Expansion of intestinal CD4+CD25high Treg cells in patients with ankylosing spondylitis: A putative role for interleukin-10 in preventing intestinal Th17 response

Arthritis and Rheumatism

Volumn 62, Issue 12, 2010, Pages 3625-3634

  Ciccia, Francesco ^a   Accardo Palumbo, Antonina ^b   Giardina, Annarita ^a   Di Maggio, Piera ^c   Principato, Alfonso ^a   Bombardieri, Michele ^d   Rizzo, Aroldo ^e   Alessandro, Riccardo ^a   Ferrante, Angelo ^a   Principe, Simona ^a   Peralta, Sergio ^a   Conte, Francesco ^b   Drago, Sandro ^c   Craxí, Antonio ^a   De Leo, Giacomo ^a   Triolo, Giovanni ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b ARNAS Ospedale Civico   (Italy)

^c BioNat Italy   (Italy)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e Ospedali Riuniti Villa Sofia Cervello   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GROWTH FACTOR; INTERLEUKIN 10; INTERLEUKIN 2; STAT5 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ANKYLOSING SPONDYLITIS; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; INTESTINE BIOPSY; LAMINA PROPRIA; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH17 CELL; UPREGULATION;

ADULT; BIOPSY; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; ILEUM; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-23; INTESTINAL MUCOSA; MALE; MIDDLE AGED; RNA, MESSENGER; SPONDYLITIS, ANKYLOSING; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 78650072547     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27699     Document Type: Article

References (25)

1. De Vos M, Mielants H, Cuvelier C, Elewaut A, Veys E,. Long-term evolution of gut inflammation in patients with spondyloarthropathy. Gastroenterology 1996; 110: 1696-703.
2. Mielants H, Veys EM, Cuvelier C, de Vos M,. Ileocolonoscopic findings in seronegative spondylarthropathies. Br J Rheumatol 1988; 27 Suppl 2: 95-105.
3. Rudwaleit M, Baeten D,. Ankylosing spondylitis and bowel disease. Best Pract Res Clin Rheumatol 2006; 20: 451-71.
4. Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, et al. Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis. Arthritis Rheum 2009; 60: 955-65.
5. H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat Immunol 2008; 9: 641-9.
6. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875-86.
7. Van der Linden S, Valkenburg HA, Cats A,. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum 1984; 27: 361-8.
8. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A,. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994; 21: 2286-91.
9. Best WR, Becktel JM, Singleton JW, Kern F Jr., Development of a Crohn's disease activity index: National Cooperative Crohn's Disease Study. Gastroenterology 1976; 70: 439-44.
10. Van Damme N, de Vos M, Baeten D, Demetter P, Mielants H, Verbruggen G, et al. Flow cytometric analysis of gut mucosal lymphocytes supports an impaired Th1 cytokine profile in spondyloarthropathy. Ann Rheum Dis 2001; 60: 495-9.
11. + T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 2003; 33: 215-23.
12. De Vos M, Cuvelier C, Mielants H, Veys E, Barbier F, Elewaut A,. Ileocolonoscopy in seronegative spondylarthropathy. Gastroenterology 1989; 96: 339-44.
13. Izcue A, Coombes JL, Powrie F,. Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 2009; 27: 313-38.
14. high T cells in inflammatory bowel disease. Gastroenterology 2005; 128: 1868-78.
15. H17 cell differentiation by antagonizing RORγt function. Nature 2008; 453: 236-40.
16. Santarlasci V, Maggi L, Capone M, Frosali F, Querci V, De Palma R, et al. TGF-β indirectly favors the development of human Th17 cells by inhibiting Th1 cells. Eur J Immunol 2009; 39: 207-15.
17. + regulatory T cells. J Immunol 2007; 178: 280-90.
18. + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 2005; 201: 723-35.
19. Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007; 26: 371-81.
20. + regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J Exp Med 2007; 204: 1757-64.
21. Berg DJ, Kuhn R, Rajewsky K, Muller W, Menon S, Davidson N, et al. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest 1995; 96: 2339-47.
22. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W,. Interleukin-10- deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-74.
23. Spencer SD, Di Marco F, Hooley J, Pitts-Meek S, Bauer M, Ryan AM, et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med 1998; 187: 571-8.
24. Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schaffer AA, Noyan F, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009; 361: 2033-45.
25. + T cells during cure of colitis. J Immunol 2006; 177: 5852-60.