-
1
-
-
64249111266
-
Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy
-
A. Abe, Y. Minami, F. Hayakawa, K. Kitamura, Y. Nomura, M. Murata, A. Katsumi, H. Kiyoi, C.H. Jamieson, J.Y. Wang, and T. Naoe Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy Int. J. Hematol. 88 2008 471 475
-
(2008)
Int. J. Hematol.
, vol.88
, pp. 471-475
-
-
Abe, A.1
Minami, Y.2
Hayakawa, F.3
Kitamura, K.4
Nomura, Y.5
Murata, M.6
Katsumi, A.7
Kiyoi, H.8
Jamieson, C.H.9
Wang, J.Y.10
Naoe, T.11
-
2
-
-
62649139996
-
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation
-
A.E. Abrahamsson, I. Geron, J. Gotlib, K.H. Dao, C.F. Barroga, I.G. Newton, F.J. Giles, J. Durocher, R.S. Creusot, and M. Karimi Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation Proc. Natl. Acad. Sci. USA 106 2009 3925 3929
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 3925-3929
-
-
Abrahamsson, A.E.1
Geron, I.2
Gotlib, J.3
Dao, K.H.4
Barroga, C.F.5
Newton, I.G.6
Giles, F.J.7
Durocher, J.8
Creusot, R.S.9
Karimi, M.10
-
3
-
-
20144388297
-
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): Evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides
-
K.J. Aichberger, M. Mayerhofer, M.T. Krauth, H. Skvara, S. Florian, K. Sonneck, C. Akgul, S. Derdak, W.F. Pickl, and V. Wacheck Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides Blood 105 2005 3303 3311
-
(2005)
Blood
, vol.105
, pp. 3303-3311
-
-
Aichberger, K.J.1
Mayerhofer, M.2
Krauth, M.T.3
Skvara, H.4
Florian, S.5
Sonneck, K.6
Akgul, C.7
Derdak, S.8
Pickl, W.F.9
Wacheck, V.10
-
4
-
-
4644299291
-
Alternative splicing of Bcl-2-related genes: Functional consequences and potential therapeutic applications
-
C. Akgul, D.A. Moulding, and S.W. Edwards Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications Cell. Mol. Life Sci. 61 2004 2189 2199
-
(2004)
Cell. Mol. Life Sci.
, vol.61
, pp. 2189-2199
-
-
Akgul, C.1
Moulding, D.A.2
Edwards, S.W.3
-
5
-
-
0032546266
-
Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with up regulation of Bcl-xL
-
G.P. Amarante-Mendes, A.J. McGahon, W.K. Nishioka, D.E. Afar, O.N. Witte, and D.R. Green Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL Oncogene 16 1998 1383 1390
-
(1998)
Oncogene
, vol.16
, pp. 1383-1390
-
-
Amarante-Mendes, G.P.1
McGahon, A.J.2
Nishioka, W.K.3
Afar, D.E.4
Witte, O.N.5
Green, D.R.6
-
6
-
-
33845664398
-
Primitive, quiescent and difficult to kill: The role of non-proliferating stem cells in chronic myeloid leukemia
-
D.J. Barnes, and J.V. Melo Primitive, quiescent and difficult to kill: the role of non-proliferating stem cells in chronic myeloid leukemia Cell Cycle 5 2006 2862 2866
-
(2006)
Cell Cycle
, vol.5
, pp. 2862-2866
-
-
Barnes, D.J.1
Melo, J.V.2
-
7
-
-
62049084053
-
MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family
-
L.J. Beverly, and H.E. Varmus MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family Oncogene 28 2009 1274 1279
-
(2009)
Oncogene
, vol.28
, pp. 1274-1279
-
-
Beverly, L.J.1
Varmus, H.E.2
-
8
-
-
55749116156
-
Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
-
N.N. Bewry, R.R. Nair, M.F. Emmons, D. Boulware, J. Pinilla-Ibarz, and L.A. Hazlehurst Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance Mol. Cancer Ther. 7 2008 3169 3175
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 3169-3175
-
-
Bewry, N.N.1
Nair, R.R.2
Emmons, M.F.3
Boulware, D.4
Pinilla-Ibarz, J.5
Hazlehurst, L.A.6
-
9
-
-
0034698122
-
Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death
-
C.D. Bingle, R.W. Craig, B.M. Swales, V. Singleton, P. Zhou, and M.K. Whyte Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death J. Biol. Chem. 275 2000 22136 22146
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 22136-22146
-
-
Bingle, C.D.1
Craig, R.W.2
Swales, B.M.3
Singleton, V.4
Zhou, P.5
Whyte, M.K.6
-
10
-
-
33846674886
-
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
-
S. Chen, Y. Dai, H. Harada, P. Dent, and S. Grant Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation Cancer Res. 67 2007 782 791
-
(2007)
Cancer Res.
, vol.67
, pp. 782-791
-
-
Chen, S.1
Dai, Y.2
Harada, H.3
Dent, P.4
Grant, S.5
-
11
-
-
84055179140
-
Chronic myeloid leukemia stem cells in the era of targeted therapies: Resistance, persistence and long-term dormancy
-
J.C. Chomel, and A.G. Turhan Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy Oncotarget 2 2011 713 727
-
(2011)
Oncotarget
, vol.2
, pp. 713-727
-
-
Chomel, J.C.1
Turhan, A.G.2
-
12
-
-
80053361301
-
Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease
-
J.C. Chomel, M.L. Bonnet, N. Sorel, A. Bertrand, M.C. Meunier, S. Fichelson, M. Melkus, A. Bennaceur-Griscelli, F. Guilhot, and A.G. Turhan Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease Blood 118 2011 3657 3660
-
(2011)
Blood
, vol.118
, pp. 3657-3660
-
-
Chomel, J.C.1
Bonnet, M.L.2
Sorel, N.3
Bertrand, A.4
Meunier, M.C.5
Fichelson, S.6
Melkus, M.7
Bennaceur-Griscelli, A.8
Guilhot, F.9
Turhan, A.G.10
-
13
-
-
78650949272
-
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
-
A.S. Corbin, A. Agarwal, M. Loriaux, J. Cortes, M.W. Deininger, and B.J. Druker Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity J. Clin. Invest. 121 2011 396 409
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 396-409
-
-
Corbin, A.S.1
Agarwal, A.2
Loriaux, M.3
Cortes, J.4
Deininger, M.W.5
Druker, B.J.6
-
14
-
-
4644341516
-
Discontinuation of imatinib therapy after achieving a molecular response
-
J. Cortes, S. O'Brien, and H. Kantarjian Discontinuation of imatinib therapy after achieving a molecular response Blood 104 2004 2204 2205
-
(2004)
Blood
, vol.104
, pp. 2204-2205
-
-
Cortes, J.1
O'Brien, S.2
Kantarjian, H.3
-
15
-
-
4544343214
-
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
-
Y. Dai, M. Rahmani, S.J. Corey, P. Dent, and S. Grant A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2 J. Biol. Chem. 279 2004 34227 34239
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34227-34239
-
-
Dai, Y.1
Rahmani, M.2
Corey, S.J.3
Dent, P.4
Grant, S.5
-
16
-
-
0025117392
-
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
-
G.Q. Daley, R.A. Van Etten, and D. Baltimore Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome Science 247 1990 824 830
-
(1990)
Science
, vol.247
, pp. 824-830
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
17
-
-
45749093747
-
Resistance and relapse with imatinib in CML: Causes and consequences
-
M. Deininger Resistance and relapse with imatinib in CML: causes and consequences J. Natl. Compr. Canc. Netw. 6 Suppl 2 2008 S11 S21
-
(2008)
J. Natl. Compr. Canc. Netw.
, vol.6
, Issue.SUPPL. 2
-
-
Deininger, M.1
-
18
-
-
34250327394
-
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer
-
Q. Ding, X. He, W. Xia, J.M. Hsu, C.T. Chen, L.Y. Li, D.F. Lee, J.Y. Yang, X. Xie, J.C. Liu, and M.C. Hung Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer Cancer Res. 67 2007 4564 4571
-
(2007)
Cancer Res.
, vol.67
, pp. 4564-4571
-
-
Ding, Q.1
He, X.2
Xia, W.3
Hsu, J.M.4
Chen, C.T.5
Li, L.Y.6
Lee, D.F.7
Yang, J.Y.8
Xie, X.9
Liu, J.C.10
Hung, M.C.11
-
19
-
-
0038722038
-
Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2
-
J. Domen, and I.L. Weissman Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2 Exp. Hematol. 31 2003 631 639
-
(2003)
Exp. Hematol.
, vol.31
, pp. 631-639
-
-
Domen, J.1
Weissman, I.L.2
-
20
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
B.J. Druker, M. Talpaz, D.J. Resta, B. Peng, E. Buchdunger, J.M. Ford, N.B. Lydon, H. Kantarjian, R. Capdeville, S. Ohno-Jones, and C.L. Sawyers Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia N. Engl. J. Med. 344 2001 1031 1037
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
21
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
IRIS Investigators
-
B.J. Druker, F. Guilhot, S.G. O'Brien, I. Gathmann, H. Kantarjian, N. Gattermann, M.W. Deininger, R.T. Silver, J.M. Goldman, R.M. Stone IRIS Investigators Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia N. Engl. J. Med. 355 2006 2408 2417
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
Gathmann, I.4
Kantarjian, H.5
Gattermann, N.6
Deininger, M.W.7
Silver, R.T.8
Goldman, J.M.9
Stone, R.M.10
-
22
-
-
80052468964
-
Stem cell gene expression programs influence clinical outcome in human leukemia
-
K. Eppert, K. Takenaka, E.R. Lechman, L. Waldron, B. Nilsson, P. van Galen, K.H. Metzeler, A. Poeppl, V. Ling, and J. Beyene Stem cell gene expression programs influence clinical outcome in human leukemia Nat. Med. 17 2011 1086 1093
-
(2011)
Nat. Med.
, vol.17
, pp. 1086-1093
-
-
Eppert, K.1
Takenaka, K.2
Lechman, E.R.3
Waldron, L.4
Nilsson, B.5
Van Galen, P.6
Metzeler, K.H.7
Poeppl, A.8
Ling, V.9
Beyene, J.10
-
23
-
-
77649335651
-
Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells
-
E.C. Forsberg, E. Passegué, S.S. Prohaska, A.J. Wagers, M. Koeva, J.M. Stuart, and I.L. Weissman Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells PLoS ONE 5 2010 e8785
-
(2010)
PLoS ONE
, vol.5
, pp. 8785
-
-
Forsberg, E.C.1
Passegué, E.2
Prohaska, S.S.3
Wagers, A.J.4
Koeva, M.5
Stuart, J.M.6
Weissman, I.L.7
-
24
-
-
0034665780
-
Bcr/Abl activates transcription of the Bcl-X gene through STAT5
-
F. Gesbert, and J.D. Griffin Bcr/Abl activates transcription of the Bcl-X gene through STAT5 Blood 96 2000 2269 2276
-
(2000)
Blood
, vol.96
, pp. 2269-2276
-
-
Gesbert, F.1
Griffin, J.D.2
-
25
-
-
78651416188
-
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia
-
N. Goardon, E. Marchi, A. Atzberger, L. Quek, A. Schuh, S. Soneji, P. Woll, A. Mead, K.A. Alford, and R. Rout Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia Cancer Cell 19 2011 138 152
-
(2011)
Cancer Cell
, vol.19
, pp. 138-152
-
-
Goardon, N.1
Marchi, E.2
Atzberger, A.3
Quek, L.4
Schuh, A.5
Soneji, S.6
Woll, P.7
Mead, A.8
Alford, K.A.9
Rout, R.10
-
26
-
-
0034732659
-
Are standardized mortality ratios valid for public health data analysis?
-
D.A. Goldman, and J.D. Brender Are standardized mortality ratios valid for public health data analysis? Stat. Med. 19 2000 1081 1088
-
(2000)
Stat. Med.
, vol.19
, pp. 1081-1088
-
-
Goldman, D.A.1
Brender, J.D.2
-
27
-
-
0037059012
-
Preferential induction of apoptosis for primary human leukemic stem cells
-
M.L. Guzman, C.F. Swiderski, D.S. Howard, B.A. Grimes, R.M. Rossi, S.J. Szilvassy, and C.T. Jordan Preferential induction of apoptosis for primary human leukemic stem cells Proc. Natl. Acad. Sci. USA 99 2002 16220 16225
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 16220-16225
-
-
Guzman, M.L.1
Swiderski, C.F.2
Howard, D.S.3
Grimes, B.A.4
Rossi, R.M.5
Szilvassy, S.J.6
Jordan, C.T.7
-
29
-
-
0029804371
-
Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor
-
D.E. Hogge, P.M. Lansdorp, D. Reid, B. Gerhard, and C.J. Eaves Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor Blood 88 1996 3765 3773
-
(1996)
Blood
, vol.88
, pp. 3765-3773
-
-
Hogge, D.E.1
Lansdorp, P.M.2
Reid, D.3
Gerhard, B.4
Eaves, C.J.5
-
30
-
-
0033568250
-
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia
-
T. Holyoake, X. Jiang, C. Eaves, and A. Eaves Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia Blood 94 1999 2056 2064
-
(1999)
Blood
, vol.94
, pp. 2056-2064
-
-
Holyoake, T.1
Jiang, X.2
Eaves, C.3
Eaves, A.4
-
31
-
-
0034689031
-
Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
-
M. Horita, E.J. Andreu, A. Benito, C. Arbona, C. Sanz, I. Benet, F. Prosper, and J.L. Fernandez-Luna Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL J. Exp. Med. 191 2000 977 984
-
(2000)
J. Exp. Med.
, vol.191
, pp. 977-984
-
-
Horita, M.1
Andreu, E.J.2
Benito, A.3
Arbona, C.4
Sanz, C.5
Benet, I.6
Prosper, F.7
Fernandez-Luna, J.L.8
-
32
-
-
0042190662
-
Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias
-
S. Jaiswal, D. Traver, T. Miyamoto, K. Akashi, E. Lagasse, and I.L. Weissman Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias Proc. Natl. Acad. Sci. USA 100 2003 10002 10007
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10002-10007
-
-
Jaiswal, S.1
Traver, D.2
Miyamoto, T.3
Akashi, K.4
Lagasse, E.5
Weissman, I.L.6
-
33
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
C.H. Jamieson, L.E. Ailles, S.J. Dylla, M. Muijtjens, C. Jones, J.L. Zehnder, J. Gotlib, K. Li, M.G. Manz, and A. Keating Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML N. Engl. J. Med. 351 2004 657 667
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 657-667
-
-
Jamieson, C.H.1
Ailles, L.E.2
Dylla, S.J.3
Muijtjens, M.4
Jones, C.5
Zehnder, J.L.6
Gotlib, J.7
Li, K.8
Manz, M.G.9
Keating, A.10
-
35
-
-
0036040031
-
The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells
-
M. Konopleva, S. Zhao, W. Hu, S. Jiang, V. Snell, D. Weidner, C.E. Jackson, X. Zhang, R. Champlin, and E. Estey The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells Br. J. Haematol. 118 2002 521 534
-
(2002)
Br. J. Haematol.
, vol.118
, pp. 521-534
-
-
Konopleva, M.1
Zhao, S.2
Hu, W.3
Jiang, S.4
Snell, V.5
Weidner, D.6
Jackson, C.E.7
Zhang, X.8
Champlin, R.9
Estey, E.10
-
36
-
-
33746498580
-
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
-
A.V. Krivtsov, D. Twomey, Z. Feng, M.C. Stubbs, Y. Wang, J. Faber, J.E. Levine, J. Wang, W.C. Hahn, and D.G. Gilliland Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9 Nature 442 2006 818 822
-
(2006)
Nature
, vol.442
, pp. 818-822
-
-
Krivtsov, A.V.1
Twomey, D.2
Feng, Z.3
Stubbs, M.C.4
Wang, Y.5
Faber, J.6
Levine, J.E.7
Wang, J.8
Hahn, W.C.9
Gilliland, D.G.10
-
37
-
-
33749510073
-
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
-
J. Kuroda, H. Puthalakath, M.S. Cragg, P.N. Kelly, P. Bouillet, D.C. Huang, S. Kimura, O.G. Ottmann, B.J. Druker, and A. Villunger Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic Proc. Natl. Acad. Sci. USA 103 2006 14907 14912
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 14907-14912
-
-
Kuroda, J.1
Puthalakath, H.2
Cragg, M.S.3
Kelly, P.N.4
Bouillet, P.5
Huang, D.C.6
Kimura, S.7
Ottmann, O.G.8
Druker, B.J.9
Villunger, A.10
-
38
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
T. Lapidot, C. Sirard, J. Vormoor, B. Murdoch, T. Hoang, J. Caceres-Cortes, M. Minden, B. Paterson, M.A. Caligiuri, and J.E. Dick A cell initiating human acute myeloid leukaemia after transplantation into SCID mice Nature 367 1994 645 648
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
Minden, M.7
Paterson, B.8
Caligiuri, M.A.9
Dick, J.E.10
-
39
-
-
84859650054
-
Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors
-
D.H. Mak, R.Y. Wang, W.D. Schober, M. Konopleva, J. Cortes, H. Kantarjian, M. Andreeff, and B.Z. Carter Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors Leukemia 26 2012 788 794
-
(2012)
Leukemia
, vol.26
, pp. 788-794
-
-
Mak, D.H.1
Wang, R.Y.2
Schober, W.D.3
Konopleva, M.4
Cortes, J.5
Kantarjian, H.6
Andreeff, M.7
Carter, B.Z.8
-
40
-
-
0019307897
-
Involvement of the B-lymphoid system in chronic myelogenous leukaemia
-
P.J. Martin, V. Najfeld, J.A. Hansen, G.K. Penfold, R.J. Jacobson, and P.J. Fialkow Involvement of the B-lymphoid system in chronic myelogenous leukaemia Nature 287 1980 49 50
-
(1980)
Nature
, vol.287
, pp. 49-50
-
-
Martin, P.J.1
Najfeld, V.2
Hansen, J.A.3
Penfold, G.K.4
Jacobson, R.J.5
Fialkow, P.J.6
-
41
-
-
75649084233
-
A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib
-
S.K. McWeeney, L.C. Pemberton, M.M. Loriaux, K. Vartanian, S.G. Willis, G. Yochum, B. Wilmot, Y. Turpaz, R. Pillai, and B.J. Druker A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib Blood 115 2010 315 325
-
(2010)
Blood
, vol.115
, pp. 315-325
-
-
McWeeney, S.K.1
Pemberton, L.C.2
Loriaux, M.M.3
Vartanian, K.4
Willis, S.G.5
Yochum, G.6
Wilmot, B.7
Turpaz, Y.8
Pillai, R.9
Druker, B.J.10
-
42
-
-
33745684527
-
Metastasis: A question of life or death
-
P. Mehlen, and A. Puisieux Metastasis: a question of life or death Nat. Rev. Cancer 6 2006 449 458
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 449-458
-
-
Mehlen, P.1
Puisieux, A.2
-
43
-
-
36048943429
-
(-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells
-
Y. Meng, Y. Li, J. Li, H. Li, J. Fu, Y. Liu, H. Liu, and X. Chen (-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells Leuk. Lymphoma 48 2007 2204 2212
-
(2007)
Leuk. Lymphoma
, vol.48
, pp. 2204-2212
-
-
Meng, Y.1
Li, Y.2
Li, J.3
Li, H.4
Fu, J.5
Liu, Y.6
Liu, H.7
Chen, X.8
-
44
-
-
77956233247
-
A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
-
M. Milyavsky, O.I. Gan, M. Trottier, M. Komosa, O. Tabach, F. Notta, E. Lechman, K.G. Hermans, K. Eppert, and Z. Konovalova A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal Cell Stem Cell 7 2010 186 197
-
(2010)
Cell Stem Cell
, vol.7
, pp. 186-197
-
-
Milyavsky, M.1
Gan, O.I.2
Trottier, M.3
Komosa, M.4
Tabach, O.5
Notta, F.6
Lechman, E.7
Hermans, K.G.8
Eppert, K.9
Konovalova, Z.10
-
45
-
-
77955662560
-
An alternative splicing network links cell-cycle control to apoptosis
-
M.J. Moore, Q. Wang, C.J. Kennedy, and P.A. Silver An alternative splicing network links cell-cycle control to apoptosis Cell 142 2010 625 636
-
(2010)
Cell
, vol.142
, pp. 625-636
-
-
Moore, M.J.1
Wang, Q.2
Kennedy, C.J.3
Silver, P.A.4
-
46
-
-
84862777672
-
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
-
K.P. Ng, A.M. Hillmer, C.T. Chuah, W.C. Juan, T.K. Ko, A.S. Teo, P.N. Ariyaratne, N. Takahashi, K. Sawada, and Y. Fei A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer Nat. Med. 18 2012 521 528
-
(2012)
Nat. Med.
, vol.18
, pp. 521-528
-
-
Ng, K.P.1
Hillmer, A.M.2
Chuah, C.T.3
Juan, W.C.4
Ko, T.K.5
Teo, A.S.6
Ariyaratne, P.N.7
Takahashi, N.8
Sawada, K.9
Fei, Y.10
-
47
-
-
33845540617
-
Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice
-
M. Ninomiya, A. Abe, A. Katsumi, J. Xu, M. Ito, F. Arai, T. Suda, M. Ito, H. Kiyoi, T. Kinoshita, and T. Naoe Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice Leukemia 21 2007 136 142
-
(2007)
Leukemia
, vol.21
, pp. 136-142
-
-
Ninomiya, M.1
Abe, A.2
Katsumi, A.3
Xu, J.4
Ito, M.5
Arai, F.6
Suda, T.7
Ito, M.8
Kiyoi, H.9
Kinoshita, T.10
Naoe, T.11
-
48
-
-
0030476922
-
The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
-
L.A. O'Reilly, D.C. Huang, and A. Strasser The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry EMBO J. 15 1996 6979 6990
-
(1996)
EMBO J.
, vol.15
, pp. 6979-6990
-
-
O'Reilly, L.A.1
Huang, D.C.2
Strasser, A.3
-
49
-
-
0030879407
-
Bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors
-
L.A. O'Reilly, A.W. Harris, and A. Strasser bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors Int. Immunol. 9 1997 1291 1301
-
(1997)
Int. Immunol.
, vol.9
, pp. 1291-1301
-
-
O'Reilly, L.A.1
Harris, A.W.2
Strasser, A.3
-
50
-
-
0031230361
-
Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo
-
L.A. O'Reilly, A.W. Harris, D.M. Tarlinton, L.M. Corcoran, and A. Strasser Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo J. Immunol. 159 1997 2301 2311
-
(1997)
J. Immunol.
, vol.159
, pp. 2301-2311
-
-
O'Reilly, L.A.1
Harris, A.W.2
Tarlinton, D.M.3
Corcoran, L.M.4
Strasser, A.5
-
51
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
T. Oltersdorf, S.W. Elmore, A.R. Shoemaker, R.C. Armstrong, D.J. Augeri, B.A. Belli, M. Bruncko, T.L. Deckwerth, J. Dinges, and P.J. Hajduk An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature 435 2005 677 681
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
-
52
-
-
79953719297
-
A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
-
W.J. Placzek, J. Wei, S. Kitada, D. Zhai, J.C. Reed, and M. Pellecchia A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy Cell Death Dis. 1 2010 e40
-
(2010)
Cell Death Dis.
, vol.1
, pp. 40
-
-
Placzek, W.J.1
Wei, J.2
Kitada, S.3
Zhai, D.4
Reed, J.C.5
Pellecchia, M.6
-
53
-
-
33644525274
-
Gene expression changes associated with progression and response in chronic myeloid leukemia
-
J.P. Radich, H. Dai, M. Mao, V. Oehler, J. Schelter, B. Druker, C. Sawyers, N. Shah, W. Stock, and C.L. Willman Gene expression changes associated with progression and response in chronic myeloid leukemia Proc. Natl. Acad. Sci. USA 103 2006 2794 2799
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2794-2799
-
-
Radich, J.P.1
Dai, H.2
Mao, M.3
Oehler, V.4
Schelter, J.5
Druker, B.6
Sawyers, C.7
Shah, N.8
Stock, W.9
Willman, C.L.10
-
54
-
-
43549112759
-
Bcl-2-family proteins and hematologic malignancies: History and future prospects
-
J.C. Reed Bcl-2-family proteins and hematologic malignancies: history and future prospects Blood 111 2008 3322 3330
-
(2008)
Blood
, vol.111
, pp. 3322-3330
-
-
Reed, J.C.1
-
55
-
-
77749317560
-
Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML
-
Y. Saito, N. Uchida, S. Tanaka, N. Suzuki, M. Tomizawa-Murasawa, A. Sone, Y. Najima, S. Takagi, Y. Aoki, and A. Wake Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML Nat. Biotechnol. 28 2010 275 280
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 275-280
-
-
Saito, Y.1
Uchida, N.2
Tanaka, S.3
Suzuki, N.4
Tomizawa-Murasawa, M.5
Sone, A.6
Najima, Y.7
Takagi, S.8
Aoki, Y.9
Wake, A.10
-
56
-
-
0029015690
-
Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2
-
I. Sánchez-García, and G. Grütz Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2 Proc. Natl. Acad. Sci. USA 92 1995 5287 5291
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5287-5291
-
-
Sánchez-García, I.1
Grütz, G.2
-
57
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
C.L. Sawyers, A. Hochhaus, E. Feldman, J.M. Goldman, C.B. Miller, O.G. Ottmann, C.A. Schiffer, M. Talpaz, F. Guilhot, and M.W. Deininger Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study Blood 99 2002 3530 3539
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
Goldman, J.M.4
Miller, C.B.5
Ottmann, O.G.6
Schiffer, C.A.7
Talpaz, M.8
Guilhot, F.9
Deininger, M.W.10
-
58
-
-
84866551054
-
Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome
-
C.I. Slape, J. Saw, J.B. Jowett, P.D. Aplan, A. Strasser, S.M. Jane, and D.J. Curtis Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome Blood 120 2012 2475 2483
-
(2012)
Blood
, vol.120
, pp. 2475-2483
-
-
Slape, C.I.1
Saw, J.2
Jowett, J.B.3
Aplan, P.D.4
Strasser, A.5
Jane, S.M.6
Curtis, D.J.7
-
59
-
-
65949096301
-
The CML stem cell: Evolution of the progenitor
-
S.A. Stuart, Y. Minami, and J.Y. Wang The CML stem cell: evolution of the progenitor Cell Cycle 8 2009 1338 1343
-
(2009)
Cell Cycle
, vol.8
, pp. 1338-1343
-
-
Stuart, S.A.1
Minami, Y.2
Wang, J.Y.3
-
60
-
-
0141790036
-
BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells
-
T. Tauchi, M. Sumi, A. Nakajima, G. Sashida, T. Shimamoto, and K. Ohyashiki BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells Clin Cancer Res. 9 2003 4267 4273
-
(2003)
Clin Cancer Res.
, vol.9
, pp. 4267-4273
-
-
Tauchi, T.1
Sumi, M.2
Nakajima, A.3
Sashida, G.4
Shimamoto, T.5
Ohyashiki, K.6
-
61
-
-
0029805403
-
Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival
-
G. Vairo, K.M. Innes, and J.M. Adams Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival Oncogene 13 1996 1511 1519
-
(1996)
Oncogene
, vol.13
, pp. 1511-1519
-
-
Vairo, G.1
Innes, K.M.2
Adams, J.M.3
-
62
-
-
78751676408
-
Cells of origin in cancer
-
J.E. Visvader Cells of origin in cancer Nature 469 2011 314 322
-
(2011)
Nature
, vol.469
, pp. 314-322
-
-
Visvader, J.E.1
-
63
-
-
66149147044
-
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
-
M. Vogler, M. Butterworth, A. Majid, R.J. Walewska, X.M. Sun, M.J. Dyer, and G.M. Cohen Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia Blood 113 2009 4403 4413
-
(2009)
Blood
, vol.113
, pp. 4403-4413
-
-
Vogler, M.1
Butterworth, M.2
Majid, A.3
Walewska, R.J.4
Sun, X.M.5
Dyer, M.J.6
Cohen, G.M.7
-
64
-
-
60849086456
-
Bcl-2 inhibitors: Small molecules with a big impact on cancer therapy
-
M. Vogler, D. Dinsdale, M.J. Dyer, and G.M. Cohen Bcl-2 inhibitors: small molecules with a big impact on cancer therapy Cell Death Differ. 16 2009 360 367
-
(2009)
Cell Death Differ.
, vol.16
, pp. 360-367
-
-
Vogler, M.1
Dinsdale, D.2
Dyer, M.J.3
Cohen, G.M.4
-
65
-
-
67650717805
-
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins
-
J. Wei, S. Kitada, M.F. Rega, J.L. Stebbins, D. Zhai, J. Cellitti, H. Yuan, A. Emdadi, R. Dahl, and Z. Zhang Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins J. Med. Chem. 52 2009 4511 4523
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4511-4523
-
-
Wei, J.1
Kitada, S.2
Rega, M.F.3
Stebbins, J.L.4
Zhai, D.5
Cellitti, J.6
Yuan, H.7
Emdadi, A.8
Dahl, R.9
Zhang, Z.10
-
66
-
-
77952719306
-
BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins
-
J. Wei, J.L. Stebbins, S. Kitada, R. Dash, W. Placzek, M.F. Rega, B. Wu, J. Cellitti, D. Zhai, and L. Yang BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins J. Med. Chem. 53 2010 4166 4176
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4166-4176
-
-
Wei, J.1
Stebbins, J.L.2
Kitada, S.3
Dash, R.4
Placzek, W.5
Rega, M.F.6
Wu, B.7
Cellitti, J.8
Zhai, D.9
Yang, L.10
-
67
-
-
77951442337
-
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
-
D. Yecies, N.E. Carlson, J. Deng, and A. Letai Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1 Blood 115 2010 3304 3313
-
(2010)
Blood
, vol.115
, pp. 3304-3313
-
-
Yecies, D.1
Carlson, N.E.2
Deng, J.3
Letai, A.4
-
68
-
-
80053900941
-
Frequent pathway mutations of splicing machinery in myelodysplasia
-
K. Yoshida, M. Sanada, Y. Shiraishi, D. Nowak, Y. Nagata, R. Yamamoto, Y. Sato, A. Sato-Otsubo, A. Kon, and M. Nagasaki Frequent pathway mutations of splicing machinery in myelodysplasia Nature 478 2011 64 69
-
(2011)
Nature
, vol.478
, pp. 64-69
-
-
Yoshida, K.1
Sanada, M.2
Shiraishi, Y.3
Nowak, D.4
Nagata, Y.5
Yamamoto, R.6
Sato, Y.7
Sato-Otsubo, A.8
Kon, A.9
Nagasaki, M.10
-
69
-
-
36649002031
-
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
-
C. Zhao, J. Blum, A. Chen, H.Y. Kwon, S.H. Jung, J.M. Cook, A. Lagoo, and T. Reya Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo Cancer Cell 12 2007 528 541
-
(2007)
Cancer Cell
, vol.12
, pp. 528-541
-
-
Zhao, C.1
Blum, J.2
Chen, A.3
Kwon, H.Y.4
Jung, S.H.5
Cook, J.M.6
Lagoo, A.7
Reya, T.8
-
70
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
C. Zhao, A. Chen, C.H. Jamieson, M. Fereshteh, A. Abrahamsson, J. Blum, H.Y. Kwon, J. Kim, J.P. Chute, and D. Rizzieri Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia Nature 458 2009 776 779
-
(2009)
Nature
, vol.458
, pp. 776-779
-
-
Zhao, C.1
Chen, A.2
Jamieson, C.H.3
Fereshteh, M.4
Abrahamsson, A.5
Blum, J.6
Kwon, H.Y.7
Kim, J.8
Chute, J.P.9
Rizzieri, D.10
-
71
-
-
33745954330
-
BCL2 family in DNA damage and cell cycle control
-
S. Zinkel, A. Gross, and E. Yang BCL2 family in DNA damage and cell cycle control Cell Death Differ. 13 2006 1351 1359
-
(2006)
Cell Death Differ.
, vol.13
, pp. 1351-1359
-
-
Zinkel, S.1
Gross, A.2
Yang, E.3
|