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Volumn 16, Issue 11, 2014, Pages 1105-1117

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN RECEPTOR A4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN TYROSINE KINASE; THY 1 ANTIGEN;

EID: 84908485098     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3041     Document Type: Article
Times cited : (363)

References (67)
  • 1
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber, M. A., Kraut, N. & Beug, H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17, 548-558 (2005).
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 2
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890 (2009).
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 3
    • 84857817163 scopus 로고    scopus 로고
    • Slug and Sox9 cooperatively determine the mammary stem cell state
    • Guo, W. et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 148, 1015-1028 (2012).
    • (2012) Cell , vol.148 , pp. 1015-1028
    • Guo, W.1
  • 4
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008).
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1
  • 5
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel, A. P. et al. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS ONE 3, e2888 (2008).
    • (2008) PLoS ONE , vol.3 , pp. e2888
    • Morel, A.P.1
  • 6
    • 33847345143 scopus 로고    scopus 로고
    • Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition
    • Buck, E. et al. Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition. Mol. Cancer Ther. 6, 532-541 (2007).
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 532-541
    • Buck, E.1
  • 7
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton, C. J. et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc. Natl Acad. Sci. USA 106, 13820-13825 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 13820-13825
    • Creighton, C.J.1
  • 8
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta, P. B. et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138, 645-659 (2009).
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1
  • 9
    • 84866307571 scopus 로고    scopus 로고
    • Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling
    • Li, H. J., Reinhardt, F., Herschman, H. R. & Weinberg, R. A. Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov. 2, 840-855 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 840-855
    • Li, H.J.1    Reinhardt, F.2    Herschman, H.R.3    Weinberg, R.A.4
  • 10
    • 84855425160 scopus 로고    scopus 로고
    • Interactions between cancer stem cells and their niche govern metastatic colonization
    • Malanchi, I. et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481, 85-89 (2011).
    • (2011) Nature , vol.481 , pp. 85-89
    • Malanchi, I.1
  • 11
    • 79955681163 scopus 로고    scopus 로고
    • The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
    • Merlos-Suarez, A. et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell 8, 511-524 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 511-524
    • Merlos-Suarez, A.1
  • 12
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn, T. A., Chawla, A. & Pollard, J. W. Macrophage biology in development, homeostasis and disease. Nature 496, 445-455 (2013).
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 13
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: A magic bullet?
    • Coussens, L. M., Zitvogel, L. & Palucka, A. K. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science 339, 286-291 (2013).
    • (2013) Science , vol.339 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 15
    • 0035177216 scopus 로고    scopus 로고
    • Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    • Elenbaas, B. et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 15, 50-65 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 50-65
    • Elenbaas, B.1
  • 16
    • 0036583926 scopus 로고    scopus 로고
    • Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
    • Ong, S. E. et al. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell. Proteom. 1, 376-386 (2002).
    • (2002) Mol. Cell. Proteom. , vol.1 , pp. 376-386
    • Ong, S.E.1
  • 17
    • 84861151032 scopus 로고    scopus 로고
    • Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition
    • Udeshi, N. D. et al. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Mol. Cell. Proteomics 11, 148-159 (2012).
    • (2012) Mol. Cell. Proteomics , vol.11 , pp. 148-159
    • Udeshi, N.D.1
  • 18
  • 19
    • 1542619244 scopus 로고    scopus 로고
    • Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    • Wetzel, A. et al. Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J. Immunol. 172, 3850-3859 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 3850-3859
    • Wetzel, A.1
  • 20
    • 77955895963 scopus 로고    scopus 로고
    • Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
    • Lim, E. et al. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res. 12, R21 (2010).
    • (2010) Breast Cancer Res. , vol.12 , pp. R21
    • Lim, E.1
  • 21
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin, M. et al. Molecular definition of breast tumor heterogeneity. Cancer Cell 11, 259-273 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 259-273
    • Shipitsin, M.1
  • 22
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu, G. et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 17, 1253-1270 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 1253-1270
    • Dontu, G.1
  • 23
    • 0018871095 scopus 로고
    • Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)
    • Tsuchiya, S. et al. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int. J. Cancer 26, 171-176 (1980).
    • (1980) Int. J. Cancer , vol.26 , pp. 171-176
    • Tsuchiya, S.1
  • 24
    • 77956603259 scopus 로고    scopus 로고
    • Localization of CD44 and CD90 positive cells to the invasive front of breast tumors
    • Donnenberg, V. S. et al. Localization of CD44 and CD90 positive cells to the invasive front of breast tumors. Cytometry B Clin. Cytom. 78, 287-301 (2010).
    • (2010) Cytometry B Clin. Cytom. , vol.78 , pp. 287-301
    • Donnenberg, V.S.1
  • 26
    • 84864828790 scopus 로고    scopus 로고
    • The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
    • Medrek, C., Ponten, F., Jirstrom, K. & Leandersson, K. The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer 12, 306 (2012).
    • (2012) BMC Cancer , vol.12 , pp. 306
    • Medrek, C.1    Ponten, F.2    Jirstrom, K.3    Leandersson, K.4
  • 27
    • 24744454660 scopus 로고    scopus 로고
    • Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density
    • Tsutsui, S. et al. Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol. Rep. 14, 425-431 (2005).
    • (2005) Oncol. Rep. , vol.14 , pp. 425-431
    • Tsutsui, S.1
  • 28
    • 84876093272 scopus 로고    scopus 로고
    • In human invasive breast ductal carcinoma, tumor stromal macrophages and tumor nest macrophages have distinct relationships with clinicopathological parameters and tumor angiogenesis
    • Ch'ng, E. S., Tuan Sharif, S. E. & Jaafar, H. In human invasive breast ductal carcinoma, tumor stromal macrophages and tumor nest macrophages have distinct relationships with clinicopathological parameters and tumor angiogenesis. Virchows Arch. 462, 257-267 (2013).
    • (2013) Virchows Arch. , vol.462 , pp. 257-267
    • Ch'Ng, E.S.1    Tuan Sharif, S.E.2    Jaafar, H.3
  • 29
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian, B. Z. & Pollard, J. W. Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39-51 (2010).
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 30
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray, P. J. & Wynn, T. A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11, 723-737 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 31
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin, E. Y., Nguyen, A. V., Russell, R. G. & Pollard, J. W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193, 727-740 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 32
    • 79960690706 scopus 로고    scopus 로고
    • The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC
    • Ohri, C. M., Shikotra, A., Green, R. H., Waller, D. A. & Bradding, P. The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC. PLoS ONE 6, e21874 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e21874
    • Ohri, C.M.1    Shikotra, A.2    Green, R.H.3    Waller, D.A.4    Bradding, P.5
  • 34
    • 84878552107 scopus 로고    scopus 로고
    • Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8
    • Hartman, Z. C. et al. Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. Cancer Res. (2013).
    • (2013) Cancer Res.
    • Hartman, Z.C.1
  • 35
    • 80053531658 scopus 로고    scopus 로고
    • Regulation of cancer stem cells by cytokine networks: Attacking cancer's inflammatory roots
    • Korkaya, H., Liu, S. & Wicha, M. S. Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots. Clin. Cancer Res. 17, 6125-6129 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6125-6129
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 36
    • 4944229701 scopus 로고    scopus 로고
    • A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
    • Wyckoff, J. et al. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res. 64, 7022-7029 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 7022-7029
    • Wyckoff, J.1
  • 37
    • 84883621632 scopus 로고    scopus 로고
    • Protein Kinase C alpha is a central signaling node and therapeutic target for breast cancer stem cells
    • Tam, W. L. et al. Protein Kinase C alpha is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell 24, 347-364 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 347-364
    • Tam, W.L.1
  • 38
    • 57049132745 scopus 로고    scopus 로고
    • Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy
    • Thomson, S., Petti, F., Sujka-Kwok, I., Epstein, D. & Haley, J. D. Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy. Clin. Exp. Metastasis 25, 843-854 (2008).
    • (2008) Clin. Exp. Metastasis , vol.25 , pp. 843-854
    • Thomson, S.1    Petti, F.2    Sujka-Kwok, I.3    Epstein, D.4    Haley, J.D.5
  • 39
  • 40
    • 77649114060 scopus 로고    scopus 로고
    • Eph receptors and ephrins in cancer: Bidirectional signalling and beyond
    • Pasquale, E. B. Eph receptors and ephrins in cancer: Bidirectional signalling and beyond. Nat. Rev. Cancer 10, 165-180 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 165-180
    • Pasquale, E.B.1
  • 41
    • 84862486945 scopus 로고    scopus 로고
    • Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor
    • Lamberto, I. et al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445, 47-56 (2012).
    • (2012) Biochem. J. , vol.445 , pp. 47-56
    • Lamberto, I.1
  • 42
    • 34248386906 scopus 로고    scopus 로고
    • EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology
    • Zhou, L. et al. EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology. J. Neurosci. 27, 5127-5138 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 5127-5138
    • Zhou, L.1
  • 43
    • 33947603008 scopus 로고    scopus 로고
    • Protein kinase C and other diacylglycerol effectors in cancer
    • Griner, E. M. & Kazanietz, M. G. Protein kinase C and other diacylglycerol effectors in cancer. Nat. Rev. Cancer 7, 281-294 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 281-294
    • Griner, E.M.1    Kazanietz, M.G.2
  • 44
    • 0032879897 scopus 로고    scopus 로고
    • Signal transfer by eph receptors
    • Kalo, M. S. & Pasquale, E. B. Signal transfer by eph receptors. Cell Tissue Res. 298, 1-9 (1999).
    • (1999) Cell Tissue Res. , vol.298 , pp. 1-9
    • Kalo, M.S.1    Pasquale, E.B.2
  • 45
    • 67651049300 scopus 로고    scopus 로고
    • Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha
    • Lu, Z. G., Liu, H., Yamaguchi, T., Miki, Y. & Yoshida, K. Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha. Cancer Res. 69, 5927-5935 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 5927-5935
    • Lu, Z.G.1    Liu, H.2    Yamaguchi, T.3    Miki, Y.4    Yoshida, K.5
  • 47
    • 78651405510 scopus 로고    scopus 로고
    • Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor
    • Sasaki, C. Y., Ghosh, P. & Longo, D. L. Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor. J. Biol. Chem. 286, 1093-1102 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 1093-1102
    • Sasaki, C.Y.1    Ghosh, P.2    Longo, D.L.3
  • 48
    • 84864147209 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 cooperatively induce IL6 in starved cancer cells
    • Yoon, S. et al. NF-kappaB and STAT3 cooperatively induce IL6 in starved cancer cells. Oncogene. 31, 3467-3481 (2012).
    • (2012) Oncogene. , vol.31 , pp. 3467-3481
    • Yoon, S.1
  • 49
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-kappaB in p53-mediated programmed cell death
    • Ryan, K. M., Ernst, M. K., Rice, N. R. & Vousden, K. H. Role of NF-kappaB in p53-mediated programmed cell death. Nature 404, 892-897 (2000).
    • (2000) Nature , vol.404 , pp. 892-897
    • Ryan, K.M.1    Ernst, M.K.2    Rice, N.R.3    Vousden, K.H.4
  • 50
    • 84864942150 scopus 로고    scopus 로고
    • TWIST1 associates with NF-kappaB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production
    • Li, S. et al. TWIST1 associates with NF-kappaB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production. BMC Biol. 10, 73 (2012).
    • (2012) BMC Biol. , vol.10 , pp. 73
    • Li, S.1
  • 51
    • 79959555698 scopus 로고    scopus 로고
    • Detection of minor subpopulations of colorectal adenocarcinoma cells expressing cancer stem cell markers
    • Gisina, A. M. et al. Detection of minor subpopulations of colorectal adenocarcinoma cells expressing cancer stem cell markers. Bull. Exp. Biol. Med. 151, 234-238 (2011).
    • (2011) Bull. Exp. Biol. Med. , vol.151 , pp. 234-238
    • Gisina, A.M.1
  • 52
    • 84862317152 scopus 로고    scopus 로고
    • CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays
    • He, J. et al. CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays. Mol. Cell. Proteomics 11, M111 010744 (2012).
    • (2012) Mol. Cell. Proteomics , vol.11 , pp. 010744
    • He, J.1
  • 53
    • 84856963775 scopus 로고    scopus 로고
    • Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype
    • Jiang, J. et al. Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype. Oncogene. 31, 671-682 (2012).
    • (2012) Oncogene. , vol.31 , pp. 671-682
    • Jiang, J.1
  • 54
    • 38549139140 scopus 로고    scopus 로고
    • Significance of CD90+ cancer stem cells in human liver cancer
    • Yang, Z. F. et al. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 13, 153-166 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 153-166
    • Yang, Z.F.1
  • 55
    • 63449085055 scopus 로고    scopus 로고
    • Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers
    • Oki, M. et al. Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers. World J. Gastroenterol. 14, 5650-5656 (2008).
    • (2008) World J. Gastroenterol. , vol.14 , pp. 5650-5656
    • Oki, M.1
  • 56
    • 54849186500 scopus 로고    scopus 로고
    • Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer
    • Oshima, T. et al. Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer. Int. J. Oncol. 33, 573-577 (2008).
    • (2008) Int. J. Oncol. , vol.33 , pp. 573-577
    • Oshima, T.1
  • 57
    • 84870853546 scopus 로고    scopus 로고
    • The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas
    • Binda, E. et al. The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas. Cancer Cell 22, 765-780 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 765-780
    • Binda, E.1
  • 58
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22, 277 genes on breast cancer prognosis using microarray data of 1, 809 patients
    • Gyorffy, B. et al. An online survival analysis tool to rapidly assess the effect of 22, 277 genes on breast cancer prognosis using microarray data of 1, 809 patients. Breast Cancer Res. Treat. 123, 725-731 (2010).
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 725-731
    • Gyorffy, B.1
  • 59
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo, A. et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335-348 (2005).
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1
  • 60
    • 68149163281 scopus 로고    scopus 로고
    • A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression
    • Yu, M. et al. A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. Genes Dev. 23, 1737-1742 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 1737-1742
    • Yu, M.1
  • 61
    • 67649849871 scopus 로고    scopus 로고
    • Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
    • Shibue, T. & Weinberg, R. A. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc. Natl Acad. Sci. USA 106, 10290-10295 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 10290-10295
    • Shibue, T.1    Weinberg, R.A.2
  • 62
    • 0036599406 scopus 로고    scopus 로고
    • P53 stabilization is decreased upon NFkappaB activation: A role for NFkappaB in acquisition of resistance to chemotherapy
    • Tergaonkar, V., Pando, M., Vafa, O., Wahl, G. & Verma, I. p53 stabilization is decreased upon NFkappaB activation: A role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell 1, 493-503 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 493-503
    • Tergaonkar, V.1    Pando, M.2    Vafa, O.3    Wahl, G.4    Verma, I.5
  • 63
    • 0344375083 scopus 로고    scopus 로고
    • Lentivirus-delivered stable gene silencing by RNAi in primary cells
    • Stewart, S. A. et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9, 493-501 (2003).
    • (2003) RNA , vol.9 , pp. 493-501
    • Stewart, S.A.1
  • 64
    • 77649191794 scopus 로고    scopus 로고
    • Tbx3 improves the germ-line competency of induced pluripotent stem cells
    • Han, J. et al. Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature 463, 1096-1100 (2010).
    • (2010) Nature , vol.463 , pp. 1096-1100
    • Han, J.1
  • 65
    • 67650444760 scopus 로고    scopus 로고
    • ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
    • Hu, Y. & Smyth, G. K. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J. Immunol. Methods 347, 70-78 (2009).
    • (2009) J. Immunol. Methods , vol.347 , pp. 70-78
    • Hu, Y.1    Smyth, G.K.2
  • 66
    • 0345178412 scopus 로고
    • Serum-free growth of human mammary epithelial cells: Rapid clonal growth in defined medium and extended serial passage with pituitary extract
    • Hammond, S. L., Ham, R. G. & Stampfer, M. R. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc. Natl Acad. Sci. USA 81, 5435-5439 (1984).
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 5435-5439
    • Hammond, S.L.1    Ham, R.G.2    Stampfer, M.R.3
  • 67
    • 84859823928 scopus 로고    scopus 로고
    • The matrisome: In silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices
    • Naba, A. et al. The matrisome: In silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell. Proteomics 11, M111 014647 (2012).
    • (2012) Mol. Cell. Proteomics , vol.11 , pp. M111014647
    • Naba, A.1


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