Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs

Journal of Clinical Immunology

Volumn 24, Issue 2, 2004, Pages 155-161

  Putheti, Prabhakar ^a   Pettersson, Asa ^a   Soderstrom, Mats ^b   Link, Hans ^a,b   Huang, Yu Min ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CD4+CD25+ T regulatory cells; Glatiramer acetate; Interferon ; Multiple sclerosis

Indexed keywords

BETA1A INTERFERON; CD4 ANTIGEN; CD45 ANTIGEN; CD69 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; GLATIRAMER; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR;

ADULT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE DURATION; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 1842607712     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOCI.0000019780.93817.82     Document Type: Article

References (21)

1. McRae BL, Semnani RT, Hayes MP, van Seventer GA: Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development. J Immunol 160:4298-304, 1998
2. Huang YM, Hussien Y, Yarilin D, Xiao BG, Liu YJ, Link H: Interferon-beta induces the development of type 2 dendritic cells. Cytokine 13:264-271, 2001
3. Vieira PL, de Jong EC, Wierenga EA, Kapsenberg ML, Kalinski P: Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol 164:4507-4512, 2000
4. Hussien Y, Sanna A, Soderstrom M, Link H, Huang YM: Glatiramer acetate and IFN-beta act on dendritic cells in multiple sclerosis. J Neuroimmunol 121:102-110, 2001
5. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 162:5317-5326, 1999
6. + subpopulations. J Immunol 165:3105-3110, 2000
7. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155:1151-1164, 1995
8. + T cells with regulatory properties isolated from peripheral blood. J. Exp. Med 193:1285-1294, 2001
9. + cells: A naturally occurring population of regulatory T cells. Blood 98:2736-2744, 2001
10. Levings MK, Sangregorio R, Roncarolo MG: Human CD25(+) CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 193:1295-1302, 2001
11. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F: An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 190:995-1004, 1999
12. Annunziato F, Cosmi L, Liotta F, Lazzeri E, Manetti R, Vanini V, Romagnani P, Maggi E, Romagnani S: Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med 196:379-387, 2002
13. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G: Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 193:1303-1310, 2001
14. + suppressor T cells: More questions than answers. Nat Rev Immunol 2:389-400, 2002
15. high regulatory cells in human peripheral blood. J Immunol 167:1245-1253, 2001
16. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188:287-296, 1998
17. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW: New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann Neurol 13:227-231, 1983
18. Kurtzke JF: Rating neurologic impairment in multiple sclerosis: An expanded disability scale. Neurology 33:1444-1452, 1983
19. + immunoregulatory T cells may not be involved in controlling autoimmune arthritis. Arthritis Res Ther 5:106-113, 2003
20. + T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 33:215-223, 2003
21. + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 169:4712-4716, 2002