ, West AB, Dawson VL, Dawson TM (2005) Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci 28:57-87.
20. Canet-Avilés RM, et al. (2004) The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 101:9103-9108.
21. Zhang L, et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: Implications for pathogenesis. Hum Mol Genet 14:2063-2073.
22. Pagliarini DJ, et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134:112-123.
23. Menzies FM, Yenisetti SC, Min KT (2005) Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr Biol 15:1578-1582.
24. Poole AC, et al. (2008) The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci USA 105:1638-1643.
25. Yang Y, et al. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci USA 105:7070-7075.
26. Vijg J, Campisi J (2008) Puzzles, promises and a cure for ageing. Nature 454: 1065-1071.
27. Hales KG, Fuller MT (1997) Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell 90:121-129.
28. Wagenfeld A, Yeung CH, Strupat K, Cooper TG (1998) Shedding of a rat epididymal sperm protein associated with infertility induced by ornidazole and alpha-chlorohydrin. Biol Reprod 58:1257-1265.
29. Welch JE, Barbee RR, Roberts NL, Suarez JD, Klinefelter GR (1998) SP22: A novel fertility protein from a highly conserved gene family. J Androl 19:385-393.
30. Whyard TC, Cheung W, Sheynkin Y, Waltzer WC, Hod Y (2000) Identification of RS as a flagellar and head sperm protein. Mol Reprod Dev 55:189-196.
31. Oberländer G, Yeung CH, Cooper TG (1996) Influence of oral administration of ornidazole on capacitation and the activity of some glycolytic enzymes of rat spermatozoa. J Reprod Fertil 106:231-239. (Pubitemid 126448890)
32. Andres-Mateos E, et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci USA 104:14807-14812.
33. Chandran JS, et al. (2008) Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis 29:505-514.
34. Moreno-Loshuertos R, et al. (2006) Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants. Nat Genet 38:1261-1268.
35. Tain LS, et al. (2009) Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death Differ 16:1118-1125.
36. Yang Y, et al. (2006) Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci USA 103:10793-10798.
37. Chen H, McCaffery JM, Chan DC (2007) Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130:548-562.
38. Outeiro TF, et al. (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317:516-519.
39. Schapira AH, et al. (1989) Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1:1269. (Pubitemid 19140359)
40. Feany MB, Bender WW (2000) A Drosophila model of Parkinson's disease. Nature 404: 394-398.