Enhancement of radiotherapy effcacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells

International Journal of Nanomedicine

Volumn 9, Issue 1, 2014, Pages 2345-2358

  Cui, Fang Bo ^a   Liu, Qin ^a   Li, Ru Tian ^a   Shen, Jie ^a   Wu, Pu Yuan ^a   Yu, Li Xia ^a   Hu, Wen Jing ^a   Wu, Feng Lei ^b   Jiang, Chun Ping ^a   Yue, Guo Feng ^b   Qian, Xiao Ping ^a   Jiang, Xi Qun ^c   Liu, Bao Rui ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Cancer stem cell like properties; Gastric cancer; Gelatinase stimuli nanoparticles; MiR 200c; Radiosensitizer

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; HERMES ANTIGEN; HISTONE H2AX; MACROGOL; MICRORNA 200C; POLYCAPROLACTONE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UVOMORULIN; ESCHERICHIA COLI PROTEIN; GELATINASE; MACROGOL DERIVATIVE; NANOCAPSULE; NANOCOMPOSITE; PEPTIDE; POLY(ETHYLENE GLYCOL)-POLY(CAPROLACTONE)-POLY(ETHYLENE GLYCOL); POLYESTER; RADIOSENSITIZING AGENT; TRAU PROTEIN, E COLI;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CANCER STEM CELL; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; IONIZING RADIATION; PROTEIN EXPRESSION; RADIOSENSITIVITY; RADIOSENSITIZATION; STOMACH CANCER; UPREGULATION; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; RADIATION RESPONSE; STOMACH NEOPLASMS; TUMOR CELL LINE; ULTRASTRUCTURE; UTILIZATION;

CELL LINE, TUMOR; ESCHERICHIA COLI PROTEINS; GELATINASES; HUMANS; NANOCAPSULES; NANOCOMPOSITES; NEOPLASTIC STEM CELLS; PEPTIDES; POLYESTERS; POLYETHYLENE GLYCOLS; RADIATION-SENSITIZING AGENTS; STOMACH NEOPLASMS;

EID: 84900795076     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S60874     Document Type: Article

References (37)

1. Yeh JM, Kuntz KM, Ezzati M, Hur C, Kong CY, Goldie SJ. Development of an empirically calibrated model of gastric cancer in two high-risk countries. Cancer Epidemiol Biomarkers Prev. 2008;17(5):1179-1187.
2. Hartgrink HH, Jansen E P, van Grieken NC, van de Velde CJ. Gastric cancer. Lancet. 2009;374(9688):477-490.
3. Diehn M, Cho RW, Lobo NA, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 2009;458(7239):780-783.
4. Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radiore-sistance by preferential activation of the DNA damage response. Nature. 2006;444(7120):756-760.
5. Baumann M, Krause M, Thames H, Trott K, Zips D. Cancer stem cells and radiotherapy. Int J Radiat Biol. 2009;85(5):391-402.
6. Takaishi S, Okumura T, Tu S, et al. Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells. 2009;27(5):1006-1020.
7. Phillips TM, McBride WH, Pajonk F. The response of CD24(-/low)/ CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst. 2006;98(24):1777-1785.
8. Chiou SH, Kao CL, Chen Y W, et al. Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. PLoS One. 2008;3(5):e2090.
9. de Jong MC, Pramana J, van der Wal JE, et al. CD44 expression predicts local recurrence after radiotherapy in larynx cancer. Clin Cancer Res. 2010;16(21):5329-5338.
10. Yaromina A, Krause M, Thames H, et al. Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation. Radiother Oncol. 2007;83(3):304-310.
11. Ponnurangam S, Mammen JM, Ramalingam S, et al. Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells. Mol Cancer Ther. 2012;11(4):963-972.
12. Kim WK, Kim JH, Yoon K, et al. Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest. Invest New Drugs. 2012;30(4): 1311-1318.
13. Shimono Y, Zabala M, Cho RW, et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell. 2009;138(3):592-603.
14. Lim YY, Wright JA, Attema JL, et al. Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. J Cell Sci. 2013;126(Pt 10):2256-2266.
15. Lo WL, Yu CC, Chiou GY, et al. MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. J Pathol. 2011;223(4):482-495.
16. Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008;22(7): 894-907.
17. Polyak K, Weinberg RA. Transitions between epithelial and mesen-chymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009;9(4):265-273.
18. Theys J, Jutten B, Habets R, et al. E-cadherin loss associated with EMT promotes radioresistance in human tumor cells. Radiother Oncol. 2011;99(3):392-397.
19. Floor S, van Staveren WC, Larsimont D, Dumont JE, Maenhaut C. Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations. Oncogene. 2011;30(46):4609-4621.
20. Muthiah M, Park IK, Cho CS. Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeutics. Expert Opin Drug Deliv. 2013;10(9):1259-1273.
21. Liu Q, Li RT, Qian HQ, et al. Gelatinase-stimuli strategy enhances the tumor delivery and therapeutic efficacy of docetaxel-loaded poly(ethylene glycol)-poly(varepsilon-caprolactone) nanoparticles. Int J Nanomedicine. 2012;7:281-295.
22. Li R, Wu W, Liu Q, et al. Intelligently targeted drug delivery and enhanced antitumor effect by gelatinase-responsive nanoparticles. PLoS One. 2013;8(7):e69643.
23. Liu Q, Li RT, Qian HQ, et al. Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles. Biomaterials. 2013;34(29):7191-7203.
24. Werner ME, Copp JA, Karve S, et al. Folate-targeted polymeric nano-particle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy. ACS Nano. 2011;5(11):8990-8998.
25. Liu N, Tang LL, Sun Y, et al. MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma. Cancer Lett. 2013;329(2):181-188.
26. Cui FB, Li RT, Liu Q, et al. Enhancement of radiotherapy efficacy by docetaxel-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer. Cancer Lett. 2014;346(1):53-62.
27. Gupta G P, Massague J. Cancer metastasis: building a framework. Cell. 2006;127(4):679-695.
28. Kurrey NK, Jalgaonkar S P, Joglekar AV, et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells. 2009;27(9):2059-2068.
29. Wang G, Guo X, Hong W, et al. Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc Natl Acad Sci U S A. 2013;110(8):2858-2863.
30. Cordes N, van Beuningen D. Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro. Br J Cancer. 2003;88(9):1470-1479.
31. Takebe N, Harris PJ, Warren RQ, Ivy S P. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol. 2011;8(2):97-106.
32. Wild-Bode C, Weller M, Rimner A, Dichgans J, Wick W. Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res. 2001;61(6):2744-2750.
33. Kaliski A, Maggiorella L, Cengel KA, et al. Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion. Mol Cancer Ther. 2005;4(11):1717-1728.
34. Qian LW, Mizumoto K, Urashima T, et al. Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023. Clin Cancer Res. 2002;8(4):1223-1227.
35. Zhou YC, Liu JY, Li J, et al. Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta-mediated epithelial-mesenchymal transition. Int J Radiat Oncol Biol Phys. 2011;81(5):1530-1537.
36. Czochor JR, Glazer PM. Micrornas in cancer cell response to ionizing radiation. Antioxid Redox Signal. February 4, 2014. [Epub ahead of print.]
37. Chow EK, Ho D. Cancer nanomedicine: from drug delivery to imaging. Sci Transl Med. 2013;5(216):216-4.