Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice

Neurotoxicology and Teratology

Volumn 46, Issue , 2014, Pages 62-67

  Dai, Ying ^a   Clark, Joanne ^a   Zheng, Kangni ^a,b   Kujoth, Gregory C ^c   Prolla, Tomas A ^d   Simon, David K ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Aging; MtDNA mutations; Neurodegeneration; Oxidative stress; Parkinson's disease; Tyrosine hydroxylase

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DNA DIRECTED DNA POLYMERASE GAMMA; DOPAMINE; MITOCHONDRIAL DNA; TYROSINE 3 MONOOXYGENASE; DNA DIRECTED DNA POLYMERASE; POLG PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL AGING; CELL COUNT; CELL STRESS; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINERGIC NERVE CELL; GENETIC SUSCEPTIBILITY; HETEROZYGOTE; HOMOZYGOTE; METABOLITE; MOLECULAR PATHOLOGY; MOUSE; MUTATIONAL ANALYSIS; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; POLG GENE; PREMATURE AGING; SOMATIC MUTATION; STRIA TERMINALIS; SUBSTANTIA NIGRA; AGING; ANIMAL; C57BL MOUSE; CHEMISTRY; CORPUS STRIATUM; DRUG EFFECTS; GENETICS; INTOXICATION; METABOLISM; MUTATION; NERVE CELL; TRANSGENIC MOUSE;

AGING; ANIMALS; CELL COUNT; CORPUS STRIATUM; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; DOPAMINE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MPTP POISONING; MUTATION; NEURONS; OXIDATIVE STRESS; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 84909630198     PISSN: 08920362     EISSN: 18729738     Source Type: Journal    
DOI: 10.1016/j.ntt.2014.10.004     Document Type: Article

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