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Volumn 6, Issue SEP, 2015, Pages

FOXP3+ Treg cells and gender bias in autoimmune diseases

Author keywords

Autoimmunity; FOXP3; Gender; Inflammation; Treg cells

Indexed keywords

GELATINASE B; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 7; NEUROPILIN 1; S PHASE KINASE ASSOCIATED PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

EID: 84946545254     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00493     Document Type: Article
Times cited : (125)

References (168)
  • 1
    • 67649518924 scopus 로고    scopus 로고
    • CTLA-4 is required by CD4(+)CD25(+) Treg to control CD4(+) T-cell lymphopenia-induced proliferation
    • Sojka DK, Hughson A, Fowell DJ. CTLA-4 is required by CD4(+)CD25(+) Treg to control CD4(+) T-cell lymphopenia-induced proliferation. Eur J Immunol (2009) 39:1544-51. doi:10.1002/eji.200838603.
    • (2009) Eur J Immunol , vol.39 , pp. 1544-1551
    • Sojka, D.K.1    Hughson, A.2    Fowell, D.J.3
  • 2
    • 58049196774 scopus 로고    scopus 로고
    • Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    • Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc Natl Acad Sci USA (2008) 105:19396-401. doi:10.1073/pnas.0806855105.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19396-19401
    • Flores-Borja, F.1    Jury, E.C.2    Mauri, C.3    Ehrenstein, M.R.4
  • 3
    • 2442429448 scopus 로고    scopus 로고
    • Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression
    • Ji HB, Liao G, Faubion WA, Abadia-Molina AC, Cozzo C, Laroux FS, et al. Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol (2004) 172:5823-7. doi:10.4049/jimmunol.172.10.5823.
    • (2004) J Immunol , vol.172 , pp. 5823-5827
    • Ji, H.B.1    Liao, G.2    Faubion, W.A.3    Abadia-Molina, A.C.4    Cozzo, C.5    Laroux, F.S.6
  • 4
    • 35449006679 scopus 로고    scopus 로고
    • Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
    • Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity (2007) 27:635-46. doi:10.1016/j.immuni.2007.08.014.
    • (2007) Immunity , vol.27 , pp. 635-646
    • Cao, X.1    Cai, S.F.2    Fehniger, T.A.3    Song, J.4    Collins, L.I.5    Piwnica-Worms, D.R.6
  • 5
    • 34547098277 scopus 로고    scopus 로고
    • Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
    • Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood (2007) 110:1225-32. doi:10.1182/blood-2006-12-064527.
    • (2007) Blood , vol.110 , pp. 1225-1232
    • Borsellino, G.1    Kleinewietfeld, M.2    Di Mitri, D.3    Sternjak, A.4    Diamantini, A.5    Giometto, R.6
  • 6
    • 70049118519 scopus 로고    scopus 로고
    • Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35-and IL-10-dependent manner
    • Collison LW, Pillai MR, Chaturvedi V, Vignali DA. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35-and IL-10-dependent manner. J Immunol (2009) 182:6121-8. doi:10.4049/jimmunol.0803646.
    • (2009) J Immunol , vol.182 , pp. 6121-6128
    • Collison, L.W.1    Pillai, M.R.2    Chaturvedi, V.3    Vignali, D.A.4
  • 8
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol (2003) 4:337-42. doi:10.1038/ni909.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 9
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 299:1057-61. doi:10.1126/science.1079490.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 10
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 4:330-6. doi:10.1038/ni904.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 11
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol (2007) 8:277-84. doi:10.1038/ni1437.
    • (2007) Nat Immunol , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 12
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 445:766-70. doi:10.1038/nature05479.
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 13
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 453:236-40. doi:10.1038/nature06878.
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1    Lopes, J.E.2    Chong, M.M.3    Ivanov, I.I.4    Min, R.5    Victora, G.D.6
  • 15
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 27:68-73. doi:10.1038/83784.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5    Yasayko, S.A.6
  • 16
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • Gambineri E, Torgerson TR, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Rheumatol (2003) 15:430-5. doi:10.1097/00002281-200307000-00010.
    • (2003) Curr Opin Rheumatol , vol.15 , pp. 430-435
    • Gambineri, E.1    Torgerson, T.R.2    Ochs, H.D.3
  • 17
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest (2000) 106:R75-81. doi:10.1172/JCI11679.
    • (2000) J Clin Invest , vol.106 , pp. R75-R81
    • Chatila, T.A.1    Blaeser, F.2    Ho, N.3    Lederman, H.M.4    Voulgaropoulos, C.5    Helms, C.6
  • 18
    • 26244454357 scopus 로고    scopus 로고
    • Analysis of a GT microsatellite in the promoter of the foxp3/scurfin gene in autoimmune diseases
    • Sanchez E, Rueda B, Orozco G, Oliver J, Vilchez JR, Paco L, et al. Analysis of a GT microsatellite in the promoter of the foxp3/scurfin gene in autoimmune diseases. Hum Immunol (2005) 66:869-73. doi:10.1016/j.humimm.2005.06.001.
    • (2005) Hum Immunol , vol.66 , pp. 869-873
    • Sanchez, E.1    Rueda, B.2    Orozco, G.3    Oliver, J.4    Vilchez, J.R.5    Paco, L.6
  • 19
    • 79953324918 scopus 로고    scopus 로고
    • Association of single-nucleotide polymorphisms in FOXP3 gene with systemic lupus erythematosus susceptibility: a case-control study
    • Lin YC, Lee JH, Wu AS, Tsai CY, Yu HH, Wang LC, et al. Association of single-nucleotide polymorphisms in FOXP3 gene with systemic lupus erythematosus susceptibility: a case-control study. Lupus (2011) 20:137-43. doi:10.1177/0961203310382428.
    • (2011) Lupus , vol.20 , pp. 137-143
    • Lin, Y.C.1    Lee, J.H.2    Wu, A.S.3    Tsai, C.Y.4    Yu, H.H.5    Wang, L.C.6
  • 20
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet (2001) 27:20-1. doi:10.1038/83713.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 21
    • 0034812349 scopus 로고    scopus 로고
    • A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA-> AAUGAA) leads to the IPEX syndrome
    • Bennett CL, Brunkow ME, Ramsdell F, O'Briant KC, Zhu Q, Fuleihan RL, et al. A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA-> AAUGAA) leads to the IPEX syndrome. Immunogenetics (2001) 53:435-9. doi:10.1007/s002510100358.
    • (2001) Immunogenetics , vol.53 , pp. 435-439
    • Bennett, C.L.1    Brunkow, M.E.2    Ramsdell, F.3    O'Briant, K.C.4    Zhu, Q.5    Fuleihan, R.L.6
  • 22
    • 18244378309 scopus 로고    scopus 로고
    • Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)
    • Kobayashi I, Shiari R, Yamada M, Kawamura N, Okano M, Yara A, et al. Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX). J Med Genet (2001) 38:874-6. doi:10.1136/jmg.38.12.874.
    • (2001) J Med Genet , vol.38 , pp. 874-876
    • Kobayashi, I.1    Shiari, R.2    Yamada, M.3    Kawamura, N.4    Okano, M.5    Yara, A.6
  • 23
    • 79952115460 scopus 로고    scopus 로고
    • A novel missense mutation of FOXP3 causes immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome in a Chinese child
    • An YF, Zhao XD, Xu F, Yang XQ. [A novel missense mutation of FOXP3 causes immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome in a Chinese child]. Zhonghua Er Ke Za Zhi (2009) 47:824-8. doi:10.3760/cma.j.issn.0578-1310.2009.11.007.
    • (2009) Zhonghua Er Ke Za Zhi , vol.47 , pp. 824-828
    • An, Y.F.1    Zhao, X.D.2    Xu, F.3    Yang, X.Q.4
  • 24
    • 0038345163 scopus 로고    scopus 로고
    • A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes
    • Bassuny WM, Ihara K, Sasaki Y, Kuromaru R, Kohno H, Matsuura N, et al. A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes. Immunogenetics (2003) 55:149-56. doi:10.1007/s00251-003-0559-8.
    • (2003) Immunogenetics , vol.55 , pp. 149-156
    • Bassuny, W.M.1    Ihara, K.2    Sasaki, Y.3    Kuromaru, R.4    Kohno, H.5    Matsuura, N.6
  • 25
    • 3042779888 scopus 로고    scopus 로고
    • No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population
    • Zavattari P, Deidda E, Pitzalis M, Zoa B, Moi L, Lampis R, et al. No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population. Diabetes (2004) 53:1911-4. doi:10.2337/diabetes.53.7.1911.
    • (2004) Diabetes , vol.53 , pp. 1911-1914
    • Zavattari, P.1    Deidda, E.2    Pitzalis, M.3    Zoa, B.4    Moi, L.5    Lampis, R.6
  • 26
    • 33747892641 scopus 로고    scopus 로고
    • Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population
    • Owen CJ, Eden JA, Jennings CE, Wilson V, Cheetham TD, Pearce SH. Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population. J Mol Endocrinol (2006) 37:97-104. doi:10.1677/jme.1.02072.
    • (2006) J Mol Endocrinol , vol.37 , pp. 97-104
    • Owen, C.J.1    Eden, J.A.2    Jennings, C.E.3    Wilson, V.4    Cheetham, T.D.5    Pearce, S.H.6
  • 27
    • 75649120798 scopus 로고    scopus 로고
    • Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families
    • Howson JMM, Walker NM, Smyth DJ, Todd J, Consortium TIDG. Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Genes Immun (2009) 10:S74-84. doi:10.1038/gene.2009.96.
    • (2009) Genes Immun , vol.10 , pp. S74-S84
    • Howson, J.M.M.1    Walker, N.M.2    Smyth, D.J.3    Todd, J.4    Consortium, T.I.D.G.5
  • 29
    • 70149124792 scopus 로고    scopus 로고
    • Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset
    • Lee HM, Hsieh CS. Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset. J Immunol (2009) 183:2261-6. doi:10.4049/jimmunol.0901304.
    • (2009) J Immunol , vol.183 , pp. 2261-2266
    • Lee, H.M.1    Hsieh, C.S.2
  • 31
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: production of CD25(+)CD4(+) naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, et al. Thymus and autoimmunity: production of CD25(+)CD4(+) naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol (1999) 162:5317-26.
    • (1999) J Immunol , vol.162 , pp. 5317-5326
    • Itoh, M.1    Takahashi, T.2    Sakaguchi, N.3    Kuniyasu, Y.4    Shimizu, J.5    Otsuka, F.6
  • 33
    • 2942724435 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen
    • Lerman MA, Larkin J III, Cozzo C, Jordan MS, Caton AJ. CD4+ CD25+ regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen. J Immunol (2004) 173:236-44. doi:10.4049/jimmunol.173.1.236.
    • (2004) J Immunol , vol.173 , pp. 236-244
    • Lerman, M.A.1    Larkin, J.2    Cozzo, C.3    Jordan, M.S.4    Caton, A.J.5
  • 34
    • 33747099523 scopus 로고    scopus 로고
    • Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells
    • Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L. Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity (2006) 25:249-59. doi:10.1016/j.immuni.2006.05.016.
    • (2006) Immunity , vol.25 , pp. 249-259
    • Pacholczyk, R.1    Ignatowicz, H.2    Kraj, P.3    Ignatowicz, L.4
  • 35
    • 22044447704 scopus 로고    scopus 로고
    • TCRalphabeta repertoire diversity of human naturally occurring CD4+CD25+ regulatory T cells
    • Fujishima M, Hirokawa M, Fujishima N, Sawada K. TCRalphabeta repertoire diversity of human naturally occurring CD4+CD25+ regulatory T cells. Immunol Lett (2005) 99:193-7. doi:10.1016/j.imlet.2005.02.011.
    • (2005) Immunol Lett , vol.99 , pp. 193-197
    • Fujishima, M.1    Hirokawa, M.2    Fujishima, N.3    Sawada, K.4
  • 36
    • 2442494076 scopus 로고    scopus 로고
    • Human CD4+CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+CD25-counterparts
    • Kasow KA, Chen X, Knowles J, Wichlan D, Handgretinger R, Riberdy JM. Human CD4+CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+CD25-counterparts. J Immunol (2004) 172:6123-8. doi:10.4049/jimmunol.172.10.6123.
    • (2004) J Immunol , vol.172 , pp. 6123-6128
    • Kasow, K.A.1    Chen, X.2    Knowles, J.3    Wichlan, D.4    Handgretinger, R.5    Riberdy, J.M.6
  • 37
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
    • Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity (2004) 21:267-77. doi:10.1016/j.immuni.2004.07.009.
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.S.1    Liang, Y.2    Tyznik, A.J.3    Self, S.G.4    Liggitt, D.5    Rudensky, A.Y.6
  • 38
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran AE, Holzapfel KL, Xing Y, Cunningham NR, Maltzman JS, Punt J, et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med (2011) 208:1279-89. doi:10.1084/jem.20110308.
    • (2011) J Exp Med , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6
  • 39
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 155:1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 40
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity (1995) 3:521-30. doi:10.1016/1074-7613(95)90180-9.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 41
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    • Suzuki H, Kundig TM, Furlonger C, Wakeham A, Timms E, Matsuyama T, et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science (1995) 268:1472-6. doi:10.1126/science.7770771.
    • (1995) Science , vol.268 , pp. 1472-1476
    • Suzuki, H.1    Kundig, T.M.2    Furlonger, C.3    Wakeham, A.4    Timms, E.5    Matsuyama, T.6
  • 42
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell (1993) 75:253-61. doi:10.1016/0092-8674(93)80067-O.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 43
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature (1991) 352:621-4. doi:10.1038/352621a0.
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 44
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek TR, Yu A, Vincek V, Scibelli P, Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity (2002) 17:167-78. doi:10.1016/S1074-7613(02)00367-9.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 45
    • 0036839102 scopus 로고    scopus 로고
    • Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    • Almeida AR, Legrand N, Papiernik M, Freitas AA. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol (2002) 169:4850-60. doi:10.4049/jimmunol.169.9.4850.
    • (2002) J Immunol , vol.169 , pp. 4850-4860
    • Almeida, A.R.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 46
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Penit C. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol (1998) 10:371-8. doi:10.1093/intimm/10.4.371.
    • (1998) Int Immunol , vol.10 , pp. 371-378
    • Papiernik, M.1    de Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 47
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    • Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol (2007) 178:280-90. doi:10.4049/jimmunol.178.1.280.
    • (2007) J Immunol , vol.178 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 48
    • 77953267301 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    • Ouyang W, Beckett O, Ma Q, Li MO. Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity (2010) 32:642-53. doi:10.1016/j.immuni.2010.04.012.
    • (2010) Immunity , vol.32 , pp. 642-653
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Li, M.O.4
  • 49
    • 84869148187 scopus 로고    scopus 로고
    • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
    • Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity (2012) 37:785-99. doi:10.1016/j.immuni.2012.09.010.
    • (2012) Immunity , vol.37 , pp. 785-799
    • Ohkura, N.1    Hamaguchi, M.2    Morikawa, H.3    Sugimura, K.4    Tanaka, A.5    Ito, Y.6
  • 50
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, et al. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 198:1875-86. doi:10.1084/jem.20030152.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6
  • 51
    • 4344696770 scopus 로고    scopus 로고
    • Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25-T cells
    • Park HB, Paik DJ, Jang E, Hong S, Youn J. Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25-T cells. Int Immunol (2004) 16:1203-13. doi:10.1093/intimm/dxh123.
    • (2004) Int Immunol , vol.16 , pp. 1203-1213
    • Park, H.B.1    Paik, D.J.2    Jang, E.3    Hong, S.4    Youn, J.5
  • 52
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 203:1701-11. doi:10.1084/jem.20060772.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3    Szot, G.L.4    Lee, M.R.5    Zhu, S.6
  • 53
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 184:3433-41. doi:10.4049/jimmunol.0904028.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6
  • 54
    • 84874232301 scopus 로고    scopus 로고
    • Helios+ and Helios-cells coexist within the natural FOXP3+ T regulatory cell subset in humans
    • Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK. Helios+ and Helios-cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol (2013) 190:2001-8. doi:10.4049/jimmunol.1201379.
    • (2013) J Immunol , vol.190 , pp. 2001-2008
    • Himmel, M.E.1    MacDonald, K.G.2    Garcia, R.V.3    Steiner, T.S.4    Levings, M.K.5
  • 55
    • 84867901322 scopus 로고    scopus 로고
    • Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    • Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med (2012) 209:S1-19. doi:10.1084/jem.20120822.
    • (2012) J Exp Med , vol.209 , pp. S1-S19
    • Yadav, M.1    Louvet, C.2    Davini, D.3    Gardner, J.M.4    Martinez-Llordella, M.5    Bailey-Bucktrout, S.6
  • 56
    • 69449086689 scopus 로고    scopus 로고
    • Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
    • Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci USA (2009) 106:13439-44. doi:10.1073/pnas.0901965106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13439-13444
    • Wang, R.1    Kozhaya, L.2    Mercer, F.3    Khaitan, A.4    Fujii, H.5    Unutmaz, D.6
  • 57
    • 84867899425 scopus 로고    scopus 로고
    • Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    • S1
    • Weiss JM, Bilate AM, Gobert M, Ding Y, Curotto de Lafaille MA, Parkhurst CN, et al. Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 209:1723-42, S1. doi:10.1084/jem.20120914.
    • (2012) J Exp Med , vol.209 , pp. 1723-1742
    • Weiss, J.M.1    Bilate, A.M.2    Gobert, M.3    Ding, Y.4    Curotto de Lafaille, M.A.5    Parkhurst, C.N.6
  • 58
    • 84887194102 scopus 로고    scopus 로고
    • Regulatory T-cell therapy in transplantation: moving to the clinic
    • Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med (2013) 3:ii:a015552. doi:10.1101/cshperspect.a015552.
    • (2013) Cold Spring Harb Perspect Med , vol.3
    • Tang, Q.1    Bluestone, J.A.2
  • 60
    • 84860187314 scopus 로고    scopus 로고
    • Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo
    • Yurchenko E, Shio MT, Huang TC, Da Silva Martins M, Szyf M, Levings MK, et al. Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS One (2012) 7:e35572. doi:10.1371/journal.pone.0035572.
    • (2012) PLoS One , vol.7
    • Yurchenko, E.1    Shio, M.T.2    Huang, T.C.3    Da Silva Martins, M.4    Szyf, M.5    Levings, M.K.6
  • 61
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 29:44-56. doi:10.1016/j.immuni.2008.05.007.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3    Kang, H.S.4    Chung, Y.5    Pappu, B.P.6
  • 62
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    • Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T, et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science (2009) 323:1488-92. doi:10.1126/science.1169152.
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1    Komatsu, N.2    Kawamoto, S.3    Suzuki, K.4    Kanagawa, O.5    Honjo, T.6
  • 63
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: regulatory T cells induce CD4+CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
    • Xu L, Kitani A, Fuss I, Strober W. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol (2007) 178:6725-9. doi:10.4049/jimmunol.178.11.6725.
    • (2007) J Immunol , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 64
    • 60549115770 scopus 로고    scopus 로고
    • Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • Komatsu N, Mariotti-Ferrandiz ME, Wang Y, Malissen B, Waldmann H, Hori S. Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci USA (2009) 106:1903-8. doi:10.1073/pnas.0811556106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1903-1908
    • Komatsu, N.1    Mariotti-Ferrandiz, M.E.2    Wang, Y.3    Malissen, B.4    Waldmann, H.5    Hori, S.6
  • 65
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martinez-Llordella M, Ashby M, et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol (2009) 10:1000-7. doi:10.1038/ni.1774.
    • (2009) Nat Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3    Penaranda, C.4    Martinez-Llordella, M.5    Ashby, M.6
  • 66
    • 77957371028 scopus 로고    scopus 로고
    • Stability of the regulatory T cell lineage in vivo
    • Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, et al. Stability of the regulatory T cell lineage in vivo. Science (2010) 329:1667-71. doi:10.1126/science.1191996.
    • (2010) Science , vol.329 , pp. 1667-1671
    • Rubtsov, Y.P.1    Niec, R.E.2    Josefowicz, S.3    Li, L.4    Darce, J.5    Mathis, D.6
  • 67
    • 84857416489 scopus 로고    scopus 로고
    • Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    • Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, et al. Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity (2012) 36:262-75. doi:10.1016/j.immuni.2011.12.012.
    • (2012) Immunity , vol.36 , pp. 262-275
    • Miyao, T.1    Floess, S.2    Setoguchi, R.3    Luche, H.4    Fehling, H.J.5    Waldmann, H.6
  • 68
    • 33644844341 scopus 로고    scopus 로고
    • Molecular mechanisms underlying FOXP3 induction in human T cells
    • Mantel PY, Ouaked N, Ruckert B, Karagiannidis C, Welz R, Blaser K, et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol (2006) 176:3593-602. doi:10.4049/jimmunol.176.6.3593.
    • (2006) J Immunol , vol.176 , pp. 3593-3602
    • Mantel, P.Y.1    Ouaked, N.2    Ruckert, B.3    Karagiannidis, C.4    Welz, R.5    Blaser, K.6
  • 69
    • 35948980739 scopus 로고    scopus 로고
    • Deacetylase inhibition promotes the generation and function of regulatory T cells
    • Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 13:1299-307. doi:10.1038/nm1652.
    • (2007) Nat Med , vol.13 , pp. 1299-1307
    • Tao, R.1    de Zoeten, E.F.2    Ozkaynak, E.3    Chen, C.4    Wang, L.5    Porrett, P.M.6
  • 70
    • 45549098562 scopus 로고    scopus 로고
    • T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
    • Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci USA (2008) 105:7797-802. doi:10.1073/pnas.0800928105.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7797-7802
    • Sauer, S.1    Bruno, L.2    Hertweck, A.3    Finlay, D.4    Leleu, M.5    Spivakov, M.6
  • 71
    • 84939532938 scopus 로고    scopus 로고
    • Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection
    • de Almeida Nagata DE, Ting HA, Cavassani KA, Schaller MA, Mukherjee S, Ptaschinski C, et al. Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection. Mucosal Immunol (2015) 8(5):1131-43. doi:10.1038/mi.2015.4.
    • (2015) Mucosal Immunol , vol.8 , Issue.5 , pp. 1131-1143
    • de Almeida Nagata, D.E.1    Ting, H.A.2    Cavassani, K.A.3    Schaller, M.A.4    Mukherjee, S.5    Ptaschinski, C.6
  • 72
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the foxp3 locus in regulatory T cells
    • Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol (2007) 5:e38. doi:10.1371/journal.pbio.0050038.
    • (2007) PLoS Biol , vol.5
    • Floess, S.1    Freyer, J.2    Siewert, C.3    Baron, U.4    Olek, S.5    Polansky, J.6
  • 74
    • 65549100376 scopus 로고    scopus 로고
    • Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1
    • Josefowicz SZ, Wilson CB, Rudensky AY. Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. J Immunol (2009) 182:6648-52. doi:10.4049/jimmunol.0803320.
    • (2009) J Immunol , vol.182 , pp. 6648-6652
    • Josefowicz, S.Z.1    Wilson, C.B.2    Rudensky, A.Y.3
  • 75
    • 70349741295 scopus 로고    scopus 로고
    • Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells
    • Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, et al. Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity (2009) 31:609-20. doi:10.1016/j.immuni.2009.09.003.
    • (2009) Immunity , vol.31 , pp. 609-620
    • Kitoh, A.1    Ono, M.2    Naoe, Y.3    Ohkura, N.4    Yamaguchi, T.5    Yaguchi, H.6
  • 76
    • 70350451993 scopus 로고    scopus 로고
    • Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells
    • Rudra D, Egawa T, Chong MM, Treuting P, Littman DR, Rudensky AY. Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 10:1170-7. doi:10.1038/ni.1795.
    • (2009) Nat Immunol , vol.10 , pp. 1170-1177
    • Rudra, D.1    Egawa, T.2    Chong, M.M.3    Treuting, P.4    Littman, D.R.5    Rudensky, A.Y.6
  • 77
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation
    • Kim HP, Leonard WJ. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med (2007) 204:1543-51. doi:10.1084/jem.20070109.
    • (2007) J Exp Med , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 78
  • 79
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome
    • Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, et al. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity (2009) 31:932-40. doi:10.1016/j.immuni.2009.10.006.
    • (2009) Immunity , vol.31 , pp. 932-940
    • Ruan, Q.1    Kameswaran, V.2    Tone, Y.3    Li, L.4    Liou, H.C.5    Greene, M.I.6
  • 80
    • 73949090725 scopus 로고    scopus 로고
    • c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
    • Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, et al. c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 206:3001-14. doi:10.1084/jem.20091411.
    • (2009) J Exp Med , vol.206 , pp. 3001-3014
    • Isomura, I.1    Palmer, S.2    Grumont, R.J.3    Bunting, K.4    Hoyne, G.5    Wilkinson, N.6
  • 81
    • 77953811224 scopus 로고    scopus 로고
    • Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
    • Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol (2010) 11:618-27. doi:10.1038/ni.1884.
    • (2010) Nat Immunol , vol.11 , pp. 618-627
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Paik, J.H.4    DePinho, R.A.5    Li, M.O.6
  • 82
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity (2007) 26:371-81. doi:10.1016/j.immuni.2007.02.009.
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3    Kanno, Y.4    Chen, Z.5    Yao, Z.6
  • 83
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD4(+)CD25(+) regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    • Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, et al. IL-2 regulates FOXP3 expression in human CD4(+)CD25(+) regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood (2006) 108:1571-9. doi:10.1182/blood-2006-02-004747.
    • (2006) Blood , vol.108 , pp. 1571-1579
    • Zorn, E.1    Nelson, E.A.2    Mohseni, M.3    Porcheray, F.4    Kim, H.5    Litsa, D.6
  • 84
    • 84945196897 scopus 로고    scopus 로고
    • Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD)
    • Mirlekar B, Ghorai S, Khetmalas M, Bopanna R, Chattopadhyay S. Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD). Mucosal Immunol (2015). doi:10.1038/mi.2015.42.
    • (2015) Mucosal Immunol
    • Mirlekar, B.1    Ghorai, S.2    Khetmalas, M.3    Bopanna, R.4    Chattopadhyay, S.5
  • 85
    • 73349115263 scopus 로고    scopus 로고
    • Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
    • Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, et al. Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med (2009) 206:2701-15. doi:10.1084/jem.20090596.
    • (2009) J Exp Med , vol.206 , pp. 2701-2715
    • Klunker, S.1    Chong, M.M.2    Mantel, P.Y.3    Palomares, O.4    Bassin, C.5    Ziegler, M.6
  • 87
    • 84866403123 scopus 로고    scopus 로고
    • Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
    • Schlenner SM, Weigmann B, Ruan Q, Chen Y, von Boehmer H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med (2012) 209:1529-35. doi:10.1084/jem.20112646.
    • (2012) J Exp Med , vol.209 , pp. 1529-1535
    • Schlenner, S.M.1    Weigmann, B.2    Ruan, Q.3    Chen, Y.4    von Boehmer, H.5
  • 88
    • 77957025756 scopus 로고    scopus 로고
    • Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
    • Xu L, Kitani A, Stuelten C, McGrady G, Fuss I, Strober W. Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity (2010) 33:313-25. doi:10.1016/j.immuni.2010.09.001.
    • (2010) Immunity , vol.33 , pp. 313-325
    • Xu, L.1    Kitani, A.2    Stuelten, C.3    McGrady, G.4    Fuss, I.5    Strober, W.6
  • 89
    • 77955498891 scopus 로고    scopus 로고
    • Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development
    • Takimoto T, Wakabayashi Y, Sekiya T, Inoue N, Morita R, Ichiyama K, et al. Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development. J Immunol (2010) 185:842-55. doi:10.4049/jimmunol.0904100.
    • (2010) J Immunol , vol.185 , pp. 842-855
    • Takimoto, T.1    Wakabayashi, Y.2    Sekiya, T.3    Inoue, N.4    Morita, R.5    Ichiyama, K.6
  • 90
    • 0035694910 scopus 로고    scopus 로고
    • Smad regulation in TGF-beta signal transduction
    • Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci (2001) 114:4359-69.
    • (2001) J Cell Sci , vol.114 , pp. 4359-4369
    • Moustakas, A.1    Souchelnytskyi, S.2    Heldin, C.H.3
  • 91
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature (2010) 463:808-12. doi:10.1038/nature08750.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 92
    • 35448967862 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling in regulatory T cell development and homeostasis
    • Burchill MA, Yang J, Vang KB, Farrar MA. Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. Immunol Lett (2007) 114:1-8. doi:10.1016/j.imlet.2007.08.005.
    • (2007) Immunol Lett , vol.114 , pp. 1-8
    • Burchill, M.A.1    Yang, J.2    Vang, K.B.3    Farrar, M.A.4
  • 93
    • 78149408519 scopus 로고    scopus 로고
    • Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    • Polansky JK, Schreiber L, Thelemann C, Ludwig L, Kruger M, Baumgrass R, et al. Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. J Mol Med (2010) 88:1029-40. doi:10.1007/s00109-010-0642-1.
    • (2010) J Mol Med , vol.88 , pp. 1029-1040
    • Polansky, J.K.1    Schreiber, L.2    Thelemann, C.3    Ludwig, L.4    Kruger, M.5    Baumgrass, R.6
  • 94
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • Long M, Park SG, Strickland I, Hayden MS, Ghosh S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity (2009) 31:921-31. doi:10.1016/j.immuni.2009.09.022.
    • (2009) Immunity , vol.31 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 95
    • 84908401913 scopus 로고    scopus 로고
    • Function of a Foxp3 cis-element in protecting regulatory T cell identity
    • Li X, Liang Y, LeBlanc M, Benner C, Zheng Y. Function of a Foxp3 cis-element in protecting regulatory T cell identity. Cell (2014) 158:734-48. doi:10.1016/j.cell.2014.07.030.
    • (2014) Cell , vol.158 , pp. 734-748
    • Li, X.1    Liang, Y.2    LeBlanc, M.3    Benner, C.4    Zheng, Y.5
  • 96
    • 84908403082 scopus 로고    scopus 로고
    • Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
    • Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell (2014) 158:749-63. doi:10.1016/j.cell.2014.07.031.
    • (2014) Cell , vol.158 , pp. 749-763
    • Feng, Y.1    Arvey, A.2    Chinen, T.3    van der Veeken, J.4    Gasteiger, G.5    Rudensky, A.Y.6
  • 97
    • 84866548843 scopus 로고    scopus 로고
    • Transcription factor Foxp3 and its protein partners form a complex regulatory network
    • Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, et al. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol (2012) 13:1010-9. doi:10.1038/ni.2402.
    • (2012) Nat Immunol , vol.13 , pp. 1010-1019
    • Rudra, D.1    deRoos, P.2    Chaudhry, A.3    Niec, R.E.4    Arvey, A.5    Samstein, R.M.6
  • 98
    • 84866548798 scopus 로고    scopus 로고
    • The Foxp3 interactome: a network perspective of T(reg) cells
    • Hori S. The Foxp3 interactome: a network perspective of T(reg) cells. Nat Immunol (2012) 13:943-5. doi:10.1038/ni.2424.
    • (2012) Nat Immunol , vol.13 , pp. 943-945
    • Hori, S.1
  • 99
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 126:375-87. doi:10.1016/j.cell.2006.05.042.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3    Feuerer, M.4    Lapan, A.D.5    Stroud, J.C.6
  • 100
    • 34247215187 scopus 로고    scopus 로고
    • Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    • Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature (2007) 446:685-9. doi:10.1038/nature05673.
    • (2007) Nature , vol.446 , pp. 685-689
    • Ono, M.1    Yaguchi, H.2    Ohkura, N.3    Kitabayashi, I.4    Nagamura, Y.5    Nomura, T.6
  • 101
    • 69549120242 scopus 로고    scopus 로고
    • Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells
    • Pan F, Yu H, Dang EV, Barbi J, Pan X, Grosso JF, et al. Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 325:1142-6. doi:10.1126/science.1176077.
    • (2009) Science , vol.325 , pp. 1142-1146
    • Pan, F.1    Yu, H.2    Dang, E.V.3    Barbi, J.4    Pan, X.5    Grosso, J.F.6
  • 102
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    • Zheng Y, Chaudhry A, Kas A, deRoos P, Kim JM, Chu TT, et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 458:351-6. doi:10.1038/nature07674.
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3    deRoos, P.4    Kim, J.M.5    Chu, T.T.6
  • 103
    • 84934949643 scopus 로고    scopus 로고
    • Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1
    • Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, et al. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci USA (2015) 112(25):E3246-54. doi:10.1073/pnas.1421463112.
    • (2015) Proc Natl Acad Sci USA , vol.112 , Issue.25 , pp. E3246-E3254
    • Gao, Y.1    Tang, J.2    Chen, W.3    Li, Q.4    Nie, J.5    Lin, F.6
  • 105
    • 80053130719 scopus 로고    scopus 로고
    • An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    • Wang Y, Su MA, Wan YY. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity (2011) 35:337-48. doi:10.1016/j.immuni.2011.08.012.
    • (2011) Immunity , vol.35 , pp. 337-348
    • Wang, Y.1    Su, M.A.2    Wan, Y.Y.3
  • 106
    • 84922986903 scopus 로고    scopus 로고
    • Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation
    • Pannu J, Belle JI, Forster M, Duerr CU, Shen S, Kane L, et al. Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation. PLoS One (2015) 10:e0117304. doi:10.1371/journal.pone.0117304.
    • (2015) PLoS One , vol.10
    • Pannu, J.1    Belle, J.I.2    Forster, M.3    Duerr, C.U.4    Shen, S.5    Kane, L.6
  • 107
    • 84875979211 scopus 로고    scopus 로고
    • Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3
    • Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, et al. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. J Biol Chem (2013) 288:9373-82. doi:10.1074/jbc. M112.374744.
    • (2013) J Biol Chem , vol.288 , pp. 9373-9382
    • Zhang, J.1    Chen, C.2    Hou, X.3    Gao, Y.4    Lin, F.5    Yang, J.6
  • 108
    • 84929120250 scopus 로고    scopus 로고
    • Th1-like ICOS+ Foxp3+ Treg cells preferentially express CXCR3 and home to beta-islets during pre-diabetes in BDC2.5 NOD mice
    • Kornete M, Mason ES, Girouard J, Lafferty EI, Qureshi S, Piccirillo CA. Th1-like ICOS+ Foxp3+ Treg cells preferentially express CXCR3 and home to beta-islets during pre-diabetes in BDC2.5 NOD mice. PLoS One (2015) 10:e0126311. doi:10.1371/journal.pone.0126311.
    • (2015) PLoS One , vol.10
    • Kornete, M.1    Mason, E.S.2    Girouard, J.3    Lafferty, E.I.4    Qureshi, S.5    Piccirillo, C.A.6
  • 109
    • 78650374915 scopus 로고    scopus 로고
    • Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-gamma-and T-bet-dependent pathway
    • Zheng J, Liu Y, Qin G, Lam KT, Guan J, Xiang Z, et al. Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-gamma-and T-bet-dependent pathway. Eur J Immunol (2011) 41:128-39. doi:10.1002/eji.201040724.
    • (2011) Eur J Immunol , vol.41 , pp. 128-139
    • Zheng, J.1    Liu, Y.2    Qin, G.3    Lam, K.T.4    Guan, J.5    Xiang, Z.6
  • 110
    • 77951643783 scopus 로고    scopus 로고
    • FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes
    • Tartar DM, VanMorlan AM, Wan X, Guloglu FB, Jain R, Haymaker CL, et al. FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes. J Immunol (2010) 184:3377-85. doi:10.4049/jimmunol.0903324.
    • (2010) J Immunol , vol.184 , pp. 3377-3385
    • Tartar, D.M.1    VanMorlan, A.M.2    Wan, X.3    Guloglu, F.B.4    Jain, R.5    Haymaker, C.L.6
  • 111
    • 84882683958 scopus 로고    scopus 로고
    • The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
    • Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity (2013) 39:272-85. doi:10.1016/j.immuni.2013.08.006.
    • (2013) Immunity , vol.39 , pp. 272-285
    • Chen, Z.1    Barbi, J.2    Bu, S.3    Yang, H.Y.4    Li, Z.5    Gao, Y.6
  • 112
    • 84882592280 scopus 로고    scopus 로고
    • Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity
    • van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, et al. Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity (2013) 39:259-71. doi:10.1016/j.immuni.2013.05.018.
    • (2013) Immunity , vol.39 , pp. 259-271
    • van Loosdregt, J.1    Fleskens, V.2    Fu, J.3    Brenkman, A.B.4    Bekker, C.P.5    Pals, C.E.6
  • 113
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 146:772-84. doi:10.1016/j.cell.2011.07.033.
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1    Barbi, J.2    Yang, H.Y.3    Jinasena, D.4    Yu, H.5    Zheng, Y.6
  • 114
    • 77649225958 scopus 로고    scopus 로고
    • Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    • van Loosdregt J, Vercoulen Y, Guichelaar T, Gent YY, Beekman JM, van Beekum O, et al. Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood (2010) 115:965-74. doi:10.1182/blood-2009-02-207118.
    • (2010) Blood , vol.115 , pp. 965-974
    • van Loosdregt, J.1    Vercoulen, Y.2    Guichelaar, T.3    Gent, Y.Y.4    Beekman, J.M.5    van Beekum, O.6
  • 116
    • 84872613658 scopus 로고    scopus 로고
    • mTORC2-PKBalpha/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 Stability by chemokine CCL3 in psoriasis
    • Chen L, Wu J, Pier E, Zhao Y, Shen Z. mTORC2-PKBalpha/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 Stability by chemokine CCL3 in psoriasis. J Invest Dermatol (2013) 133:418-28. doi:10.1038/jid.2012.333.
    • (2013) J Invest Dermatol , vol.133 , pp. 418-428
    • Chen, L.1    Wu, J.2    Pier, E.3    Zhao, Y.4    Shen, Z.5
  • 117
    • 34248379172 scopus 로고    scopus 로고
    • FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
    • Li B, Samanta A, Song X, Iacono KT, Bembas K, Tao R, et al. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci USA (2007) 104:4571-6. doi:10.1073/pnas.0700298104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4571-4576
    • Li, B.1    Samanta, A.2    Song, X.3    Iacono, K.T.4    Bembas, K.5    Tao, R.6
  • 118
    • 84875153425 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis
    • Nie H, Zheng Y, Li R, Guo TB, He D, Fang L, et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis. Nat Med (2013) 19:322-8. doi:10.1038/nm.3085.
    • (2013) Nat Med , vol.19 , pp. 322-328
    • Nie, H.1    Zheng, Y.2    Li, R.3    Guo, T.B.4    He, D.5    Fang, L.6
  • 119
    • 84907588706 scopus 로고    scopus 로고
    • PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation
    • Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, et al. PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation. J Biol Chem (2014) 289:26872-81. doi:10.1074/jbc. M114.586651.
    • (2014) J Biol Chem , vol.289 , pp. 26872-26881
    • Li, Z.1    Lin, F.2    Zhuo, C.3    Deng, G.4    Chen, Z.5    Yin, S.6
  • 120
    • 84883164348 scopus 로고    scopus 로고
    • Foxp3 protein stability is regulated by cyclin-dependent kinase 2
    • Morawski PA, Mehra P, Chen C, Bhatti T, Wells AD. Foxp3 protein stability is regulated by cyclin-dependent kinase 2. J Biol Chem (2013) 288:24494-502. doi:10.1074/jbc. M113.467704.
    • (2013) J Biol Chem , vol.288 , pp. 24494-24502
    • Morawski, P.A.1    Mehra, P.2    Chen, C.3    Bhatti, T.4    Wells, A.D.5
  • 121
    • 70349466655 scopus 로고    scopus 로고
    • Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate
    • Wang LZ, Liu RH, Li WQ, Chen C, Katoh H, Chen GY, et al. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell (2009) 16:336-46. doi:10.1016/j.ccr.2009.08.016.
    • (2009) Cancer Cell , vol.16 , pp. 336-346
    • Wang, L.Z.1    Liu, R.H.2    Li, W.Q.3    Chen, C.4    Katoh, H.5    Chen, G.Y.6
  • 122
    • 34250863911 scopus 로고    scopus 로고
    • FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
    • Zuo T, Wang LZ, Morrison C, Chang X, Zhang HM, Li WQ, et al. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell (2007) 129:1275-86. doi:10.1016/j.cell.2007.04.034.
    • (2007) Cell , vol.129 , pp. 1275-1286
    • Zuo, T.1    Wang, L.Z.2    Morrison, C.3    Chang, X.4    Zhang, H.M.5    Li, W.Q.6
  • 123
    • 84885402966 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion
    • Nakahira K, Morita A, Kim NS, Yanagihara I. Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion. PLoS One (2013) 8:e77099. doi:10.1371/journal.pone.0077099.
    • (2013) PLoS One , vol.8
    • Nakahira, K.1    Morita, A.2    Kim, N.S.3    Yanagihara, I.4
  • 124
    • 0036379775 scopus 로고    scopus 로고
    • X-chromosome inactivation analysis in a female carrier of FOXP3 mutation
    • Tommasini A, Ferrari S, Moratto D, Badolato R, Boniotto M, Pirulli D, et al. X-chromosome inactivation analysis in a female carrier of FOXP3 mutation. Clin Exp Immunol (2002) 130:127-30. doi:10.1046/j.1365-2249.2002.01940.x.
    • (2002) Clin Exp Immunol , vol.130 , pp. 127-130
    • Tommasini, A.1    Ferrari, S.2    Moratto, D.3    Badolato, R.4    Boniotto, M.5    Pirulli, D.6
  • 125
    • 2142646374 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis (EAE) by CD4+CD25+ regulatory T cells
    • discussion52-4, 106-14
    • Kohm AP, Carpentier PA, Miller SD. Regulation of experimental autoimmune encephalomyelitis (EAE) by CD4+CD25+ regulatory T cells. Novartis Found Symp (2003) 252:45-52;discussion52-4, 106-14. doi:10.1002/0470871628.ch4.
    • (2003) Novartis Found Symp , vol.252 , pp. 45-52
    • Kohm, A.P.1    Carpentier, P.A.2    Miller, S.D.3
  • 126
    • 23844478869 scopus 로고    scopus 로고
    • Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system
    • McGeachy MJ, Stephens LA, Anderton SM. Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system. J Immunol (2005) 175:3025-32. doi:10.4049/jimmunol.175.5.3025.
    • (2005) J Immunol , vol.175 , pp. 3025-3032
    • McGeachy, M.J.1    Stephens, L.A.2    Anderton, S.M.3
  • 127
    • 21044453903 scopus 로고    scopus 로고
    • Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen
    • Yu P, Gregg RK, Bell JJ, Ellis JS, Divekar R, Lee HH, et al. Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen. J Immunol (2005) 174:6772-80. doi:10.4049/jimmunol.174.11.6772.
    • (2005) J Immunol , vol.174 , pp. 6772-6780
    • Yu, P.1    Gregg, R.K.2    Bell, J.J.3    Ellis, J.S.4    Divekar, R.5    Lee, H.H.6
  • 128
    • 27944499757 scopus 로고    scopus 로고
    • Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
    • Haas J, Hug A, Viehover A, Fritzsching B, Falk CS, Filser A, et al. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol (2005) 35:3343-52. doi:10.1002/eji.200526065.
    • (2005) Eur J Immunol , vol.35 , pp. 3343-3352
    • Haas, J.1    Hug, A.2    Viehover, A.3    Fritzsching, B.4    Falk, C.S.5    Filser, A.6
  • 129
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med (2004) 199:971-9. doi:10.1084/jem.20031579.
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 130
    • 33846817153 scopus 로고    scopus 로고
    • Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
    • Feger U, Luther C, Poeschel S, Melms A, Tolosa E, Wiendl H. Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. Clin Exp Immunol (2007) 147:412-8. doi:10.1111/j.1365-2249.2006.03271.x.
    • (2007) Clin Exp Immunol , vol.147 , pp. 412-418
    • Feger, U.1    Luther, C.2    Poeschel, S.3    Melms, A.4    Tolosa, E.5    Wiendl, H.6
  • 131
    • 1842607712 scopus 로고    scopus 로고
    • Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs
    • Putheti P, Pettersson A, Soderstrom M, Link H, Huang YM. Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs. J Clin Immunol (2004) 24:155-61. doi:10.1023/B:JOCI.0000019780.93817.82.
    • (2004) J Clin Immunol , vol.24 , pp. 155-161
    • Putheti, P.1    Pettersson, A.2    Soderstrom, M.3    Link, H.4    Huang, Y.M.5
  • 132
    • 84903766845 scopus 로고    scopus 로고
    • Gender differences in autoimmune disease
    • Ngo ST, Steyn FJ, McCombe PA. Gender differences in autoimmune disease. Front Neuroendocrinol (2014) 35:347-69. doi:10.1016/j.yfrne.2014.04.004.
    • (2014) Front Neuroendocrinol , vol.35 , pp. 347-369
    • Ngo, S.T.1    Steyn, F.J.2    McCombe, P.A.3
  • 133
    • 33748075167 scopus 로고    scopus 로고
    • Symptoms of multiple sclerosis in women in relation to sex steroid exposure
    • Holmqvist P, Wallberg M, Hammar M, Landtblom AM, Brynhildsen J. Symptoms of multiple sclerosis in women in relation to sex steroid exposure. Maturitas (2006) 54:149-53. doi:10.1016/j.maturitas.2005.10.003.
    • (2006) Maturitas , vol.54 , pp. 149-153
    • Holmqvist, P.1    Wallberg, M.2    Hammar, M.3    Landtblom, A.M.4    Brynhildsen, J.5
  • 134
    • 0036052570 scopus 로고    scopus 로고
    • The premenstrual period and exacerbations in multiple sclerosis
    • Zorgdrager A, De Keyser J. The premenstrual period and exacerbations in multiple sclerosis. Eur Neurol (2002) 48:204-6. doi:10.1159/000066166.
    • (2002) Eur Neurol , vol.48 , pp. 204-206
    • Zorgdrager, A.1    De Keyser, J.2
  • 136
    • 0021166361 scopus 로고
    • Activity of multiple sclerosis during pregnancy and puerperium
    • Korn-Lubetzki I, Kahana E, Cooper G, Abramsky O. Activity of multiple sclerosis during pregnancy and puerperium. Ann Neurol (1984) 16:229-31. doi:10.1002/ana.410160211.
    • (1984) Ann Neurol , vol.16 , pp. 229-231
    • Korn-Lubetzki, I.1    Kahana, E.2    Cooper, G.3    Abramsky, O.4
  • 137
    • 78650335342 scopus 로고    scopus 로고
    • Estrogen receptor-beta ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease
    • Du S, Sandoval F, Trinh P, Umeda E, Voskuhl R. Estrogen receptor-beta ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease. Eur J Immunol (2011) 41:140-50. doi:10.1002/eji.201040796.
    • (2011) Eur J Immunol , vol.41 , pp. 140-150
    • Du, S.1    Sandoval, F.2    Trinh, P.3    Umeda, E.4    Voskuhl, R.5
  • 138
    • 0141760337 scopus 로고    scopus 로고
    • The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha
    • Polanczyk M, Zamora A, Subramanian S, Matejuk A, Hess DL, Blankenhorn EP, et al. The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha. Am J Pathol (2003) 163:1599-605. doi:10.1016/S0002-9440(10)63516-X.
    • (2003) Am J Pathol , vol.163 , pp. 1599-1605
    • Polanczyk, M.1    Zamora, A.2    Subramanian, S.3    Matejuk, A.4    Hess, D.L.5    Blankenhorn, E.P.6
  • 139
    • 80051946730 scopus 로고    scopus 로고
    • Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells
    • Lee JH, Ulrich B, Cho J, Park J, Kim CH. Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol (2011) 187:1778-87. doi:10.4049/jimmunol.1003919.
    • (2011) J Immunol , vol.187 , pp. 1778-1787
    • Lee, J.H.1    Ulrich, B.2    Cho, J.3    Park, J.4    Kim, C.H.5
  • 140
    • 78049493627 scopus 로고    scopus 로고
    • Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice
    • Mao G, Wang J, Kang Y, Tai P, Wen J, Zou Q, et al. Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice. Endocrinology (2010) 151:5477-88. doi:10.1210/en.2010-0426.
    • (2010) Endocrinology , vol.151 , pp. 5477-5488
    • Mao, G.1    Wang, J.2    Kang, Y.3    Tai, P.4    Wen, J.5    Zou, Q.6
  • 141
  • 142
    • 33645824326 scopus 로고    scopus 로고
    • Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation
    • Prieto GA, Rosenstein Y. Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation. Immunology (2006) 118:58-65. doi:10.1111/j.1365-2567.2006.02339.x.
    • (2006) Immunology , vol.118 , pp. 58-65
    • Prieto, G.A.1    Rosenstein, Y.2
  • 143
    • 0035253377 scopus 로고    scopus 로고
    • Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains
    • Bebo BF Jr, Fyfe-Johnson A, Adlard K, Beam AG, Vandenbark AA, Offner H. Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains. J Immunol (2001) 166:2080-9. doi:10.4049/jimmunol.166.3.2080.
    • (2001) J Immunol , vol.166 , pp. 2080-2089
    • Bebo, B.F.1    Fyfe-Johnson, A.2    Adlard, K.3    Beam, A.G.4    Vandenbark, A.A.5    Offner, H.6
  • 144
    • 33847345997 scopus 로고    scopus 로고
    • Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)
    • Polanczyk MJ, Hopke C, Vandenbark AA, Offner H. Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1). Int Immunol (2007) 19:337-43. doi:10.1093/intimm/dxl151.
    • (2007) Int Immunol , vol.19 , pp. 337-343
    • Polanczyk, M.J.1    Hopke, C.2    Vandenbark, A.A.3    Offner, H.4
  • 145
    • 79952467245 scopus 로고    scopus 로고
    • Estrogen enhances the functions of CD4(+)CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro
    • Luo CY, Wang L, Sun C, Li DJ. Estrogen enhances the functions of CD4(+)CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro. Cell Mol Immunol (2011) 8:50-8. doi:10.1038/cmi.2010.54.
    • (2011) Cell Mol Immunol , vol.8 , pp. 50-58
    • Luo, C.Y.1    Wang, L.2    Sun, C.3    Li, D.J.4
  • 146
    • 84867216518 scopus 로고    scopus 로고
    • Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability
    • Lee JH, Lydon JP, Kim CH. Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability. Eur J Immunol (2012) 42:2683-96. doi:10.1002/eji.201142317.
    • (2012) Eur J Immunol , vol.42 , pp. 2683-2696
    • Lee, J.H.1    Lydon, J.P.2    Kim, C.H.3
  • 147
    • 84870449949 scopus 로고    scopus 로고
    • Sex-hormone receptors pattern on regulatory T-cells: clinical implications for multiple sclerosis
    • Aristimuno C, Teijeiro R, Valor L, Alonso B, Tejera-Alhambra M, de Andres C, et al. Sex-hormone receptors pattern on regulatory T-cells: clinical implications for multiple sclerosis. Clin Exp Med (2012) 12:247-55. doi:10.1007/s10238-011-0172-3.
    • (2012) Clin Exp Med , vol.12 , pp. 247-255
    • Aristimuno, C.1    Teijeiro, R.2    Valor, L.3    Alonso, B.4    Tejera-Alhambra, M.5    de Andres, C.6
  • 148
    • 33846899223 scopus 로고    scopus 로고
    • Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction
    • Arruvito L, Sanz M, Banham AH, Fainboim L. Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction. J Immunol (2007) 178:2572-8. doi:10.4049/jimmunol.178.4.2572.
    • (2007) J Immunol , vol.178 , pp. 2572-2578
    • Arruvito, L.1    Sanz, M.2    Banham, A.H.3    Fainboim, L.4
  • 149
    • 37349033910 scopus 로고    scopus 로고
    • Induction of regulatory T cells by physiological level estrogen
    • Tai P, Wang J, Jin H, Song X, Yan J, Kang Y, et al. Induction of regulatory T cells by physiological level estrogen. J Cell Physiol (2008) 214:456-64. doi:10.1002/jcp.21221.
    • (2008) J Cell Physiol , vol.214 , pp. 456-464
    • Tai, P.1    Wang, J.2    Jin, H.3    Song, X.4    Yan, J.5    Kang, Y.6
  • 150
    • 84919331292 scopus 로고    scopus 로고
    • Pregnancy level of estrogen attenuates experimental autoimmune encephalomyelitis in both ovariectomized and pregnant C57BL/6 mice through expansion of Treg and Th2 cells
    • Haghmorad D, Amini AA, Mahmoudi MB, Rastin M, Hosseini M, Mahmoudi M. Pregnancy level of estrogen attenuates experimental autoimmune encephalomyelitis in both ovariectomized and pregnant C57BL/6 mice through expansion of Treg and Th2 cells. J Neuroimmunol (2014) 277:85-95. doi:10.1016/j.jneuroim.2014.10.004.
    • (2014) J Neuroimmunol , vol.277 , pp. 85-95
    • Haghmorad, D.1    Amini, A.A.2    Mahmoudi, M.B.3    Rastin, M.4    Hosseini, M.5    Mahmoudi, M.6
  • 151
    • 84904615466 scopus 로고    scopus 로고
    • Patients with systemic lupus erythematosus and secondary antiphospholipid syndrome have decreased numbers of circulating CD4(+)CD25(+)Foxp3(+) Treg and CD3(-)CD19(+) B cells
    • Dal Ben ER, do Prado CH, Baptista TS, Bauer ME, Staub HL. Patients with systemic lupus erythematosus and secondary antiphospholipid syndrome have decreased numbers of circulating CD4(+)CD25(+)Foxp3(+) Treg and CD3(-)CD19(+) B cells. Revista Bras Reumatol (2014) 54:241-6. doi:10.1016/j.rbre.2013.09.001.
    • (2014) Revista Bras Reumatol , vol.54 , pp. 241-246
    • Dal Ben, E.R.1    do Prado, C.H.2    Baptista, T.S.3    Bauer, M.E.4    Staub, H.L.5
  • 152
    • 84908066786 scopus 로고    scopus 로고
    • Peripheral blood Th17/Treg imbalance in patients with low-active systemic lupus erythematosus
    • Szmyrka-Kaczmarek M, Kosmaczewska A, Ciszak L, Szteblich A, Wiland P. Peripheral blood Th17/Treg imbalance in patients with low-active systemic lupus erythematosus. Postepy Hig Med Dosw (2014) 68:893-8. doi:10.5604/17322693.1111127.
    • (2014) Postepy Hig Med Dosw , vol.68 , pp. 893-898
    • Szmyrka-Kaczmarek, M.1    Kosmaczewska, A.2    Ciszak, L.3    Szteblich, A.4    Wiland, P.5
  • 153
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: regulator of Treg/Th17 balance
    • Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol (2010) 40:1830-5. doi:10.1002/eji.201040391.
    • (2010) Eur J Immunol , vol.40 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 155
    • 33847395836 scopus 로고    scopus 로고
    • Correlation between levels of TNF-alpha and IL-6 and hematological involvement in SLE Egyptian patients with lupus nephritis
    • Sabry A, Elbasyouni SR, Sheashaa HA, Alhusseini AA, Mahmoud K, George SK, et al. Correlation between levels of TNF-alpha and IL-6 and hematological involvement in SLE Egyptian patients with lupus nephritis. Int Urol Nephrol (2006) 38:731-7. doi:10.1007/s11255-006-0047-9.
    • (2006) Int Urol Nephrol , vol.38 , pp. 731-737
    • Sabry, A.1    Elbasyouni, S.R.2    Sheashaa, H.A.3    Alhusseini, A.A.4    Mahmoud, K.5    George, S.K.6
  • 156
    • 19544390172 scopus 로고    scopus 로고
    • Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia
    • Ripley BJ, Goncalves B, Isenberg DA, Latchman DS, Rahman A. Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia. Ann Rheum Dis (2005) 64:849-53. doi:10.1136/ard.2004.022681.
    • (2005) Ann Rheum Dis , vol.64 , pp. 849-853
    • Ripley, B.J.1    Goncalves, B.2    Isenberg, D.A.3    Latchman, D.S.4    Rahman, A.5
  • 158
    • 77950608746 scopus 로고    scopus 로고
    • Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans
    • Isse K, Specht SM, Lunz JG III, Kang LI, Mizuguchi Y, Demetris AJ. Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans. Hepatology (2010) 51:869-80. doi:10.1002/hep.23386.
    • (2010) Hepatology , vol.51 , pp. 869-880
    • Isse, K.1    Specht, S.M.2    Lunz, J.G.3    Kang, L.I.4    Mizuguchi, Y.5    Demetris, A.J.6
  • 160
    • 84919334570 scopus 로고    scopus 로고
    • Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model
    • Mao X, Wu Y, Diao H, Hao J, Tian G, Jia Z, et al. Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model. Clin Rheumatol (2014) 33:1585-93. doi:10.1007/s10067-014-2717-9.
    • (2014) Clin Rheumatol , vol.33 , pp. 1585-1593
    • Mao, X.1    Wu, Y.2    Diao, H.3    Hao, J.4    Tian, G.5    Jia, Z.6
  • 161
    • 84879691837 scopus 로고    scopus 로고
    • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
    • International Genetics of Ankylosing Spondylitis C, Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 45:730-8. doi:10.1038/ng.2667.
    • (2013) Nat Genet , vol.45 , pp. 730-738
    • Cortes, A.1    Hadler, J.2    Pointon, J.P.3    Robinson, P.C.4    Karaderi, T.5
  • 162
    • 84927631241 scopus 로고    scopus 로고
    • Hla-B27
    • Bowness P. Hla-B27. Annu Rev Immunol (2015) 33:29-48. doi:10.1146/annurev-immunol-032414-112110.
    • (2015) Annu Rev Immunol , vol.33 , pp. 29-48
    • Bowness, P.1
  • 163
    • 77954311602 scopus 로고    scopus 로고
    • Pathogenesis of ankylosing spondylitis
    • Tam LS, Gu J, Yu D. Pathogenesis of ankylosing spondylitis. Nat Rev Rheumatol (2010) 6:399-405. doi:10.1038/nrrheum.2010.79.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 399-405
    • Tam, L.S.1    Gu, J.2    Yu, D.3
  • 164
    • 84885126123 scopus 로고    scopus 로고
    • The impact of tumor necrosis factor alpha inhibitors on radiographic progression in ankylosing spondylitis
    • Haroon N, Inman RD, Learch TJ, Weisman MH, Lee M, Rahbar MH, et al. The impact of tumor necrosis factor alpha inhibitors on radiographic progression in ankylosing spondylitis. Arthritis Rheum (2013) 65:2645-54. doi:10.1002/art.38070.
    • (2013) Arthritis Rheum , vol.65 , pp. 2645-2654
    • Haroon, N.1    Inman, R.D.2    Learch, T.J.3    Weisman, M.H.4    Lee, M.5    Rahbar, M.H.6
  • 165
    • 78650072547 scopus 로고    scopus 로고
    • Expansion of intestinal CD4+CD25(high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response
    • Ciccia F, Accardo-Palumbo A, Giardina A, Di Maggio P, Principato A, Bombardieri M, et al. Expansion of intestinal CD4+CD25(high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response. Arthritis Rheum (2010) 62:3625-34. doi:10.1002/art.27699.
    • (2010) Arthritis Rheum , vol.62 , pp. 3625-3634
    • Ciccia, F.1    Accardo-Palumbo, A.2    Giardina, A.3    Di Maggio, P.4    Principato, A.5    Bombardieri, M.6
  • 166
    • 84961918691 scopus 로고    scopus 로고
    • Regulatory T cells in ankylosing spondylitis and the response after adalimumab treatment
    • Liao HT, Lin YF, Tsai CY, Chou CT. Regulatory T cells in ankylosing spondylitis and the response after adalimumab treatment. Joint Bone Spine (2015). doi:10.1016/j.jbspin.2015.03.003.
    • (2015) Joint Bone Spine
    • Liao, H.T.1    Lin, Y.F.2    Tsai, C.Y.3    Chou, C.T.4
  • 167
    • 84948568042 scopus 로고    scopus 로고
    • Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation
    • Lin F, Luo X, Tsun A, Li Z, Li D, Li B. Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation. Int Immunopharmacol (2015). doi:10.1016/j.intimp.2015.03.044.
    • (2015) Int Immunopharmacol
    • Lin, F.1    Luo, X.2    Tsun, A.3    Li, Z.4    Li, D.5    Li, B.6
  • 168
    • 84875836920 scopus 로고    scopus 로고
    • Effect of all-transretinoic acid on Th17 and T regulatory cell subsets in patients with ankylosing spondylitis
    • Bidad K, Salehi E, Jamshidi A, Saboor-Yaraghi AA, Oraei M, Meysamie A, et al. Effect of all-transretinoic acid on Th17 and T regulatory cell subsets in patients with ankylosing spondylitis. J Rheumatol (2013) 40:476-83. doi:10.3899/jrheum.121100.
    • (2013) J Rheumatol , vol.40 , pp. 476-483
    • Bidad, K.1    Salehi, E.2    Jamshidi, A.3    Saboor-Yaraghi, A.A.4    Oraei, M.5    Meysamie, A.6


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