Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling

Molecular Cancer Therapeutics

Volumn 13, Issue 7, 2014, Pages 1758-1771

  Balic, Anamaria ^a   Sørensen, Morten Drbæy ^a,b   Trabulo, Sara Maria ^a,d   Sainz Jr , Bruno ^a   Cioffi, Michele ^a   Vieira, Catarina R ^a   Miranda Lorenzo, Irene ^a   Hidalgo, Manuel ^a   Kleeff, Joerg ^c   Erkan, Mert ^c   Heeschen, Christopher ^a,d  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b AARHUS UNIVERSITY   (Denmark)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXY 1 METHYLTETRALIN; ACTIVIN; CD133 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CHLOROQUINE; GEMCITABINE; MESSENGER RNA; NODAL SIGNALING PROTEIN; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; STAT3 PROTEIN; STROMAL CELL DERIVED FACTOR 1; CXCR4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CANCER STEM CELL; CANCER SURVIVAL; CARCINOGENICITY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN CONTENT; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, PANCREATIC DUCTAL; CELL MOTION; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; GENETIC TRANSFECTION; METABOLISM; PANCREATIC NEOPLASMS; PATHOLOGY; RANDOMIZATION;

ANIMALS; AUTOPHAGY; CARCINOMA, PANCREATIC DUCTAL; CELL MOVEMENT; CELL PROLIFERATION; CHLOROQUINE; HEDGEHOG PROTEINS; HUMANS; MICE; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; RANDOM ALLOCATION; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84904168687     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-13-0948     Document Type: Article

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