Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel

Journal of Controlled Release

Volumn 140, Issue 3, 2009, Pages 277-283

  Liu, Changxing ^a   Zhao, Gang ^b   Liu, Jian ^b   Ma, Nianchun ^b   Chivukula, Padmanabh ^b   Perelman, Loren ^b   Okada, Keisaku ^b   Chen, Zongyou ^a   Gough, David ^c   Yu, Lei ^b  

^a FUDAN UNIVERSITY   (China)

^b Biomedical Group   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Gene delivery; Nanoparticle; Non viral carrier and lipid nanoparticle; siRNA delivery

Indexed keywords

ANTI-CANCER THERAPIES; CARRIER SYSTEMS; CELL POPULATIONS; CHEMOSENSITIVITY; COLON CANCER; DRUG RESISTANCE; GENE DELIVERY; GENE SILENCING; HUMAN COLON; HUMAN COLON CANCER; HYDROPHILIC POLYMERS; IN-VITRO; KEY FACTORS; LIPID COMPOSITION; LIPID NANOPARTICLES; MULTIDRUG RESISTANCE; NONVIRAL; OPTIMUM RATIO; PACLITAXEL; PHYSICOCHEMICAL PROPERTY; SIRNA DELIVERY; SPECIFIC SUBSET; STEM CELL; SURFACE CHARGE ANALYSIS;

BIODEGRADABLE POLYMERS; CELL CULTURE; CELL PROLIFERATION; CHEMOTHERAPY; CROSSLINKING; CRYOGENIC LIQUIDS; GENE TRANSFER; NANOPARTICLES; NUCLEIC ACIDS; PARTICLE SIZE ANALYSIS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMERS;

RNA;

CD133 ANTIGEN; MACROGOL; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; POLYETHYLENEIMINE; SMALL INTERFERING RNA;

ARTICLE; BIODEGRADABILITY; CANCER CELL CULTURE; CANCER STEM CELL; COLON CANCER; CONTROLLED STUDY; DRUG EFFICACY; DRUG SENSITIVITY; DRUG TARGETING; ENCAPSULATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID COMPOSITION; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURFACE CHARGE; SYNTHESIS;

ADJUVANTS, PHARMACEUTIC; ANTIGENS, CD; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATIONS; CELL LINE, TUMOR; COLONIC NEOPLASMS; CROSS-LINKING REAGENTS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; GLYCOPROTEINS; HUMANS; LIPIDS; LUCIFERASES; MOLECULAR WEIGHT; P-GLYCOPROTEIN; PACLITAXEL; PARTICLE SIZE; PEPTIDES; POLYETHYLENE GLYCOLS; POLYMERS; RNA, SMALL INTERFERING; SOLUBILITY; TRANSFECTION; WATER;

EID: 70449708980     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.08.013     Document Type: Article

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