Estrogen enhances the functions of CD4 CD25 Foxp3 regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro

Cellular and Molecular Immunology

Volumn 8, Issue 1, 2011, Pages 50-58

  Luo, C Y ^a,b   Wang, L ^a   Sun, C ^a   Li, D J ^a,c  

^a FUDAN UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c HAINAN MEDICAL UNIVERSITY   (China)

Author keywords

bone resorption; osteoclast; PMO; regulatory T cells

Indexed keywords

ESTRADIOL; INTERLEUKIN 10; PROTEIN ANTIBODY; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; BONE METABOLISM; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELL STIMULATION; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EMBRYO; ESTROGEN ACTIVITY; HORMONAL REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MALE; MITOSIS INHIBITION; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

ADULT; ANTIGENS, CD; BONE MARROW CELLS; BONE RESORPTION; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ESTRADIOL; FEMALE; HUMANS; INTERLEUKIN-10; OSTEOCLASTS; OSTEOPOROSIS, POSTMENOPAUSAL; RECEPTOR CROSS-TALK; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79952467245     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2010.54     Document Type: Article

References (32)

1. Walsh MC, Kim N, Kadono Y, Rho J, Lee SY, Lorenzo J et al. Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol 2006;24:33-63.
2. Teitelbaum SL. Bone resorption by osteoclasts. Science 2000; 289: 1504-1508.
3. D'Amelio P, Grimaldi A, Di Bella S, Tamone C, Brianza SZ, Ravazzoli MG et al. Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis. Bone 2008; 43: 92-100.
4. Tanaka S, Takahashi N, Udagawa N, Tamura T, Akatsu T, Stanley ER et al. Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest 1993; 91: 257-263. (Pubitemid 23037280)
5. Theill LE, Boyle WJ, Penninger JM. RANKL and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 2002; 20: 795-823. (Pubitemid 34293440)
6. Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. JClin Invest 2000; 106: 1481-1488. (Pubitemid 32038586)
7. Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immuneand bonesystems. Nat Rev Immunol 2007; 7: 292-304. (Pubitemid 46480961)
8. Lubberts E, Koenders MI, van den Berg WB. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 2005; 7: 29-37. (Pubitemid 40214525)
9. Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S et al. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independentof theODF/RANKL-RANKinteraction. J Exp Med 2000; 191: 275-286.
10. Lee SK, Lorenzo J. Cytokines regulatingosteoclast formation and function. Curr Opin Rheumatol 2006; 18:411-418.
11. + regulatory T cells on the osteoclast differentiation and bone resorption. Chin J Endocrinol Metab 2009; 25: 434-437.
12. Arron JR, Choi Y. Osteoimmunology: boneversus immunesystem. Nature 2000; 408: 535-536.
13. Mundy GR. Osteoporosis and inflammation. Nutr Rev 2007; 65: S147-S151.
14. + regulatoryT cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells. Biochem Biophys Res Commun 2007; 357: 1046-1052. (Pubitemid 46693677)
15. Zaiss MM, Axmann R, Zwerina J, Polzer K, Guckel E, Skapenko A et al. Treg cells suppress osteoclast formation: a new link between the immune system and bone. Arhritis Rheum 2007; 56: 4104-4112. (Pubitemid 350262338)
16. Lee SH, Kim T, Jeong D, Kim N, Choi Y. The tec familytyrosine kinase Btk regulates RANKL-induced osteoclast maturation. J Biol Chem 2008; 283: 11526-11534.
17. Kruisbeek AM, Shevach E, Thornton AM. Proliferativeassaysfor Tcell function. Curr Protoc Immunol 2004: Chapter3: 3.12.11-3.12.15.
18. Roodman GD. Regulationof osteoclastdifferentiation. Ann NYAcad Sci 2006; 1068: 100-109.
19. + regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004; 50:2775-2785. (Pubitemid 39209514)
20. + regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 2004; 6: R335-R346.
21. Nakajima T, Ueki-Maruyama K, Oda T, Ohsawa Y, Ito H, Seymour GJ et al. Regulatory T-cells infiltrate periodontal diseasetissues. J Dent Res 2005; 84: 639-643. (Pubitemid 43827846)
22. Ernst CW, Lee JE, Nakanishi T, Karimbux NY, Rezende TM, Stashenko P et al. Diminished forkhead box P3/CD25 double-positive T regulatorycells are associated withthe increased nuclearfactor-kappaB ligand (RANKL̄) Tcells in boneresorption lesion of periodontal disease. Clin Exp Immunol 2007; 148: 271-280. (Pubitemid 46587581)
23. + regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Ann Rheum Dis 2009; 68: 744-750.
24. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061. (Pubitemid 36222930)
25. + regulatory T cells. Nat Immunol 2003; 4: 330-336. (Pubitemid 36432314)
26. Askenasy N, Kaminitz A, Yarkoni S. Mechanisms of T regulatory cell function. Autoimmun Rev 2008; 7: 370-375.
27. Riggs BL. The mechanism of estrogen regulation of bone resorption. J Clin Invest 2006;106: 1203-1204.
28. Tai P, Wang J, Jin H, Song X, Yan J, Kang Y et al. Induction of regulatory T cells by physiological level estrogen. J Cell Physiol 2008; 214: 456-464. (Pubitemid 350309002)
29. Mohamed SG, Sugiyama E, Shinoda K, Taki H, Hounoki H, Abdel-Aziz HO et al. Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells. Bone 2007;41:592-602. (Pubitemid 47385426)
30. Evans KE, Fox SW. Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus. BMC Cell Biol 2007; 8: 1-9.
31. Park-Min KH, Ji JD, Antoniv T, Reid AC, Silver RB, Humphrey MB et al. IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression. J Immunol 2009; 183: 2444-2455.
32. Fox SW, Evans KE, Lovibond AC Transforming growth factor-ß enables NFATc1 expression during osteoclastogenesis. Biochem Biophys Res Commun 2008; 366: 123-128. (Pubitemid 50008464)