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Volumn 5, Issue , 2004, Pages

Parkin counteracts symptoms in a Drosophila model of Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; PARKIN; PROTEASOME; UBIQUITIN PROTEIN LIGASE;

EID: 2642516493     PISSN: 14712202     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2202-5-14     Document Type: Review
Times cited : (105)

References (62)
  • 2
    • 0033377945 scopus 로고    scopus 로고
    • The genetics of Parkinson's disease
    • Spacey SD, Wood NW: The genetics of Parkinson's disease. Curr Opin Neruol 1999, 12:427-432.
    • (1999) Curr. Opin. Neruol. , vol.12 , pp. 427-432
    • Spacey, S.D.1    Wood, N.W.2
  • 3
    • 0034646514 scopus 로고    scopus 로고
    • New Animal Models for Parkinson's Disease
    • Dawson TM: New Animal Models for Parkinson's Disease. Cell 2000, 101:115-118.
    • (2000) Cell , vol.101 , pp. 115-118
    • Dawson, T.M.1
  • 4
    • 0035959931 scopus 로고    scopus 로고
    • Parkin and the molecular pathways of Parkinson's disease
    • Giasson BI, Lee VM: Parkin and the molecular pathways of Parkinson's disease. Neuron 2001, 31:885-8.
    • (2001) Neuron. , vol.31 , pp. 885-888
    • Giasson, B.I.1    Lee, V.M.2
  • 5
    • 0036775723 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease and biochemical studies of implicated gene products
    • Lansbury PT Jr, Brice A: Genetics of Parkinson's disease and biochemical studies of implicated gene products. Curr Opin Cell Biol 2002, 14:653-60.
    • (2002) Curr. Opin. Cell. Biol. , vol.14 , pp. 653-660
    • Lansbury Jr., P.T.1    Brice, A.2
  • 8
    • 10544234193 scopus 로고    scopus 로고
    • Mapping of a gene for Parkinson's disease to chromosome 4q21-q23
    • Polymeropoulos MH, Higgins JJ, Golbe LI, Nussbaum RL: Mapping of a gene for Parkinson's disease to chromosome 4q21-q23. Science 1996, 274:1197-1198.
    • (1996) Science , vol.274 , pp. 1197-1198
    • Polymeropoulos, M.H.1    Higgins, J.J.2    Golbe, L.I.3    Nussbaum, R.L.4
  • 10
    • 0028277520 scopus 로고
    • Identification of two distinct synucleins from human brain
    • Jakes R, Spillantini MG, Goedert M: Identification of two distinct synucleins from human brain. FEBS Letters 1994, 345:27-32.
    • (1994) FEBS Letters , vol.345 , pp. 27-32
    • Jakes, R.1    Spillantini, M.G.2    Goedert, M.3
  • 11
    • 0032102455 scopus 로고    scopus 로고
    • The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
    • Clayton DF, George JM: The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 1998, 21:249-254.
    • (1998) Trends Neurosci. , vol.21 , pp. 249-254
    • Clayton, D.F.1    George, J.M.2
  • 14
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
    • Conway KA, Harper JD, Lansbury P: Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 1998, 4:1318-1320.
    • (1998) Nat. Med. , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.3
  • 15
    • 0034646391 scopus 로고    scopus 로고
    • Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
    • Conway KA, Harper JD, Lansbury PT: Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 2000, 39:2552-2563.
    • (2000) Biochemistry , vol.39 , pp. 2552-2563
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 16
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
    • Conway KA, Lee SJ, Rochet JC, Ding TT, Williamson RE, Lansbury PT Jr: Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc Natl Acad Sci USA 2000, 97:571-6.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 571-576
    • Conway, K.A.1    Lee, S.J.2    Rochet, J.C.3    Ding, T.T.4    Williamson, R.E.5    Lansbury Jr., P.T.6
  • 19
    • 0343517605 scopus 로고    scopus 로고
    • A new mutation in the parkin gene in a patient with atypical autosomal recessive juvenile parkinsonism
    • Munoz E, Pastor P, Marti MJ, Oliva R, Tolosa E: A new mutation in the parkin gene in a patient with atypical autosomal recessive juvenile parkinsonism. Neurosci Lett 2000, 289:66-8.
    • (2000) Neurosci. Lett. , vol.289 , pp. 66-68
    • Munoz, E.1    Pastor, P.2    Marti, M.J.3    Oliva, R.4    Tolosa, E.5
  • 20
    • 0030015934 scopus 로고    scopus 로고
    • Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism
    • Ishikawa A, Tsuji S: Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism. Neurology 1996, 47:160-166.
    • (1996) Neurology , vol.47 , pp. 160-166
    • Ishikawa, A.1    Tsuji, S.2
  • 25
    • 0034915764 scopus 로고    scopus 로고
    • Mechanisms underlying ubiquitination
    • Pickart CM: Mechanisms underlying ubiquitination. Annu Rev Biochem 2001, 70:503-33.
    • (2001) Annu. Rev. Biochem. , vol.70 , pp. 503-533
    • Pickart, C.M.1
  • 27
    • 0035967883 scopus 로고    scopus 로고
    • An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
    • Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R: An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 2001, 105:891-902.
    • (2001) Cell , vol.105 , pp. 891-902
    • Imai, Y.1    Soda, M.2    Inoue, H.3    Hattori, N.4    Mizuno, Y.5    Takahashi, R.6
  • 28
    • 0034700158 scopus 로고    scopus 로고
    • Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
    • Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM: Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci U S A 2000, 97:13354-9.
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 13354-13359
    • Zhang, Y.1    Gao, J.2    Chung, K.K.3    Huang, H.4    Dawson, V.L.5    Dawson, T.M.6
  • 29
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin- 1: Implications for Lewy-body formation in Parkinson disease
    • Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM: Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin- 1: implications for Lewy-body formation in Parkinson disease. Nat Med 2001, 7:1144-50.
    • (2001) Nat. Med. , vol.7 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 30
    • 0034680913 scopus 로고    scopus 로고
    • Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity
    • Imai Y, Soda M, Takahashi R: Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity. J Biol Chem 2000, 275:35661-35664.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35661-35664
    • Imai, Y.1    Soda, M.2    Takahashi, R.3
  • 32
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany MB, Bender WW: A Drosophila model of Parkinson's disease. Nature 2000, 404:394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 33
    • 0141841634 scopus 로고    scopus 로고
    • Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease
    • Scherzer CR, Jensen RV, Gullans SR, Feany MB: Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. Hum Mol Genet 2003, 12:2457-66.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2457-2466
    • Scherzer, C.R.1    Jensen, R.V.2    Gullans, S.R.3    Feany, M.B.4
  • 34
    • 0036137083 scopus 로고    scopus 로고
    • Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster
    • Pendleton RG, Parvez F, Sayed M, Hillman R: Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster. J Pharmacol Exp Ther 2002, 300:91-6.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 91-96
    • Pendleton, R.G.1    Parvez, F.2    Sayed, M.3    Hillman, R.4
  • 35
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
    • Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM: Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 2002, 295:865-8.
    • (2002) Science , vol.295 , pp. 865-868
    • Auluck, P.K.1    Chan, H.Y.2    Trojanowski, J.Q.3    Lee, V.M.4    Bonini, N.M.5
  • 36
    • 0036852712 scopus 로고    scopus 로고
    • Pharmacological prevention of Parkinson disease in Drosophila
    • Auluck PK, Bonini NM: Pharmacological prevention of Parkinson disease in Drosophila. Nat Med 2002, 8:1185-6.
    • (2002) Nat. Med. , vol.8 , pp. 1185-1186
    • Auluck, P.K.1    Bonini, N.M.2
  • 37
    • 0037468831 scopus 로고    scopus 로고
    • Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    • Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B: Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron 2003, 37:911-24.
    • (2003) Neuron. , vol.37 , pp. 911-924
    • Yang, Y.1    Nishimura, I.2    Imai, Y.3    Takahashi, R.4    Lu, B.5
  • 38
    • 0023664018 scopus 로고
    • Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates
    • Cavener DR: Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. Nucleic Acids Res 1987, 15:1353-61.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 1353-1361
    • Cavener, D.R.1
  • 39
    • 0030731696 scopus 로고    scopus 로고
    • Codon usage bias and tRNA abundance in Drosophila
    • Moriyama EN, Powell JR: Codon usage bias and tRNA abundance in Drosophila. J Mol Evol 1997, 45:514-23.
    • (1997) J. Mol. Evol. , vol.45 , pp. 514-523
    • Moriyama, E.N.1    Powell, J.R.2
  • 42
    • 0034326934 scopus 로고    scopus 로고
    • Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
    • Kahle PJ, Leimer U, Haass C: Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism? Trends Biochem Sci 2000, 25:524-7.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 524-527
    • Kahle, P.J.1    Leimer, U.2    Haass, C.3
  • 43
    • 0033961923 scopus 로고    scopus 로고
    • RING for destruction?
    • Freemont PS: RING for destruction? Curr Biol 2000, 10:R84-7.
    • (2000) Curr. Biol. , vol.10
    • Freemont, P.S.1
  • 44
    • 0033151716 scopus 로고    scopus 로고
    • A novel transactivation domain in parkin
    • Morett E, Bork P: A novel transactivation domain in parkin. Trends Biochem Sci 1999, 24:229-31.
    • (1999) Trends. Biochem. Sci. , vol.24 , pp. 229-231
    • Morett, E.1    Bork, P.2
  • 45
    • 0345304849 scopus 로고    scopus 로고
    • Genomic organization and expression of parkin in Drosophila melanogaster
    • Bae YJ, Park KS, Kang SJ: Genomic organization and expression of parkin in Drosophila melanogaster. Exp Mol Med 2003, 35:393-402.
    • (2003) Exp. Mol. Med. , vol.35 , pp. 393-402
    • Bae, Y.J.1    Park, K.S.2    Kang, S.J.3
  • 46
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand AH, Perrimon N: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415.
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 48
    • 0026528074 scopus 로고
    • Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity
    • Le Bourg E, Lints FA: Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity. Gerontology 1992, 38:59-64.
    • (1992) Gerontology , vol.38 , pp. 59-64
    • Le Bourg, E.1    Lints, F.A.2
  • 49
    • 0017138542 scopus 로고
    • Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster
    • Miquel J, Lundgren PR, Bensch KG, Atlan H: Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster. Mech Ageing Dev 1976, 5:347-70.
    • (1976) Mech. Ageing Dev. , vol.5 , pp. 347-370
    • Miquel, J.1    Lundgren, P.R.2    Bensch, K.G.3    Atlan, H.4
  • 54
    • 0036898892 scopus 로고    scopus 로고
    • Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily
    • Marin I, Ferrus AP: Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily. Mol Biol Evol 2002, 19:2039-50.
    • (2002) Mol. Biol. Evol. , vol.19 , pp. 2039-2050
    • Marin, I.1    Ferrus, A.P.2
  • 55
    • 84891909542 scopus 로고    scopus 로고
    • BLAST Search
    • BLAST Search [http://flybase.net/blast/]
  • 58
    • 84891921533 scopus 로고    scopus 로고
    • Pôle Bio-Informatique Lyonnais
    • Pôle Bio-Informatique Lyonnais [http://pbil.univ-lyon1.fr/]
  • 59
    • 0027968068 scopus 로고
    • CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994, 22:4673-4680.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 60
    • 0034708147 scopus 로고    scopus 로고
    • Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster
    • Li H, Chaney S, Roberts IJ, Forte M, Hirsh J: Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Curr Biol 2000, 10:211-214.
    • (2000) Curr. Biol. , vol.10 , pp. 211-214
    • Li, H.1    Chaney, S.2    Roberts, I.J.3    Forte, M.4    Hirsh, J.5
  • 61
    • 0030584086 scopus 로고    scopus 로고
    • Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    • Freeman M: Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 1996, 87:651-60.
    • (1996) Cell , vol.87 , pp. 651-660
    • Freeman, M.1
  • 62
    • 0025681888 scopus 로고
    • Phenotypic consequences of copper-zinc superoxide dismutase overexpression in Drosophila melanogaster
    • Staveley BE, Phillips JP, Hilliker AJ: Phenotypic consequences of copper-zinc superoxide dismutase overexpression in Drosophila melanogaster. Genome 1990, 33:867-72.
    • (1990) Genome , vol.33 , pp. 867-872
    • Staveley, B.E.1    Phillips, J.P.2    Hilliker, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.