Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model

Journal of Controlled Release

Volumn 184, Issue 1, 2014, Pages 67-78

  Andey, Terrick ^a   Marepally, Srujan ^a   Patel, Apurva ^a   Jackson, Tanise ^a   Sarkar, Shubhashish ^b   O'Connell, Malaney ^b   Reddy, Rakesh C ^c   Chellappan, Srikumar ^d   Singh, Pomila ^b   Singh, Mandip ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Annexin A2 shRNA; Gene delivery; Liposome delivery; Lung cancer stem cell; RNA interference; Tumor resistance

Indexed keywords

ANTIBIOTICS; BIOLOGICAL ORGANS; CHEMOTHERAPY; DISEASES; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GENE TRANSFER; MAMMALS; PLATINUM COMPOUNDS; POLYMERASE CHAIN REACTION; PROTEINS; RNA; STEM CELLS; TUMORS;

ANNEXINS; CAMPTOTHECIN (CPT); FLUORESCENCE IMAGING; GENE DELIVERY; LUNG CANCER; PROTEIN EXPRESSIONS; RNA INTERFERENCE; THERAPEUTIC EFFICACY;

CYTOLOGY;

ANXA2 PROTEIN; BETA CATENIN; CAMPTOTHECIN; CISPLATIN; DOCETAXEL; FLUOROURACIL; GEMCITABINE; LIPID; LIPOCORTIN 2; PLACEBO; PROTEIN; S100A10 PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MESSENGER RNA; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER SIZE; CANCER STEM CELL; CELL VIABILITY; CONTROLLED STUDY; FLUORESCENCE IMAGING; FLUORESCENCE MICROSCOPY; IN VIVO STUDY; LUNG CANCER; MALE; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; HUMAN; LUNG; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANNEXIN A2; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; LIPIDS; LUNG; LUNG NEOPLASMS; MALE; MICE; NEOPLASTIC STEM CELLS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR BURDEN;

EID: 84899802268     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.03.049     Document Type: Article

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