-
1
-
-
0242363670
-
Molecular pathways of neurodegeneration in Parkinson's disease
-
Dawson TM, Dawson VL, (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819-822.
-
(2003)
Science
, vol.302
, pp. 819-822
-
-
Dawson, T.M.1
Dawson, V.L.2
-
2
-
-
37349004102
-
Parkinson's disease
-
Thomas B, Beal MF, (2007) Parkinson's disease. Hum Mol Genet 16 Spec No. 2: R183-194.
-
(2007)
Hum Mol Genet
, vol.16
, Issue.SPEC. NO. 2
-
-
Thomas, B.1
Beal, M.F.2
-
3
-
-
77956218282
-
Mitochondrial iron metabolism and its role in neurodegeneration
-
Horowitz MP, Greenamyre JT, (2010) Mitochondrial iron metabolism and its role in neurodegeneration. J Alzheimers Dis 20 Suppl 2: S551-568.
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.SUPPL. 2
-
-
Horowitz, M.P.1
Greenamyre, J.T.2
-
4
-
-
0025963530
-
Selective increase of iron in substantia nigra zona compacta of parkinsonian brains
-
Sofic E, Paulus W, Jellinger K, Riederer P, Youdim MB, (1991) Selective increase of iron in substantia nigra zona compacta of parkinsonian brains. J Neurochem 56: 978-982.
-
(1991)
J Neurochem
, vol.56
, pp. 978-982
-
-
Sofic, E.1
Paulus, W.2
Jellinger, K.3
Riederer, P.4
Youdim, M.B.5
-
5
-
-
0025047351
-
Normal mitochondrial genome in brain from patients with Parkinson's disease and complex I defect
-
Lestienne P, Nelson J, Riederer P, Jellinger K, Reichmann H, (1990) Normal mitochondrial genome in brain from patients with Parkinson's disease and complex I defect. J Neurochem 55: 1810-1812.
-
(1990)
J Neurochem
, vol.55
, pp. 1810-1812
-
-
Lestienne, P.1
Nelson, J.2
Riederer, P.3
Jellinger, K.4
Reichmann, H.5
-
6
-
-
0024390719
-
Mitochondrial complex I deficiency in Parkinson's disease
-
Schapira AH, Cooper JM, Dexter D, Jenner P, Clark JB, et al. (1989) Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1: 1269.
-
(1989)
Lancet
, vol.1
, pp. 1269
-
-
Schapira, A.H.1
Cooper, J.M.2
Dexter, D.3
Jenner, P.4
Clark, J.B.5
-
7
-
-
77953666105
-
Genetic animal models of Parkinson's disease
-
Dawson TM, Ko HS, Dawson VL, (2010) Genetic animal models of Parkinson's disease. Neuron 66: 646-661.
-
(2010)
Neuron
, vol.66
, pp. 646-661
-
-
Dawson, T.M.1
Ko, H.S.2
Dawson, V.L.3
-
8
-
-
75749087622
-
The roles of PINK1 and Parkin in Parkinson's disease
-
doi:10.1371/journal.pbio.1000299
-
Jones R, (2010) The roles of PINK1 and Parkin in Parkinson's disease. PLoS Biol 8: e1000299 doi:10.1371/journal.pbio.1000299.
-
(2010)
PLoS Biol
, vol.8
-
-
Jones, R.1
-
9
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, et al. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441: 1162-1166.
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
Cao, J.H.4
Huh, J.R.5
-
10
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park J, Lee SB, Lee S, Kim Y, Song S, et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441: 1157-1161.
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
Kim, Y.4
Song, S.5
-
11
-
-
84861204926
-
PINK1- and Parkin-mediated mitophagy at a glance
-
Jin SM, Youle RJ, (2012) PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci 125: 795-799.
-
(2012)
J Cell Sci
, vol.125
, pp. 795-799
-
-
Jin, S.M.1
Youle, R.J.2
-
12
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng H, Dodson MW, Huang H, Guo M, (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A 105: 14503-14508.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
13
-
-
39449088321
-
The PINK1/Parkin pathway regulates mitochondrial morphology
-
Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, et al. (2008) The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A 105: 1638-1643.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 1638-1643
-
-
Poole, A.C.1
Thomas, R.E.2
Andrews, L.A.3
McBride, H.M.4
Whitworth, A.J.5
-
14
-
-
44349195101
-
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
-
Yang Y, Ouyang Y, Yang L, Beal MF, McQuibban A, et al. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A 105: 7070-7075.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 7070-7075
-
-
Yang, Y.1
Ouyang, Y.2
Yang, L.3
Beal, M.F.4
McQuibban, A.5
-
15
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
doi:10.1371/journal.pbio.1000298
-
Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, et al. (2010) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8: e1000298 doi:10.1371/journal.pbio.1000298.
-
(2010)
PLoS Biol
, vol.8
-
-
Narendra, D.P.1
Jin, S.M.2
Tanaka, A.3
Suen, D.F.4
Gautier, C.A.5
-
16
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
-
Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, et al. (2006) Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A 103: 10793-10798.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 10793-10798
-
-
Yang, Y.1
Gehrke, S.2
Imai, Y.3
Huang, Z.4
Ouyang, Y.5
-
17
-
-
49649097747
-
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
-
Gautier CA, Kitada T, Shen J, (2008) Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A 105: 11364-11369.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 11364-11369
-
-
Gautier, C.A.1
Kitada, T.2
Shen, J.3
-
18
-
-
77953666757
-
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
-
Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, et al. (2009) Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med 1: 99-111.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 99-111
-
-
Morais, V.A.1
Verstreken, P.2
Roethig, A.3
Smet, J.4
Snellinx, A.5
-
19
-
-
84857462488
-
The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants
-
doi:10.1371/journal.pgen.1002456
-
Vilain S, Esposito G, Haddad D, Schaap O, Dobreva MP, et al. (2012) The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. PLoS Genet 8: e1002456 doi:10.1371/journal.pgen.1002456.
-
(2012)
PLoS Genet
, vol.8
-
-
Vilain, S.1
Esposito, G.2
Haddad, D.3
Schaap, O.4
Dobreva, M.P.5
-
20
-
-
79961233786
-
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
-
Liu W, Acin-Perez R, Geghman KD, Manfredi G, Lu B, et al. (2011) Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc Natl Acad Sci U S A 108: 12920-12924.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 12920-12924
-
-
Liu, W.1
Acin-Perez, R.2
Geghman, K.D.3
Manfredi, G.4
Lu, B.5
-
21
-
-
84861983560
-
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency
-
Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, et al. (2012) Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science 336: 1306-1310.
-
(2012)
Science
, vol.336
, pp. 1306-1310
-
-
Vos, M.1
Esposito, G.2
Edirisinghe, J.N.3
Vilain, S.4
Haddad, D.M.5
-
22
-
-
0027141376
-
Aconitase, a two-faced protein: enzyme and iron regulatory factor
-
Beinert H, Kennedy MC, (1993) Aconitase, a two-faced protein: enzyme and iron regulatory factor. FASEB J 7: 1442-1449.
-
(1993)
FASEB J
, vol.7
, pp. 1442-1449
-
-
Beinert, H.1
Kennedy, M.C.2
-
23
-
-
0026587755
-
Crystal structures of aconitase with isocitrate and nitroisocitrate bound
-
Lauble H, Kennedy MC, Beinert H, Stout CD, (1992) Crystal structures of aconitase with isocitrate and nitroisocitrate bound. Biochemistry 31: 2735-2748.
-
(1992)
Biochemistry
, vol.31
, pp. 2735-2748
-
-
Lauble, H.1
Kennedy, M.C.2
Beinert, H.3
Stout, C.D.4
-
24
-
-
20544470501
-
The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila
-
Hiesinger PR, Fayyazuddin A, Mehta SQ, Rosenmund T, Schulze KL, et al. (2005) The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell 121: 607-620.
-
(2005)
Cell
, vol.121
, pp. 607-620
-
-
Hiesinger, P.R.1
Fayyazuddin, A.2
Mehta, S.Q.3
Rosenmund, T.4
Schulze, K.L.5
-
25
-
-
79953270683
-
Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins
-
Uytterhoeven V, Kuenen S, Kasprowicz J, Miskiewicz K, Verstreken P, (2011) Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins. Cell 145: 117-132.
-
(2011)
Cell
, vol.145
, pp. 117-132
-
-
Uytterhoeven, V.1
Kuenen, S.2
Kasprowicz, J.3
Miskiewicz, K.4
Verstreken, P.5
-
26
-
-
67651124954
-
Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling
-
Verstreken P, Ohyama T, Haueter C, Habets RL, Lin YQ, et al. (2009) Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Neuron 63: 203-215.
-
(2009)
Neuron
, vol.63
, pp. 203-215
-
-
Verstreken, P.1
Ohyama, T.2
Haueter, C.3
Habets, R.L.4
Lin, Y.Q.5
-
27
-
-
0027491617
-
The inactivation of Fe-S cluster containing hydro-lyases by superoxide
-
Flint DH, Tuminello JF, Emptage MH, (1993) The inactivation of Fe-S cluster containing hydro-lyases by superoxide. J Biol Chem 268: 22369-22376.
-
(1993)
J Biol Chem
, vol.268
, pp. 22369-22376
-
-
Flint, D.H.1
Tuminello, J.F.2
Emptage, M.H.3
-
28
-
-
0026011632
-
Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase
-
Gardner PR, Fridovich I, (1991) Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase. J Biol Chem 266: 1478-1483.
-
(1991)
J Biol Chem
, vol.266
, pp. 1478-1483
-
-
Gardner, P.R.1
Fridovich, I.2
-
29
-
-
0026045587
-
Superoxide sensitivity of the Escherichia coli aconitase
-
Gardner PR, Fridovich I, (1991) Superoxide sensitivity of the Escherichia coli aconitase. J Biol Chem 266: 19328-19333.
-
(1991)
J Biol Chem
, vol.266
, pp. 19328-19333
-
-
Gardner, P.R.1
Fridovich, I.2
-
30
-
-
0039174315
-
Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation
-
Vasquez-Vivar J, Kalyanaraman B, Kennedy MC, (2000) Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation. J Biol Chem 275: 14064-14069.
-
(2000)
J Biol Chem
, vol.275
, pp. 14064-14069
-
-
Vasquez-Vivar, J.1
Kalyanaraman, B.2
Kennedy, M.C.3
-
31
-
-
0032211437
-
Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical
-
Benov L, Sztejnberg L, Fridovich I, (1998) Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic Biol Med 25: 826-831.
-
(1998)
Free Radic Biol Med
, vol.25
, pp. 826-831
-
-
Benov, L.1
Sztejnberg, L.2
Fridovich, I.3
-
32
-
-
77949535410
-
Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis
-
Horak P, Crawford AR, Vadysirisack DD, Nash ZM, DeYoung MP, et al. (2010) Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc Natl Acad Sci U S A 107: 4675-4680.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 4675-4680
-
-
Horak, P.1
Crawford, A.R.2
Vadysirisack, D.D.3
Nash, Z.M.4
DeYoung, M.P.5
-
33
-
-
79958723738
-
Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12)
-
Wang YC, Lee CM, Lee LC, Tung LC, Hsieh-Li HM, et al. (2011) Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12). J Biol Chem 286: 21742-21754.
-
(2011)
J Biol Chem
, vol.286
, pp. 21742-21754
-
-
Wang, Y.C.1
Lee, C.M.2
Lee, L.C.3
Tung, L.C.4
Hsieh-Li, H.M.5
-
34
-
-
0037083893
-
Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor
-
Petrat F, Weisheit D, Lensen M, de Groot H, Sustmann R, et al. (2002) Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor. Biochem J 362: 137-147.
-
(2002)
Biochem J
, vol.362
, pp. 137-147
-
-
Petrat, F.1
Weisheit, D.2
Lensen, M.3
de Groot, H.4
Sustmann, R.5
-
35
-
-
0028276577
-
The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation
-
Philpott CC, Klausner RD, Rouault TA, (1994) The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation. Proc Natl Acad Sci U S A 91: 7321-7325.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 7321-7325
-
-
Philpott, C.C.1
Klausner, R.D.2
Rouault, T.A.3
-
36
-
-
33645827980
-
Characterization of mitochondrial ferritin in Drosophila
-
Missirlis F, Holmberg S, Georgieva T, Dunkov BC, Rouault TA, et al. (2006) Characterization of mitochondrial ferritin in Drosophila. Proc Natl Acad Sci U S A 103: 5893-5898.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5893-5898
-
-
Missirlis, F.1
Holmberg, S.2
Georgieva, T.3
Dunkov, B.C.4
Rouault, T.A.5
-
37
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, et al. (2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 12: 119-131.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmstrom, K.M.2
Skujat, D.3
Fiesel, F.C.4
Rothfuss, O.C.5
-
38
-
-
77957673363
-
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
-
Geisler S, Holmstrom KM, Treis A, Skujat D, Weber SS, et al. (2010) The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy 6: 871-878.
-
(2010)
Autophagy
, vol.6
, pp. 871-878
-
-
Geisler, S.1
Holmstrom, K.M.2
Treis, A.3
Skujat, D.4
Weber, S.S.5
-
39
-
-
84864471700
-
PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity
-
Koh H, Chung J, (2012) PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity. Mol Cells 34: 7-13.
-
(2012)
Mol Cells
, vol.34
, pp. 7-13
-
-
Koh, H.1
Chung, J.2
-
40
-
-
79960826207
-
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
-
Yu W, Sun Y, Guo S, Lu B, (2011) The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet 20: 3227-3240.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3227-3240
-
-
Yu, W.1
Sun, Y.2
Guo, S.3
Lu, B.4
-
41
-
-
84855474847
-
Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder
-
Imai Y, Lu B, (2012) Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder. Curr Opin Neurobiol 21: 935-941.
-
(2012)
Curr Opin Neurobiol
, vol.21
, pp. 935-941
-
-
Imai, Y.1
Lu, B.2
-
42
-
-
79954571354
-
The interplay between mitochondrial dynamics and mitophagy
-
Twig G, Shirihai OS, (2011) The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal 14: 1939-1951.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 1939-1951
-
-
Twig, G.1
Shirihai, O.S.2
-
43
-
-
70349464469
-
Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures
-
doi:10.1371/journal.pone.0007095
-
Cantu D, Schaack J, Patel M, (2009) Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures. PLoS ONE 4: e7095 doi:10.1371/journal.pone.0007095.
-
(2009)
PLoS ONE
, vol.4
-
-
Cantu, D.1
Schaack, J.2
Patel, M.3
-
44
-
-
0028177211
-
The role of O2.- in the production of HO.: in vitro and in vivo
-
Liochev SI, Fridovich I, (1994) The role of O2.- in the production of HO.: in vitro and in vivo. Free Radic Biol Med 16: 29-33.
-
(1994)
Free Radic Biol Med
, vol.16
, pp. 29-33
-
-
Liochev, S.I.1
Fridovich, I.2
-
45
-
-
0033973908
-
Mitochondrial permeability transition induced by 1-hydroxyethyl radical
-
Sakurai K, Stoyanovsky DA, Fujimoto Y, Cederbaum AI, (2000) Mitochondrial permeability transition induced by 1-hydroxyethyl radical. Free Radic Biol Med 28: 273-280.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 273-280
-
-
Sakurai, K.1
Stoyanovsky, D.A.2
Fujimoto, Y.3
Cederbaum, A.I.4
-
46
-
-
33845399346
-
Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to mitochondrial permeability transition
-
Srivastava S, Chan C, (2007) Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to mitochondrial permeability transition. Free Radic Res 41: 38-49.
-
(2007)
Free Radic Res
, vol.41
, pp. 38-49
-
-
Srivastava, S.1
Chan, C.2
-
47
-
-
0030982120
-
The role of reactive oxygen species in mitochondrial permeability transition
-
Vercesi AE, Kowaltowski AJ, Grijalba MT, Meinicke AR, Castilho RF, (1997) The role of reactive oxygen species in mitochondrial permeability transition. Biosci Rep 17: 43-52.
-
(1997)
Biosci Rep
, vol.17
, pp. 43-52
-
-
Vercesi, A.E.1
Kowaltowski, A.J.2
Grijalba, M.T.3
Meinicke, A.R.4
Castilho, R.F.5
-
48
-
-
0030056515
-
Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
-
Pitkanen S, Robinson BH, (1996) Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J Clin Invest 98: 345-351.
-
(1996)
J Clin Invest
, vol.98
, pp. 345-351
-
-
Pitkanen, S.1
Robinson, B.H.2
-
49
-
-
0030969868
-
Superoxide production by the mitochondrial respiratory chain
-
Turrens JF, (1997) Superoxide production by the mitochondrial respiratory chain. Biosci Rep 17: 3-8.
-
(1997)
Biosci Rep
, vol.17
, pp. 3-8
-
-
Turrens, J.F.1
-
50
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, et al. (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3: 1301-1306.
-
(2000)
Nat Neurosci
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
MacKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
-
51
-
-
64449085359
-
A highly reproducible rotenone model of Parkinson's disease
-
Cannon JR, Tapias V, Na HM, Honick AS, Drolet RE, et al. (2009) A highly reproducible rotenone model of Parkinson's disease. Neurobiol Dis 34: 279-290.
-
(2009)
Neurobiol Dis
, vol.34
, pp. 279-290
-
-
Cannon, J.R.1
Tapias, V.2
Na, H.M.3
Honick, A.S.4
Drolet, R.E.5
-
52
-
-
10044292870
-
Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster
-
Coulom H, Birman S, (2004) Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster. J Neurosci 24: 10993-10998.
-
(2004)
J Neurosci
, vol.24
, pp. 10993-10998
-
-
Coulom, H.1
Birman, S.2
-
53
-
-
0141741347
-
Parkinson's disease: mechanisms and models
-
Dauer W, Przedborski S, (2003) Parkinson's disease: mechanisms and models. Neuron 39: 889-909.
-
(2003)
Neuron
, vol.39
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
54
-
-
84859759299
-
Silent information regulator 2 (Sir2) and Forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant
-
Koh H, Kim H, Kim MJ, Park J, Lee HJ, et al. (2012) Silent information regulator 2 (Sir2) and Forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant. J Biol Chem 287: 12750-12758.
-
(2012)
J Biol Chem
, vol.287
, pp. 12750-12758
-
-
Koh, H.1
Kim, H.2
Kim, M.J.3
Park, J.4
Lee, H.J.5
-
55
-
-
0032842038
-
Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease
-
Berman SB, Hastings TG, (1999) Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease. J Neurochem 73: 1127-1137.
-
(1999)
J Neurochem
, vol.73
, pp. 1127-1137
-
-
Berman, S.B.1
Hastings, T.G.2
-
56
-
-
0028215392
-
Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease
-
Zhang F, Dryhurst G, (1994) Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease. J Med Chem 37: 1084-1098.
-
(1994)
J Med Chem
, vol.37
, pp. 1084-1098
-
-
Zhang, F.1
Dryhurst, G.2
-
57
-
-
18144416872
-
Dopamine-derived dopaminochrome promotes H(2)O(2) release at mitochondrial complex I: stimulation by rotenone, control by Ca(2+), and relevance to Parkinson disease
-
Zoccarato F, Toscano P, Alexandre A, (2005) Dopamine-derived dopaminochrome promotes H(2)O(2) release at mitochondrial complex I: stimulation by rotenone, control by Ca(2+), and relevance to Parkinson disease. J Biol Chem 280: 15587-15594.
-
(2005)
J Biol Chem
, vol.280
, pp. 15587-15594
-
-
Zoccarato, F.1
Toscano, P.2
Alexandre, A.3
-
58
-
-
67349112729
-
Iron, the substantia nigra and related neurological disorders
-
Snyder AM, Connor JR, (2009) Iron, the substantia nigra and related neurological disorders. Biochim Biophys Acta 1790: 606-614.
-
(2009)
Biochim Biophys Acta
, vol.1790
, pp. 606-614
-
-
Snyder, A.M.1
Connor, J.R.2
-
59
-
-
22544458436
-
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila
-
Cha GH, Kim S, Park J, Lee E, Kim M, et al. (2005) Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc Natl Acad Sci U S A 102: 10345-10350.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 10345-10350
-
-
Cha, G.H.1
Kim, S.2
Park, J.3
Lee, E.4
Kim, M.5
-
60
-
-
2542560342
-
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
-
Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, et al. (2004) Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development 131: 2183-2194.
-
(2004)
Development
, vol.131
, pp. 2183-2194
-
-
Pesah, Y.1
Pham, T.2
Burgess, H.3
Middlebrooks, B.4
Verstreken, P.5
-
61
-
-
23044506102
-
Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions
-
Verstreken P, Ly CV, Venken KJ, Koh TW, Zhou Y, et al. (2005) Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 47: 365-378.
-
(2005)
Neuron
, vol.47
, pp. 365-378
-
-
Verstreken, P.1
Ly, C.V.2
Venken, K.J.3
Koh, T.W.4
Zhou, Y.5
-
62
-
-
34447530305
-
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
-
Dietzl G, Chen D, Schnorrer F, Su KC, Barinova Y, et al. (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448: 151-156.
-
(2007)
Nature
, vol.448
, pp. 151-156
-
-
Dietzl, G.1
Chen, D.2
Schnorrer, F.3
Su, K.C.4
Barinova, Y.5
-
63
-
-
33847660443
-
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases
-
Bischof J, Maeda RK, Hediger M, Karch F, Basler K, (2007) An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A 104: 3312-3317.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3312-3317
-
-
Bischof, J.1
Maeda, R.K.2
Hediger, M.3
Karch, F.4
Basler, K.5
-
64
-
-
33845698104
-
P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster
-
Venken KJ, He Y, Hoskins RA, Bellen HJ, (2006) P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science 314: 1747-1751.
-
(2006)
Science
, vol.314
, pp. 1747-1751
-
-
Venken, K.J.1
He, Y.2
Hoskins, R.A.3
Bellen, H.J.4
-
65
-
-
34248652102
-
A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining
-
Wu JS, Luo L, (2006) A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining. Nat Protoc 1: 2110-2115.
-
(2006)
Nat Protoc
, vol.1
, pp. 2110-2115
-
-
Wu, J.S.1
Luo, L.2
|