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Volumn 2, Issue , 2015, Pages 1605-1636

Physiological Mechanisms for the Metabolic Control of Reproduction

Author keywords

Ghrelin; GnRH; Insulin; Kiss1; Kisspeptins; Leptin; Metabolism; Obesity; Puberty; Reproduction

Indexed keywords


EID: 84942918803     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-397175-3.00035-1     Document Type: Chapter
Times cited : (9)

References (253)
  • 1
    • 84864067222 scopus 로고    scopus 로고
    • Kisspeptins and reproduction: physiological roles and regulatory mechanisms
    • Pinilla L., Aguilar E., Dieguez C., Millar R.P., Tena-Sempere M. Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev 2012, 92:1235-1316.
    • (2012) Physiol Rev , vol.92 , pp. 1235-1316
    • Pinilla, L.1    Aguilar, E.2    Dieguez, C.3    Millar, R.P.4    Tena-Sempere, M.5
  • 3
    • 84874407275 scopus 로고    scopus 로고
    • PI3K: an attractive candidate for the central integration of metabolism and reproduction
    • Acosta-Martinez M. PI3K: an attractive candidate for the central integration of metabolism and reproduction. Front Endocrinol (Lausanne) 2012, 2:110.
    • (2012) Front Endocrinol (Lausanne) , vol.2 , pp. 110
    • Acosta-Martinez, M.1
  • 4
    • 84873718098 scopus 로고    scopus 로고
    • Leptin signaling and circuits in puberty and fertility
    • Elias C.F., Purohit D. Leptin signaling and circuits in puberty and fertility. Cell Mol Life Sci 2012, 70:841-862.
    • (2012) Cell Mol Life Sci , vol.70 , pp. 841-862
    • Elias, C.F.1    Purohit, D.2
  • 5
    • 84855220278 scopus 로고    scopus 로고
    • Leptin action in pubertal development: recent advances and unanswered questions
    • Elias C.F. Leptin action in pubertal development: recent advances and unanswered questions. Trends Endocrinol Metab 2012, 23:9-15.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 9-15
    • Elias, C.F.1
  • 6
    • 33745902547 scopus 로고    scopus 로고
    • Novel signals for the integration of energy balance and reproduction
    • Fernandez-Fernandez R., Martini A.C., Navarro V.M., et al. Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol 2006, 254-255:127-132.
    • (2006) Mol Cell Endocrinol , pp. 127-132
    • Fernandez-Fernandez, R.1    Martini, A.C.2    Navarro, V.M.3
  • 7
    • 35948995689 scopus 로고    scopus 로고
    • Roles of ghrelin and leptin in the control of reproductive function
    • Tena-Sempere M. Roles of ghrelin and leptin in the control of reproductive function. Neuroendocrinology 2007, 86:229-241.
    • (2007) Neuroendocrinology , vol.86 , pp. 229-241
    • Tena-Sempere, M.1
  • 8
    • 77953915672 scopus 로고    scopus 로고
    • Insulin and NPY pathways and the control of GnRH function and puberty onset
    • Pralong F.P. Insulin and NPY pathways and the control of GnRH function and puberty onset. Mol Cell Endocrinol 2010, 324:82-86.
    • (2010) Mol Cell Endocrinol , vol.324 , pp. 82-86
    • Pralong, F.P.1
  • 9
    • 75449148131 scopus 로고
    • Body weight and food intake as initiating factors for puberty in the rat
    • Kennedy G.C., Mitra J. Body weight and food intake as initiating factors for puberty in the rat. J Physiol 1963, 166:408-418.
    • (1963) J Physiol , vol.166 , pp. 408-418
    • Kennedy, G.C.1    Mitra, J.2
  • 10
    • 0014960635 scopus 로고
    • Height and weight at menarche and a hypothesis of critical body weights and adolescent events
    • Frisch R.E., Revelle R. Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science 1970, 169:397-399.
    • (1970) Science , vol.169 , pp. 397-399
    • Frisch, R.E.1    Revelle, R.2
  • 11
    • 0015139115 scopus 로고
    • Height and weight at menarche and a hypothesis of menarche
    • Frisch R.E., Revelle R. Height and weight at menarche and a hypothesis of menarche. Arch Dis Child 1971, 46:695-701.
    • (1971) Arch Dis Child , vol.46 , pp. 695-701
    • Frisch, R.E.1    Revelle, R.2
  • 12
    • 0032739022 scopus 로고    scopus 로고
    • Neuroendocrine regulation and actions of leptin
    • Casanueva F.F., Dieguez C. Neuroendocrine regulation and actions of leptin. Front Neuroendocrinol 1999, 20:317-363.
    • (1999) Front Neuroendocrinol , vol.20 , pp. 317-363
    • Casanueva, F.F.1    Dieguez, C.2
  • 15
    • 0018279665 scopus 로고
    • Menarche and fatness: reexamination of the critical body composition hypothesis
    • Trussell J. Menarche and fatness: reexamination of the critical body composition hypothesis. Science 1978, 200:1506-1513.
    • (1978) Science , vol.200 , pp. 1506-1513
    • Trussell, J.1
  • 16
    • 0020320999 scopus 로고
    • Critical fat, menarche, and the maintenance of menstrual cycles: a critical review
    • Scott E.C., Johnston F.E. Critical fat, menarche, and the maintenance of menstrual cycles: a critical review. J Adolesc Health Care 1982, 2:249-260.
    • (1982) J Adolesc Health Care , vol.2 , pp. 249-260
    • Scott, E.C.1    Johnston, F.E.2
  • 18
    • 72449127495 scopus 로고    scopus 로고
    • Ovarian function and obesity-interrelationship, impact on women's reproductive lifespan and treatment options
    • Rachon D., Teede H. Ovarian function and obesity-interrelationship, impact on women's reproductive lifespan and treatment options. Mol Cell Endocrinol 2010, 316:172-179.
    • (2010) Mol Cell Endocrinol , vol.316 , pp. 172-179
    • Rachon, D.1    Teede, H.2
  • 19
    • 77951948444 scopus 로고    scopus 로고
    • Childhood obesity and adult morbidities
    • Biro F.M., Wien M. Childhood obesity and adult morbidities. Am J Clin Nutr 2010, 91:1499S-1505S.
    • (2010) Am J Clin Nutr , vol.91 , pp. 1499S-1505S
    • Biro, F.M.1    Wien, M.2
  • 21
    • 66149160246 scopus 로고    scopus 로고
    • Obesity and its relationship to infertility in men and women
    • [ix]
    • Loret de Mola J.R. Obesity and its relationship to infertility in men and women. Obstet Gynecol Clin North Am 2009, 36:333-346. [ix].
    • (2009) Obstet Gynecol Clin North Am , vol.36 , pp. 333-346
    • Loret de Mola, J.R.1
  • 22
    • 56649102174 scopus 로고    scopus 로고
    • Ghrelin as a pleotrophic modulator of gonadal function and reproduction
    • Tena-Sempere M. Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nat Clin Pract Endocrinol Metab 2008, 4:666-674.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 666-674
    • Tena-Sempere, M.1
  • 23
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas J.L., Gajiwala K.S., Maffei M., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995, 269:543-546.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 24
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague C.T., Farooqi I.S., Whitehead J.P., et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997, 387:903-908.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3
  • 26
    • 0141814637 scopus 로고    scopus 로고
    • Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    • de Roux N., Genin E., Carel J.C., Matsuda F., Chaussain J.L., Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 2003, 100:10972-10976.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10972-10976
    • de Roux, N.1    Genin, E.2    Carel, J.C.3    Matsuda, F.4    Chaussain, J.L.5    Milgrom, E.6
  • 27
    • 0142091653 scopus 로고    scopus 로고
    • The GPR54 gene as a regulator of puberty
    • Oct 23
    • Seminara S.B., Messager S., Chatzidaki E.E., et al. The GPR54 gene as a regulator of puberty. N Engl J Med 2003 Oct 23, 349(17):1614-1627.
    • (2003) N Engl J Med , vol.349 , Issue.17 , pp. 1614-1627
    • Seminara, S.B.1    Messager, S.2    Chatzidaki, E.E.3
  • 28
    • 0141794168 scopus 로고    scopus 로고
    • A rat model for the energetic regulation of gonadotropin secretion: role of the glucose-sensing mechanism in the brain
    • Kinoshita M., Moriyama R., Tsukamura H., Maeda K.I. A rat model for the energetic regulation of gonadotropin secretion: role of the glucose-sensing mechanism in the brain. Domest Anim Endocrinol 2003, 25:109-120.
    • (2003) Domest Anim Endocrinol , vol.25 , pp. 109-120
    • Kinoshita, M.1    Moriyama, R.2    Tsukamura, H.3    Maeda, K.I.4
  • 29
    • 44249092535 scopus 로고    scopus 로고
    • Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats
    • Sajapitak S., Iwata K., Shahab M., et al. Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats. Endocrinology 2008, 149:3016-3024.
    • (2008) Endocrinology , vol.149 , pp. 3016-3024
    • Sajapitak, S.1    Iwata, K.2    Shahab, M.3
  • 34
    • 0031014413 scopus 로고    scopus 로고
    • Early onset of reproductive function in normal female mice treated with leptin
    • Chehab F.F., Mounzih K., Lu R., Lim M.E. Early onset of reproductive function in normal female mice treated with leptin. Science 1997, 275:88-90.
    • (1997) Science , vol.275 , pp. 88-90
    • Chehab, F.F.1    Mounzih, K.2    Lu, R.3    Lim, M.E.4
  • 35
    • 0033575993 scopus 로고    scopus 로고
    • Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    • Farooqi I.S., Jebb S.A., Langmack G., et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999, 341:879-884.
    • (1999) N Engl J Med , vol.341 , pp. 879-884
    • Farooqi, I.S.1    Jebb, S.A.2    Langmack, G.3
  • 36
    • 0029953957 scopus 로고    scopus 로고
    • Leptin is a metabolic signal to the reproductive system
    • Barash I.A., Cheung C.C., Weigle D.S., et al. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996, 137:3144-3147.
    • (1996) Endocrinology , vol.137 , pp. 3144-3147
    • Barash, I.A.1    Cheung, C.C.2    Weigle, D.S.3
  • 37
    • 57849148921 scopus 로고    scopus 로고
    • KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications
    • Castellano J.M., Roa J., Luque R.M., et al. KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications. Peptides 2009, 30:139-145.
    • (2009) Peptides , vol.30 , pp. 139-145
    • Castellano, J.M.1    Roa, J.2    Luque, R.M.3
  • 38
    • 0030964490 scopus 로고    scopus 로고
    • Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage
    • Garcia-Mayor R.V., Andrade M.A., Rios M., Lage M., Dieguez C., Casanueva F.F. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab 1997, 82:2849-2855.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2849-2855
    • Garcia-Mayor, R.V.1    Andrade, M.A.2    Rios, M.3    Lage, M.4    Dieguez, C.5    Casanueva, F.F.6
  • 39
    • 0030930441 scopus 로고    scopus 로고
    • Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca mulatta)
    • Plant T.M., Durrant A.R. Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca mulatta). Endocrinology 1997, 138:4505-4508.
    • (1997) Endocrinology , vol.138 , pp. 4505-4508
    • Plant, T.M.1    Durrant, A.R.2
  • 41
    • 0037651108 scopus 로고    scopus 로고
    • The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    • Chan J.L., Heist K., DePaoli A.M., Veldhuis J.D., Mantzoros C.S. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 2003, 111:1409-1421.
    • (2003) J Clin Invest , vol.111 , pp. 1409-1421
    • Chan, J.L.1    Heist, K.2    DePaoli, A.M.3    Veldhuis, J.D.4    Mantzoros, C.S.5
  • 42
    • 80054742593 scopus 로고    scopus 로고
    • Leptin is not the critical signal for kisspeptin or luteinising hormone restoration during exit from negative energy balance
    • True C., Kirigiti M.A., Kievit P., Grove K.L., Susan Smith M. Leptin is not the critical signal for kisspeptin or luteinising hormone restoration during exit from negative energy balance. J Neuroendocrinol 2011, 23:1099-1112.
    • (2011) J Neuroendocrinol , vol.23 , pp. 1099-1112
    • True, C.1    Kirigiti, M.A.2    Kievit, P.3    Grove, K.L.4    Susan Smith, M.5
  • 43
    • 34248661282 scopus 로고    scopus 로고
    • Changes in insulin, glucose and ketone bodies, but not leptin or body fat content precede restoration of luteinising hormone secretion in ewes
    • Szymanski L.A., Schneider J.E., Friedman M.I., et al. Changes in insulin, glucose and ketone bodies, but not leptin or body fat content precede restoration of luteinising hormone secretion in ewes. J Neuroendocrinol 2007, 19:449-460.
    • (2007) J Neuroendocrinol , vol.19 , pp. 449-460
    • Szymanski, L.A.1    Schneider, J.E.2    Friedman, M.I.3
  • 45
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning J.C., Gautam D., Burks D.J., et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000, 289:2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 46
    • 0141673466 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone secretion from hypothalamic neurons: stimulation by insulin and potentiation by leptin
    • Burcelin R., Thorens B., Glauser M., Gaillard R.C., Pralong F.P. Gonadotropin-releasing hormone secretion from hypothalamic neurons: stimulation by insulin and potentiation by leptin. Endocrinology 2003, 144:4484-4491.
    • (2003) Endocrinology , vol.144 , pp. 4484-4491
    • Burcelin, R.1    Thorens, B.2    Glauser, M.3    Gaillard, R.C.4    Pralong, F.P.5
  • 47
    • 61749097633 scopus 로고    scopus 로고
    • Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients
    • Moret M., Stettler R., Rodieux F., et al. Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients. Neuroendocrinology 2009, 89:131-139.
    • (2009) Neuroendocrinology , vol.89 , pp. 131-139
    • Moret, M.1    Stettler, R.2    Rodieux, F.3
  • 48
    • 33846032275 scopus 로고    scopus 로고
    • Gastrointestinal regulation of food intake
    • Cummings D.E., Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007, 117:13-23.
    • (2007) J Clin Invest , vol.117 , pp. 13-23
    • Cummings, D.E.1    Overduin, J.2
  • 49
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • van der Lely A.J., Tschop M., Heiman M.L., Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004, 25:426-457.
    • (2004) Endocr Rev , vol.25 , pp. 426-457
    • van der Lely, A.J.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4
  • 50
    • 35948929766 scopus 로고    scopus 로고
    • Central and peripheral roles of ghrelin on glucose homeostasis
    • Sun Y., Asnicar M., Smith R.G. Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology 2007, 86:215-228.
    • (2007) Neuroendocrinology , vol.86 , pp. 215-228
    • Sun, Y.1    Asnicar, M.2    Smith, R.G.3
  • 51
    • 0043030280 scopus 로고    scopus 로고
    • Minireview: from anorexia to obesity-the yin and yang of body weight control
    • Zigman J.M., Elmquist J.K. Minireview: from anorexia to obesity-the yin and yang of body weight control. Endocrinology 2003, 144:3749-3756.
    • (2003) Endocrinology , vol.144 , pp. 3749-3756
    • Zigman, J.M.1    Elmquist, J.K.2
  • 52
    • 35648974703 scopus 로고    scopus 로고
    • Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis
    • Tena-Sempere M. Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis. Vitam Horm 2008, 77:285-300.
    • (2008) Vitam Horm , vol.77 , pp. 285-300
    • Tena-Sempere, M.1
  • 53
    • 33744459206 scopus 로고    scopus 로고
    • Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies
    • Fernandez-Fernandez R., Tena-Sempere M., Navarro V.M., et al. Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies. Neuroendocrinology 2005, 82:245-255.
    • (2005) Neuroendocrinology , vol.82 , pp. 245-255
    • Fernandez-Fernandez, R.1    Tena-Sempere, M.2    Navarro, V.M.3
  • 54
    • 33645882953 scopus 로고    scopus 로고
    • Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats
    • Martini A.C., Fernandez-Fernandez R., Tovar S., et al. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 2006, 147:2374-2382.
    • (2006) Endocrinology , vol.147 , pp. 2374-2382
    • Martini, A.C.1    Fernandez-Fernandez, R.2    Tovar, S.3
  • 55
    • 22144497185 scopus 로고    scopus 로고
    • Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat
    • Fernandez-Fernandez R., Navarro V.M., Barreiro M.L., et al. Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology 2005, 146:3018-3025.
    • (2005) Endocrinology , vol.146 , pp. 3018-3025
    • Fernandez-Fernandez, R.1    Navarro, V.M.2    Barreiro, M.L.3
  • 56
    • 0347755156 scopus 로고    scopus 로고
    • Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures
    • Soriano-Guillen L., Barrios V., Chowen J.A., et al. Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures. J Pediatr 2004, 144:30-35.
    • (2004) J Pediatr , vol.144 , pp. 30-35
    • Soriano-Guillen, L.1    Barrios, V.2    Chowen, J.A.3
  • 57
    • 0035834586 scopus 로고    scopus 로고
    • Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats
    • Furuta M., Funabashi T., Kimura F. Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun 2001, 288:780-785.
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 780-785
    • Furuta, M.1    Funabashi, T.2    Kimura, F.3
  • 59
    • 8744313973 scopus 로고    scopus 로고
    • Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey
    • Vulliemoz N.R., Xiao E., Xia-Zhang L., Germond M., Rivier J., Ferin M. Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab 2004, 89:5718-5723.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5718-5723
    • Vulliemoz, N.R.1    Xiao, E.2    Xia-Zhang, L.3    Germond, M.4    Rivier, J.5    Ferin, M.6
  • 60
    • 29344456423 scopus 로고    scopus 로고
    • Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep
    • Iqbal J., Kurose Y., Canny B., Clarke I.J. Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology 2006, 147:510-519.
    • (2006) Endocrinology , vol.147 , pp. 510-519
    • Iqbal, J.1    Kurose, Y.2    Canny, B.3    Clarke, I.J.4
  • 62
    • 51649085619 scopus 로고    scopus 로고
    • Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH, in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis
    • Lanfranco F., Bonelli L., Baldi M., Me E., Broglio F., Ghigo E. Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH, in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. J Clin Endocrinol Metab 2008, 93:3633-3639.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3633-3639
    • Lanfranco, F.1    Bonelli, L.2    Baldi, M.3    Me, E.4    Broglio, F.5    Ghigo, E.6
  • 63
    • 42449138247 scopus 로고    scopus 로고
    • Photoperiod influences the central effects of ghrelin on food intake, GH and LH secretion in sheep
    • Harrison J.L., Miller D.W., Findlay P.A., Adam C.L. Photoperiod influences the central effects of ghrelin on food intake, GH and LH secretion in sheep. Neuroendocrinology 2008, 87:182-192.
    • (2008) Neuroendocrinology , vol.87 , pp. 182-192
    • Harrison, J.L.1    Miller, D.W.2    Findlay, P.A.3    Adam, C.L.4
  • 64
    • 84926112143 scopus 로고    scopus 로고
    • Ghrelin and anterior pituitary function
    • Lanfranco F., Motta G., Baldi M., et al. Ghrelin and anterior pituitary function. Front Horm Res 2010, 38:206-211.
    • (2010) Front Horm Res , vol.38 , pp. 206-211
    • Lanfranco, F.1    Motta, G.2    Baldi, M.3
  • 65
    • 84863372155 scopus 로고    scopus 로고
    • Role of ghrelin on estrogen and progesterone secretion in the adult rat ovary during estrous cycle
    • Fang F., Wang L., Zhang Y., Li Y., Su S., Zhang X. Role of ghrelin on estrogen and progesterone secretion in the adult rat ovary during estrous cycle. Syst Biol Reprod Med 2012, 58:116-119.
    • (2012) Syst Biol Reprod Med , vol.58 , pp. 116-119
    • Fang, F.1    Wang, L.2    Zhang, Y.3    Li, Y.4    Su, S.5    Zhang, X.6
  • 66
    • 47649098401 scopus 로고    scopus 로고
    • Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats
    • Sirotkin A.V., Chrenkova M., Nitrayova S., et al. Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats. Peptides 2008, 29:1362-1368.
    • (2008) Peptides , vol.29 , pp. 1362-1368
    • Sirotkin, A.V.1    Chrenkova, M.2    Nitrayova, S.3
  • 67
    • 70349234464 scopus 로고    scopus 로고
    • Ghrelin and leptin levels in relation to puberty and reproductive function in patients with beta-thalassemia
    • Moshtaghi-Kashanian G.R., Razavi F. Ghrelin and leptin levels in relation to puberty and reproductive function in patients with beta-thalassemia. Hormones (Athens) 2009, 8:207-213.
    • (2009) Hormones (Athens) , vol.8 , pp. 207-213
    • Moshtaghi-Kashanian, G.R.1    Razavi, F.2
  • 69
    • 58149380112 scopus 로고    scopus 로고
    • The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training
    • Fernandez-Real J.M., Izquierdo M., Ortega F., et al. The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab 2009, 94:237-245.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 237-245
    • Fernandez-Real, J.M.1    Izquierdo, M.2    Ortega, F.3
  • 70
    • 79959208070 scopus 로고    scopus 로고
    • Osteocalcin: a new link between bone and energy metabolism. Some evolutionary clues
    • Fernandez-Real J.M., Ricart W. Osteocalcin: a new link between bone and energy metabolism. Some evolutionary clues. Curr Opin Clin Nutr Metab Care 2011, 14:360-366.
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , pp. 360-366
    • Fernandez-Real, J.M.1    Ricart, W.2
  • 71
    • 79952289069 scopus 로고    scopus 로고
    • Endocrine regulation of male fertility by the skeleton
    • Oury F., Sumara G., Sumara O., et al. Endocrine regulation of male fertility by the skeleton. Cell 2011, 144:796-809.
    • (2011) Cell , vol.144 , pp. 796-809
    • Oury, F.1    Sumara, G.2    Sumara, O.3
  • 72
    • 84866285290 scopus 로고    scopus 로고
    • Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons
    • Wen J.P., Liu C., Bi W.K., et al. Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons. J Endocrinol 2012, 214:177-189.
    • (2012) J Endocrinol , vol.214 , pp. 177-189
    • Wen, J.P.1    Liu, C.2    Bi, W.K.3
  • 73
    • 44349194320 scopus 로고    scopus 로고
    • Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential
    • Wen J.P., Lv W.S., Yang J., et al. Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential. Biochem Biophys Res Commun 2008, 371:756-761.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 756-761
    • Wen, J.P.1    Lv, W.S.2    Yang, J.3
  • 74
    • 40849092830 scopus 로고    scopus 로고
    • Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes
    • Lu M., Tang Q., Olefsky J.M., Mellon P.L., Webster N.J. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol 2008, 22:760-771.
    • (2008) Mol Endocrinol , vol.22 , pp. 760-771
    • Lu, M.1    Tang, Q.2    Olefsky, J.M.3    Mellon, P.L.4    Webster, N.J.5
  • 76
    • 84870839791 scopus 로고    scopus 로고
    • Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic beta-cell impairments in type 2 diabetes
    • Dalle S., Burcelin R., Gourdy P., et al. Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic beta-cell impairments in type 2 diabetes. Cell Signal 2013, 25:570-4579.
    • (2013) Cell Signal , vol.25 , pp. 570-4579
    • Dalle, S.1    Burcelin, R.2    Gourdy, P.3
  • 78
    • 84870343305 scopus 로고    scopus 로고
    • Minireview: the year in review of estrogen regulation of metabolism
    • Clegg D.J. Minireview: the year in review of estrogen regulation of metabolism. Mol Endocrinol 2012, 26:1957-1960.
    • (2012) Mol Endocrinol , vol.26 , pp. 1957-1960
    • Clegg, D.J.1
  • 79
    • 80053899725 scopus 로고    scopus 로고
    • Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction
    • Xu Y., Nedungadi T.P., Zhu L., et al. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab 2011, 14:453-465.
    • (2011) Cell Metab , vol.14 , pp. 453-465
    • Xu, Y.1    Nedungadi, T.P.2    Zhu, L.3
  • 80
    • 66649136446 scopus 로고    scopus 로고
    • Leptin indirectly regulates gonadotropin-releasing hormone neuronal function
    • Quennell J.H., Mulligan A.C., Tups A., et al. Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology 2009, 150:2805-2812.
    • (2009) Endocrinology , vol.150 , pp. 2805-2812
    • Quennell, J.H.1    Mulligan, A.C.2    Tups, A.3
  • 81
    • 0032919990 scopus 로고    scopus 로고
    • Leptin's actions on the reproductive axis: perspectives and mechanisms
    • Cunningham M.J., Clifton D.K., Steiner R.A. Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 1999, 60:216-222.
    • (1999) Biol Reprod , vol.60 , pp. 216-222
    • Cunningham, M.J.1    Clifton, D.K.2    Steiner, R.A.3
  • 82
    • 0034777246 scopus 로고    scopus 로고
    • New evidence for estrogen receptors in gonadotropin-releasing hormone neurons
    • Herbison A.E., Pape J.R. New evidence for estrogen receptors in gonadotropin-releasing hormone neurons. Front Neuroendocrinol 2001, 22:292-308.
    • (2001) Front Neuroendocrinol , vol.22 , pp. 292-308
    • Herbison, A.E.1    Pape, J.R.2
  • 83
    • 84055191689 scopus 로고    scopus 로고
    • Sex steroids and the control of the Kiss1 system: developmental roles and major regulatory actions
    • Garcia-Galiano D., Pinilla L., Tena-Sempere M. Sex steroids and the control of the Kiss1 system: developmental roles and major regulatory actions. J Neuroendocrinol 2012, 24:22-33.
    • (2012) J Neuroendocrinol , vol.24 , pp. 22-33
    • Garcia-Galiano, D.1    Pinilla, L.2    Tena-Sempere, M.3
  • 85
    • 0031963436 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
    • Hakansson M.L., Brown H., Ghilardi N., Skoda R.C., Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 1998, 18:559-572.
    • (1998) J Neurosci , vol.18 , pp. 559-572
    • Hakansson, M.L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 86
    • 77955291345 scopus 로고    scopus 로고
    • Divergent roles of growth factors in the GnRH regulation of puberty in mice
    • Divall S.A., Williams T.R., Carver S.E., et al. Divergent roles of growth factors in the GnRH regulation of puberty in mice. J Clin Invest 2010, 120:2900-2909.
    • (2010) J Clin Invest , vol.120 , pp. 2900-2909
    • Divall, S.A.1    Williams, T.R.2    Carver, S.E.3
  • 87
    • 0033057428 scopus 로고    scopus 로고
    • Expression of a leptin receptor in immortalized gonadotropin-releasing hormone-secreting neurons
    • Magni P., Vettor R., Pagano C., et al. Expression of a leptin receptor in immortalized gonadotropin-releasing hormone-secreting neurons. Endocrinology 1999, 140:1581-1585.
    • (1999) Endocrinology , vol.140 , pp. 1581-1585
    • Magni, P.1    Vettor, R.2    Pagano, C.3
  • 88
    • 30944466103 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone-expressing neurons immortalized conditionally are activated by insulin: implication of the mitogen-activated protein kinase pathway
    • Salvi R., Castillo E., Voirol M.J., et al. Gonadotropin-releasing hormone-expressing neurons immortalized conditionally are activated by insulin: implication of the mitogen-activated protein kinase pathway. Endocrinology 2006, 147:816-826.
    • (2006) Endocrinology , vol.147 , pp. 816-826
    • Salvi, R.1    Castillo, E.2    Voirol, M.J.3
  • 89
    • 34247622216 scopus 로고    scopus 로고
    • Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin
    • DiVall S.A., Radovick S., Wolfe A. Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin. Mol Cell Endocrinol 2007, 270:64-72.
    • (2007) Mol Cell Endocrinol , vol.270 , pp. 64-72
    • DiVall, S.A.1    Radovick, S.2    Wolfe, A.3
  • 90
    • 33846837280 scopus 로고    scopus 로고
    • Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty
    • Lebrethon M.C., Aganina A., Fournier M., Gerard A., Parent A.S., Bourguignon J.P. Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty. J Neuroendocrinol 2007, 19:181-188.
    • (2007) J Neuroendocrinol , vol.19 , pp. 181-188
    • Lebrethon, M.C.1    Aganina, A.2    Fournier, M.3    Gerard, A.4    Parent, A.S.5    Bourguignon, J.P.6
  • 91
    • 40849116453 scopus 로고    scopus 로고
    • Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey
    • Vulliemoz N.R., Xiao E., Xia-Zhang L., Rivier J., Ferin M. Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey. Endocrinology 2008, 149:869-874.
    • (2008) Endocrinology , vol.149 , pp. 869-874
    • Vulliemoz, N.R.1    Xiao, E.2    Xia-Zhang, L.3    Rivier, J.4    Ferin, M.5
  • 92
    • 57849161861 scopus 로고    scopus 로고
    • From KISS1 to kisspeptins: an historical perspective and suggested nomenclature
    • Gottsch M.L., Clifton D.K., Steiner R.A. From KISS1 to kisspeptins: an historical perspective and suggested nomenclature. Peptides 2009, 30:4-9.
    • (2009) Peptides , vol.30 , pp. 4-9
    • Gottsch, M.L.1    Clifton, D.K.2    Steiner, R.A.3
  • 94
    • 83555176139 scopus 로고    scopus 로고
    • Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility
    • Navarro V.M., Tena-Sempere M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol 2012, 8:40-53.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 40-53
    • Navarro, V.M.1    Tena-Sempere, M.2
  • 95
    • 23844455323 scopus 로고    scopus 로고
    • Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition
    • Castellano J.M., Navarro V.M., Fernandez-Fernandez R., et al. Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology 2005, 146:3917-3925.
    • (2005) Endocrinology , vol.146 , pp. 3917-3925
    • Castellano, J.M.1    Navarro, V.M.2    Fernandez-Fernandez, R.3
  • 96
    • 37549000647 scopus 로고    scopus 로고
    • KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake
    • Brown R.E., Imran S.A., Ur E., Wilkinson M. KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake. Mol Cell Endocrinol 2008, 281:64-72.
    • (2008) Mol Cell Endocrinol , vol.281 , pp. 64-72
    • Brown, R.E.1    Imran, S.A.2    Ur, E.3    Wilkinson, M.4
  • 97
    • 82855178922 scopus 로고    scopus 로고
    • Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats
    • Matsuzaki T., Iwasa T., Kinouchi R., et al. Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats. Endocr J 2011, 58:1003-1012.
    • (2011) Endocr J , vol.58 , pp. 1003-1012
    • Matsuzaki, T.1    Iwasa, T.2    Kinouchi, R.3
  • 98
    • 34748840772 scopus 로고    scopus 로고
    • Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line
    • Luque R.M., Kineman R.D., Tena-Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 2007, 148:4601-4611.
    • (2007) Endocrinology , vol.148 , pp. 4601-4611
    • Luque, R.M.1    Kineman, R.D.2    Tena-Sempere, M.3
  • 99
    • 33750591860 scopus 로고    scopus 로고
    • Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats
    • Castellano J.M., Navarro V.M., Fernandez-Fernandez R., et al. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 2006, 55:2602-2610.
    • (2006) Diabetes , vol.55 , pp. 2602-2610
    • Castellano, J.M.1    Navarro, V.M.2    Fernandez-Fernandez, R.3
  • 100
    • 59649113096 scopus 로고    scopus 로고
    • Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences
    • Castellano J.M., Navarro V.M., Roa J., et al. Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology 2009, 150:784-794.
    • (2009) Endocrinology , vol.150 , pp. 784-794
    • Castellano, J.M.1    Navarro, V.M.2    Roa, J.3
  • 101
    • 70350266820 scopus 로고    scopus 로고
    • The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
    • Roa J., Garcia-Galiano D., Varela L., et al. The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology 2009, 150:5016-5026.
    • (2009) Endocrinology , vol.150 , pp. 5016-5026
    • Roa, J.1    Garcia-Galiano, D.2    Varela, L.3
  • 103
    • 49549089117 scopus 로고    scopus 로고
    • Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats
    • Kalamatianos T., Grimshaw S.E., Poorun R., Hahn J.D., Coen C.W. Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats. J Neuroendocrinol 2008, 20:1089-1097.
    • (2008) J Neuroendocrinol , vol.20 , pp. 1089-1097
    • Kalamatianos, T.1    Grimshaw, S.E.2    Poorun, R.3    Hahn, J.D.4    Coen, C.W.5
  • 104
    • 78650118707 scopus 로고    scopus 로고
    • Characterisation of arcuate nucleus kisspeptin/neurokinin B neuronal projections and regulation during lactation in the rat
    • True C., Kirigiti M., Ciofi P., Grove K.L., Smith M.S. Characterisation of arcuate nucleus kisspeptin/neurokinin B neuronal projections and regulation during lactation in the rat. J Neuroendocrinol 2011, 23:52-64.
    • (2011) J Neuroendocrinol , vol.23 , pp. 52-64
    • True, C.1    Kirigiti, M.2    Ciofi, P.3    Grove, K.L.4    Smith, M.S.5
  • 105
    • 77953148020 scopus 로고    scopus 로고
    • Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells
    • Backholer K., Smith J.T., Rao A., et al. Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology 2010, 151:2233-2243.
    • (2010) Endocrinology , vol.151 , pp. 2233-2243
    • Backholer, K.1    Smith, J.T.2    Rao, A.3
  • 106
    • 71949094687 scopus 로고    scopus 로고
    • Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge
    • Smith J.T., Li Q., Pereira A., Clarke I.J. Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge. Endocrinology 2009, 150:5530-5538.
    • (2009) Endocrinology , vol.150 , pp. 5530-5538
    • Smith, J.T.1    Li, Q.2    Pereira, A.3    Clarke, I.J.4
  • 107
    • 77953434412 scopus 로고    scopus 로고
    • Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects
    • Castellano J.M., Bentsen A.H., Romero M., et al. Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects. Am J Physiol Endocrinol Metab 2010, 299:E54-E61.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E54-E61
    • Castellano, J.M.1    Bentsen, A.H.2    Romero, M.3
  • 108
    • 79953209692 scopus 로고    scopus 로고
    • Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice
    • Quennell J.H., Howell C.S., Roa J., Augustine R.A., Grattan D.R., Anderson G.M. Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology 2011, 152:1541-1550.
    • (2011) Endocrinology , vol.152 , pp. 1541-1550
    • Quennell, J.H.1    Howell, C.S.2    Roa, J.3    Augustine, R.A.4    Grattan, D.R.5    Anderson, G.M.6
  • 109
    • 84865404360 scopus 로고    scopus 로고
    • High-fat diet increases LH pulse frequency and kisspeptin-neurokinin B expression in puberty-advanced female rats
    • Feng Li X., Lin Y.S., Kinsey-Jones J.S., O'Byrne K.T. High-fat diet increases LH pulse frequency and kisspeptin-neurokinin B expression in puberty-advanced female rats. Endocrinology 2012, 153:4422-4431.
    • (2012) Endocrinology , vol.153 , pp. 4422-4431
    • Feng Li, X.1    Lin, Y.S.2    Kinsey-Jones, J.S.3    O'Byrne, K.T.4
  • 110
    • 80052455176 scopus 로고    scopus 로고
    • Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system
    • Castellano J.M., Bentsen A.H., Sanchez-Garrido M.A., et al. Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system. Endocrinology 2011, 152:3396-3408.
    • (2011) Endocrinology , vol.152 , pp. 3396-3408
    • Castellano, J.M.1    Bentsen, A.H.2    Sanchez-Garrido, M.A.3
  • 111
    • 84864004002 scopus 로고    scopus 로고
    • Preweaning over- and underfeeding alters onset of puberty in the rat without affecting kisspeptin
    • Smith J.T., Spencer S.J. Preweaning over- and underfeeding alters onset of puberty in the rat without affecting kisspeptin. Biol Reprod 2012, 86:1-8.
    • (2012) Biol Reprod , vol.86 , pp. 1-8
    • Smith, J.T.1    Spencer, S.J.2
  • 112
    • 84865045713 scopus 로고    scopus 로고
    • Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function
    • Caron E., Ciofi P., Prevot V., Bouret S.G. Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. J Neurosci 2012, 32:11486-11494.
    • (2012) J Neurosci , vol.32 , pp. 11486-11494
    • Caron, E.1    Ciofi, P.2    Prevot, V.3    Bouret, S.G.4
  • 113
    • 84878530524 scopus 로고    scopus 로고
    • Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism
    • George J.T., Veldhuis J.D., Tena-Sempere M., Millar R.P., Anderson R.A. Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clin Endocrinol (Oxf) 2013.
    • (2013) Clin Endocrinol (Oxf)
    • George, J.T.1    Veldhuis, J.D.2    Tena-Sempere, M.3    Millar, R.P.4    Anderson, R.A.5
  • 114
    • 33646792207 scopus 로고    scopus 로고
    • Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats
    • Tovar S., Vazquez M.J., Navarro V.M., et al. Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats. Endocrinology 2006, 147:2696-2704.
    • (2006) Endocrinology , vol.147 , pp. 2696-2704
    • Tovar, S.1    Vazquez, M.J.2    Navarro, V.M.3
  • 115
    • 47549101608 scopus 로고    scopus 로고
    • Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states
    • Roa J., Vigo E., Garcia-Galiano D., et al. Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. Am J Physiol Endocrinol Metab 2008, 294:E1088-E1096.
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. E1088-E1096
    • Roa, J.1    Vigo, E.2    Garcia-Galiano, D.3
  • 116
    • 54949113577 scopus 로고    scopus 로고
    • Short-term fasting attenuates the response of the HPG axis to kisspeptin challenge in the adult male rhesus monkey (Macaca mulatta)
    • Wahab F., Aziz F., Irfan S., Zaman W.U., Shahab M. Short-term fasting attenuates the response of the HPG axis to kisspeptin challenge in the adult male rhesus monkey (Macaca mulatta). Life Sci 2008, 83:633-637.
    • (2008) Life Sci , vol.83 , pp. 633-637
    • Wahab, F.1    Aziz, F.2    Irfan, S.3    Zaman, W.U.4    Shahab, M.5
  • 117
    • 45549104270 scopus 로고    scopus 로고
    • Hypothalamic pathways linking energy balance and reproduction
    • Hill J.W., Elmquist J.K., Elias C.F. Hypothalamic pathways linking energy balance and reproduction. Am J Physiol Endocrinol Metab 2008, 294:E827-E832.
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. E827-E832
    • Hill, J.W.1    Elmquist, J.K.2    Elias, C.F.3
  • 118
    • 42949164617 scopus 로고    scopus 로고
    • Sex steroids and leptin regulate the "first Kiss" (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts
    • Morelli A., Marini M., Mancina R., et al. Sex steroids and leptin regulate the "first Kiss" (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts. J Sex Med 2008, 5:1097-1113.
    • (2008) J Sex Med , vol.5 , pp. 1097-1113
    • Morelli, A.1    Marini, M.2    Mancina, R.3
  • 119
    • 78650678254 scopus 로고    scopus 로고
    • Characterization of Kiss1 neurons using transgenic mouse models
    • Cravo R.M., Margatho L.O., Osborne-Lawrence S., et al. Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience 2011, 173:37-56.
    • (2011) Neuroscience , vol.173 , pp. 37-56
    • Cravo, R.M.1    Margatho, L.O.2    Osborne-Lawrence, S.3
  • 120
    • 58149499180 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • Villanueva E.C., Myers M.G. Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond) 2008, 32(Suppl. 7):S8-S12.
    • (2008) Int J Obes (Lond) , vol.32 , pp. S8-S12
    • Villanueva, E.C.1    Myers, M.G.2
  • 121
    • 79953211082 scopus 로고    scopus 로고
    • Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels
    • Qiu J., Fang Y., Bosch M.A., Ronnekleiv O.K., Kelly M.J. Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. Endocrinology 2011, 152:1503-1514.
    • (2011) Endocrinology , vol.152 , pp. 1503-1514
    • Qiu, J.1    Fang, Y.2    Bosch, M.A.3    Ronnekleiv, O.K.4    Kelly, M.J.5
  • 122
    • 78650956096 scopus 로고    scopus 로고
    • Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
    • Donato J., Cravo R.M., Frazao R., et al. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest 2011, 121:355-368.
    • (2011) J Clin Invest , vol.121 , pp. 355-368
    • Donato, J.1    Cravo, R.M.2    Frazao, R.3
  • 124
    • 65549098301 scopus 로고    scopus 로고
    • The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion
    • Donato J., Silva R.J., Sita L.V., et al. The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion. J Neurosci 2009, 29:5240-5250.
    • (2009) J Neurosci , vol.29 , pp. 5240-5250
    • Donato, J.1    Silva, R.J.2    Sita, L.V.3
  • 125
    • 84876452980 scopus 로고    scopus 로고
    • Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition
    • Donato J., Lee C., Ratra D., Franci C.R., Canteras N.S., Elias C.F. Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition. Neuroscience 2013, 241:67-79.
    • (2013) Neuroscience , vol.241 , pp. 67-79
    • Donato, J.1    Lee, C.2    Ratra, D.3    Franci, C.R.4    Canteras, N.S.5    Elias, C.F.6
  • 126
    • 67349194989 scopus 로고    scopus 로고
    • Effects of ghrelin on kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat
    • Forbes S., Li X.F., Kinsey-Jones J., O'Byrne K. Effects of ghrelin on kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat. Neurosci Lett 2009, 460:143-147.
    • (2009) Neurosci Lett , vol.460 , pp. 143-147
    • Forbes, S.1    Li, X.F.2    Kinsey-Jones, J.3    O'Byrne, K.4
  • 127
    • 84874623222 scopus 로고    scopus 로고
    • Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from kiss1 cells
    • Qiu X., Dowling A.R., Marino J.S., et al. Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from kiss1 cells. Endocrinology 2013, 154:1337-1348.
    • (2013) Endocrinology , vol.154 , pp. 1337-1348
    • Qiu, X.1    Dowling, A.R.2    Marino, J.S.3
  • 128
    • 58149473441 scopus 로고    scopus 로고
    • Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat
    • Hiney J.K., Srivastava V.K., Pine M.D., Les Dees W. Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat. Endocrinology 2009, 150:376-384.
    • (2009) Endocrinology , vol.150 , pp. 376-384
    • Hiney, J.K.1    Srivastava, V.K.2    Pine, M.D.3    Les Dees, W.4
  • 129
    • 34548283961 scopus 로고    scopus 로고
    • Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats
    • Todd B.J., Fraley G.S., Peck A.C., Schwartz G.J., Etgen A.M. Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats. Biol Reprod 2007, 77:492-503.
    • (2007) Biol Reprod , vol.77 , pp. 492-503
    • Todd, B.J.1    Fraley, G.S.2    Peck, A.C.3    Schwartz, G.J.4    Etgen, A.M.5
  • 130
    • 77954895859 scopus 로고    scopus 로고
    • Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion
    • Lehman M.N., Coolen L.M., Goodman R.L. Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology 2010, 151:3479-3489.
    • (2010) Endocrinology , vol.151 , pp. 3479-3489
    • Lehman, M.N.1    Coolen, L.M.2    Goodman, R.L.3
  • 131
    • 84866761591 scopus 로고    scopus 로고
    • Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept
    • Hrabovszky E., Sipos M.T., Molnar C.S., et al. Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept. Endocrinology 2012, 153:4978-4989.
    • (2012) Endocrinology , vol.153 , pp. 4978-4989
    • Hrabovszky, E.1    Sipos, M.T.2    Molnar, C.S.3
  • 132
    • 61349091041 scopus 로고    scopus 로고
    • TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction
    • Topaloglu A.K., Reimann F., Guclu M., et al. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction. Nat Genet 2009, 41:354-358.
    • (2009) Nat Genet , vol.41 , pp. 354-358
    • Topaloglu, A.K.1    Reimann, F.2    Guclu, M.3
  • 133
    • 77952769687 scopus 로고    scopus 로고
    • TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans
    • Young J., Bouligand J., Francou B., et al. TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans. J Clin Endocrinol Metab 2010, 95:2287-2295.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2287-2295
    • Young, J.1    Bouligand, J.2    Francou, B.3
  • 134
    • 77954517193 scopus 로고    scopus 로고
    • TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood
    • Gianetti E., Tusset C., Noel S.D., et al. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab 2010, 95:2857-2867.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2857-2867
    • Gianetti, E.1    Tusset, C.2    Noel, S.D.3
  • 135
    • 77954164175 scopus 로고    scopus 로고
    • Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep
    • Billings H.J., Connors J.M., Altman S.N., et al. Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology 2010, 151:3836-3846.
    • (2010) Endocrinology , vol.151 , pp. 3836-3846
    • Billings, H.J.1    Connors, J.M.2    Altman, S.N.3
  • 136
    • 77956043908 scopus 로고    scopus 로고
    • Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus
    • Ramaswamy S., Seminara S.B., Ali B., Ciofi P., Amin N.A., Plant T.M. Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. Endocrinology 2010, 151:4494-4503.
    • (2010) Endocrinology , vol.151 , pp. 4494-4503
    • Ramaswamy, S.1    Seminara, S.B.2    Ali, B.3    Ciofi, P.4    Amin, N.A.5    Plant, T.M.6
  • 137
    • 78650767326 scopus 로고    scopus 로고
    • Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat
    • Navarro V.M., Castellano J.M., McConkey S.M., et al. Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab 2011, 300:E202-E210.
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , pp. E202-E210
    • Navarro, V.M.1    Castellano, J.M.2    McConkey, S.M.3
  • 138
    • 84455188563 scopus 로고    scopus 로고
    • Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice
    • Garcia-Galiano D., van Ingen Schenau D., Leon S., et al. Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology 2012, 153:316-328.
    • (2012) Endocrinology , vol.153 , pp. 316-328
    • Garcia-Galiano, D.1    van Ingen Schenau, D.2    Leon, S.3
  • 139
    • 70349342734 scopus 로고    scopus 로고
    • Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    • Navarro V.M., Gottsch M.L., Chavkin C., Okamura H., Clifton D.K., Steiner R.A. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci 2009, 29:11859-11866.
    • (2009) J Neurosci , vol.29 , pp. 11859-11866
    • Navarro, V.M.1    Gottsch, M.L.2    Chavkin, C.3    Okamura, H.4    Clifton, D.K.5    Steiner, R.A.6
  • 140
    • 84857080556 scopus 로고    scopus 로고
    • Role of neurokinin B in the control of female puberty and its modulation by metabolic status
    • Navarro V.M., Ruiz-Pino F., Sanchez-Garrido M.A., et al. Role of neurokinin B in the control of female puberty and its modulation by metabolic status. J Neurosci 2012, 32:2388-2397.
    • (2012) J Neurosci , vol.32 , pp. 2388-2397
    • Navarro, V.M.1    Ruiz-Pino, F.2    Sanchez-Garrido, M.A.3
  • 141
    • 84861303041 scopus 로고    scopus 로고
    • Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight
    • Mittelman-Smith M.A., Williams H., Krajewski-Hall S.J., et al. Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology 2012, 153:2800-2812.
    • (2012) Endocrinology , vol.153 , pp. 2800-2812
    • Mittelman-Smith, M.A.1    Williams, H.2    Krajewski-Hall, S.J.3
  • 142
    • 84862150019 scopus 로고    scopus 로고
    • Hypothalamic neuropeptides and the regulation of appetite
    • Parker J.A., Bloom S.R. Hypothalamic neuropeptides and the regulation of appetite. Neuropharmacology 2012, 63:18-30.
    • (2012) Neuropharmacology , vol.63 , pp. 18-30
    • Parker, J.A.1    Bloom, S.R.2
  • 143
    • 33845595901 scopus 로고    scopus 로고
    • Gut peptides in the regulation of food intake and energy homeostasis
    • Murphy K.G., Dhillo W.S., Bloom S.R. Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev 2006, 27:719-727.
    • (2006) Endocr Rev , vol.27 , pp. 719-727
    • Murphy, K.G.1    Dhillo, W.S.2    Bloom, S.R.3
  • 144
    • 84874376748 scopus 로고    scopus 로고
    • Cross-talk between metabolism and reproduction: the role of POMC and SF1 neurons
    • Xu Y., Faulkner L.D., Hill J.W. Cross-talk between metabolism and reproduction: the role of POMC and SF1 neurons. Front Endocrinol (Lausanne) 2012, 2:98.
    • (2012) Front Endocrinol (Lausanne) , vol.2 , pp. 98
    • Xu, Y.1    Faulkner, L.D.2    Hill, J.W.3
  • 145
    • 0030272305 scopus 로고    scopus 로고
    • Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network
    • Kalra S.P., Kalra P.S. Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network. Front Neuroendocrinol 1996, 17:371-401.
    • (1996) Front Neuroendocrinol , vol.17 , pp. 371-401
    • Kalra, S.P.1    Kalra, P.S.2
  • 146
    • 0025318842 scopus 로고
    • Interaction between beta-endorphin and alpha-melanocyte-stimulating hormone in the control of prolactin and luteinizing hormone secretion in the primate
    • Wardlaw S.L., Ferin M. Interaction between beta-endorphin and alpha-melanocyte-stimulating hormone in the control of prolactin and luteinizing hormone secretion in the primate. Endocrinology 1990, 126:2035-2040.
    • (1990) Endocrinology , vol.126 , pp. 2035-2040
    • Wardlaw, S.L.1    Ferin, M.2
  • 147
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar D., Lynch C.A., Fairchild-Huntress V., et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997, 88:131-141.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3
  • 148
    • 0036553037 scopus 로고    scopus 로고
    • The melanocortin receptors: lessons from knockout models
    • Butler A.A., Cone R.D. The melanocortin receptors: lessons from knockout models. Neuropeptides 2002, 36:77-84.
    • (2002) Neuropeptides , vol.36 , pp. 77-84
    • Butler, A.A.1    Cone, R.D.2
  • 149
    • 2942733252 scopus 로고    scopus 로고
    • Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    • Balthasar N., Coppari R., McMinn J., et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004, 42:983-991.
    • (2004) Neuron , vol.42 , pp. 983-991
    • Balthasar, N.1    Coppari, R.2    McMinn, J.3
  • 150
    • 77950264425 scopus 로고    scopus 로고
    • Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
    • Hill J.W., Elias C.F., Fukuda M., et al. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab 2010, 11:286-297.
    • (2010) Cell Metab , vol.11 , pp. 286-297
    • Hill, J.W.1    Elias, C.F.2    Fukuda, M.3
  • 151
    • 71949110404 scopus 로고    scopus 로고
    • Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe
    • Backholer K., Smith J., Clarke I.J. Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe. Endocrinology 2009, 150:5488-5497.
    • (2009) Endocrinology , vol.150 , pp. 5488-5497
    • Backholer, K.1    Smith, J.2    Clarke, I.J.3
  • 152
    • 77955373372 scopus 로고    scopus 로고
    • Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism
    • Fu L.Y., van den Pol A.N. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci 2010, 30:10205-10219.
    • (2010) J Neurosci , vol.30 , pp. 10205-10219
    • Fu, L.Y.1    van den Pol, A.N.2
  • 153
    • 84867764901 scopus 로고    scopus 로고
    • Direct regulation of GnRH neuron excitability by arcuate nucleus POMC and NPY neuron neuropeptides in female mice
    • Roa J., Herbison A.E. Direct regulation of GnRH neuron excitability by arcuate nucleus POMC and NPY neuron neuropeptides in female mice. Endocrinology 2012, 153:5587-5599.
    • (2012) Endocrinology , vol.153 , pp. 5587-5599
    • Roa, J.1    Herbison, A.E.2
  • 154
    • 1942424812 scopus 로고    scopus 로고
    • Hypothalamic cocaine- and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats
    • Rondini T.A., Baddini S.P., Sousa L.F., Bittencourt J.C., Elias C.F. Hypothalamic cocaine- and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats. Neuroscience 2004, 125:735-748.
    • (2004) Neuroscience , vol.125 , pp. 735-748
    • Rondini, T.A.1    Baddini, S.P.2    Sousa, L.F.3    Bittencourt, J.C.4    Elias, C.F.5
  • 155
    • 0242468477 scopus 로고    scopus 로고
    • Origin of neuropeptide Y-containing afferents to gonadotropin-releasing hormone neurons in male mice
    • Turi G.F., Liposits Z., Moenter S.M., Fekete C., Hrabovszky E. Origin of neuropeptide Y-containing afferents to gonadotropin-releasing hormone neurons in male mice. Endocrinology 2003, 144:4967-4974.
    • (2003) Endocrinology , vol.144 , pp. 4967-4974
    • Turi, G.F.1    Liposits, Z.2    Moenter, S.M.3    Fekete, C.4    Hrabovszky, E.5
  • 156
    • 0026514151 scopus 로고
    • Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone
    • Kalra S.P., Crowley W.R. Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone. Front Neuroendocrinol 1992, 13:1-46.
    • (1992) Front Neuroendocrinol , vol.13 , pp. 1-46
    • Kalra, S.P.1    Crowley, W.R.2
  • 157
    • 1342332152 scopus 로고    scopus 로고
    • The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions
    • Gonzales C., Voirol M.J., Giacomini M., Gaillard R.C., Pedrazzini T., Pralong F.P. The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions. FASEB J 2004, 18:137-139.
    • (2004) FASEB J , vol.18 , pp. 137-139
    • Gonzales, C.1    Voirol, M.J.2    Giacomini, M.3    Gaillard, R.C.4    Pedrazzini, T.5    Pralong, F.P.6
  • 158
    • 0036584250 scopus 로고    scopus 로고
    • The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions
    • Pralong F.P., Gonzales C., Voirol M.J., et al. The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions. FASEB J 2002, 16:712-714.
    • (2002) FASEB J , vol.16 , pp. 712-714
    • Pralong, F.P.1    Gonzales, C.2    Voirol, M.J.3
  • 159
    • 0034711589 scopus 로고    scopus 로고
    • Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors
    • Pralong F.P., Voirol M., Giacomini M., Gaillard R.C., Grouzmann E. Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors. Regul Pept 2000, 95:47-52.
    • (2000) Regul Pept , vol.95 , pp. 47-52
    • Pralong, F.P.1    Voirol, M.2    Giacomini, M.3    Gaillard, R.C.4    Grouzmann, E.5
  • 160
    • 77957277596 scopus 로고    scopus 로고
    • Kisspeptin directly regulates neuropeptide Y synthesis and secretion via the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways in NPY-secreting hypothalamic neurons
    • Kim G.L., Dhillon S.S., Belsham D.D. Kisspeptin directly regulates neuropeptide Y synthesis and secretion via the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways in NPY-secreting hypothalamic neurons. Endocrinology 2010, 151:5038-5047.
    • (2010) Endocrinology , vol.151 , pp. 5038-5047
    • Kim, G.L.1    Dhillon, S.S.2    Belsham, D.D.3
  • 162
    • 4344595580 scopus 로고    scopus 로고
    • NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy
    • Kalra S.P., Kalra P.S. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 2004, 38:201-211.
    • (2004) Neuropeptides , vol.38 , pp. 201-211
    • Kalra, S.P.1    Kalra, P.S.2
  • 163
    • 0035953163 scopus 로고    scopus 로고
    • Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats
    • Schioth H.B., Kakizaki Y., Kohsaka A., Suda T., Watanobe H. Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats. Neuroreport 2001, 12:687-690.
    • (2001) Neuroreport , vol.12 , pp. 687-690
    • Schioth, H.B.1    Kakizaki, Y.2    Kohsaka, A.3    Suda, T.4    Watanobe, H.5
  • 164
    • 12344274258 scopus 로고    scopus 로고
    • Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey
    • Vulliemoz N.R., Xiao E., Xia-Zhang L., Wardlaw S.L., Ferin M. Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey. Endocrinology 2005, 146:784-789.
    • (2005) Endocrinology , vol.146 , pp. 784-789
    • Vulliemoz, N.R.1    Xiao, E.2    Xia-Zhang, L.3    Wardlaw, S.L.4    Ferin, M.5
  • 165
    • 0033303662 scopus 로고    scopus 로고
    • Agouti related peptide (Agrp) stimulates the hypothalamo pituitary gonadal axis in vivo & in vitro in male rats
    • Stanley S.A., Small C.J., Kim M.S., et al. Agouti related peptide (Agrp) stimulates the hypothalamo pituitary gonadal axis in vivo & in vitro in male rats. Endocrinology 1999, 140:5459-5462.
    • (1999) Endocrinology , vol.140 , pp. 5459-5462
    • Stanley, S.A.1    Small, C.J.2    Kim, M.S.3
  • 166
    • 84857374972 scopus 로고    scopus 로고
    • Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
    • Wu Q., Whiddon B.B., Palmiter R.D. Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility. Proc Natl Acad Sci USA 2012, 109:3155-3160.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 3155-3160
    • Wu, Q.1    Whiddon, B.B.2    Palmiter, R.D.3
  • 167
    • 78049488476 scopus 로고    scopus 로고
    • Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons
    • Donato J., Frazao R., Fukuda M., Vianna C.R., Elias C.F. Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. Endocrinology 2010, 151:5415-5427.
    • (2010) Endocrinology , vol.151 , pp. 5415-5427
    • Donato, J.1    Frazao, R.2    Fukuda, M.3    Vianna, C.R.4    Elias, C.F.5
  • 168
    • 63849216885 scopus 로고    scopus 로고
    • Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus
    • Leshan R.L., Louis G.W., Jo Y.H., Rhodes C.J., Munzberg H., Myers M.G. Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci 2009, 29:3138-3147.
    • (2009) J Neurosci , vol.29 , pp. 3138-3147
    • Leshan, R.L.1    Louis, G.W.2    Jo, Y.H.3    Rhodes, C.J.4    Munzberg, H.5    Myers, M.G.6
  • 169
    • 3042630496 scopus 로고    scopus 로고
    • Galanin-like peptide as a link in the integration of metabolism and reproduction
    • Gottsch M.L., Clifton D.K., Steiner R.A. Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends Endocrinol Metab 2004, 15:215-221.
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 215-221
    • Gottsch, M.L.1    Clifton, D.K.2    Steiner, R.A.3
  • 170
    • 78651450815 scopus 로고    scopus 로고
    • Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction
    • Lawrence C., Fraley G.S. Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction. Front Neuroendocrinol 2011, 32:1-9.
    • (2011) Front Neuroendocrinol , vol.32 , pp. 1-9
    • Lawrence, C.1    Fraley, G.S.2
  • 171
    • 33845455133 scopus 로고    scopus 로고
    • Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty
    • Castellano J.M., Navarro V.M., Fernandez-Fernandez R., et al. Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty. Am J Physiol Endocrinol Metab 2006, 291:E1281-E1289.
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. E1281-E1289
    • Castellano, J.M.1    Navarro, V.M.2    Fernandez-Fernandez, R.3
  • 172
    • 84867685356 scopus 로고    scopus 로고
    • Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats
    • Mohr M.A., Leathley E., Fraley G.S. Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats. J Neuroendocrinol 2012, 24:1412-1422.
    • (2012) J Neuroendocrinol , vol.24 , pp. 1412-1422
    • Mohr, M.A.1    Leathley, E.2    Fraley, G.S.3
  • 174
    • 53149092080 scopus 로고    scopus 로고
    • Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide
    • Dungan Lemko H.M., Clifton D.K., Steiner R.A., Fraley G.S. Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide. Am J Physiol Endocrinol Metab 2008, 295:E605-E612.
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. E605-E612
    • Dungan Lemko, H.M.1    Clifton, D.K.2    Steiner, R.A.3    Fraley, G.S.4
  • 175
    • 3242774778 scopus 로고    scopus 로고
    • Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide
    • Krasnow S.M., Hohmann J.G., Gragerov A., Clifton D.K., Steiner R.A. Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide. Neuroendocrinology 2004, 79:268-277.
    • (2004) Neuroendocrinology , vol.79 , pp. 268-277
    • Krasnow, S.M.1    Hohmann, J.G.2    Gragerov, A.3    Clifton, D.K.4    Steiner, R.A.5
  • 176
    • 77956335324 scopus 로고    scopus 로고
    • Alarin stimulates food intake and gonadotrophin release in male rats
    • Boughton C.K., Patterson M., Bewick G.A., et al. Alarin stimulates food intake and gonadotrophin release in male rats. Br J Pharmacol 2010, 161:601-613.
    • (2010) Br J Pharmacol , vol.161 , pp. 601-613
    • Boughton, C.K.1    Patterson, M.2    Bewick, G.A.3
  • 177
    • 77950864319 scopus 로고    scopus 로고
    • Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)
    • Lopez M., Tena-Sempere M., Dieguez C., et al. Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes). Front Neuroendocrinol 2010, 31:113-627.
    • (2010) Front Neuroendocrinol , vol.31 , pp. 113-627
    • Lopez, M.1    Tena-Sempere, M.2    Dieguez, C.3
  • 178
    • 70350127131 scopus 로고    scopus 로고
    • Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction
    • Wu M., Dumalska I., Morozova E., van den Pol A., Alreja M. Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. Proc Natl Acad Sci USA 2009, 106:17217-17222.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17217-17222
    • Wu, M.1    Dumalska, I.2    Morozova, E.3    van den Pol, A.4    Alreja, M.5
  • 179
    • 0034008410 scopus 로고    scopus 로고
    • The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats
    • Piper D.C., Upton N., Smith M.I., Hunter A.J. The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats. Eur J Neurosci 2000, 12:726-730.
    • (2000) Eur J Neurosci , vol.12 , pp. 726-730
    • Piper, D.C.1    Upton, N.2    Smith, M.I.3    Hunter, A.J.4
  • 180
    • 0037387349 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers
    • Campbell R.E., Grove K.L., Smith M.S. Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers. Endocrinology 2003, 144:1542-1548.
    • (2003) Endocrinology , vol.144 , pp. 1542-1548
    • Campbell, R.E.1    Grove, K.L.2    Smith, M.S.3
  • 181
    • 0038649174 scopus 로고    scopus 로고
    • Central orexin A has site-specific effects on luteinizing hormone release in female rats
    • Small C.J., Goubillon M.L., Murray J.F., et al. Central orexin A has site-specific effects on luteinizing hormone release in female rats. Endocrinology 2003, 144:3225-3336.
    • (2003) Endocrinology , vol.144 , pp. 3225-3336
    • Small, C.J.1    Goubillon, M.L.2    Murray, J.F.3
  • 182
    • 0035213697 scopus 로고    scopus 로고
    • Orexin A interactions in the hypothalamo-pituitary gonadal axis
    • Russell S.H., Small C.J., Kennedy A.R., et al. Orexin A interactions in the hypothalamo-pituitary gonadal axis. Endocrinology 2001, 142:5294-5302.
    • (2001) Endocrinology , vol.142 , pp. 5294-5302
    • Russell, S.H.1    Small, C.J.2    Kennedy, A.R.3
  • 183
    • 0033582175 scopus 로고    scopus 로고
    • Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
    • Date Y., Ueta Y., Yamashita H., et al. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA 1999, 96:748-753.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 748-753
    • Date, Y.1    Ueta, Y.2    Yamashita, H.3
  • 184
    • 18544411695 scopus 로고    scopus 로고
    • Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner
    • Pu S., Jain M.R., Kalra P.S., Kalra S.P. Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Regul Pept 1998, 78:133-136.
    • (1998) Regul Pept , vol.78 , pp. 133-136
    • Pu, S.1    Jain, M.R.2    Kalra, P.S.3    Kalra, S.P.4
  • 185
    • 77950620742 scopus 로고    scopus 로고
    • Gonadotropin inhibitory hormone function in mammals
    • Smith J.T., Clarke I.J. Gonadotropin inhibitory hormone function in mammals. Trends Endocrinol Metab 2010, 21:255-260.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 255-260
    • Smith, J.T.1    Clarke, I.J.2
  • 186
    • 67651227185 scopus 로고    scopus 로고
    • Evidence that RF-amide related peptides are inhibitors of reproduction in mammals
    • Clarke I.J., Qi Y., Puspita Sari I., Smith J.T. Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Front Neuroendocrinol 2009, 30:371-378.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 371-378
    • Clarke, I.J.1    Qi, Y.2    Puspita Sari, I.3    Smith, J.T.4
  • 187
    • 77953421665 scopus 로고    scopus 로고
    • Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies
    • Pineda R., Garcia-Galiano D., Sanchez-Garrido M.A., et al. Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies. Am J Physiol Endocrinol Metab 2010, 299:E39-E46.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E39-E46
    • Pineda, R.1    Garcia-Galiano, D.2    Sanchez-Garrido, M.A.3
  • 188
    • 77954162594 scopus 로고    scopus 로고
    • Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction
    • Tsutsui K., Bentley G.E., Kriegsfeld L.J., Osugi T., Seong J.Y., Vaudry H. Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction. J Neuroendocrinol 2010, 22:716-727.
    • (2010) J Neuroendocrinol , vol.22 , pp. 716-727
    • Tsutsui, K.1    Bentley, G.E.2    Kriegsfeld, L.J.3    Osugi, T.4    Seong, J.Y.5    Vaudry, H.6
  • 189
    • 33751101599 scopus 로고    scopus 로고
    • Driving reproduction: RFamide peptides behind the wheel
    • Kriegsfeld L.J. Driving reproduction: RFamide peptides behind the wheel. Horm Behav 2006, 50:655-666.
    • (2006) Horm Behav , vol.50 , pp. 655-666
    • Kriegsfeld, L.J.1
  • 190
    • 84862766066 scopus 로고    scopus 로고
    • Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding
    • Clarke I.J., Smith J.T., Henry B.A., et al. Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding. Neuroendocrinology 2012, 95:305-316.
    • (2012) Neuroendocrinology , vol.95 , pp. 305-316
    • Clarke, I.J.1    Smith, J.T.2    Henry, B.A.3
  • 191
    • 8544235028 scopus 로고    scopus 로고
    • Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis
    • Thompson E.L., Patterson M., Murphy K.G., et al. Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J Neuroendocrinol 2004, 16:850-858.
    • (2004) J Neuroendocrinol , vol.16 , pp. 850-858
    • Thompson, E.L.1    Patterson, M.2    Murphy, K.G.3
  • 192
    • 33646356466 scopus 로고    scopus 로고
    • Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis
    • Navarro V.M., Fernandez-Fernandez R., Nogueiras R., et al. Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis. J Physiol 2006, 573:237-249.
    • (2006) J Physiol , vol.573 , pp. 237-249
    • Navarro, V.M.1    Fernandez-Fernandez, R.2    Nogueiras, R.3
  • 193
    • 50449086962 scopus 로고    scopus 로고
    • Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats
    • Patel S.R., Murphy K.G., Thompson E.L., et al. Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats. Endocrinology 2008, 149:4747-4754.
    • (2008) Endocrinology , vol.149 , pp. 4747-4754
    • Patel, S.R.1    Murphy, K.G.2    Thompson, E.L.3
  • 194
    • 0034627239 scopus 로고    scopus 로고
    • Involvement of prolactin-releasing peptide in the preovulatory luteinizing hormone and prolactin surges in the rat
    • Hizume T., Watanobe H., Yoneda M., Suda T., Schioth H.B. Involvement of prolactin-releasing peptide in the preovulatory luteinizing hormone and prolactin surges in the rat. Biochem Biophys Res Commun 2000, 279:35-39.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 35-39
    • Hizume, T.1    Watanobe, H.2    Yoneda, M.3    Suda, T.4    Schioth, H.B.5
  • 195
    • 0036150908 scopus 로고    scopus 로고
    • PRL-releasing peptide interacts with leptin to reduce food intake and body weight
    • Ellacott K.L., Lawrence C.B., Rothwell N.J., Luckman S.M. PRL-releasing peptide interacts with leptin to reduce food intake and body weight. Endocrinology 2002, 143:368-374.
    • (2002) Endocrinology , vol.143 , pp. 368-374
    • Ellacott, K.L.1    Lawrence, C.B.2    Rothwell, N.J.3    Luckman, S.M.4
  • 196
    • 36148929381 scopus 로고    scopus 로고
    • Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod
    • Vigo E., Roa J., Pineda R., et al. Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod. Am J Physiol Endocrinol Metab 2007, 293:E1265-E1273.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. E1265-E1273
    • Vigo, E.1    Roa, J.2    Pineda, R.3
  • 197
    • 33846463483 scopus 로고    scopus 로고
    • Neuromedin S as novel putative regulator of luteinizing hormone secretion
    • Vigo E., Roa J., Lopez M., et al. Neuromedin S as novel putative regulator of luteinizing hormone secretion. Endocrinology 2007, 148:813-823.
    • (2007) Endocrinology , vol.148 , pp. 813-823
    • Vigo, E.1    Roa, J.2    Lopez, M.3
  • 198
    • 84871602246 scopus 로고    scopus 로고
    • Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem
    • Beale K., Gardiner J.V., Bewick G.A., et al. Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem. Br J Pharmacol 2013, 168:403-410.
    • (2013) Br J Pharmacol , vol.168 , pp. 403-410
    • Beale, K.1    Gardiner, J.V.2    Bewick, G.A.3
  • 199
    • 84867673196 scopus 로고    scopus 로고
    • Prokineticin 2 is involved in the thermoregulation and energy expenditure
    • Zhou W., Li J.D., Hu W.P., Cheng M.Y., Zhou Q.Y. Prokineticin 2 is involved in the thermoregulation and energy expenditure. Regul Pept 2012, 179:84-90.
    • (2012) Regul Pept , vol.179 , pp. 84-90
    • Zhou, W.1    Li, J.D.2    Hu, W.P.3    Cheng, M.Y.4    Zhou, Q.Y.5
  • 200
    • 79951597966 scopus 로고    scopus 로고
    • Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge
    • Williams W.P., Jarjisian S.G., Mikkelsen J.D., Kriegsfeld L.J. Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge. Endocrinology 2012, 152:595-606.
    • (2012) Endocrinology , vol.152 , pp. 595-606
    • Williams, W.P.1    Jarjisian, S.G.2    Mikkelsen, J.D.3    Kriegsfeld, L.J.4
  • 201
    • 0026440579 scopus 로고
    • Effect of food deprivation and refeeding on the concentration of vasopressin and oxytocin in discrete hypothalamic sites
    • Burlet A.J., Jhanwar-Uniyal M., Chapleur-Chateau M., Burlet C.R., Leibowitz S.F. Effect of food deprivation and refeeding on the concentration of vasopressin and oxytocin in discrete hypothalamic sites. Pharmacol Biochem Behav 1992, 43:897-905.
    • (1992) Pharmacol Biochem Behav , vol.43 , pp. 897-905
    • Burlet, A.J.1    Jhanwar-Uniyal, M.2    Chapleur-Chateau, M.3    Burlet, C.R.4    Leibowitz, S.F.5
  • 202
    • 33749859790 scopus 로고    scopus 로고
    • Identification of nesfatin-1 as a satiety molecule in the hypothalamus
    • Oh I.S., Shimizu H., Satoh T., et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006, 443:709-712.
    • (2006) Nature , vol.443 , pp. 709-712
    • Oh, I.S.1    Shimizu, H.2    Satoh, T.3
  • 204
    • 77953525385 scopus 로고    scopus 로고
    • The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat
    • Garcia-Galiano D., Navarro V.M., Roa J., et al. The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J Neurosci 2010, 30:7783-7792.
    • (2010) J Neurosci , vol.30 , pp. 7783-7792
    • Garcia-Galiano, D.1    Navarro, V.M.2    Roa, J.3
  • 205
    • 84869051723 scopus 로고    scopus 로고
    • Nesfatin suppresses feeding and stimulates the hypothalamo-pituitary-gonadal axis
    • 14th International Congress of Endocrinology
    • Tadross J.A., Patterson M., Wynne K.J., et al. Nesfatin suppresses feeding and stimulates the hypothalamo-pituitary-gonadal axis. Endocr J (Kyoto, Jpn) 2010, S442. 14th International Congress of Endocrinology.
    • (2010) Endocr J (Kyoto, Jpn) , pp. S442
    • Tadross, J.A.1    Patterson, M.2    Wynne, K.J.3
  • 206
    • 79960617185 scopus 로고    scopus 로고
    • Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
    • Kim K.W., Zhao L., Donato J., et al. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci USA 2011, 108:10673-10678.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 10673-10678
    • Kim, K.W.1    Zhao, L.2    Donato, J.3
  • 207
    • 77954824974 scopus 로고    scopus 로고
    • CNS-specific ablation of steroidogenic factor 1 results in impaired female reproductive function
    • Kim K.W., Li S., Zhao H., et al. CNS-specific ablation of steroidogenic factor 1 results in impaired female reproductive function. Mol Endocrinol 2010, 24:1240-1250.
    • (2010) Mol Endocrinol , vol.24 , pp. 1240-1250
    • Kim, K.W.1    Li, S.2    Zhao, H.3
  • 208
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 209
    • 35348820823 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network in cancer
    • Chiang G.G., Abraham R.T. Targeting the mTOR signaling network in cancer. Trends Mol Med 2007, 13:433-442.
    • (2007) Trends Mol Med , vol.13 , pp. 433-442
    • Chiang, G.G.1    Abraham, R.T.2
  • 210
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang C.K., Qi H., Liu L.F., Zheng X.F. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 2007, 12:112-124.
    • (2007) Drug Discov Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.4
  • 211
    • 15044350668 scopus 로고    scopus 로고
    • The expanding TOR signaling network
    • Martin D.E., Hall M.N. The expanding TOR signaling network. Curr Opin Cell Biol 2005, 17:158-166.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 158-166
    • Martin, D.E.1    Hall, M.N.2
  • 212
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell 2000, 103:253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 213
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • Cota D., Proulx K., Smith K.A., et al. Hypothalamic mTOR signaling regulates food intake. Science 2006, 312:927-930.
    • (2006) Science , vol.312 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Smith, K.A.3
  • 214
    • 50949092240 scopus 로고    scopus 로고
    • Regulation of food intake through hypothalamic signaling networks involving mTOR
    • Woods S.C., Seeley R.J., Cota D. Regulation of food intake through hypothalamic signaling networks involving mTOR. Annu Rev Nutr 2008, 28:295-311.
    • (2008) Annu Rev Nutr , vol.28 , pp. 295-311
    • Woods, S.C.1    Seeley, R.J.2    Cota, D.3
  • 215
    • 84867304944 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin
    • Martins L., Fernandez-Mallo D., et al. Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin. PLoS One 2012, 7:e46923.
    • (2012) PLoS One , vol.7
    • Martins, L.1    Fernandez-Mallo, D.2
  • 216
    • 64549127790 scopus 로고    scopus 로고
    • PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    • Canto C., Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 2009, 20:98-105.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 98-105
    • Canto, C.1    Auwerx, J.2
  • 218
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn B.B., Alquier T., Carling D., Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005, 1:15-25.
    • (2005) Cell Metab , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 219
    • 34247886103 scopus 로고    scopus 로고
    • The role of CNS fuel sensing in energy and glucose regulation
    • Cota D., Proulx K., Seeley R.J. The role of CNS fuel sensing in energy and glucose regulation. Gastroenterology 2007, 132:2158-2168.
    • (2007) Gastroenterology , vol.132 , pp. 2158-2168
    • Cota, D.1    Proulx, K.2    Seeley, R.J.3
  • 220
    • 1842582870 scopus 로고    scopus 로고
    • AMP-activated protein kinase plays a role in the control of food intake
    • Andersson U., Filipsson K., Abbott C.R., et al. AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004, 279:12005-12008.
    • (2004) J Biol Chem , vol.279 , pp. 12005-12008
    • Andersson, U.1    Filipsson, K.2    Abbott, C.R.3
  • 221
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 222
    • 39549114798 scopus 로고    scopus 로고
    • The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats
    • Coyral-Castel S., Tosca L., Ferreira G., et al. The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats. J Neuroendocrinol 2008, 20:335-346.
    • (2008) J Neuroendocrinol , vol.20 , pp. 335-346
    • Coyral-Castel, S.1    Tosca, L.2    Ferreira, G.3
  • 223
    • 53549133638 scopus 로고    scopus 로고
    • The Creb1 coactivator Crtc1 is required for energy balance and fertility
    • Altarejos J.Y., Goebel N., Conkright M.D., et al. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med 2008, 14:1112-1117.
    • (2008) Nat Med , vol.14 , pp. 1112-1117
    • Altarejos, J.Y.1    Goebel, N.2    Conkright, M.D.3
  • 225
    • 70350389400 scopus 로고    scopus 로고
    • Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    • Al-Qassab H., Smith M.A., Irvine E.E., et al. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab 2009, 10:343-354.
    • (2009) Cell Metab , vol.10 , pp. 343-354
    • Al-Qassab, H.1    Smith, M.A.2    Irvine, E.E.3
  • 226
    • 80052935067 scopus 로고    scopus 로고
    • The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
    • Williams K.W., Sohn J.W., Donato J., et al. The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus. J Neurosci 2011, 31:13147-13156.
    • (2011) J Neurosci , vol.31 , pp. 13147-13156
    • Williams, K.W.1    Sohn, J.W.2    Donato, J.3
  • 227
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • Bates S.H., Stearns W.H., Dundon T.A., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003, 421:856-859.
    • (2003) Nature , vol.421 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3
  • 228
    • 34548820963 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition
    • Zhang C., Bosch M.A., Levine J.E., Ronnekleiv O.K., Kelly M.J. Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition. J Neurosci 2007, 27:10153-10164.
    • (2007) J Neurosci , vol.27 , pp. 10153-10164
    • Zhang, C.1    Bosch, M.A.2    Levine, J.E.3    Ronnekleiv, O.K.4    Kelly, M.J.5
  • 229
    • 57349185737 scopus 로고    scopus 로고
    • Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels
    • Huang W., Acosta-Martinez M., Horton T.H., Levine J.E. Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels. Am J Physiol Endocrinol Metab 2008, 295:E1439-E1446.
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. E1439-E1446
    • Huang, W.1    Acosta-Martinez, M.2    Horton, T.H.3    Levine, J.E.4
  • 230
    • 34548604499 scopus 로고    scopus 로고
    • Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    • Parton L.E., Ye C.P., Coppari R., et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 2007, 449:228-232.
    • (2007) Nature , vol.449 , pp. 228-232
    • Parton, L.E.1    Ye, C.P.2    Coppari, R.3
  • 231
    • 84925844514 scopus 로고    scopus 로고
    • Ghrelin, the gonadal axis and the onset of puberty
    • Tena-Sempere M. Ghrelin, the gonadal axis and the onset of puberty. Endocr Dev 2013, 25:69-82.
    • (2013) Endocr Dev , vol.25 , pp. 69-82
    • Tena-Sempere, M.1
  • 232
    • 78650835266 scopus 로고    scopus 로고
    • The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity
    • Childs G.V., Akhter N., Haney A., et al. The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity. Endocrinology 2011, 152:69-81.
    • (2011) Endocrinology , vol.152 , pp. 69-81
    • Childs, G.V.1    Akhter, N.2    Haney, A.3
  • 233
    • 0030776182 scopus 로고    scopus 로고
    • Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland
    • Yu W.H., Walczewska A., Karanth S., McCann S.M. Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland. Endocrinology 1997, 138:5055-5058.
    • (1997) Endocrinology , vol.138 , pp. 5055-5058
    • Yu, W.H.1    Walczewska, A.2    Karanth, S.3    McCann, S.M.4
  • 234
    • 84865087203 scopus 로고    scopus 로고
    • Female reproduction and type 1 diabetes: from mechanisms to clinical findings
    • Codner E., Merino P.M., Tena-Sempere M. Female reproduction and type 1 diabetes: from mechanisms to clinical findings. Hum Reprod Update 2012, 18:568-585.
    • (2012) Hum Reprod Update , vol.18 , pp. 568-585
    • Codner, E.1    Merino, P.M.2    Tena-Sempere, M.3
  • 235
    • 77956336197 scopus 로고    scopus 로고
    • Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor
    • Brothers K.J., Wu S., DiVall S.A., et al. Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab 2010, 12:295-305.
    • (2010) Cell Metab , vol.12 , pp. 295-305
    • Brothers, K.J.1    Wu, S.2    DiVall, S.A.3
  • 236
    • 34547588537 scopus 로고    scopus 로고
    • Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen
    • Fernandez-Fernandez R., Tena-Sempere M., Roa J., et al. Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen. Reproduction 2007, 133:1223-1232.
    • (2007) Reproduction , vol.133 , pp. 1223-1232
    • Fernandez-Fernandez, R.1    Tena-Sempere, M.2    Roa, J.3
  • 237
    • 3042735648 scopus 로고    scopus 로고
    • The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    • Gnanapavan S., Kola B., Bustin S.A., et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002, 87:2988.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2988
    • Gnanapavan, S.1    Kola, B.2    Bustin, S.A.3
  • 238
    • 0037169830 scopus 로고    scopus 로고
    • Leptin in male reproduction: the testis paradigm
    • Tena-Sempere M., Barreiro M.L. Leptin in male reproduction: the testis paradigm. Mol Cell Endocrinol 2002, 188:9-13.
    • (2002) Mol Cell Endocrinol , vol.188 , pp. 9-13
    • Tena-Sempere, M.1    Barreiro, M.L.2
  • 241
    • 18244390529 scopus 로고    scopus 로고
    • Novel expression and functional role of ghrelin in rat testis
    • Tena-Sempere M., Barreiro M.L., Gonzalez L.C., et al. Novel expression and functional role of ghrelin in rat testis. Endocrinology 2002, 143:717-725.
    • (2002) Endocrinology , vol.143 , pp. 717-725
    • Tena-Sempere, M.1    Barreiro, M.L.2    Gonzalez, L.C.3
  • 242
  • 243
    • 9244247597 scopus 로고    scopus 로고
    • Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis
    • Barreiro M.L., Gaytan F., Castellano J.M., et al. Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis. Endocrinology 2004, 145:4825-4834.
    • (2004) Endocrinology , vol.145 , pp. 4825-4834
    • Barreiro, M.L.1    Gaytan, F.2    Castellano, J.M.3
  • 244
    • 42049092078 scopus 로고    scopus 로고
    • Ghrelin inhibits steroid biosynthesis by cultured granulosa-lutein cells
    • Viani I., Vottero A., Tassi F., et al. Ghrelin inhibits steroid biosynthesis by cultured granulosa-lutein cells. J Clin Endocrinol Metab 2008, 93:1476-1481.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1476-1481
    • Viani, I.1    Vottero, A.2    Tassi, F.3
  • 245
    • 34547801816 scopus 로고    scopus 로고
    • Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells
    • Tropea A., Tiberi F., Minici F., et al. Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells. J Clin Endocrinol Metab 2007, 92:3239-3245.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3239-3245
    • Tropea, A.1    Tiberi, F.2    Minici, F.3
  • 246
    • 84859425084 scopus 로고    scopus 로고
    • Expression of ghrelin and the ghrelin receptor in different stages of porcine corpus luteum development and the inhibitory effects of ghrelin on progesterone secretion, 3beta-hydroxysteroid dehydrogenase (3beta-honestly significant difference (HSD)) activity and protein expression
    • Rak-Mardyla A., Gregoraszczuk E.L., Karpeta A., Duda M. Expression of ghrelin and the ghrelin receptor in different stages of porcine corpus luteum development and the inhibitory effects of ghrelin on progesterone secretion, 3beta-hydroxysteroid dehydrogenase (3beta-honestly significant difference (HSD)) activity and protein expression. Theriogenology 2012, 77:1505-1512.
    • (2012) Theriogenology , vol.77 , pp. 1505-1512
    • Rak-Mardyla, A.1    Gregoraszczuk, E.L.2    Karpeta, A.3    Duda, M.4
  • 248
    • 79959900851 scopus 로고    scopus 로고
    • Effect of inhibitor and activator of ghrelin receptor (GHS-R1a) on porcine ovarian granulosa cell functions
    • Sirotkin A.V., Meszarosova M., Grossmann R., Benco A., Valenzuela F. Effect of inhibitor and activator of ghrelin receptor (GHS-R1a) on porcine ovarian granulosa cell functions. Gen Comp Endocrinol 2011, 173:105-110.
    • (2011) Gen Comp Endocrinol , vol.173 , pp. 105-110
    • Sirotkin, A.V.1    Meszarosova, M.2    Grossmann, R.3    Benco, A.4    Valenzuela, F.5
  • 249
    • 61849086775 scopus 로고    scopus 로고
    • Role of ghrelin in regulating rabbit ovarian function and the response to LH and IGF-I
    • Sirotkin A.V., Rafay J., Kotwica J., Darlak K., Valenzuela F. Role of ghrelin in regulating rabbit ovarian function and the response to LH and IGF-I. Domest Anim Endocrinol 2009, 36:162-172.
    • (2009) Domest Anim Endocrinol , vol.36 , pp. 162-172
    • Sirotkin, A.V.1    Rafay, J.2    Kotwica, J.3    Darlak, K.4    Valenzuela, F.5
  • 250
    • 46349085720 scopus 로고    scopus 로고
    • Novel expression and direct effects of adiponectin in the rat testis
    • Caminos J.E., Nogueiras R., Gaytan F., et al. Novel expression and direct effects of adiponectin in the rat testis. Endocrinology 2008, 149:3390-3402.
    • (2008) Endocrinology , vol.149 , pp. 3390-3402
    • Caminos, J.E.1    Nogueiras, R.2    Gaytan, F.3
  • 251
    • 4344649881 scopus 로고    scopus 로고
    • Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors
    • Nogueiras R., Barreiro M.L., Caminos J.E., et al. Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. J Cell Sci 2004, 117:3247-3257.
    • (2004) J Cell Sci , vol.117 , pp. 3247-3257
    • Nogueiras, R.1    Barreiro, M.L.2    Caminos, J.E.3
  • 252
    • 27844483384 scopus 로고    scopus 로고
    • Pattern of orexin expression and direct biological actions of orexin-a in rat testis
    • Barreiro M.L., Pineda R., Gaytan F., et al. Pattern of orexin expression and direct biological actions of orexin-a in rat testis. Endocrinology 2005, 146:5164-5175.
    • (2005) Endocrinology , vol.146 , pp. 5164-5175
    • Barreiro, M.L.1    Pineda, R.2    Gaytan, F.3
  • 253
    • 84859416910 scopus 로고    scopus 로고
    • Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis
    • Garcia-Galiano D., Pineda R., Ilhan T., et al. Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Endocrinology 2012, 153:1959-1971.
    • (2012) Endocrinology , vol.153 , pp. 1959-1971
    • Garcia-Galiano, D.1    Pineda, R.2    Ilhan, T.3


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