메뉴 건너뛰기




Volumn 51, Issue 12, 2008, Pages 1040-1046

Pink1 suppresses α-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease

Author keywords

synuclein; Climbing ability; Developmental defects; Drosophila; Ommatidial array; Pink1

Indexed keywords

ALPHA SYNUCLEIN; DROSOPHILA PROTEIN; PINK1 PROTEIN, DROSOPHILA; PROTEIN SERINE THREONINE KINASE;

EID: 57149110259     PISSN: 08312796     EISSN: None     Source Type: Journal    
DOI: 10.1139/G08-085     Document Type: Article
Times cited : (66)

References (38)
  • 1
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
    • PMID:11823645, doi:10.1126/science.1067389
    • Auluck, P.K., Chan, H.Y., Trojanowski, J.Q., Lee, V.M., and Bonini, N.M. 2002. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science, 295(5556): 865-868. doi:10.1126/science.1067389. PMID:11823645.
    • (2002) Science , vol.295 , Issue.5556 , pp. 865-868
    • Auluck, P.K.1    Chan, H.Y.2    Trojanowski, J.Q.3    Lee, V.M.4    Bonini, N.M.5
  • 2
    • 33745612296 scopus 로고    scopus 로고
    • Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin-proteasome system
    • PMID:16439141, doi:10.1016/j.nbd.2005.12.003
    • Betarbet, R., Canet-Aviles, R.M., Sherer, T.B., Mastroberardino, P.G., McLendon, C., Kim, J.H., et al. 2006. Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin-proteasome system. Neurobiol. Dis. 22(2): 404-420. doi:10.1016/j.nbd.2005.12.003. PMID:16439141.
    • (2006) Neurobiol. Dis , vol.22 , Issue.2 , pp. 404-420
    • Betarbet, R.1    Canet-Aviles, R.M.2    Sherer, T.B.3    Mastroberardino, P.G.4    McLendon, C.5    Kim, J.H.6
  • 3
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • PMID:16672981, doi:10.1038/nature04779
    • Clark, I.E., Dodson, M.W., Jiang, C., Cao, J.H., Huh, J.R., Seol, J.H., et al. 2006. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature, 441(7097): 1162-1166. doi:10.1038/nature04779. PMID:16672981.
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6
  • 4
    • 0037195109 scopus 로고    scopus 로고
    • Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP
    • PMID:12376616, doi:10.1073/pnas.172514599
    • Dauer, W., Kholodilov, N., Vila, M., Trillat, A.C., Goodchild, R., Larsen, K.E., et al. 2002. Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP. Proc. Natl. Acad. Sci. U.S.A. 99(22): 14524-14529. doi:10.1073/pnas.172514599. PMID:12376616.
    • (2002) Proc. Natl. Acad. Sci. U.S.A , vol.99 , Issue.22 , pp. 14524-14529
    • Dauer, W.1    Kholodilov, N.2    Vila, M.3    Trillat, A.C.4    Goodchild, R.5    Larsen, K.E.6
  • 5
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • PMID:14593166, doi:10.1126/science.1087753
    • Dawson, T.M., and Dawson, V.L. 2003. Molecular pathways of neurodegeneration in Parkinson's disease. Science, 302(5646): 819-822. doi:10.1126/science.1087753. PMID:14593166.
    • (2003) Science , vol.302 , Issue.5646 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 6
    • 36049038504 scopus 로고    scopus 로고
    • Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
    • PMID:17989306, doi:10.1523/JNEUROSCI.0719-07.2007
    • Exner, N., Treske, B., Paquet, D., Holmstrom, K., Schiesling, C., Gispert, S., et al. 2007. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J. Neurosci. 27(45): 12413-12418. doi:10.1523/JNEUROSCI.0719-07.2007. PMID:17989306.
    • (2007) J. Neurosci , vol.27 , Issue.45 , pp. 12413-12418
    • Exner, N.1    Treske, B.2    Paquet, D.3    Holmstrom, K.4    Schiesling, C.5    Gispert, S.6
  • 7
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • PMID:10746727, doi:10.1038/35006074
    • Feany, M.B., and Bender, W.W. 2000. A Drosophila model of Parkinson's disease. Nature, 404(6776): 394-398. doi:10.1038/35006074. PMID:10746727.
    • (2000) Nature , vol.404 , Issue.6776 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 8
    • 20044385568 scopus 로고    scopus 로고
    • Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
    • PMID:15716361, doi:10.1073/pnas.0409713102
    • Fornai, F., Schluter, O.M., Lenzi, P., Gesi, M., Ruffoli, R., Ferrucci, M., et al. 2005. Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and α-synuclein. Proc. Natl. Acad. Sci. U.S.A. 102(9): 3413-3418. doi:10.1073/pnas.0409713102. PMID:15716361.
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , Issue.9 , pp. 3413-3418
    • Fornai, F.1    Schluter, O.M.2    Lenzi, P.3    Gesi, M.4    Ruffoli, R.5    Ferrucci, M.6
  • 9
    • 0030584086 scopus 로고    scopus 로고
    • Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    • PMID:8929534, doi:10.1016/S0092-8674(00)81385-9
    • Freeman, M. 1996. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell, 87(4): 651-660. doi:10.1016/S0092-8674(00)81385-9. PMID:8929534.
    • (1996) Cell , vol.87 , Issue.4 , pp. 651-660
    • Freeman, M.1
  • 10
    • 36248985106 scopus 로고    scopus 로고
    • Update on the genetics of Parkinson's disease
    • doi:10.1002/mds.21676
    • Gasser, T. 2007. Update on the genetics of Parkinson's disease. Mov. Disord. 22(S17): S343-S350. doi:10.1002/mds.21676.
    • (2007) Mov. Disord , vol.22 , Issue.S17
    • Gasser, T.1
  • 11
    • 39449098267 scopus 로고    scopus 로고
    • Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP
    • PMID:18218782, doi:10.1073/pnas.0705363105
    • Haque, M.E., Thomas, K.J., D'Souza, C., Callaghan, S., Kitada, T., Slack, R.S., et al. 2008. Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc. Natl. Acad. Sci. U.S.A. 105(5): 1716-1721. doi:10.1073/pnas.0705363105. PMID:18218782.
    • (2008) Proc. Natl. Acad. Sci. U.S.A , vol.105 , Issue.5 , pp. 1716-1721
    • Haque, M.E.1    Thomas, K.J.2    D'Souza, C.3    Callaghan, S.4    Kitada, T.5    Slack, R.S.6
  • 12
    • 2642516493 scopus 로고    scopus 로고
    • parkin counteracts symptoms in a Drosophila model of Parkinson's disease
    • PMID:15090075, doi:10.1186/1471-2202-5-14
    • Haywood, A.F., and Staveley, B.E. 2004. parkin counteracts symptoms in a Drosophila model of Parkinson's disease. BMC Neurosci. 5: 14. doi:10.1186/1471-2202-5-14. PMID:15090075.
    • (2004) BMC Neurosci , vol.5 , pp. 14
    • Haywood, A.F.1    Staveley, B.E.2
  • 13
    • 33846288002 scopus 로고    scopus 로고
    • Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6
    • PMID:17141510, doi:10.1016/j.nbd.2006.10.007
    • Hoepken, H.H., Gispert, S., Morales, B., Wingerter, O., Del Turco, D., Mulsch, A., et al. 2007. Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol. Dis. 25(2): 401-411. doi:10.1016/j.nbd.2006.10.007. PMID:17141510.
    • (2007) Neurobiol. Dis , vol.25 , Issue.2 , pp. 401-411
    • Hoepken, H.H.1    Gispert, S.2    Morales, B.3    Wingerter, O.4    Del Turco, D.5    Mulsch, A.6
  • 14
    • 0033890821 scopus 로고    scopus 로고
    • α-Synuclein promotes mitochondrial deficit and oxidative stress
    • PMID:10934145
    • Hsu, L.J., Sagara, Y., Arroyo, A., Rockenstein, E., Sisk, A., Mallory, M., et al. 2000. α-Synuclein promotes mitochondrial deficit and oxidative stress. Am. J. Pathol. 157(2): 401-410. PMID:10934145.
    • (2000) Am. J. Pathol , vol.157 , Issue.2 , pp. 401-410
    • Hsu, L.J.1    Sagara, Y.2    Arroyo, A.3    Rockenstein, E.4    Sisk, A.5    Mallory, M.6
  • 15
    • 4644236043 scopus 로고    scopus 로고
    • Causal relation between α-synuclein gene duplication and familial Parkinson's disease
    • PMID:15451225, doi:10.1016/S0140-6736(04)17104-3
    • Ibanez, P., Bonnet, A.M., Debarges, B., Lohmann, E., Tison, F., Pollak, P., et al. 2004. Causal relation between α-synuclein gene duplication and familial Parkinson's disease. Lancet, 364(9440): 1169-1171. doi:10.1016/S0140-6736(04)17104-3. PMID:15451225.
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1169-1171
    • Ibanez, P.1    Bonnet, A.M.2    Debarges, B.3    Lohmann, E.4    Tison, F.5    Pollak, P.6
  • 16
    • 33244460534 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein are resistant to mitochondrial toxins
    • PMID:16298531, doi:10.1016/j.nbd.2005.08.018
    • Klivenyi, P., Siwek, D., Gardian, G., Yang, L., Starkov, A., Cleren, C., et al. 2006. Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiol. Dis. 21(3): 541-548. doi:10.1016/j.nbd.2005.08.018. PMID:16298531.
    • (2006) Neurobiol. Dis , vol.21 , Issue.3 , pp. 541-548
    • Klivenyi, P.1    Siwek, D.2    Gardian, G.3    Yang, L.4    Starkov, A.5    Cleren, C.6
  • 17
    • 2942651986 scopus 로고    scopus 로고
    • GAL4 causes developmental defects and apoptosis when expressed in the developing eye of Drosophila melanogaster
    • PMID:12917801
    • Kramer, J.M., and Staveley, B.E. 2003. GAL4 causes developmental defects and apoptosis when expressed in the developing eye of Drosophila melanogaster. Genet. Mol. Res. 2(1): 43-47. PMID:12917801.
    • (2003) Genet. Mol. Res , vol.2 , Issue.1 , pp. 43-47
    • Kramer, J.M.1    Staveley, B.E.2
  • 18
    • 0026528074 scopus 로고
    • Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity
    • PMID:1612462
    • Le Bourg, E., and Lints, F.A. 1992. Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity. Gerontology, 38(1-2): 59-64. PMID:1612462.
    • (1992) Gerontology , vol.38 , Issue.1-2 , pp. 59-64
    • Le Bourg, E.1    Lints, F.A.2
  • 19
    • 0034708147 scopus 로고    scopus 로고
    • Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster
    • PMID:10704417, doi:10.1016/S0960-9822(00)00340-7
    • Li, H., Chaney, S., Roberts, I.J., Forte, M., and Hirsh, J. 2000. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Curr. Biol. 10(4): 211-214. doi:10.1016/S0960-9822(00)00340-7. PMID:10704417.
    • (2000) Curr. Biol , vol.10 , Issue.4 , pp. 211-214
    • Li, H.1    Chaney, S.2    Roberts, I.J.3    Forte, M.4    Hirsh, J.5
  • 20
    • 30644471051 scopus 로고    scopus 로고
    • Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
    • PMID:16399671, doi:10.1523/JNEUROSCI.4308-05.2006
    • Martin, L.J., Pan, Y., Price, A.C., Sterling, W., Copeland, N.G., Jenkins, N.A., et al. 2006. Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci. 26(1): 41-50. doi:10.1523/JNEUROSCI.4308-05.2006. PMID:16399671.
    • (2006) J. Neurosci , vol.26 , Issue.1 , pp. 41-50
    • Martin, L.J.1    Pan, Y.2    Price, A.C.3    Sterling, W.4    Copeland, N.G.5    Jenkins, N.A.6
  • 21
    • 31544457062 scopus 로고    scopus 로고
    • Pathophysiology of synuclein aggregation in Lewy body disease
    • PMID:16297436, doi:10.1016/j.mad.2005.09.014
    • Mukaetova-Ladinska, E.B., and McKeith, I.G. 2006. Pathophysiology of synuclein aggregation in Lewy body disease. Mech. Ageing Dev. 127(2): 188-202. doi:10.1016/j.mad.2005.09.014. PMID:16297436.
    • (2006) Mech. Ageing Dev , vol.127 , Issue.2 , pp. 188-202
    • Mukaetova-Ladinska, E.B.1    McKeith, I.G.2
  • 22
    • 33745602748 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
    • PMID:16672980, doi:10.1038/nature04788
    • Park, J., Lee, S.B., Lee, S., Kim, Y., Song, S., Kim, S., et al. 2006. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature, 441(7097): 1157-1161. doi:10.1038/nature04788. PMID:16672980.
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1157-1161
    • Park, J.1    Lee, S.B.2    Lee, S.3    Kim, Y.4    Song, S.5    Kim, S.6
  • 23
    • 26644440926 scopus 로고    scopus 로고
    • Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
    • PMID:16079129, doi:10.1074/jbc.M505143200
    • Petit, A., Kawarai, T., Paitel, E., Sanjo, N., Maj, M., Scheid, M., et al. 2005. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J. Biol. Chem. 280(40): 34025-34032. doi:10.1074/jbc.M505143200. PMID:16079129.
    • (2005) J. Biol. Chem , vol.280 , Issue.40 , pp. 34025-34032
    • Petit, A.1    Kawarai, T.2    Paitel, E.3    Sanjo, N.4    Maj, M.5    Scheid, M.6
  • 24
    • 35748935851 scopus 로고    scopus 로고
    • The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
    • PMID:17906618, doi:10.1038/ncb1644
    • Plun-Favreau, H., Klupsch, K., Moisoi, N., Gandhi, S., Kjaer, S., Frith, D., et al. 2007. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat. Cell Biol. 9(11): 1243-1252. doi:10.1038/ncb1644. PMID:17906618.
    • (2007) Nat. Cell Biol , vol.9 , Issue.11 , pp. 1243-1252
    • Plun-Favreau, H.1    Klupsch, K.2    Moisoi, N.3    Gandhi, S.4    Kjaer, S.5    Frith, D.6
  • 26
    • 34547127902 scopus 로고    scopus 로고
    • PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
    • PMID:17579517, doi:10.1371/journal.pbio.0050172
    • Pridgeon, J.W., Olzmann, J.A., Chin, L.S., and Li, L. 2007. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 5(7): e172. doi:10.1371/journal.pbio.0050172. PMID:17579517.
    • (2007) PLoS Biol , vol.5 , Issue.7
    • Pridgeon, J.W.1    Olzmann, J.A.2    Chin, L.S.3    Li, L.4
  • 27
    • 0034708827 scopus 로고    scopus 로고
    • A Drosophila complementary DNA resource
    • PMID:10731138, doi:10.1126/science.287.5461. 2222
    • Rubin, G.M., Hong, L., Brokstein, P., Evans-Holm, M., Frise, E., Stapleton, M., and Harvey, D.A. 2000. A Drosophila complementary DNA resource. Science, 287(5461): 2222-2224. doi:10.1126/science.287.5461. 2222. PMID:10731138.
    • (2000) Science , vol.287 , Issue.5461 , pp. 2222-2224
    • Rubin, G.M.1    Hong, L.2    Brokstein, P.3    Evans-Holm, M.4    Frise, E.5    Stapleton, M.6    Harvey, D.A.7
  • 28
    • 37049004489 scopus 로고    scopus 로고
    • Mitochondria in the aetiology and pathogenesis of Parkinson's disease
    • PMID:18093566, doi:10.1016/S1474- 4422(07)70327-7
    • Schapira, A.H. 2008. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol. 7(1): 97-109. doi:10.1016/S1474- 4422(07)70327-7. PMID:18093566.
    • (2008) Lancet Neurol , vol.7 , Issue.1 , pp. 97-109
    • Schapira, A.H.1
  • 29
    • 0025681888 scopus 로고
    • Phenotypic consequences of copper-zinc superoxide dismutase overexpression in Drosophila melanogaster
    • PMID:1964925, doi:10.1139/g90-130
    • Staveley, B.E., Phillips, J.P., and Hilliker, A.J. 1990. Phenotypic consequences of copper-zinc superoxide dismutase overexpression in Drosophila melanogaster. Genome, 33(6): 867-872. doi:10.1139/g90-130. PMID:1964925.
    • (1990) Genome , vol.33 , Issue.6 , pp. 867-872
    • Staveley, B.E.1    Phillips, J.P.2    Hilliker, A.J.3
  • 30
    • 57149088584 scopus 로고    scopus 로고
    • Novel assay and analysis for measuring climbing ability in Drosophila
    • Todd, A.M., and Staveley, B.E. 2004. Novel assay and analysis for measuring climbing ability in Drosophila. Drosoph. Inf. Serv. 87: 101-107.
    • (2004) Drosoph. Inf. Serv , vol.87 , pp. 101-107
    • Todd, A.M.1    Staveley, B.E.2
  • 31
    • 2442668926 scopus 로고    scopus 로고
    • Hereditary early-onset Parkinson's disease caused by mutations in PINK1
    • PMID:15087508, doi:10.1126/science.1096284
    • Valente, E.M., Abou-Sleiman, P.M., Caputo, V., Muqit, M.M., Harvey, K., Gispert, S., et al. 2004a. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science, 304(5674): 1158-1160. doi:10.1126/science.1096284. PMID:15087508.
    • (2004) Science , vol.304 , Issue.5674 , pp. 1158-1160
    • Valente, E.M.1    Abou-Sleiman, P.M.2    Caputo, V.3    Muqit, M.M.4    Harvey, K.5    Gispert, S.6
  • 32
    • 4444274910 scopus 로고    scopus 로고
    • PINK1 mutations are associated with sporadic early-onset parkinsonism
    • PMID:15349860, doi:10.1002/ana.20256
    • Valente, E.M., Salvi, S., Ialongo, T., Marongiu, R., Elia, A.E., Caputo, V., et al. 2004b. PINK1 mutations are associated with sporadic early-onset parkinsonism. Ann. Neurol. 56(3): 336-341. doi:10.1002/ana.20256. PMID:15349860.
    • (2004) Ann. Neurol , vol.56 , Issue.3 , pp. 336-341
    • Valente, E.M.1    Salvi, S.2    Ialongo, T.3    Marongiu, R.4    Elia, A.E.5    Caputo, V.6
  • 33
    • 0035800097 scopus 로고    scopus 로고
    • Vesicle permeabilization by protofibrillar α-synuclein: Implications for the pathogenesis and treatment of Parkinson's disease
    • PMID:11425308, doi:10.1021/bi0102398
    • Volles, M.J., Lee, S.J., Rochet, J.C., Shtilerman, M.D., Ding, T.T., Kessler, J.C., and Lansbury, P.T., Jr. 2001. Vesicle permeabilization by protofibrillar α-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry, 40(26): 7812-7819. doi:10.1021/bi0102398. PMID:11425308.
    • (2001) Biochemistry , vol.40 , Issue.26 , pp. 7812-7819
    • Volles, M.J.1    Lee, S.J.2    Rochet, J.C.3    Shtilerman, M.D.4    Ding, T.T.5    Kessler, J.C.6    Lansbury Jr., P.T.7
  • 34
    • 35349030746 scopus 로고    scopus 로고
    • PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c
    • PMID:17707122, doi:10.1016/j.nbd.2007.07.010
    • Wang, H.L., Chou, A.H., Yeh, T.H., Li, A.H., Chen, Y.L., Kuo, Y.L., et al. 2007. PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c. Neurobiol. Dis. 28(2): 216-226. doi:10.1016/j.nbd.2007.07.010. PMID:17707122.
    • (2007) Neurobiol. Dis , vol.28 , Issue.2 , pp. 216-226
    • Wang, H.L.1    Chou, A.H.2    Yeh, T.H.3    Li, A.H.4    Chen, Y.L.5    Kuo, Y.L.6
  • 35
    • 41349111452 scopus 로고    scopus 로고
    • Weintraub, D., Comella, C.L., and Horn, S. 2008. Parkinson's disease - Part 1: pathophysiology, symptoms, burden, diagnosis, and assessment. Am. J. Manag. Care, 14(2 Suppl.): S40-S48. PMID:18402507.
    • Weintraub, D., Comella, C.L., and Horn, S. 2008. Parkinson's disease - Part 1: pathophysiology, symptoms, burden, diagnosis, and assessment. Am. J. Manag. Care, 14(2 Suppl.): S40-S48. PMID:18402507.
  • 36
    • 33644862373 scopus 로고    scopus 로고
    • Drosophila models pioneer a new approach to drug discovery for Parkinson's disease
    • PMID:16533709, doi:10.1016/S1359-6446(05)03693-7
    • Whitworth, A.J., Wes, P.D., and Pallanck, L.J. 2006. Drosophila models pioneer a new approach to drug discovery for Parkinson's disease. Drug Discov. Today, 11(3-4): 119-126. doi:10.1016/S1359-6446(05)03693-7. PMID:16533709.
    • (2006) Drug Discov. Today , vol.11 , Issue.3-4 , pp. 119-126
    • Whitworth, A.J.1    Wes, P.D.2    Pallanck, L.J.3
  • 37
    • 49349087497 scopus 로고    scopus 로고
    • Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A.S., Miljan, E.A., Keen, G., et al. 2008. PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One, 3(6): e2455. doi:10.1371/journal.pone. 0002455. PMID:18560593.
    • Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A.S., Miljan, E.A., Keen, G., et al. 2008. PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One, 3(6): e2455. doi:10.1371/journal.pone. 0002455. PMID:18560593.
  • 38
    • 33746080412 scopus 로고    scopus 로고
    • Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
    • PMID:16818890, doi:10.1073/pnas. 0602493103
    • Yang, Y., Gehrke, S., Imai, Y., Huang, Z., Ouyang, Y., Wang, J.W., et al. 2006. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl. Acad. Sci. U.S.A. 103(28): 10793-10798. doi:10.1073/pnas. 0602493103. PMID:16818890.
    • (2006) Proc. Natl. Acad. Sci. U.S.A , vol.103 , Issue.28 , pp. 10793-10798
    • Yang, Y.1    Gehrke, S.2    Imai, Y.3    Huang, Z.4    Ouyang, Y.5    Wang, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.