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Volumn 400, Issue 1-2, 2007, Pages 158-165

Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits

Author keywords

Climbing ability; Neurodegeneration; Paraquat; Parkinson's disease

Indexed keywords

DJ 1 PROTEIN; PARAQUAT;

EID: 34548021452     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2007.06.013     Document Type: Article
Times cited : (78)

References (34)
  • 1
  • 2
    • 0037428241 scopus 로고    scopus 로고
    • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    • Bonifati V., et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299 (2003) 256-259
    • (2003) Science , vol.299 , pp. 256-259
    • Bonifati, V.1
  • 3
    • 2942684871 scopus 로고    scopus 로고
    • The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
    • Canet-Aviles R.M., et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 9103-9108
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 9103-9108
    • Canet-Aviles, R.M.1
  • 4
    • 20444367300 scopus 로고    scopus 로고
    • Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice
    • Chen L., et al. Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J. Biol. Chem. 280 (2005) 21418-21426
    • (2005) J. Biol. Chem. , vol.280 , pp. 21418-21426
    • Chen, L.1
  • 5
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: mechanisms and models
    • Dauer W., and Przedborski S. Parkinson's disease: mechanisms and models. Neuron 39 (2003) 889-909
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 6
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • Dawson T.M., and Dawson V.L. Molecular pathways of neurodegeneration in Parkinson's disease. Science 302 (2003) 819-822
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 7
    • 0042767676 scopus 로고    scopus 로고
    • Parkinson's disease: piecing together a genetic jigsaw
    • Dekker M.C., Bonifati V., and van Duijn C.M. Parkinson's disease: piecing together a genetic jigsaw. Brain 126 (2003) 1722-1733
    • (2003) Brain , vol.126 , pp. 1722-1733
    • Dekker, M.C.1    Bonifati, V.2    van Duijn, C.M.3
  • 8
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany M.B., and Bender W.W. A Drosophila model of Parkinson's disease. Nature 404 (2000) 394-398
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 9
    • 0037370716 scopus 로고    scopus 로고
    • Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase
    • Friggi-Grelin F., Coulom H., Meller M., Gomez D., Hirsh J., and Birman S. Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase. J. Neurobiol. 54 (2003) 618-627
    • (2003) J. Neurobiol. , vol.54 , pp. 618-627
    • Friggi-Grelin, F.1    Coulom, H.2    Meller, M.3    Gomez, D.4    Hirsh, J.5    Birman, S.6
  • 10
    • 0031727163 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease
    • Gasser T. Genetics of Parkinson's disease. Clin. Genet. 54 (1998) 259-265
    • (1998) Clin. Genet. , vol.54 , pp. 259-265
    • Gasser, T.1
  • 11
    • 0038784529 scopus 로고    scopus 로고
    • Are ubiquitination pathways central to Parkinson's disease?
    • Giasson B.I., and Lee V.M. Are ubiquitination pathways central to Parkinson's disease?. Cell 114 (2003) 1-8
    • (2003) Cell , vol.114 , pp. 1-8
    • Giasson, B.I.1    Lee, V.M.2
  • 12
    • 0036185054 scopus 로고    scopus 로고
    • RNAi triggered by symmetrically transcribed transgenes in Drosophila melanogaster
    • Giordano E., Rendina R., Peluso I., and Furia M. RNAi triggered by symmetrically transcribed transgenes in Drosophila melanogaster. Genetics 160 (2002) 637-648
    • (2002) Genetics , vol.160 , pp. 637-648
    • Giordano, E.1    Rendina, R.2    Peluso, I.3    Furia, M.4
  • 13
    • 13844253723 scopus 로고    scopus 로고
    • Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
    • Goldberg M.S., et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45 (2005) 489-496
    • (2005) Neuron , vol.45 , pp. 489-496
    • Goldberg, M.S.1
  • 15
    • 20144389422 scopus 로고    scopus 로고
    • Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
    • Kim R.H., et al. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5215-5220
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 5215-5220
    • Kim, R.H.1
  • 16
    • 1842740232 scopus 로고    scopus 로고
    • Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells
    • Kinumi T., Kimata J., Taira T., Ariga H., and Niki E. Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 317 (2004) 722-728
    • (2004) Biochem. Biophys. Res. Commun. , vol.317 , pp. 722-728
    • Kinumi, T.1    Kimata, J.2    Taira, T.3    Ariga, H.4    Niki, E.5
  • 17
    • 33644610520 scopus 로고    scopus 로고
    • The genetics of Parkinson disease: implications for neurological care
    • Klein C., and Schlossmacher M.G. The genetics of Parkinson disease: implications for neurological care. Nat. Clin. Pract. Neurol. 2 (2006) 136-146
    • (2006) Nat. Clin. Pract. Neurol. , vol.2 , pp. 136-146
    • Klein, C.1    Schlossmacher, M.G.2
  • 18
    • 24044506249 scopus 로고    scopus 로고
    • Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress
    • Menzies F.M., Yenisetti S.C., and Min K.T. Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr. Biol. 15 (2005) 1578-1582
    • (2005) Curr. Biol. , vol.15 , pp. 1578-1582
    • Menzies, F.M.1    Yenisetti, S.C.2    Min, K.T.3
  • 19
    • 24044472010 scopus 로고    scopus 로고
    • Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
    • Meulener M., et al. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr. Biol. 15 (2005) 1572-1577
    • (2005) Curr. Biol. , vol.15 , pp. 1572-1577
    • Meulener, M.1
  • 20
    • 33747611218 scopus 로고    scopus 로고
    • Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging
    • Meulener M.C., Xu K., Thomson L., Ischiropoulos H., and Bonini N.M. Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 12517-12522
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 12517-12522
    • Meulener, M.C.1    Xu, K.2    Thomson, L.3    Ischiropoulos, H.4    Bonini, N.M.5
  • 21
    • 0034906096 scopus 로고    scopus 로고
    • Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat
    • Mitsumoto A., Nakagawa Y., Takeuchi A., Okawa K., Iwamatsu A., and Takanezawa Y. Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat. Free Radic. Res. 35 (2001) 301-310
    • (2001) Free Radic. Res. , vol.35 , pp. 301-310
    • Mitsumoto, A.1    Nakagawa, Y.2    Takeuchi, A.3    Okawa, K.4    Iwamatsu, A.5    Takanezawa, Y.6
  • 23
    • 27144519984 scopus 로고    scopus 로고
    • Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
    • Park J., Kim S.Y., Cha G.H., Lee S.B., Kim S., and Chung J. Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene 361 (2005) 133-139
    • (2005) Gene , vol.361 , pp. 133-139
    • Park, J.1    Kim, S.Y.2    Cha, G.H.3    Lee, S.B.4    Kim, S.5    Chung, J.6
  • 24
    • 0036137083 scopus 로고    scopus 로고
    • Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster
    • Pendleton R.G., Parvez F., Sayed M., and Hillman R. Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster. J. Pharmacol. Exp. Ther. 300 (2002) 91-96
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 91-96
    • Pendleton, R.G.1    Parvez, F.2    Sayed, M.3    Hillman, R.4
  • 25
    • 0029834756 scopus 로고    scopus 로고
    • The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
    • Riesgo-Escovar J.R., Jenni M., Fritz A., and Hafen E. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 10 (1996) 2759-2768
    • (1996) Genes Dev. , vol.10 , pp. 2759-2768
    • Riesgo-Escovar, J.R.1    Jenni, M.2    Fritz, A.3    Hafen, E.4
  • 26
    • 13944267769 scopus 로고    scopus 로고
    • DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
    • Shendelman S., Jonason A., Martinat C., Leete T., and Abeliovich A. DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol. 2 (2004) e362
    • (2004) PLoS Biol. , vol.2
    • Shendelman, S.1    Jonason, A.2    Martinat, C.3    Leete, T.4    Abeliovich, A.5
  • 28
    • 5444255433 scopus 로고    scopus 로고
    • Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration
    • Uversky V.N. Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res. 318 (2004) 225-241
    • (2004) Cell Tissue Res. , vol.318 , pp. 225-241
    • Uversky, V.N.1
  • 29
    • 33750840222 scopus 로고    scopus 로고
    • Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant
    • Walker D.W., et al. Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 16382-16387
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 16382-16387
    • Walker, D.W.1
  • 30
    • 0242362732 scopus 로고    scopus 로고
    • JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
    • Wang M.C., Bohmann D., and Jasper H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev. Cell 5 (2003) 811-816
    • (2003) Dev. Cell , vol.5 , pp. 811-816
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 31
    • 33644862373 scopus 로고    scopus 로고
    • Drosophila models pioneer a new approach to drug discovery for Parkinson's disease
    • Whitworth A.J., Wes P.D., and Pallanck L.J. Drosophila models pioneer a new approach to drug discovery for Parkinson's disease. Drug Discov. Today 11 (2006) 119-126
    • (2006) Drug Discov. Today , vol.11 , pp. 119-126
    • Whitworth, A.J.1    Wes, P.D.2    Pallanck, L.J.3
  • 32
    • 26444489693 scopus 로고    scopus 로고
    • Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
    • Yang Y., et al. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 13670-13675
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 13670-13675
    • Yang, Y.1
  • 33
    • 0345357664 scopus 로고    scopus 로고
    • Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
    • Yokota T., Sugawara K., Ito K., Takahashi R., Ariga H., and Mizusawa H. Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun. 312 (2003) 1342-1348
    • (2003) Biochem. Biophys. Res. Commun. , vol.312 , pp. 1342-1348
    • Yokota, T.1    Sugawara, K.2    Ito, K.3    Takahashi, R.4    Ariga, H.5    Mizusawa, H.6
  • 34
    • 31344464179 scopus 로고    scopus 로고
    • The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein
    • Zhou W., Zhu M., Wilson M.A., Petsko G.A., and Fink A.L. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J. Mol. Biol. 356 (2006) 1036-1048
    • (2006) J. Mol. Biol. , vol.356 , pp. 1036-1048
    • Zhou, W.1    Zhu, M.2    Wilson, M.A.3    Petsko, G.A.4    Fink, A.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.