Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

DMM Disease Models and Mechanisms

Volumn 7, Issue 12, 2014, Pages 1351-1363

  Dodson, Mark W ^a,b,c   Leung, Lok K ^a   Lone, Mohiddin ^a   Lizzio, Michael A ^a,d   Guo, Ming ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d Bldg 142   (United States)

Author keywords

Autophagy; Drosophila; Endosomes; LRRK2; Lysosome; Parkinson's disease; Rab7; Rab9

Indexed keywords

GUANOSINE TRIPHOSPHATASE; LEUCINE RICH REPEAT KINASE 2; MESYLIC ACID ETHYL ESTER; RAB7 PROTEIN; RAB9 PROTEIN; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; LRRK2 PROTEIN, DROSOPHILA; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; STOP CODON;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; ENDOSOME; EXON; FEMALE; FEMALE FERTILITY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; LYSOSOME; MEMBRANE TRANSPORT; MITOCHONDRIAL TARGETING SIGNAL; MOTONEURON; NONHUMAN; NONSENSE MUTATION; NULL ALLELE; OVARY FOLLICLE CELL; PARKINSON DISEASE; TRANS GOLGI NETWORK; ALLELE; ANIMAL; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOSOL; DROSOPHILA MELANOGASTER; FLUORESCENCE MICROSCOPY; GENETICS; HUMAN; METABOLISM; MUTATION; PHENOTYPE; PHYSIOLOGY; STOP CODON; TRANSGENIC ANIMAL; TUNEL ASSAY;

ALLELES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; CODON, NONSENSE; CYTOSOL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOSOMES; ETHYL METHANESULFONATE; FEMALE; HUMANS; IN SITU NICK-END LABELING; LYSOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MUTATION; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES;

EID: 84919674911     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.017020     Document Type: Article

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