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Volumn 151, Issue 10, 2010, Pages 5038-5047

Kisspeptin directly regulates neuropeptide Y synthesis and secretion via the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways in NPY-secreting hypothalamic neurons

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; AGOUTI PROTEIN; GHRELIN; KISSPEPTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPEPTIDE Y; NEUROTENSIN; G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; KISS1 PROTEIN, MOUSE; KISS1R PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

EID: 77957277596     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0521     Document Type: Article
Times cited : (55)

References (55)
  • 6
    • 33751538038 scopus 로고    scopus 로고
    • Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons
    • Clarkson J, Herbison AE 2006 Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin- releasing hormone neurons. Endocrinology 147:5817-5825
    • (2006) Endocrinology , vol.147 , pp. 5817-5825
    • Clarkson, J.1    Herbison, A.E.2
  • 7
    • 73649131642 scopus 로고    scopus 로고
    • Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons
    • Herbison AE, de Tassigny X, Doran J, Colledge WH 2010 Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. Endocrinology 151:312-321
    • (2010) Endocrinology , vol.151 , pp. 312-321
    • Herbison, A.E.1    De Tassigny, X.2    Doran, J.3    Colledge, W.H.4
  • 10
    • 4644289298 scopus 로고    scopus 로고
    • Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide
    • Navarro VM, Castellano JM, Fernández-Fernández R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M 2004 Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145:4565-4574
    • (2004) Endocrinology , vol.145 , pp. 4565-4574
    • Navarro, V.M.1    Castellano, J.M.2    Fernández-Fernández, R.3    Barreiro, M.L.4    Roa, J.5    Sanchez-Criado, J.E.6    Aguilar, E.7    Dieguez, C.8    Pinilla, L.9    Tena-Sempere, M.10
  • 14
    • 50449087725 scopus 로고    scopus 로고
    • Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels
    • Liu X, Lee K, Herbison AE 2008 Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology 149:4605-4614
    • (2008) Endocrinology , vol.149 , pp. 4605-4614
    • Liu, X.1    Lee, K.2    Herbison, A.E.3
  • 15
    • 69249219124 scopus 로고    scopus 로고
    • Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines
    • Novaira HJ, Ng Y, Wolfe A, Radovick S 2009 Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol 311:126-134
    • (2009) Mol Cell Endocrinol , vol.311 , pp. 126-134
    • Novaira, H.J.1    Ng, Y.2    Wolfe, A.3    Radovick, S.4
  • 17
    • 41549121999 scopus 로고    scopus 로고
    • Kisspeptin acts directly and indirectly to increase gonadotropin- releasing hormone neuron activity and its effects are modulated by estradiol
    • Pielecka-Fortuna J, Chu Z, Moenter SM 2008 Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology 149:1979-1986
    • (2008) Endocrinology , vol.149 , pp. 1979-1986
    • Pielecka-Fortuna, J.1    Chu, Z.2    Moenter, S.M.3
  • 18
    • 0033303823 scopus 로고    scopus 로고
    • Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin-releasing hormone neurons and the possible involvement of NPY Y1 receptors
    • Li C, Chen P, Smith MS 1999 Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin-releasing hormone neurons and the possible involvement of NPY Y1 receptors. Endocrinology 140:5382-5390
    • (1999) Endocrinology , vol.140 , pp. 5382-5390
    • Li, C.1    Chen, P.2    Smith, M.S.3
  • 19
    • 0034722849 scopus 로고    scopus 로고
    • Topography and associations of luteinizing hormone-releasing hormone and neuropeptide Y-immunoreactive neuronal systems in the human diencephalon
    • Dudás B, Mihály A, Merchenthaler I 2000 Topography and associations of luteinizing hormone-releasing hormone and neuropeptide Y-immunoreactive neuronal systems in the human diencephalon. J Comp Neurol 427:593-603
    • (2000) J Comp Neurol , vol.427 , pp. 593-603
    • Dudás, B.1    Mihály, A.2    Merchenthaler, I.3
  • 20
    • 0025721025 scopus 로고
    • Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
    • Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS 1991 Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 88:10931-10935
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10931-10935
    • Kalra, S.P.1    Dube, M.G.2    Sahu, A.3    Phelps, C.P.4    Kalra, P.S.5
  • 21
    • 0026474999 scopus 로고
    • Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone-induced LH secretion only under conditions leading to preovulatory LH surges
    • Bauer-Dantoin AC, McDonald JK, Levine JE 1992 Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone-induced LH secretion only under conditions leading to preovulatory LH surges. Endocrinology 131:2946-2952
    • (1992) Endocrinology , vol.131 , pp. 2946-2952
    • Bauer-Dantoin, A.C.1    McDonald, J.K.2    Levine, J.E.3
  • 22
    • 0023154209 scopus 로고
    • Neuropeptide Y enhances the release of luteinizing hormone (LH) induced by LH-releasing hormone
    • Crowley WR, Hassid A, Kalra SP 1987 Neuropeptide Y enhances the release of luteinizing hormone (LH) induced by LH-releasing hormone. Endocrinology 120:941-945
    • (1987) Endocrinology , vol.120 , pp. 941-945
    • Crowley, W.R.1    Hassid, A.2    Kalra, S.P.3
  • 23
    • 0037869111 scopus 로고    scopus 로고
    • Regulation of gonadotropin releasing hormone release by neuropeptide Y at the median eminence during the preovulatory period in ewes
    • Advis JP, Klein J, Kuljis RO, Sarkar DK, McDonald JM, Conover CA 2003 Regulation of gonadotropin releasing hormone release by neuropeptide Y at the median eminence during the preovulatory period in ewes. Neuroendocrinology 77:246-257
    • (2003) Neuroendocrinology , vol.77 , pp. 246-257
    • Advis, J.P.1    Klein, J.2    Kuljis, R.O.3    Sarkar, D.K.4    McDonald, J.M.5    Conover, C.A.6
  • 24
    • 0027965835 scopus 로고
    • Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells
    • Besecke LM, Wolfe AM, Pierce ME, Takahashi JS, Levine JE 1994 Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells. Endocrinology 135:1621-1627
    • (1994) Endocrinology , vol.135 , pp. 1621-1627
    • Besecke, L.M.1    Wolfe, A.M.2    Pierce, M.E.3    Takahashi, J.S.4    Levine, J.E.5
  • 25
    • 0034528940 scopus 로고    scopus 로고
    • Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice
    • Xu M, Hill JW, Levine JE 2000 Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice. Neuroendocrinology 72:263-271
    • (2000) Neuroendocrinology , vol.72 , pp. 263-271
    • Xu, M.1    Hill, J.W.2    Levine, J.E.3
  • 26
    • 0023793018 scopus 로고
    • Evidence that neuropeptide Y (NPY) released into the hypophysial-portal circulation participates in priming gonadotropes to the effects of gonadotropin releasing hormone (GnRH)
    • Sutton SW, Toyama TT, Otto S, Plotsky PM 1988 Evidence that neuropeptide Y (NPY) released into the hypophysial-portal circulation participates in priming gonadotropes to the effects of gonadotropin releasing hormone (GnRH). Endocrinology 123:1208-1210
    • (1988) Endocrinology , vol.123 , pp. 1208-1210
    • Sutton, S.W.1    Toyama, T.T.2    Otto, S.3    Plotsky, P.M.4
  • 27
    • 1342332152 scopus 로고    scopus 로고
    • The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions
    • Gonzales C, Voirol MJ, Giacomini M, Gaillard RC, Pedrazzini T, Pralong FP 2004 The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions. FASEB J 18:137-139
    • (2004) FASEB J , vol.18 , pp. 137-139
    • Gonzales, C.1    Voirol, M.J.2    Giacomini, M.3    Gaillard, R.C.4    Pedrazzini, T.5    Pralong, F.P.6
  • 28
    • 0028925181 scopus 로고
    • Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the female rat
    • Pierroz DD, Gruaz NM, d'Alièves V, Aubert ML 1995 Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the female rat. Neuroendocrinology 61:293-300
    • (1995) Neuroendocrinology , vol.61 , pp. 293-300
    • Pierroz, D.D.1    Gruaz, N.M.2    D'Alièves, V.3    Aubert, M.L.4
  • 29
    • 0024413592 scopus 로고
    • Neuropeptide-Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: Possible site of action
    • McDonald JK, Lumpkin MD, DePaolo LV 1989 Neuropeptide-Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: possible site of action. Endocrinology 125:186-191
    • (1989) Endocrinology , vol.125 , pp. 186-191
    • McDonald, J.K.1    Lumpkin, M.D.2    DePaolo, L.V.3
  • 30
    • 0024994253 scopus 로고
    • Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus macaques
    • Kaynard AH, Pau KY, Hess DL, Spies HG 1990 Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus macaques. Endocrinology 127:2437-2444
    • (1990) Endocrinology , vol.127 , pp. 2437-2444
    • Kaynard, A.H.1    Pau, K.Y.2    Hess, D.L.3    Spies, H.G.4
  • 31
    • 0027475201 scopus 로고
    • Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats
    • Catzeflis C, Pierroz DD, Rohner-Jeanrenaud F, Rivier JE, Sizonenko PC, Aubert ML 1993 Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology 132:224-234
    • (1993) Endocrinology , vol.132 , pp. 224-234
    • Catzeflis, C.1    Pierroz, D.D.2    Rohner-Jeanrenaud, F.3    Rivier, J.E.4    Sizonenko, P.C.5    Aubert, M.L.6
  • 32
    • 0023114303 scopus 로고
    • Bimodal effects of neuropeptide Y on hypothalamic release of gonadotropin-releasing hormone in conscious rabbits
    • Khorram O, Pau KY, Spies HG 1987 Bimodal effects of neuropeptide Y on hypothalamic release of gonadotropin-releasing hormone in conscious rabbits. Neuroendocrinology 45:290-297
    • (1987) Neuroendocrinology , vol.45 , pp. 290-297
    • Khorram, O.1    Pau, K.Y.2    Spies, H.G.3
  • 33
    • 0347717868 scopus 로고    scopus 로고
    • Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders
    • Belsham DD, Cai F, Cui H, Smukler SR, Salapatek AM, Shkreta L 2004 Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders. Endocrinology 145:393-400
    • (2004) Endocrinology , vol.145 , pp. 393-400
    • Belsham, D.D.1    Cai, F.2    Cui, H.3    Smukler, S.R.4    Salapatek, A.M.5    Shkreta, L.6
  • 34
    • 33747813597 scopus 로고    scopus 로고
    • Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) α to ERβ in clonal hypothalamic neurons
    • Titolo D, Cai F, Belsham DD 2006 Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) α to ERβ in clonal hypothalamic neurons. Mol Endocrinol 20:2080-2092
    • (2006) Mol Endocrinol , vol.20 , pp. 2080-2092
    • Titolo, D.1    Cai, F.2    Belsham, D.D.3
  • 35
    • 67449128198 scopus 로고    scopus 로고
    • Neuropeptide Y induces gonadotropin-releasing hormone gene expression directly and through conditioned medium from mHypoE-38 NPY neurons
    • Dhillon SS, Gingerich S, Belsham DD 2009 Neuropeptide Y induces gonadotropin-releasing hormone gene expression directly and through conditioned medium from mHypoE-38 NPY neurons. Regul Pept 156:96-103
    • (2009) Regul Pept , vol.156 , pp. 96-103
    • Dhillon, S.S.1    Gingerich, S.2    Belsham, D.D.3
  • 36
    • 77953148020 scopus 로고    scopus 로고
    • Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells
    • Backholer K, Smith JT, Rao A, Pereira A, Iqbal J, Ogawa S, Li Q, Clarke IJ 2010 Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology 151:2233-2243
    • (2010) Endocrinology , vol.151 , pp. 2233-2243
    • Backholer, K.1    Smith, J.T.2    Rao, A.3    Pereira, A.4    Iqbal, J.5    Ogawa, S.6    Li, Q.7    Clarke, I.J.8
  • 38
    • 34748840772 scopus 로고    scopus 로고
    • Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: Analyses using mouse models and a cell line
    • Luque RM, Kineman RD, Tena-Sempere M 2007 Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 148:4601-4611
    • (2007) Endocrinology , vol.148 , pp. 4601-4611
    • Luque, R.M.1    Kineman, R.D.2    Tena-Sempere, M.3
  • 39
    • 49549089117 scopus 로고    scopus 로고
    • Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): Effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats
    • Kalamatianos T, Grimshaw SE, Poorun R, Hahn JD, Coen CW 2008 Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats. J Neuroendocrinol 20:1089-1097
    • (2008) J Neuroendocrinol , vol.20 , pp. 1089-1097
    • Kalamatianos, T.1    Grimshaw, S.E.2    Poorun, R.3    Hahn, J.D.4    Coen, C.W.5
  • 41
    • 62649100136 scopus 로고    scopus 로고
    • Kisspeptins and GnRH neuronal signalling
    • Colledge WH 2009 Kisspeptins and GnRH neuronal signalling. Trends Endocrinol Metab 20:115-121
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 115-121
    • Colledge, W.H.1
  • 46
    • 0036791113 scopus 로고    scopus 로고
    • Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor
    • Stafford LJ, Xia C, Ma W, Cai Y, Liu M 2002 Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res 62:5399-5404
    • (2002) Cancer Res , vol.62 , pp. 5399-5404
    • Stafford, L.J.1    Xia, C.2    Ma, W.3    Cai, Y.4    Liu, M.5
  • 47
    • 24344448213 scopus 로고    scopus 로고
    • KiSS-1/G protein-coupled receptor 54 metastasis suppressor pathway increases myocyte-enriched calcineurin interacting protein 1 expression and chronically inhibits calcineurin activity
    • Stathatos N, Bourdeau I, Espinosa AV, Saji M, Vasko VV, Burman KD, Stratakis CA, Ringel MD 2005 KiSS-1/G protein-coupled receptor 54 metastasis suppressor pathway increases myocyte-enriched calcineurin interacting protein 1 expression and chronically inhibits calcineurin activity. J Clin Endocrinol Metab 90:5432-5440
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5432-5440
    • Stathatos, N.1    Bourdeau, I.2    Espinosa, A.V.3    Saji, M.4    Vasko, V.V.5    Burman, K.D.6    Stratakis, C.A.7    Ringel, M.D.8
  • 49
    • 0033782054 scopus 로고    scopus 로고
    • Neuropeptides and obesity
    • Beck B 2000 Neuropeptides and obesity. Nutrition 16:916-923
    • (2000) Nutrition , vol.16 , pp. 916-923
    • Beck, B.1
  • 54
    • 56649102174 scopus 로고    scopus 로고
    • Ghrelin as a pleotrophic modulator of gonadal function and reproduction
    • Tena-Sempere M 2008 Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nat Clin Pract Endocrinol Metab 4:666-674
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 666-674
    • Tena-Sempere, M.1
  • 55
    • 63849260648 scopus 로고    scopus 로고
    • Kisspeptin offers a novel therapeutic target in reproduction
    • Jayasena CN, Dhillo WS 2009 Kisspeptin offers a novel therapeutic target in reproduction. Curr Opin Investig Drugs 10:311-318
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 311-318
    • Jayasena, C.N.1    Dhillo, W.S.2


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