Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration

Journal of Visualized Experiments

Volumn , Issue 49, 2011, Pages

  Ali, Yousuf O ^a   Escala, Wilfredo ^a   Ruan, Kai ^a   Zhai, R Grace ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80355139374     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2504     Document Type: Article

References (11)

1. Bonini, N. M., Fortini, M.E. Human neurodegenerative disease modeling using Drosophila. Annual Review of Neuroscience 26, 627-656 (2003).
2. Lloyd, T. E. & Taylor, J. P. Flightless flies: Drosophila models of neuromuscular disease. Ann N Y Acad Sci 1184, e1-20 (2010).
3. Benzer, S. Behavioral mutants of Drosophila isolated by countercurrent distribution. Proc. Natl. Acad. Sci. USA 58, 1112-1119 (1967).
4. Le Bourg, E., Buecher, C. Learned suppression of photopositive tendencies in Drosophila melanogaster. Animal Learning & Behavior 30, 330-341 (2002).
5. Seugnet, L., Suzuki, Y., Stidd, R. & Shaw, P. J. Aversive phototaxic suppression: evaluation of a short-term memory assay in Drosophila melanogaster. Genes Brain Behav 8, 377-89 (2009).
6. Nilsen, S. P., Chan, Y-B, Huber, R., Kravitz, E.A. Gender-selective patterns of aggressive behavior in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 101, 12342-12347 (2004).
7. Leal, S. M., Neckameyer, W.S. Pharmacological evidence for GABAergic regulation of specific behaviors in Drosophila melanogaster. J Neurobiol. 50, 245-61 (2002).
8. Wittmann, C. W., Wszolek, M.F., Shulman, J.M., Salvaterra, P.M., Lewis, J., Hutton, M., Feany, M.B. Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles Science 293, 711-714 (2001).
9. Mershin, A., Pavlopoulos, E., Fitch, O., Braden, B.C., Nanopoulos, D.V., Skoulakis, E.M. Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons. Learn Mem. 11, 277-87 (2004).
10. Ganetzky, B. & Wu, C. F. Indirect Suppression Involving Behavioral Mutants with Altered Nerve Excitability in DROSOPHILA MELANOGASTER. Genetics 100, 597-614 (1982).
11. Greenspan, R. J., Finn, J. A., Jr. & Hall, J. C. Acetylcholinesterase mutants in Drosophila and their effects on the structure and function of the central nervous system. J Comp Neurol 189, 741-74 (1980).