Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability

European Journal of Immunology

Volumn 42, Issue 10, 2012, Pages 2683-2696

  Lee, Jee H ^a   Lydon, John P ^b   Kim, Chang H ^a  

^a PURDUE UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

FoxP3; Inflammation; MTOR; Progesterone; Treg cells

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROGESTERONE; PROGESTERONE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; FEMALE; HORMONE ACTION; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IN VITRO STUDY; INDUCED REGULATORY T CELL; INFLAMMATION; INTRACELLULAR SIGNALING; MALE; MOLECULAR STABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOSUPPRESSION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PROGESTERONE; RECEPTORS, PROGESTERONE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TOR SERINE-THREONINE KINASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84867216518     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142317     Document Type: Article

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