PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

Science

Volumn 344, Issue 6180, 2014, Pages 203-207

  Morais, Vanessa A ^a,b   Haddad, Dominik ^a,b   Craessaerts, Katleen ^a,b   De Bock, Pieter Jan ^a,c   Swerts, Jef ^a,b   Vilain, Sven ^a,b   Aerts, Liesbeth ^a,b   Overbergh, Lut ^d   Grun̈ewald, Anne ^e   Seibler, Philip ^e   Klein, Christine ^e,f   Gevaert, Kris ^a,c   Verstreken, Patrik ^a,b   De Strooper, Bart ^a,b,g  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY OF LÜBECK   (Germany)

^f NEWCASTLE UNIVERSITY   (United Kingdom)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINONE; NDUFA10 PROTEIN, MOUSE; PROTEIN KINASE; PROTEOME; PTEN-INDUCED PUTATIVE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SERINE;

BRAIN; FLY; MITOCHONDRION; MUTATION; NERVOUS SYSTEM DISORDER; PATHOGENICITY; PUBLIC HEALTH; RODENT;

ARTICLE; BRAIN; ENZYME PHOSPHORYLATION; HUMAN; KNOCKOUT MOUSE; LIVER; LOSS OF FUNCTION MUTATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PINK1 MUTANT (DROSOPHILA); PRIORITY JOURNAL; REDUCTION; SYNAPTIC TRANSMISSION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; PARKINSON DISEASE; PHOSPHORYLATION;

MUS;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; ELECTRON TRANSPORT COMPLEX I; HUMANS; LIVER; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; NADH DEHYDROGENASE; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN KINASES; PROTEOME; SERINE;

EID: 84898023373     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1249161     Document Type: Article

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