메뉴 건너뛰기




Volumn 74, Issue , 2016, Pages 1-18

Nanomedicine-mediated cancer stem cell therapy

Author keywords

ATP binding cassette transporter; Cancer stem cells; CSC specific agents; Drug delivery; Drug resistant; Nanomedicine

Indexed keywords

BINS; CELLS; CYTOLOGY; DISEASES; DRUG DELIVERY; DRUG THERAPY; NUCLEIC ACIDS; STEM CELLS; TUMORS;

EID: 84945161573     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.09.037     Document Type: Review
Times cited : (119)

References (218)
  • 1
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell P.C. The clonal evolution of tumor cell populations. Science 1976, 194:23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 2
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • Quintana E., Shackleton M., Foster H.R., Fullen D.R., Sabel M.S., Johnson T.M., et al. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 2010, 18:510-513.
    • (2010) Cancer Cell , vol.18 , pp. 510-513
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3    Fullen, D.R.4    Sabel, M.S.5    Johnson, T.M.6
  • 3
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • Meacham C.E., Morrison S.J. Tumour heterogeneity and cancer cell plasticity. Nature 2013, 501:328-337.
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 4
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3:730-737.
    • (1997) Nat. Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 7
    • 73149110562 scopus 로고    scopus 로고
    • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    • Pece S., Tosoni D., Confalonieri S., Mazzarol G., Vecchi M., Ronzoni S., et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 2010, 140:62-73.
    • (2010) Cell , vol.140 , pp. 62-73
    • Pece, S.1    Tosoni, D.2    Confalonieri, S.3    Mazzarol, G.4    Vecchi, M.5    Ronzoni, S.6
  • 10
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien C.A., Pollett A., Gallinger S., Dick J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 12
    • 33845874094 scopus 로고    scopus 로고
    • Cancer stem cells and radiotherapy: new insights into tumor radioresistance
    • Diehn M., Clarke M.F. Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J. Natl. Cancer Inst. 2006, 98:1755-1757.
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 1755-1757
    • Diehn, M.1    Clarke, M.F.2
  • 13
    • 38549139140 scopus 로고    scopus 로고
    • Significance of CD90+ cancer stem cells in human liver cancer
    • Yang Z.F., Ho D.W., Ng M.N., Lau C.K., Yu W.C., Ngai P., et al. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 2008, 13:153-166.
    • (2008) Cancer Cell , vol.13 , pp. 153-166
    • Yang, Z.F.1    Ho, D.W.2    Ng, M.N.3    Lau, C.K.4    Yu, W.C.5    Ngai, P.6
  • 15
    • 77649208749 scopus 로고    scopus 로고
    • Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? an analysis
    • Maenhaut C., Dumont J.E., Roger P.P., van Staveren W.C. Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? an analysis. Carcinogenesis 2010, 31:149-158.
    • (2010) Carcinogenesis , vol.31 , pp. 149-158
    • Maenhaut, C.1    Dumont, J.E.2    Roger, P.P.3    van Staveren, W.C.4
  • 17
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J., Li Y., Yu T.S., McKay R.M., Burns D.K., Kernie S.G., et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 2012, 488:522-526.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6
  • 20
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu F., Yao H., Zhu P., Zhang X., Pan Q., Gong C., et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007, 131:1109-1123.
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1    Yao, H.2    Zhu, P.3    Zhang, X.4    Pan, Q.5    Gong, C.6
  • 21
    • 49149107236 scopus 로고    scopus 로고
    • Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy
    • Dylla S.J., Beviglia L., Park I.K., Chartier C., Raval J., Ngan L., et al. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PloS One 2008, 3:e2428.
    • (2008) PloS One , vol.3 , pp. e2428
    • Dylla, S.J.1    Beviglia, L.2    Park, I.K.3    Chartier, C.4    Raval, J.5    Ngan, L.6
  • 22
    • 84872005140 scopus 로고    scopus 로고
    • Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling
    • Liu Y.P., Yang C.J., Huang M.S., Yeh C.T., Wu A.T., Lee Y.C., et al. Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling. Cancer Res. 2013, 73:406-416.
    • (2013) Cancer Res. , vol.73 , pp. 406-416
    • Liu, Y.P.1    Yang, C.J.2    Huang, M.S.3    Yeh, C.T.4    Wu, A.T.5    Lee, Y.C.6
  • 23
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M., Cho R.W., Lobo N.A., Kalisky T., Dorie M.J., Kulp A.N., et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009, 458:780-783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3    Kalisky, T.4    Dorie, M.J.5    Kulp, A.N.6
  • 24
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M., Fojo T., Bates S. Tumour stem cells and drug resistance. Nat. Rev. Cancer 2005, 5:275-284.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 25
    • 84859450097 scopus 로고    scopus 로고
    • Cancer stem cells and drug resistance: the potential of nanomedicine
    • Vinogradov S., Wei X. Cancer stem cells and drug resistance: the potential of nanomedicine. Nanomedicine (Lond) 2012, 7:597-615.
    • (2012) Nanomedicine (Lond) , vol.7 , pp. 597-615
    • Vinogradov, S.1    Wei, X.2
  • 26
    • 40749150740 scopus 로고    scopus 로고
    • CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • Ma S., Lee T.K., Zheng B.J., Chan K.W., Guan X.Y. CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008, 27:1749-1758.
    • (2008) Oncogene , vol.27 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.J.3    Chan, K.W.4    Guan, X.Y.5
  • 27
    • 84860873820 scopus 로고    scopus 로고
    • The role of cancer stem cells in relapse of solid tumors
    • Yu Y., Ramena G., Elble R.C. The role of cancer stem cells in relapse of solid tumors. Front. Biosci. (Elite Ed.) 2012, 4:1528-1541.
    • (2012) Front. Biosci. (Elite Ed.) , vol.4 , pp. 1528-1541
    • Yu, Y.1    Ramena, G.2    Elble, R.C.3
  • 29
    • 84924045052 scopus 로고    scopus 로고
    • Cancer stem cells: targeting the root of cancer relapse
    • Flemming A. Cancer stem cells: targeting the root of cancer relapse. Nat. Rev. Drug Discov. 2015, 14:165.
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 165
    • Flemming, A.1
  • 30
    • 84884558125 scopus 로고    scopus 로고
    • Unravelling cancer stem cell potential
    • Beck B., Blanpain C. Unravelling cancer stem cell potential. Nat. Rev. Cancer 2013, 13:727-738.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 727-738
    • Beck, B.1    Blanpain, C.2
  • 31
    • 84881453720 scopus 로고    scopus 로고
    • Understanding and targeting cancer stem cells: therapeutic implications and challenges
    • Chen K., Huang Y.H., Chen J.L. Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol. Sin. 2013, 34:732-740.
    • (2013) Acta Pharmacol. Sin. , vol.34 , pp. 732-740
    • Chen, K.1    Huang, Y.H.2    Chen, J.L.3
  • 32
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6
  • 33
    • 84896119766 scopus 로고    scopus 로고
    • Targeting cancer stem cells by curcumin and clinical applications
    • Li Y., Zhang T. Targeting cancer stem cells by curcumin and clinical applications. Cancer Lett. 2014, 346:197-205.
    • (2014) Cancer Lett. , vol.346 , pp. 197-205
    • Li, Y.1    Zhang, T.2
  • 34
    • 84861995326 scopus 로고    scopus 로고
    • Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells
    • Sachlos E., Risueno R.M., Laronde S., Shapovalova Z., Lee J.H., Russell J., et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell 2012, 149:1284-1297.
    • (2012) Cell , vol.149 , pp. 1284-1297
    • Sachlos, E.1    Risueno, R.M.2    Laronde, S.3    Shapovalova, Z.4    Lee, J.H.5    Russell, J.6
  • 35
    • 77951730125 scopus 로고    scopus 로고
    • Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    • Li Y., Zhang T., Korkaya H., Liu S., Lee H.F., Newman B., et al. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin. Cancer Res. 2010, 16:2580-2590.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2580-2590
    • Li, Y.1    Zhang, T.2    Korkaya, H.3    Liu, S.4    Lee, H.F.5    Newman, B.6
  • 36
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • Liu C., Kelnar K., Liu B., Chen X., Calhoun-Davis T., Li H., et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat. Med. 2011, 17:211-215.
    • (2011) Nat. Med. , vol.17 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3    Chen, X.4    Calhoun-Davis, T.5    Li, H.6
  • 37
    • 78649681554 scopus 로고    scopus 로고
    • MiR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    • Ma S., Tang K.H., Chan Y.P., Lee T.K., Kwan P.S., Castilho A., et al. miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010, 7:694-707.
    • (2010) Cell Stem Cell , vol.7 , pp. 694-707
    • Ma, S.1    Tang, K.H.2    Chan, Y.P.3    Lee, T.K.4    Kwan, P.S.5    Castilho, A.6
  • 38
    • 78649633829 scopus 로고    scopus 로고
    • Small-molecule delivery by nanoparticles for anticancer therapy
    • Chen Z.G. Small-molecule delivery by nanoparticles for anticancer therapy. Trends Mol. Med. 2010, 16:594-602.
    • (2010) Trends Mol. Med. , vol.16 , pp. 594-602
    • Chen, Z.G.1
  • 39
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: an emerging treatment modality for cancer
    • Davis M.E., Chen Z.G., Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 2008, 7:771-782.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.G.2    Shin, D.M.3
  • 42
    • 84861669644 scopus 로고    scopus 로고
    • Doxil(R)-the first FDA-approved nano-drug: lessons learned
    • Barenholz Y. Doxil(R)-the first FDA-approved nano-drug: lessons learned. J. Control. Releas. 2012, 160:117-134.
    • (2012) J. Control. Releas. , vol.160 , pp. 117-134
    • Barenholz, Y.1
  • 43
    • 0035879099 scopus 로고    scopus 로고
    • Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan
    • Gordon A.N., Fleagle J.T., Guthrie D., Parkin D.E., Gore M.E., Lacave A.J. Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan. J. Clin. Oncol. 2001, 19:3312-3322.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3312-3322
    • Gordon, A.N.1    Fleagle, J.T.2    Guthrie, D.3    Parkin, D.E.4    Gore, M.E.5    Lacave, A.J.6
  • 44
    • 4644225190 scopus 로고    scopus 로고
    • Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a phase 3 randomized study of recurrent and refractory epithelial ovarian cancer
    • Gordon A.N., Tonda M., Sun S., Rackoff W. Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a phase 3 randomized study of recurrent and refractory epithelial ovarian cancer. Gynecol. Oncol. 2004, 95:1-8.
    • (2004) Gynecol. Oncol. , vol.95 , pp. 1-8
    • Gordon, A.N.1    Tonda, M.2    Sun, S.3    Rackoff, W.4
  • 46
    • 79952341098 scopus 로고    scopus 로고
    • A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors
    • Lim K.J., Bisht S., Bar E.E., Maitra A., Eberhart C.G. A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol. Ther. 2011, 11:464-473.
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 464-473
    • Lim, K.J.1    Bisht, S.2    Bar, E.E.3    Maitra, A.4    Eberhart, C.G.5
  • 47
    • 84922212608 scopus 로고    scopus 로고
    • Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells
    • Sun R., Liu Y., Li S.Y., Shen S., Du X.J., Xu C.F., et al. Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells. Biomaterials 2015, 37:405-414.
    • (2015) Biomaterials , vol.37 , pp. 405-414
    • Sun, R.1    Liu, Y.2    Li, S.Y.3    Shen, S.4    Du, X.J.5    Xu, C.F.6
  • 48
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 50
    • 84924249260 scopus 로고    scopus 로고
    • The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?
    • Plaks V., Kong N., Werb Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?. Cell Stem Cell 2015, 16:225-238.
    • (2015) Cell Stem Cell , vol.16 , pp. 225-238
    • Plaks, V.1    Kong, N.2    Werb, Z.3
  • 51
    • 84876489727 scopus 로고    scopus 로고
    • Cancer stem cells: the challenges ahead
    • Medema J.P. Cancer stem cells: the challenges ahead. Nat. Cell Biol. 2013, 15:338-344.
    • (2013) Nat. Cell Biol. , vol.15 , pp. 338-344
    • Medema, J.P.1
  • 52
    • 70349224237 scopus 로고    scopus 로고
    • Hoechst 33342 side population identification is a conserved and unified mechanism in urological cancers
    • Oates J.E., Grey B.R., Addla S.K., Samuel J.D., Hart C.A., Ramani V.A., et al. Hoechst 33342 side population identification is a conserved and unified mechanism in urological cancers. Stem Cells Dev. 2009, 18:1515-1522.
    • (2009) Stem Cells Dev. , vol.18 , pp. 1515-1522
    • Oates, J.E.1    Grey, B.R.2    Addla, S.K.3    Samuel, J.D.4    Hart, C.A.5    Ramani, V.A.6
  • 53
    • 85047690508 scopus 로고    scopus 로고
    • Opinion: the origin of the cancer stem cell: current controversies and new insights
    • Bjerkvig R., Tysnes B.B., Aboody K.S., Najbauer J., Terzis A.J. Opinion: the origin of the cancer stem cell: current controversies and new insights. Nat. Rev. Cancer 2005, 5:899-904.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 899-904
    • Bjerkvig, R.1    Tysnes, B.B.2    Aboody, K.S.3    Najbauer, J.4    Terzis, A.J.5
  • 54
    • 84864328500 scopus 로고    scopus 로고
    • The origin of cancer stem cells
    • Bu Y., Cao D. The origin of cancer stem cells. Front. Biosci. Sch. Ed. 2012, 4:819-830.
    • (2012) Front. Biosci. Sch. Ed. , vol.4 , pp. 819-830
    • Bu, Y.1    Cao, D.2
  • 55
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 56
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S., Wu Q., McLendon R.E., Hao Y., Shi Q., Hjelmeland A.B., et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006, 444:756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6
  • 58
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman M.M., Fojo T., Bates S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2002, 2:48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 60
    • 0029958876 scopus 로고    scopus 로고
    • Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
    • Goodell M.A., Brose K., Paradis G., Conner A.S., Mulligan R.C. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 1996, 183:1797-1806.
    • (1996) J. Exp. Med. , vol.183 , pp. 1797-1806
    • Goodell, M.A.1    Brose, K.2    Paradis, G.3    Conner, A.S.4    Mulligan, R.C.5
  • 61
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • Ho M.M., Ng A.V., Lam S., Hung J.Y. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res. 2007, 67:4827-4833.
    • (2007) Cancer Res. , vol.67 , pp. 4827-4833
    • Ho, M.M.1    Ng, A.V.2    Lam, S.3    Hung, J.Y.4
  • 63
    • 0033966957 scopus 로고    scopus 로고
    • Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein
    • Rabindran S.K., Ross D.D., Doyle L.A., Yang W., Greenberger L.M. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 2000, 60:47-50.
    • (2000) Cancer Res. , vol.60 , pp. 47-50
    • Rabindran, S.K.1    Ross, D.D.2    Doyle, L.A.3    Yang, W.4    Greenberger, L.M.5
  • 64
    • 0242300545 scopus 로고    scopus 로고
    • Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A
    • Woehlecke H., Osada H., Herrmann A., Lage H. Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A. Int. J. Cancer 2003, 107:721-728.
    • (2003) Int. J. Cancer , vol.107 , pp. 721-728
    • Woehlecke, H.1    Osada, H.2    Herrmann, A.3    Lage, H.4
  • 65
    • 33745746815 scopus 로고    scopus 로고
    • Pharmacological strategies for overcoming multidrug resistance
    • Nobili S., Landini I., Giglioni B., Mini E. Pharmacological strategies for overcoming multidrug resistance. Curr. Drug Targets 2006, 7:861-879.
    • (2006) Curr. Drug Targets , vol.7 , pp. 861-879
    • Nobili, S.1    Landini, I.2    Giglioni, B.3    Mini, E.4
  • 66
    • 77955761867 scopus 로고    scopus 로고
    • Overexpression of CD133 promotes drug resistance in C6 glioma cells
    • Angelastro J.M., Lame M.W. Overexpression of CD133 promotes drug resistance in C6 glioma cells. Mol. Cancer Res. 2010, 8:1105-1115.
    • (2010) Mol. Cancer Res. , vol.8 , pp. 1105-1115
    • Angelastro, J.M.1    Lame, M.W.2
  • 67
    • 0344012471 scopus 로고    scopus 로고
    • Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter
    • Frank N.Y., Pendse S.S., Lapchak P.H., Margaryan A., Shlain D., Doeing C., et al. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J. Biol. Chem. 2003, 278:47156-47165.
    • (2003) J. Biol. Chem. , vol.278 , pp. 47156-47165
    • Frank, N.Y.1    Pendse, S.S.2    Lapchak, P.H.3    Margaryan, A.4    Shlain, D.5    Doeing, C.6
  • 68
    • 20144364789 scopus 로고    scopus 로고
    • ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma
    • Frank N.Y., Margaryan A., Huang Y., Schatton T., Waaga-Gasser A.M., Gasser M., et al. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 2005, 65:4320-4333.
    • (2005) Cancer Res. , vol.65 , pp. 4320-4333
    • Frank, N.Y.1    Margaryan, A.2    Huang, Y.3    Schatton, T.4    Waaga-Gasser, A.M.5    Gasser, M.6
  • 69
    • 0037358040 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein
    • Thomas H., Coley H.M. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control. 2003, 10:159-165.
    • (2003) Cancer Control. , vol.10 , pp. 159-165
    • Thomas, H.1    Coley, H.M.2
  • 70
    • 77953715690 scopus 로고    scopus 로고
    • Targeting Wnt signaling: can we safely eradicate cancer stem cells?
    • Takahashi-Yanaga F., Kahn M. Targeting Wnt signaling: can we safely eradicate cancer stem cells?. Clin. Cancer Res. 2010, 16:3153-3162.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 71
    • 77953693899 scopus 로고    scopus 로고
    • Targeting Hedgehog-a cancer stem cell pathway
    • Merchant A.A., Matsui W. Targeting Hedgehog-a cancer stem cell pathway. Clin. Cancer Res. 2010, 16:3130-3140.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3130-3140
    • Merchant, A.A.1    Matsui, W.2
  • 73
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Takebe N., Harris P.J., Warren R.Q., Ivy S.P. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat. Rev. Clin. Oncol. 2011, 8:97-106.
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 74
    • 47149090942 scopus 로고    scopus 로고
    • Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects
    • Campbell C., Risueno R.M., Salati S., Guezguez B., Bhatia M. Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects. Curr. Opin. Hematol. 2008, 15:319-325.
    • (2008) Curr. Opin. Hematol. , vol.15 , pp. 319-325
    • Campbell, C.1    Risueno, R.M.2    Salati, S.3    Guezguez, B.4    Bhatia, M.5
  • 75
    • 79960668961 scopus 로고    scopus 로고
    • Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer
    • McGowan P.M., Simedrea C., Ribot E.J., Foster P.J., Palmieri D., Steeg P.S., et al. Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer. Mol. Cancer Res. 2011, 9:834-844.
    • (2011) Mol. Cancer Res. , vol.9 , pp. 834-844
    • McGowan, P.M.1    Simedrea, C.2    Ribot, E.J.3    Foster, P.J.4    Palmieri, D.5    Steeg, P.S.6
  • 76
    • 18344377028 scopus 로고    scopus 로고
    • Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
    • He B., Reguart N., You L., Mazieres J., Xu Z., Lee A.Y., et al. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene 2005, 24:3054-3058.
    • (2005) Oncogene , vol.24 , pp. 3054-3058
    • He, B.1    Reguart, N.2    You, L.3    Mazieres, J.4    Xu, Z.5    Lee, A.Y.6
  • 77
    • 52649169761 scopus 로고    scopus 로고
    • Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer
    • Feldmann G., Habbe N., Dhara S., Bisht S., Alvarez H., Fendrich V., et al. Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut 2008, 57:1420-1430.
    • (2008) Gut , vol.57 , pp. 1420-1430
    • Feldmann, G.1    Habbe, N.2    Dhara, S.3    Bisht, S.4    Alvarez, H.5    Fendrich, V.6
  • 78
    • 6044243650 scopus 로고    scopus 로고
    • Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    • Karhadkar S.S., Bova G.S., Abdallah N., Dhara S., Gardner D., Maitra A., et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004, 431:707-712.
    • (2004) Nature , vol.431 , pp. 707-712
    • Karhadkar, S.S.1    Bova, G.S.2    Abdallah, N.3    Dhara, S.4    Gardner, D.5    Maitra, A.6
  • 79
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown J.M., Attardi L.D. The role of apoptosis in cancer development and treatment response. Nat. Rev. Cancer 2005, 5:231-237.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 231-237
    • Brown, J.M.1    Attardi, L.D.2
  • 80
    • 0034677173 scopus 로고    scopus 로고
    • The role of apoptosis in the regulation of hematopoietic stem cells: overexpression of Bcl-2 increases both their number and repopulation potential
    • Domen J., Cheshier S.H., Weissman I.L. The role of apoptosis in the regulation of hematopoietic stem cells: overexpression of Bcl-2 increases both their number and repopulation potential. J. Exp. Med. 2000, 191:253-264.
    • (2000) J. Exp. Med. , vol.191 , pp. 253-264
    • Domen, J.1    Cheshier, S.H.2    Weissman, I.L.3
  • 81
    • 84875131206 scopus 로고    scopus 로고
    • A pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition
    • Goff D.J., Court Recart A., Sadarangani A., Chun H.J., Barrett C.L., Krajewska M., et al. A pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell 2013, 12:316-328.
    • (2013) Cell Stem Cell , vol.12 , pp. 316-328
    • Goff, D.J.1    Court Recart, A.2    Sadarangani, A.3    Chun, H.J.4    Barrett, C.L.5    Krajewska, M.6
  • 82
    • 80052594392 scopus 로고    scopus 로고
    • BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment
    • Lang J.Y., Hsu J.L., Meric-Bernstam F., Chang C.J., Wang Q., Bao Y., et al. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell 2011, 20:341-356.
    • (2011) Cancer Cell , vol.20 , pp. 341-356
    • Lang, J.Y.1    Hsu, J.L.2    Meric-Bernstam, F.3    Chang, C.J.4    Wang, Q.5    Bao, Y.6
  • 83
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    • Baud V., Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug Discov. 2009, 8:33-40.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 84
    • 84883682803 scopus 로고    scopus 로고
    • Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappaB signaling in glioblastoma cancer stem cells regulates the Notch pathway
    • Garner J.M., Fan M., Yang C.H., Du Z., Sims M., Davidoff A.M., et al. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappaB signaling in glioblastoma cancer stem cells regulates the Notch pathway. J. Biol. Chem. 2013, 288:26167-26176.
    • (2013) J. Biol. Chem. , vol.288 , pp. 26167-26176
    • Garner, J.M.1    Fan, M.2    Yang, C.H.3    Du, Z.4    Sims, M.5    Davidoff, A.M.6
  • 85
    • 84920374751 scopus 로고    scopus 로고
    • Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFkappaB signaling
    • Chung S.S., Vadgama J.V. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFkappaB signaling. Anticancer Res. 2015, 35:39-46.
    • (2015) Anticancer Res. , vol.35 , pp. 39-46
    • Chung, S.S.1    Vadgama, J.V.2
  • 86
    • 34848866647 scopus 로고    scopus 로고
    • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    • Todaro M., Alea M.P., Di Stefano A.B., Cammareri P., Vermeulen L., Iovino F., et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 2007, 1:389-402.
    • (2007) Cell Stem Cell , vol.1 , pp. 389-402
    • Todaro, M.1    Alea, M.P.2    Di Stefano, A.B.3    Cammareri, P.4    Vermeulen, L.5    Iovino, F.6
  • 87
    • 76649113726 scopus 로고    scopus 로고
    • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    • Ginestier C., Liu S., Diebel M.E., Korkaya H., Luo M., Brown M., et al. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J. Clin. Invest. 2010, 120:485-497.
    • (2010) J. Clin. Invest. , vol.120 , pp. 485-497
    • Ginestier, C.1    Liu, S.2    Diebel, M.E.3    Korkaya, H.4    Luo, M.5    Brown, M.6
  • 88
    • 84896113460 scopus 로고    scopus 로고
    • Metastatic stem cells: sources, niches, and vital pathways
    • Oskarsson T., Batlle E., Massague J. Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell 2014, 14:306-321.
    • (2014) Cell Stem Cell , vol.14 , pp. 306-321
    • Oskarsson, T.1    Batlle, E.2    Massague, J.3
  • 89
    • 84902968221 scopus 로고    scopus 로고
    • The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment
    • Ye J., Wu D., Wu P., Chen Z., Huang J. The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment. Tumor Biol. 2014, 35:3945-3951.
    • (2014) Tumor Biol. , vol.35 , pp. 3945-3951
    • Ye, J.1    Wu, D.2    Wu, P.3    Chen, Z.4    Huang, J.5
  • 90
    • 80055003796 scopus 로고    scopus 로고
    • A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours
    • Beck B., Driessens G., Goossens S., Youssef K.K., Kuchnio A., Caauwe A., et al. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature 2011, 478:399-403.
    • (2011) Nature , vol.478 , pp. 399-403
    • Beck, B.1    Driessens, G.2    Goossens, S.3    Youssef, K.K.4    Kuchnio, A.5    Caauwe, A.6
  • 91
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S., Wu Q., Sathornsumetee S., Hao Y., Li Z., Hjelmeland A.B., et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 2006, 66:7843-7848.
    • (2006) Cancer Res. , vol.66 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3    Hao, Y.4    Li, Z.5    Hjelmeland, A.B.6
  • 93
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Li Z., Bao S., Wu Q., Wang H., Eyler C., Sathornsumetee S., et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009, 15:501-513.
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3    Wang, H.4    Eyler, C.5    Sathornsumetee, S.6
  • 95
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • Jin L., Hope K.J., Zhai Q., Smadja-Joffe F., Dick J.E. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat. Med. 2006, 12:1167-1174.
    • (2006) Nat. Med. , vol.12 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 96
    • 67649200331 scopus 로고    scopus 로고
    • Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells
    • Jin L., Lee E.M., Ramshaw H.S., Busfield S.J., Peoppl A.G., Wilkinson L., et al. Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell 2009, 5:31-42.
    • (2009) Cell Stem Cell , vol.5 , pp. 31-42
    • Jin, L.1    Lee, E.M.2    Ramshaw, H.S.3    Busfield, S.J.4    Peoppl, A.G.5    Wilkinson, L.6
  • 99
    • 70349479538 scopus 로고    scopus 로고
    • Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    • Bertolini G., Roz L., Perego P., Tortoreto M., Fontanella E., Gatti L., et al. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:16281-16286.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 16281-16286
    • Bertolini, G.1    Roz, L.2    Perego, P.3    Tortoreto, M.4    Fontanella, E.5    Gatti, L.6
  • 100
    • 62549136153 scopus 로고    scopus 로고
    • Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice
    • Rountree C.B., Ding W., He L., Stiles B. Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells 2009, 27:290-299.
    • (2009) Stem Cells , vol.27 , pp. 290-299
    • Rountree, C.B.1    Ding, W.2    He, L.3    Stiles, B.4
  • 102
    • 84873660610 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi A.M., Ryter S.W., Levine B. Autophagy in human health and disease. N. Engl. J. Med. 2013, 368:651-662.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 103
    • 84887437596 scopus 로고    scopus 로고
    • Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
    • Sui X., Chen R., Wang Z., Huang Z., Kong N., Zhang M., et al. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 2013, 4:e838.
    • (2013) Cell Death Dis. , vol.4 , pp. e838
    • Sui, X.1    Chen, R.2    Wang, Z.3    Huang, Z.4    Kong, N.5    Zhang, M.6
  • 105
    • 80053302394 scopus 로고    scopus 로고
    • Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity
    • Zhuang W., Li B., Long L., Chen L., Huang Q., Liang Z. Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int. J. Cancer 2011, 129:2720-2731.
    • (2011) Int. J. Cancer , vol.129 , pp. 2720-2731
    • Zhuang, W.1    Li, B.2    Long, L.3    Chen, L.4    Huang, Q.5    Liang, Z.6
  • 107
    • 84928034921 scopus 로고    scopus 로고
    • Autophagy supports breast cancer stem cell maintenance by regulating IL6 secretion
    • Maycotte P., Jones K.L., Goodall M.L., Thorburn J., Thorburn A. Autophagy supports breast cancer stem cell maintenance by regulating IL6 secretion. Mol. Cancer Res. 2015, 13:651-658.
    • (2015) Mol. Cancer Res. , vol.13 , pp. 651-658
    • Maycotte, P.1    Jones, K.L.2    Goodall, M.L.3    Thorburn, J.4    Thorburn, A.5
  • 108
    • 36048963331 scopus 로고    scopus 로고
    • Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    • Zhou J., Wulfkuhle J., Zhang H., Gu P., Yang Y., Deng J., et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:16158-16163.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 16158-16163
    • Zhou, J.1    Wulfkuhle, J.2    Zhang, H.3    Gu, P.4    Yang, Y.5    Deng, J.6
  • 109
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch H.A., Iliopoulos D., Tsichlis P.N., Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009, 69:7507-7511.
    • (2009) Cancer Res. , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 110
    • 84904168687 scopus 로고    scopus 로고
    • Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling
    • Balic A., Sorensen M.D., Trabulo S.M., Sainz B., Cioffi M., Vieira C.R., et al. Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Mol. Cancer Ther. 2014, 13:1758-1771.
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 1758-1771
    • Balic, A.1    Sorensen, M.D.2    Trabulo, S.M.3    Sainz, B.4    Cioffi, M.5    Vieira, C.R.6
  • 111
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • Ward P.S., Thompson C.B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 113
    • 84884893986 scopus 로고    scopus 로고
    • Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
    • Flavahan W.A., Wu Q., Hitomi M., Rahim N., Kim Y., Sloan A.E., et al. Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nat. Neurosci. 2013, 16:1373-1382.
    • (2013) Nat. Neurosci. , vol.16 , pp. 1373-1382
    • Flavahan, W.A.1    Wu, Q.2    Hitomi, M.3    Rahim, N.4    Kim, Y.5    Sloan, A.E.6
  • 114
    • 84862902027 scopus 로고    scopus 로고
    • Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target
    • Ginestier C., Monville F., Wicinski J., Cabaud O., Cervera N., Josselin E., et al. Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. Stem Cells 2012, 30:1327-1337.
    • (2012) Stem Cells , vol.30 , pp. 1327-1337
    • Ginestier, C.1    Monville, F.2    Wicinski, J.3    Cabaud, O.4    Cervera, N.5    Josselin, E.6
  • 115
    • 84872529696 scopus 로고    scopus 로고
    • Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
    • Hirsch H.A., Iliopoulos D., Struhl K. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:972-977.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 972-977
    • Hirsch, H.A.1    Iliopoulos, D.2    Struhl, K.3
  • 116
    • 84872294586 scopus 로고    scopus 로고
    • Metformin selectively affects human glioblastoma tumor-initiating cell viability: a role for metformin-induced inhibition of Akt
    • Wurth R., Pattarozzi A., Gatti M., Bajetto A., Corsaro A., Parodi A., et al. Metformin selectively affects human glioblastoma tumor-initiating cell viability: a role for metformin-induced inhibition of Akt. Cell Cycle 2013, 12:145-156.
    • (2013) Cell Cycle , vol.12 , pp. 145-156
    • Wurth, R.1    Pattarozzi, A.2    Gatti, M.3    Bajetto, A.4    Corsaro, A.5    Parodi, A.6
  • 117
    • 84864696659 scopus 로고    scopus 로고
    • Nanotechnology applied to overcome tumor drug resistance
    • Gao Z., Zhang L., Sun Y. Nanotechnology applied to overcome tumor drug resistance. J. Control. Release 2012, 162:45-55.
    • (2012) J. Control. Release , vol.162 , pp. 45-55
    • Gao, Z.1    Zhang, L.2    Sun, Y.3
  • 118
    • 84893021888 scopus 로고    scopus 로고
    • Surface markers of cancer stem cells in solid tumors
    • Xia P. Surface markers of cancer stem cells in solid tumors. Curr. Stem Cell Res. Ther. 2014, 9:102-111.
    • (2014) Curr. Stem Cell Res. Ther. , vol.9 , pp. 102-111
    • Xia, P.1
  • 119
    • 77956224494 scopus 로고    scopus 로고
    • Oxygen in stem cell biology: a critical component of the stem cell niche
    • Mohyeldin A., Garzon-Muvdi T., Quinones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 2010, 7:150-161.
    • (2010) Cell Stem Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzon-Muvdi, T.2    Quinones-Hinojosa, A.3
  • 121
    • 84888205791 scopus 로고    scopus 로고
    • Rationally designed nanovehicles to overcome cancer chemoresistance
    • Livney Y.D., Assaraf Y.G. Rationally designed nanovehicles to overcome cancer chemoresistance. Adv. Drug Deliv. Rev. 2013, 65:1716-1730.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1716-1730
    • Livney, Y.D.1    Assaraf, Y.G.2
  • 122
    • 84872293839 scopus 로고    scopus 로고
    • Targeting cancer stem cells: a new therapy to cure cancer patients
    • Hu Y., Fu L. Targeting cancer stem cells: a new therapy to cure cancer patients. Am. J. Cancer Res. 2012, 2:340-356.
    • (2012) Am. J. Cancer Res. , vol.2 , pp. 340-356
    • Hu, Y.1    Fu, L.2
  • 123
    • 84906779006 scopus 로고    scopus 로고
    • The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells
    • Yao H.J., Zhang Y.G., Sun L., Liu Y. The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells. Biomaterials 2014, 35:9208-9223.
    • (2014) Biomaterials , vol.35 , pp. 9208-9223
    • Yao, H.J.1    Zhang, Y.G.2    Sun, L.3    Liu, Y.4
  • 124
    • 84870359511 scopus 로고    scopus 로고
    • Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells
    • Wang K., Zhang T., Liu L., Wang X., Wu P., Chen Z., et al. Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells. Int. J. Nanomed. 2012, 7:4487-4497.
    • (2012) Int. J. Nanomed. , vol.7 , pp. 4487-4497
    • Wang, K.1    Zhang, T.2    Liu, L.3    Wang, X.4    Wu, P.5    Chen, Z.6
  • 125
    • 83555176260 scopus 로고    scopus 로고
    • Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells
    • Zhou Y., Yang J., Kopecek J. Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells. Biomaterials 2012, 33:1863-1872.
    • (2012) Biomaterials , vol.33 , pp. 1863-1872
    • Zhou, Y.1    Yang, J.2    Kopecek, J.3
  • 126
    • 84886751441 scopus 로고    scopus 로고
    • Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds
    • Sun T.M., Wang Y.C., Wang F., Du J.Z., Mao C.Q., Sun C.Y., et al. Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds. Biomaterials 2014, 35:836-845.
    • (2014) Biomaterials , vol.35 , pp. 836-845
    • Sun, T.M.1    Wang, Y.C.2    Wang, F.3    Du, J.Z.4    Mao, C.Q.5    Sun, C.Y.6
  • 127
    • 84870324628 scopus 로고    scopus 로고
    • Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer
    • Wang K., Liu L., Zhang T., Zhu Y.L., Qiu F., Wu X.G., et al. Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer. Int. J. Nanomed. 2011, 6:3207-3218.
    • (2011) Int. J. Nanomed. , vol.6 , pp. 3207-3218
    • Wang, K.1    Liu, L.2    Zhang, T.3    Zhu, Y.L.4    Qiu, F.5    Wu, X.G.6
  • 128
    • 84905459955 scopus 로고    scopus 로고
    • ITEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopic breast tumors
    • Zhao P., Dong S., Bhattacharyya J., Chen M. iTEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopic breast tumors. Mol. Pharm. 2014, 11:2703-2712.
    • (2014) Mol. Pharm. , vol.11 , pp. 2703-2712
    • Zhao, P.1    Dong, S.2    Bhattacharyya, J.3    Chen, M.4
  • 129
    • 84876484728 scopus 로고    scopus 로고
    • Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors
    • Wei X., Senanayake T.H., Warren G., Vinogradov S.V. Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors. Bioconjugate Chem. 2013, 24:658-668.
    • (2013) Bioconjugate Chem. , vol.24 , pp. 658-668
    • Wei, X.1    Senanayake, T.H.2    Warren, G.3    Vinogradov, S.V.4
  • 130
    • 84906782604 scopus 로고    scopus 로고
    • Phenformin-loaded polymeric micelles for targeting both cancer cells and cancer stem cells in vitro and in vivo
    • Krishnamurthy S., Ng V.W., Gao S., Tan M.H., Yang Y.Y. Phenformin-loaded polymeric micelles for targeting both cancer cells and cancer stem cells in vitro and in vivo. Biomaterials 2014, 35:9177-9186.
    • (2014) Biomaterials , vol.35 , pp. 9177-9186
    • Krishnamurthy, S.1    Ng, V.W.2    Gao, S.3    Tan, M.H.4    Yang, Y.Y.5
  • 131
    • 84939990355 scopus 로고    scopus 로고
    • Delivery of bortezomib with nanoparticles for basal-like triple-negative breast cancer therapy
    • Shen S., Du X.J., Liu J., Sun R., Zhu Y.H., Wang J. Delivery of bortezomib with nanoparticles for basal-like triple-negative breast cancer therapy. J. Control. Release 2015, 208:14-24.
    • (2015) J. Control. Release , vol.208 , pp. 14-24
    • Shen, S.1    Du, X.J.2    Liu, J.3    Sun, R.4    Zhu, Y.H.5    Wang, J.6
  • 132
    • 84919779810 scopus 로고    scopus 로고
    • Epirubicin-adsorbed nanodiamonds kill chemoresistant hepatic cancer stem cells
    • Wang X., Low X.C., Hou W., Abdullah L.N., Toh T.B., Mohd Abdul Rashid M., et al. Epirubicin-adsorbed nanodiamonds kill chemoresistant hepatic cancer stem cells. ACS Nano 2014, 8:12151-12166.
    • (2014) ACS Nano , vol.8 , pp. 12151-12166
    • Wang, X.1    Low, X.C.2    Hou, W.3    Abdullah, L.N.4    Toh, T.B.5    Mohd Abdul Rashid, M.6
  • 133
    • 3142514670 scopus 로고    scopus 로고
    • Progress in the development of nucleic acid therapeutics for cancer
    • Kalota A., Shetzline S.E., Gewirtz A.M. Progress in the development of nucleic acid therapeutics for cancer. Cancer Biol. Ther. 2004, 3:4-12.
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 4-12
    • Kalota, A.1    Shetzline, S.E.2    Gewirtz, A.M.3
  • 135
    • 53049104709 scopus 로고    scopus 로고
    • Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis
    • Hu T., Liu S., Breiter D.R., Wang F., Tang Y., Sun S. Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res. 2008, 68:6533-6540.
    • (2008) Cancer Res. , vol.68 , pp. 6533-6540
    • Hu, T.1    Liu, S.2    Breiter, D.R.3    Wang, F.4    Tang, Y.5    Sun, S.6
  • 136
    • 84882333003 scopus 로고    scopus 로고
    • Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeutics
    • Muthiah M., Park I.K., Cho C.S. Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeutics. Expert Opin. Drug Deliv. 2013, 10:1259-1273.
    • (2013) Expert Opin. Drug Deliv. , vol.10 , pp. 1259-1273
    • Muthiah, M.1    Park, I.K.2    Cho, C.S.3
  • 137
    • 79961043075 scopus 로고    scopus 로고
    • MicroRNA delivery by cationic lipoplexes for lung cancer therapy
    • Wu Y., Crawford M., Yu B., Mao Y., Nana-Sinkam S.P., Lee L.J. MicroRNA delivery by cationic lipoplexes for lung cancer therapy. Mol. Pharm. 2011, 8:1381-1389.
    • (2011) Mol. Pharm. , vol.8 , pp. 1381-1389
    • Wu, Y.1    Crawford, M.2    Yu, B.3    Mao, Y.4    Nana-Sinkam, S.P.5    Lee, L.J.6
  • 138
    • 83355166283 scopus 로고    scopus 로고
    • Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI
    • Yang Y.P., Chien Y., Chiou G.Y., Cherng J.Y., Wang M.L., Lo W.L., et al. Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI. Biomaterials 2012, 33:1462-1476.
    • (2012) Biomaterials , vol.33 , pp. 1462-1476
    • Yang, Y.P.1    Chien, Y.2    Chiou, G.Y.3    Cherng, J.Y.4    Wang, M.L.5    Lo, W.L.6
  • 139
    • 84861902017 scopus 로고    scopus 로고
    • Lipid-based nanoparticle delivery of Pre-miR-107 inhibits the tumorigenicity of head and neck squamous cell carcinoma
    • Piao L., Zhang M., Datta J., Xie X., Su T., Li H., et al. Lipid-based nanoparticle delivery of Pre-miR-107 inhibits the tumorigenicity of head and neck squamous cell carcinoma. Mol. Ther. 2012, 20:1261-1269.
    • (2012) Mol. Ther. , vol.20 , pp. 1261-1269
    • Piao, L.1    Zhang, M.2    Datta, J.3    Xie, X.4    Su, T.5    Li, H.6
  • 140
    • 84875740719 scopus 로고    scopus 로고
    • Systemic delivery of microRNA-34a for cancer stem cell therapy
    • Shi S., Han L., Gong T., Zhang Z., Sun X. Systemic delivery of microRNA-34a for cancer stem cell therapy. Angew. Chem. Int. Ed. 2013, 52:3901-3905.
    • (2013) Angew. Chem. Int. Ed. , vol.52 , pp. 3901-3905
    • Shi, S.1    Han, L.2    Gong, T.3    Zhang, Z.4    Sun, X.5
  • 142
    • 84899802268 scopus 로고    scopus 로고
    • Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model
    • Andey T., Marepally S., Patel A., Jackson T., Sarkar S., O'Connell M., et al. Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model. J. Control. Release 2014, 184:67-78.
    • (2014) J. Control. Release , vol.184 , pp. 67-78
    • Andey, T.1    Marepally, S.2    Patel, A.3    Jackson, T.4    Sarkar, S.5    O'Connell, M.6
  • 143
    • 84924865111 scopus 로고    scopus 로고
    • Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy
    • Xu C.F., Liu Y., Shen S., Zhu Y.H., Wang J. Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy. Biomaterials 2015, 51:1-11.
    • (2015) Biomaterials , vol.51 , pp. 1-11
    • Xu, C.F.1    Liu, Y.2    Shen, S.3    Zhu, Y.H.4    Wang, J.5
  • 144
    • 70449708980 scopus 로고    scopus 로고
    • Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel
    • Liu C., Zhao G., Liu J., Ma N., Chivukula P., Perelman L., et al. Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. J. Control. Release 2009, 140:277-283.
    • (2009) J. Control. Release , vol.140 , pp. 277-283
    • Liu, C.1    Zhao, G.2    Liu, J.3    Ma, N.4    Chivukula, P.5    Perelman, L.6
  • 145
    • 84862808036 scopus 로고    scopus 로고
    • Cationic polyurethanes-short branch PEI-mediated delivery of miR145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma
    • Chiou G.Y., Cherng J.Y., Hsu H.S., Wang M.L., Tsai C.M., Lu K.H., et al. Cationic polyurethanes-short branch PEI-mediated delivery of miR145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma. J. Control. Release 2012, 159:240-250.
    • (2012) J. Control. Release , vol.159 , pp. 240-250
    • Chiou, G.Y.1    Cherng, J.Y.2    Hsu, H.S.3    Wang, M.L.4    Tsai, C.M.5    Lu, K.H.6
  • 146
    • 84900795076 scopus 로고    scopus 로고
    • Enhancement of radiotherapy efficacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells
    • Cui F.B., Liu Q., Li R.T., Shen J., Wu P.Y., Yu L.X., et al. Enhancement of radiotherapy efficacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells. Int. J. Nanomed 2014, 9:2345-2358.
    • (2014) Int. J. Nanomed , vol.9 , pp. 2345-2358
    • Cui, F.B.1    Liu, Q.2    Li, R.T.3    Shen, J.4    Wu, P.Y.5    Yu, L.X.6
  • 147
    • 84862827155 scopus 로고    scopus 로고
    • Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous cell carcinoma-derived cancer stem cells
    • Lo W.L., Chien Y., Chiou G.Y., Tseng L.M., Hsu H.S., Chang Y.L., et al. Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous cell carcinoma-derived cancer stem cells. Biomaterials 2012, 33:3693-3709.
    • (2012) Biomaterials , vol.33 , pp. 3693-3709
    • Lo, W.L.1    Chien, Y.2    Chiou, G.Y.3    Tseng, L.M.4    Hsu, H.S.5    Chang, Y.L.6
  • 149
    • 80055112766 scopus 로고    scopus 로고
    • The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles
    • Zhang Y., Zhang H., Wang X., Wang J., Zhang X., Zhang Q. The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles. Biomaterials 2012, 33:679-691.
    • (2012) Biomaterials , vol.33 , pp. 679-691
    • Zhang, Y.1    Zhang, H.2    Wang, X.3    Wang, J.4    Zhang, X.5    Zhang, Q.6
  • 150
    • 84887161387 scopus 로고    scopus 로고
    • HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects
    • Zhou Y., Yang J., Rhim J.S., Kopecek J. HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects. J. Control. Release 2013, 172:946-953.
    • (2013) J. Control. Release , vol.172 , pp. 946-953
    • Zhou, Y.1    Yang, J.2    Rhim, J.S.3    Kopecek, J.4
  • 151
    • 84887626984 scopus 로고    scopus 로고
    • Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells
    • Ke X.Y., Lin Ng V.W., Gao S.J., Tong Y.W., Hedrick J.L., Yang Y.Y. Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells. Biomaterials 2014, 35:1096-1108.
    • (2014) Biomaterials , vol.35 , pp. 1096-1108
    • Ke, X.Y.1    Lin Ng, V.W.2    Gao, S.J.3    Tong, Y.W.4    Hedrick, J.L.5    Yang, Y.Y.6
  • 152
    • 68049114782 scopus 로고    scopus 로고
    • Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    • Shimono Y., Zabala M., Cho R.W., Lobo N., Dalerba P., Qian D., et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009, 138:592-603.
    • (2009) Cell , vol.138 , pp. 592-603
    • Shimono, Y.1    Zabala, M.2    Cho, R.W.3    Lobo, N.4    Dalerba, P.5    Qian, D.6
  • 153
    • 84879604991 scopus 로고    scopus 로고
    • Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles
    • Liu Q., Li R.T., Qian H.Q., Wei J., Xie L., Shen J., et al. Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles. Biomaterials 2013, 34:7191-7203.
    • (2013) Biomaterials , vol.34 , pp. 7191-7203
    • Liu, Q.1    Li, R.T.2    Qian, H.Q.3    Wei, J.4    Xie, L.5    Shen, J.6
  • 154
    • 84896496412 scopus 로고    scopus 로고
    • Anti-ABCG2 monoclonal antibody in combination with paclitaxel nanoparticles against cancer stem-like cell activity in multiple myeloma
    • Yang C., Xiong F., Wang J., Dou J., Chen J., Chen D., et al. Anti-ABCG2 monoclonal antibody in combination with paclitaxel nanoparticles against cancer stem-like cell activity in multiple myeloma. Nanomedicine (Lond) 2014, 9:45-60.
    • (2014) Nanomedicine (Lond) , vol.9 , pp. 45-60
    • Yang, C.1    Xiong, F.2    Wang, J.3    Dou, J.4    Chen, J.5    Chen, D.6
  • 155
    • 84926456748 scopus 로고    scopus 로고
    • Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells
    • Li S.Y., Sun R., Wang H.X., Shen S., Liu Y., Du X.J., et al. Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells. J. Control. Release 2015, 205:7-14.
    • (2015) J. Control. Release , vol.205 , pp. 7-14
    • Li, S.Y.1    Sun, R.2    Wang, H.X.3    Shen, S.4    Liu, Y.5    Du, X.J.6
  • 156
    • 84880934120 scopus 로고    scopus 로고
    • The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel
    • Wang D., Huang J., Wang X., Yu Y., Zhang H., Chen Y., et al. The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel. Biomaterials 2013, 34:7662-7673.
    • (2013) Biomaterials , vol.34 , pp. 7662-7673
    • Wang, D.1    Huang, J.2    Wang, X.3    Yu, Y.4    Zhang, H.5    Chen, Y.6
  • 157
    • 44649133215 scopus 로고    scopus 로고
    • A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes
    • Liu Y., Lu W.L., Guo J., Du J., Li T., Wu J.W., et al. A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes. J. Control. Release 2008, 129:18-25.
    • (2008) J. Control. Release , vol.129 , pp. 18-25
    • Liu, Y.1    Lu, W.L.2    Guo, J.3    Du, J.4    Li, T.5    Wu, J.W.6
  • 158
    • 84903477100 scopus 로고    scopus 로고
    • A nanoparticle carrying the p53 gene targets tumors including cancer stem cells, sensitizes glioblastoma to chemotherapy and improves survival
    • Kim S.S., Rait A., Kim E., Pirollo K.F., Nishida M., Farkas N., et al. A nanoparticle carrying the p53 gene targets tumors including cancer stem cells, sensitizes glioblastoma to chemotherapy and improves survival. ACS Nano 2014, 8:5494-5514.
    • (2014) ACS Nano , vol.8 , pp. 5494-5514
    • Kim, S.S.1    Rait, A.2    Kim, E.3    Pirollo, K.F.4    Nishida, M.5    Farkas, N.6
  • 159
    • 84892938139 scopus 로고    scopus 로고
    • CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer
    • Swaminathan S.K., Roger E., Toti U., Niu L., Ohlfest J.R., Panyam J. CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer. J. Control. Release 2013, 171:280-287.
    • (2013) J. Control. Release , vol.171 , pp. 280-287
    • Swaminathan, S.K.1    Roger, E.2    Toti, U.3    Niu, L.4    Ohlfest, J.R.5    Panyam, J.6
  • 160
    • 84874266729 scopus 로고    scopus 로고
    • Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors
    • Ganesh S., Iyer A.K., Morrissey D.V., Amiji M.M. Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors. Biomaterials 2013, 34:3489-3502.
    • (2013) Biomaterials , vol.34 , pp. 3489-3502
    • Ganesh, S.1    Iyer, A.K.2    Morrissey, D.V.3    Amiji, M.M.4
  • 161
    • 84935022493 scopus 로고    scopus 로고
    • Chitosan-decorated doxorubicin-encapsulated nanoparticle targets and eliminates tumor reinitiating cancer stem-like cells
    • Rao W., Wang H., Han J., Zhao S., Dumbleton J., Agarwal P., et al. Chitosan-decorated doxorubicin-encapsulated nanoparticle targets and eliminates tumor reinitiating cancer stem-like cells. ACS Nano 2015, 9:5725-5740.
    • (2015) ACS Nano , vol.9 , pp. 5725-5740
    • Rao, W.1    Wang, H.2    Han, J.3    Zhao, S.4    Dumbleton, J.5    Agarwal, P.6
  • 162
    • 84860380857 scopus 로고    scopus 로고
    • CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma
    • Wang L., Su W., Liu Z., Zhou M., Chen S., Chen Y., et al. CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma. Biomaterials 2012, 33:5107-5114.
    • (2012) Biomaterials , vol.33 , pp. 5107-5114
    • Wang, L.1    Su, W.2    Liu, Z.3    Zhou, M.4    Chen, S.5    Chen, Y.6
  • 163
    • 84895902330 scopus 로고    scopus 로고
    • The clinical potential of targeted nanomedicine: delivering to cancer stem-like cells
    • Kim S.S., Rait A., Rubab F., Rao A.K., Kiritsy M.C., Pirollo K.F., et al. The clinical potential of targeted nanomedicine: delivering to cancer stem-like cells. Mol. Ther. 2014, 22:278-291.
    • (2014) Mol. Ther. , vol.22 , pp. 278-291
    • Kim, S.S.1    Rait, A.2    Rubab, F.3    Rao, A.K.4    Kiritsy, M.C.5    Pirollo, K.F.6
  • 164
    • 84928746155 scopus 로고    scopus 로고
    • Targeted therapy of glioblastoma stem-like cells and tumor non-stem cells using cetuximab-conjugated iron-oxide nanoparticles
    • Kaluzova M., Bouras A., Machaidze R., Hadjipanayis C.G. Targeted therapy of glioblastoma stem-like cells and tumor non-stem cells using cetuximab-conjugated iron-oxide nanoparticles. Oncotarget 2015, 6:8788-8806.
    • (2015) Oncotarget , vol.6 , pp. 8788-8806
    • Kaluzova, M.1    Bouras, A.2    Machaidze, R.3    Hadjipanayis, C.G.4
  • 165
    • 84869103855 scopus 로고    scopus 로고
    • Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities
    • Cheng Z., Al Zaki A., Hui J.Z., Muzykantov V.R., Tsourkas A. Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities. Science 2012, 338:903-910.
    • (2012) Science , vol.338 , pp. 903-910
    • Cheng, Z.1    Al Zaki, A.2    Hui, J.Z.3    Muzykantov, V.R.4    Tsourkas, A.5
  • 166
    • 34848883058 scopus 로고    scopus 로고
    • Decreased circulation time offsets increased efficacy of PEGylated nanocarriers targeting folate receptors of glioma
    • McNeeley K.M., Annapragada A., Bellamkonda R.V. Decreased circulation time offsets increased efficacy of PEGylated nanocarriers targeting folate receptors of glioma. Nanotechnology 2007, 18:385101-385112.
    • (2007) Nanotechnology , vol.18 , pp. 385101-385112
    • McNeeley, K.M.1    Annapragada, A.2    Bellamkonda, R.V.3
  • 167
    • 77955251549 scopus 로고    scopus 로고
    • The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles
    • Lee H., Fonge H., Hoang B., Reilly R.M., Allen C. The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. Mol. Pharm. 2010, 7:1195-1208.
    • (2010) Mol. Pharm. , vol.7 , pp. 1195-1208
    • Lee, H.1    Fonge, H.2    Hoang, B.3    Reilly, R.M.4    Allen, C.5
  • 168
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • Keith B., Simon M.C. Hypoxia-inducible factors, stem cells, and cancer. Cell 2007, 129:465-472.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 169
    • 77956292811 scopus 로고    scopus 로고
    • The role of HER2 in cancer therapy and targeted drug delivery
    • Tai W., Mahato R., Cheng K. The role of HER2 in cancer therapy and targeted drug delivery. J. Control. Release 2010, 146:264-275.
    • (2010) J. Control. Release , vol.146 , pp. 264-275
    • Tai, W.1    Mahato, R.2    Cheng, K.3
  • 171
    • 77956036859 scopus 로고    scopus 로고
    • Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives
    • Knop K., Hoogenboom R., Fischer D., Schubert U.S. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew. Chem. Int. Ed. 2010, 49:6288-6308.
    • (2010) Angew. Chem. Int. Ed. , vol.49 , pp. 6288-6308
    • Knop, K.1    Hoogenboom, R.2    Fischer, D.3    Schubert, U.S.4
  • 172
    • 2942632966 scopus 로고    scopus 로고
    • PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles
    • Mishra S., Webster P., Davis M.E. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur. J. Cell Biol. 2004, 83:97-111.
    • (2004) Eur. J. Cell Biol. , vol.83 , pp. 97-111
    • Mishra, S.1    Webster, P.2    Davis, M.E.3
  • 173
    • 84875648834 scopus 로고    scopus 로고
    • Tumor-targeting and microenvironment-responsive smart nanoparticles for combination therapy of antiangiogenesis and apoptosis
    • Huang S., Shao K., Liu Y., Kuang Y., Li J., An S., et al. Tumor-targeting and microenvironment-responsive smart nanoparticles for combination therapy of antiangiogenesis and apoptosis. ACS Nano 2013, 7:2860-2871.
    • (2013) ACS Nano , vol.7 , pp. 2860-2871
    • Huang, S.1    Shao, K.2    Liu, Y.3    Kuang, Y.4    Li, J.5    An, S.6
  • 174
    • 84886292840 scopus 로고    scopus 로고
    • Stimuli-responsive nanocarriers for drug delivery
    • Mura S., Nicolas J., Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nat. Mater 2013, 12:991-1003.
    • (2013) Nat. Mater , vol.12 , pp. 991-1003
    • Mura, S.1    Nicolas, J.2    Couvreur, P.3
  • 175
    • 77950485832 scopus 로고    scopus 로고
    • Environment-responsive multifunctional liposomes
    • Kale A.A., Torchilin V.P. Environment-responsive multifunctional liposomes. Methods Mol. Biol. 2010, 605:213-242.
    • (2010) Methods Mol. Biol. , vol.605 , pp. 213-242
    • Kale, A.A.1    Torchilin, V.P.2
  • 176
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • Kessenbrock K., Plaks V., Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010, 141:52-67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 177
    • 84902551145 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2-responsive micelle for siRNA delivery
    • Wang H.X., Yang X.Z., Sun C.Y., Mao C.Q., Zhu Y.H., Wang J. Matrix metalloproteinase 2-responsive micelle for siRNA delivery. Biomaterials 2014, 35:7622-7634.
    • (2014) Biomaterials , vol.35 , pp. 7622-7634
    • Wang, H.X.1    Yang, X.Z.2    Sun, C.Y.3    Mao, C.Q.4    Zhu, Y.H.5    Wang, J.6
  • 178
    • 75349091751 scopus 로고    scopus 로고
    • Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    • Charles N., Ozawa T., Squatrito M., Bleau A.M., Brennan C.W., Hambardzumyan D., et al. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 2010, 6:141-152.
    • (2010) Cell Stem Cell , vol.6 , pp. 141-152
    • Charles, N.1    Ozawa, T.2    Squatrito, M.3    Bleau, A.M.4    Brennan, C.W.5    Hambardzumyan, D.6
  • 179
    • 84892619683 scopus 로고    scopus 로고
    • Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts
    • Liu S., Cong Y., Wang D., Sun Y., Deng L., Liu Y., et al. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Rep. 2014, 2:78-91.
    • (2014) Stem Cell Rep. , vol.2 , pp. 78-91
    • Liu, S.1    Cong, Y.2    Wang, D.3    Sun, Y.4    Deng, L.5    Liu, Y.6
  • 182
    • 83555166219 scopus 로고    scopus 로고
    • Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
    • Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotechnol. 2011, 6:815-823.
    • (2011) Nat. Nanotechnol. , vol.6 , pp. 815-823
    • Cabral, H.1    Matsumoto, Y.2    Mizuno, K.3    Chen, Q.4    Murakami, M.5    Kimura, M.6
  • 183
    • 84864125045 scopus 로고    scopus 로고
    • Peptides as targeting elements and tissue penetration devices for nanoparticles
    • Ruoslahti E. Peptides as targeting elements and tissue penetration devices for nanoparticles. Adv. Mater 2012, 24:3747-3756.
    • (2012) Adv. Mater , vol.24 , pp. 3747-3756
    • Ruoslahti, E.1
  • 184
    • 84914129134 scopus 로고    scopus 로고
    • Integration of nanoassembly functions for an effective delivery cascade for cancer drugs
    • Sun Q., Sun X., Ma X., Zhou Z., Jin E., Zhang B., et al. Integration of nanoassembly functions for an effective delivery cascade for cancer drugs. Adv. Mater 2014, 26:7615-7621.
    • (2014) Adv. Mater , vol.26 , pp. 7615-7621
    • Sun, Q.1    Sun, X.2    Ma, X.3    Zhou, Z.4    Jin, E.5    Zhang, B.6
  • 185
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto D., Rossi J.J. The promises and pitfalls of RNA-interference-based therapeutics. Nature 2009, 457:426-433.
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 186
    • 1942499451 scopus 로고    scopus 로고
    • Improving the efficiency of RNA interference in mammals
    • Mittal V. Improving the efficiency of RNA interference in mammals. Nat. Rev. Genet. 2004, 5:355-365.
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 355-365
    • Mittal, V.1
  • 187
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • Jackson A.L., Linsley P.S. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat. Rev. Drug Discov. 2010, 9:57-67.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 188
    • 33845914020 scopus 로고    scopus 로고
    • A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences
    • Smith J., Grizot S., Arnould S., Duclert A., Epinat J.C., Chames P., et al. A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences. Nucleic Acids Res. 2006, 34:e149.
    • (2006) Nucleic Acids Res. , vol.34 , pp. e149
    • Smith, J.1    Grizot, S.2    Arnould, S.3    Duclert, A.4    Epinat, J.C.5    Chames, P.6
  • 189
  • 191
    • 0037510038 scopus 로고    scopus 로고
    • Enhancing gene targeting with designed zinc finger nucleases
    • Bibikova M., Beumer K., Trautman J.K., Carroll D. Enhancing gene targeting with designed zinc finger nucleases. Science 2003, 300:764.
    • (2003) Science , vol.300 , pp. 764
    • Bibikova, M.1    Beumer, K.2    Trautman, J.K.3    Carroll, D.4
  • 194
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong L., Ran F.A., Cox D., Lin S., Barretto R., Habib N., et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013, 339:819-823.
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1    Ran, F.A.2    Cox, D.3    Lin, S.4    Barretto, R.5    Habib, N.6
  • 196
    • 84923106217 scopus 로고    scopus 로고
    • Therapeutic genome editing: prospects and challenges
    • Cox D.B., Platt R.J., Zhang F. Therapeutic genome editing: prospects and challenges. Nat. Med. 2015, 21:121-131.
    • (2015) Nat. Med. , vol.21 , pp. 121-131
    • Cox, D.B.1    Platt, R.J.2    Zhang, F.3
  • 197
    • 84929687810 scopus 로고    scopus 로고
    • Choosing the right tool for the job: RNAi, TALEN, or CRISPR
    • Boettcher M., McManus M.T. Choosing the right tool for the job: RNAi, TALEN, or CRISPR. Mol. Cell 2015, 58:575-585.
    • (2015) Mol. Cell , vol.58 , pp. 575-585
    • Boettcher, M.1    McManus, M.T.2
  • 199
    • 84874687019 scopus 로고    scopus 로고
    • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    • Qi L.S., Larson M.H., Gilbert L.A., Doudna J.A., Weissman J.S., Arkin A.P., et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 2013, 152:1173-1183.
    • (2013) Cell , vol.152 , pp. 1173-1183
    • Qi, L.S.1    Larson, M.H.2    Gilbert, L.A.3    Doudna, J.A.4    Weissman, J.S.5    Arkin, A.P.6
  • 200
    • 84938945636 scopus 로고    scopus 로고
    • Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice
    • Aida T., Chiyo K., Usami T., Ishikubo H., Imahashi R., Wada Y., et al. Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice. Genome Biol. 2015, 16:87.
    • (2015) Genome Biol. , vol.16 , pp. 87
    • Aida, T.1    Chiyo, K.2    Usami, T.3    Ishikubo, H.4    Imahashi, R.5    Wada, Y.6
  • 201
    • 84912101598 scopus 로고    scopus 로고
    • CRISPR-Cas9 knockin mice for genome editing and cancer modeling
    • Platt R.J., Chen S., Zhou Y., Yim M.J., Swiech L., Kempton H.R., et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell 2014, 159:440-455.
    • (2014) Cell , vol.159 , pp. 440-455
    • Platt, R.J.1    Chen, S.2    Zhou, Y.3    Yim, M.J.4    Swiech, L.5    Kempton, H.R.6
  • 202
    • 84865133667 scopus 로고    scopus 로고
    • BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma
    • Zhang L., Sun H., Zhao F., Lu P., Ge C., Li H., et al. BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma. Cancer Res. 2012, 72:4276-4285.
    • (2012) Cancer Res. , vol.72 , pp. 4276-4285
    • Zhang, L.1    Sun, H.2    Zhao, F.3    Lu, P.4    Ge, C.5    Li, H.6
  • 203
    • 74049085498 scopus 로고    scopus 로고
    • Effect of genome size on AAV vector packaging
    • Wu Z., Yang H., Colosi P. Effect of genome size on AAV vector packaging. Mol. Ther. 2010, 18:80-86.
    • (2010) Mol. Ther. , vol.18 , pp. 80-86
    • Wu, Z.1    Yang, H.2    Colosi, P.3
  • 204
    • 5444275097 scopus 로고    scopus 로고
    • Immune responses to gene therapy vectors: influence on vector function and effector mechanisms
    • Bessis N., GarciaCozar F.J., Boissier M.C. Immune responses to gene therapy vectors: influence on vector function and effector mechanisms. Gene Ther. 2004, 11(Suppl. 1):S10-S17.
    • (2004) Gene Ther. , vol.11 , pp. S10-S17
    • Bessis, N.1    GarciaCozar, F.J.2    Boissier, M.C.3
  • 205
    • 84961288301 scopus 로고    scopus 로고
    • Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
    • Zuris J.A., Thompson D.B., Shu Y., Guilinger J.P., Bessen J.L., Hu J.H., et al. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nat. Biotechnol. 2015, 33:73-80.
    • (2015) Nat. Biotechnol. , vol.33 , pp. 73-80
    • Zuris, J.A.1    Thompson, D.B.2    Shu, Y.3    Guilinger, J.P.4    Bessen, J.L.5    Hu, J.H.6
  • 206
    • 80053401068 scopus 로고    scopus 로고
    • Breast cancer stem cells, cytokine networks, and the tumor microenvironment
    • Korkaya H., Liu S., Wicha M.S. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J. Clin. Invest 2011, 121:3804-3809.
    • (2011) J. Clin. Invest , vol.121 , pp. 3804-3809
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 207
    • 84931560629 scopus 로고    scopus 로고
    • Concise reviews: targeting cancer stem cells using immunologic approaches
    • Pan Q., Li Q., Liu S., Ning N., Zhang X., Xu Y., et al. Concise reviews: targeting cancer stem cells using immunologic approaches. Stem Cells 2015, 33:2085-2092.
    • (2015) Stem Cells , vol.33 , pp. 2085-2092
    • Pan, Q.1    Li, Q.2    Liu, S.3    Ning, N.4    Zhang, X.5    Xu, Y.6
  • 208
    • 84908485098 scopus 로고    scopus 로고
    • A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
    • Lu H., Clauser K.R., Tam W.L., Frose J., Ye X., Eaton E.N., et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat. Cell Biol. 2014, 16:1105-1117.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 1105-1117
    • Lu, H.1    Clauser, K.R.2    Tam, W.L.3    Frose, J.4    Ye, X.5    Eaton, E.N.6
  • 209
    • 84908131966 scopus 로고    scopus 로고
    • Metastatic consequences of immune escape from NK cell cytotoxicity by human breast cancer stem cells
    • Wang B., Wang Q., Wang Z., Jiang J., Yu S.C., Ping Y.F., et al. Metastatic consequences of immune escape from NK cell cytotoxicity by human breast cancer stem cells. Cancer Res. 2014, 74:5746-5757.
    • (2014) Cancer Res. , vol.74 , pp. 5746-5757
    • Wang, B.1    Wang, Q.2    Wang, Z.3    Jiang, J.4    Yu, S.C.5    Ping, Y.F.6
  • 210
    • 80053542413 scopus 로고    scopus 로고
    • Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8(+) T cells
    • Visus C., Wang Y., Lozano-Leon A., Ferris R.L., Silver S., Szczepanski M.J., et al. Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8(+) T cells. Clin. Cancer Res. 2011, 17:6174-6184.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6174-6184
    • Visus, C.1    Wang, Y.2    Lozano-Leon, A.3    Ferris, R.L.4    Silver, S.5    Szczepanski, M.J.6
  • 211
    • 84859394263 scopus 로고    scopus 로고
    • Cancer stem cell vaccination confers significant antitumor immunity
    • Ning N., Pan Q., Zheng F., Teitz-Tennenbaum S., Egenti M., Yet J., et al. Cancer stem cell vaccination confers significant antitumor immunity. Cancer Res. 2012, 72:1853-1864.
    • (2012) Cancer Res. , vol.72 , pp. 1853-1864
    • Ning, N.1    Pan, Q.2    Zheng, F.3    Teitz-Tennenbaum, S.4    Egenti, M.5    Yet, J.6
  • 212
    • 84928179333 scopus 로고    scopus 로고
    • Glioma stem cells and immunotherapy for the treatment of malignant gliomas
    • Toda M. Glioma stem cells and immunotherapy for the treatment of malignant gliomas. ISRN Oncol. 2013, 2013:673793.
    • (2013) ISRN Oncol. , vol.2013 , pp. 673793
    • Toda, M.1
  • 213
    • 84874818661 scopus 로고    scopus 로고
    • Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model
    • Duarte S., Momier D., Baque P., Casanova V., Loubat A., Samson M., et al. Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model. Stem Cells 2013, 31:423-432.
    • (2013) Stem Cells , vol.31 , pp. 423-432
    • Duarte, S.1    Momier, D.2    Baque, P.3    Casanova, V.4    Loubat, A.5    Samson, M.6
  • 214
    • 84927161447 scopus 로고    scopus 로고
    • Immunoengineering: how nanotechnology can enhance cancer immunotherapy
    • Goldberg M.S. Immunoengineering: how nanotechnology can enhance cancer immunotherapy. Cell 2015, 161:201-204.
    • (2015) Cell , vol.161 , pp. 201-204
    • Goldberg, M.S.1
  • 215
  • 217
    • 84883567844 scopus 로고    scopus 로고
    • Targeting of tumor-associated macrophages made possible by PEG-sheddable, mannose-modified Nan particles
    • Zhu S., Niu M., O'Mary H., Cui Z. Targeting of tumor-associated macrophages made possible by PEG-sheddable, mannose-modified Nan particles. Mol. Pharm. 2013, 10:3525-3530.
    • (2013) Mol. Pharm. , vol.10 , pp. 3525-3530
    • Zhu, S.1    Niu, M.2    O'Mary, H.3    Cui, Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.