Mevalonate metabolism regulates basal breast cancer stem cells and is a potential therapeutic target

Stem Cells

Volumn 30, Issue 7, 2012, Pages 1327-1337

  Ginestier, Christophe ^a   Monville, Florence ^a   Wicinski, Julien ^a   Cabaud, Olivier ^a   Cervera, Nathalie ^a   Josselin, Emmanuelle ^a   Finetti, Pascal ^a   Guille, Arnaud ^a   Larderet, Gaelle ^a   Viens, Patrice ^a,b   Sebti, Said ^c,d   Bertucci, François ^a,b   Birnbaum, Daniel ^a   Charafe Jauffret, Emmanuelle ^a,b  

^a INSTITUT PAOLI CALMETTES   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Breast cancer; Cancer stem cells; Clinical translation; Gene expression

Indexed keywords

DOCETAXEL; GERANYLGERANYL PYROPHOSPHATE; GGTI 288; MEVALONIC ACID; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER STEM CELL; CARCINOGENICITY; CELL CYCLE PROGRESSION; CELL METABOLISM; CELL SUBPOPULATION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HUMAN; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR XENOGRAFT; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MEVALONIC ACID; MICE; MICE, SCID; NEOPLASMS, BASAL CELL; NEOPLASTIC STEM CELLS; TAXOIDS;

EID: 84862902027     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1122     Document Type: Article

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