CNS-specific ablation of steroidogenic factor 1 results in impaired female reproductive function

Molecular Endocrinology

Volumn 24, Issue 6, 2010, Pages 1240-1250

  Kim, Ki Woo ^a,b   Li, Shen ^c   Zhao, Hongyu ^c   Peng, Boya ^c   Tobet, Stuart A ^d   Elmquist, Joel K ^a   Parker, Keith L ^b   Zhao, Liping ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^d Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADOTROPIN; LUTEINIZING HORMONE; STEROID RECEPTOR; STEROIDOGENIC FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CORPUS LUTEUM; FEMALE; FEMALE INFERTILITY; HORMONE RELEASE; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; LORDOSIS; MALE; MOUSE; NONHUMAN; OVARY; OVULATION; PRIORITY JOURNAL; SEXUAL BEHAVIOR;

ANIMALS; CENTRAL NERVOUS SYSTEM; ESTRADIOL; ESTROUS CYCLE; FEMALE; FERTILITY; FOLLICLE STIMULATING HORMONE; GENE EXPRESSION REGULATION; HYPOTHALAMUS; INTEGRASES; LUTEINIZING HORMONE; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; OVARY; OVULATION; PROGESTERONE; REPRODUCTION; SEXUAL BEHAVIOR, ANIMAL; STEROIDOGENIC FACTOR 1;

MUS;

EID: 77954824974     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0206     Document Type: Article

References (60)

1. Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA, Stallings N, Schimmer BP 2002 Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res 57:19-36
2. Luo X, Ikeda Y, Parker KL 1994 A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77:481-490
3. Luo X, Ikeda Y, Lala DS, Baity LA, Meade JC, Parker KL 1995 A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. Endocr Res 21:517-524
4. Shinoda K, Lei H, Yoshii H, Nomura M, Nagano M, Shiba H, Sasaki H, Osawa Y, Ninomiya Y, Niwa O, Morohashi K, Li E 1995 Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz-F1 disrupted mice. Dev Dyn 204:22-29
5. Davis AM, Seney ML, Stallings NR, Zhao L, Parker KL, Tobet SA 2004 Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus. J Neurobiol 60:424-436
6. Dellovade TL, Young M, Ross EP, Henderson R, Caron K, Parker K, Tobet SA 2000 Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes. J Comp Neurol 423:579-589
7. Majdic G, Young M, Gomez-Sanchez E, Anderson P, Szczepaniak LS, Dobbins RL, McGarry JD, Parker KL 2002 Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 143:607-614
8. Zhao L, Kim KW, Ikeda Y, Anderson KK, Beck L, Chase S, Tobet SA, Parker KL 2008 Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior. Mol Endocrinol 22:1403-1415
9. Tran PV, Lee MB, Marín O, Xu B, Jones KR, Reichardt LF, Rubenstein JR, Ingraham HA 2003 Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neurosci 22:441-453
10. Kim KW, Jo YH, Zhao L, Stallings NR, Chua Jr SC, Parker KL 2008 Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Mol Endocrinol 22:1950-1961
11. Kim KW, Zhao L, Parker KL 2009 Central nervous system-specific knockout of steroidogenic factor 1. Mol Cell Endocrinol 300:132-136
12. Grgurevic N, Büdefeld T, Rissman EF, Tobet SA, Majdic G 2008 Aggressive behaviors in adult SF-1 knockout mice that are not exposed to gonadal steroids during development. Behav Neurosci 122:876-884
13. Smith MJ, Jennes L 2001 Neural signals that regulate GnRH neurones directly during the oestrous cycle. Reproduction 122:1-10 (Pubitemid 32677143)
14. Anderson ST, Walsh JP, Tillet Y, Clarke IJ, Curlewis JD 2001 Dopaminergic input to the ventromedial hypothalamus facilitates the oestrogen-induced luteinizing hormone surge in ewes. Neuroendocrinology 73:91-101
15. Dobson H, Ghuman S, Prabhakar S, Smith R 2003 A conceptual model of the influence of stress on female reproduction. Reproduction 125:151-163 (Pubitemid 36284887)
16. Canteras NS, Simerly RB, Swanson LW 1994 Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris- leucoagglutinin study in the rat. J Comp Neurol 348:41-79
17. Sinchak K, Dewing P, Cook M, Micevych P 2007 Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosis. Horm Behav 51:406-412
18. Pfaff DW, Schwartz-Giblin S 1988 Cellular mechanism of female reproductive behaviors. The physiology of reproduction. New York: Raven Press; 1487-1568
19. Ikeda Y, Nagai A, Ikeda MA, Hayashi S 2003 Sexually dimorphic and estrogen-dependent expression of estrogen receptor β in the ventromedial hypothalamus during rat postnatal development. Endocrinology 144:5098-5104
20. Moffatt CA, Rissman EF, Shupnik MA, Blaustein JD 1998 Induction of progestin receptors by estradiol in the forebrain of estrogen receptor-α gene-disrupted mice. J Neurosci 18:9556-9563
21. Floody OR 2002 Time course of VMN lesion effects on lordosis and proceptive behavior in female hamsters. Horm Behav 41:366-376
22. Pompolo S, Rawson JA, Clarke IJ 2001 Projections from the arcuate/ventromedial region of the hypothalamus to the preoptic area and bed nucleus of stria terminalis in the brain of the ewe; lack of direct input to gonadotropin-releasing hormone neurons. Brain Res 904:1-12
23. Flanagan-Cato LM, Calizo LH, Daniels D 2001 The synaptic organization of VMH neurons that mediate the effects of estrogen on sexual behavior. Horm Behav 40:178-182
24. Sterneck E, Tessarollo L, Johnson PF 1997 An essential role for C/EBPβ in female reproduction. Genes Dev 11:2153-2162 (Pubitemid 27387967)
25. Melo AI, Pérez-Ledezma M, Clapp C, Arnold E, Rivera JC, Fleming AS 2009 Effects of prolactin deficiency during the early postnatal period on the development of maternal behavior in female rats: mother's milk makes the difference. Horm Behav 56:281-291
26. Stallings NR, Hanley NA, Majdic G, Zhao L, Bakke M, Parker KL 2002 Development of a transgenic green fluorescent protein lineage marker for steroidogenic factor 1. Mol Endocrinol 16:2360-2370 (Pubitemid 35155546)
27. Olster DH, Blaustein JD 1989 Development of progesterone-facilitated lordosis in female guinea pigs: relationship to neural estrogen and progestin receptors. Brain Res 484:168-176
28. Kalra SP 1993 Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocr Rev 14:507-538
29. McGinnis MY, Krey LC, MacLusky NJ, McEwen BS 1981 Steroid receptor levels in intact and ovariectomized estrogen-treated rats: an examination of quantitative, temporal and endocrine factors influencing the efficacy of an estradiol stimulus. Neuroendocrinology 33:158-165
30. Blaustein JD, Feder HH 1980 Nuclear progestin receptors in guinea pig brain measured by an in vitro exchange assay after hormonal treatments that affect lordosis. Endocrinology 106:1061-1069
31. Mani SK, Blaustein JD, O'Malley BW 1997 Progesterone receptor function from a behavioral perspective. Horm Behav 31:244-255
32. Rubin BS, Barfield RJ 1983 Induction of estrous behavior in ovariectomized rats by sequential replacement of estrogen and progesterone to the ventromedial hypothalamus. Neuroendocrinology 37:218-224
33. Rubin BS, Barfield RJ 1983 Progesterone in the ventromedial hypothalamus facilitates estrous behavior in ovariectomized, estrogen-primed rats. Endocrinology 113:797-804
34. Gleiberman AS, Michurina T, Encinas JM, Roig JL, Krasnov P, Balordi F, Fishell G, Rosenfeld MG, Enikolopov G 2008 Genetic approaches identify adult pituitary stem cells. Proc Natl Acad Sci USA 105:6332-6337
35. Boehm U, Zou Z, Buck LB 2005 Feedback loops link odor and pheromone signaling with reproduction. Cell 123:683-695
36. Yoon H, Enquist LW, Dulac C 2005 Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. Cell 123:669-682
37. Harding SM, McGinnis MY 2003 Effects of testosterone in the VMN on copulation, partner preference, and vocalizations in male rats. Horm Behav 43:327-335
38. McGinnis MY, Williams GW, Lumia AR 1996 Inhibition of male sex behavior by androgen receptor blockade in preoptic area or hypothalamus, but not amygdala or septum. Physiol Behav 60:783-789
39. Ginton A, Merari A 1977 Long range effects of MPOA lesion on mating behavior in the male rat. Brain Res 120:158-163
40. Christensen LW, Nance DM, Gorski RA 1977 Effects of hypothalamic and preoptic lesions on reproductive behavior in male rats. Brain Res Bull 2:137-141
41. Malsbury CW 1971 Facilitation of male rat copulatory behavior by electrical stimulation of the medial preoptic area. Physiol Behav 7:797-805
42. Levine JE, Chappell PE, Schneider JS, Sleiter NC, Szabo M 2001 Progesterone receptors as neuroendocrine integrators. Front Neuroendocrinol 22:69-106
43. Davis PG, Barfield RJ 1979 Activation of feminine sexual behavior in castrated male rats by intrahypothalamic implants of estradiol benzoate. Neuroendocrinology 28:228-233 (Pubitemid 9143350)
44. Robarts DW, Baum MJ 2007 Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets. Horm Behav 51:104-113
45. Pfaff DW, Sakuma Y 1979 Deficit in the lordosis reflex of female rats caused by lesions in the ventromedial nucleus of the hypothalamus. J Physiol 288:203-210 (Pubitemid 9146882)
46. Pfaff DW, Sakuma Y 1979 Facilitation of the lordosis reflex of female rats from the ventromedial nucleus of the hypothalamus. J Physiol 288:189-202 (Pubitemid 9146881)
47. Calizo LH, Flanagan-Cato LM 2002 Estrogen-induced dendritic spine elimination on female rat ventromedial hypothalamic neurons that project to the periaqueductal gray. J Comp Neurol 447:234-248
48. Parker KL, Schedl A, Schimmer BP 1999 Gene interactions in gonadal development. Annu Rev Physiol 61:417-433
49. Parker KL, Schimmer BP 1994 The role of nuclear receptors in steroid hormone production. Semin Cancer Biol 5:317-325 (Pubitemid 124006785)
50. Chappell PE, Lydon JP, Conneely OM, O'Malley BW, Levine JE 1997 Endocrine defects in mice carrying a null mutation for the progesterone receptor gene. Endocrinology 138:4147-4152
51. Bachelot A, Binart N 2007 Reproductive role of prolactin. Reproduction 133:361-369
52. Haug E 1979 Progesterone suppression of estrogen-stimulated prolactin secretion and estrogen receptor levels in rat pituitary cells. Endocrinology 104:429-437 (Pubitemid 9135855)
53. Cho BN, Suh YH, Yoon YD, Lee CC, Kim K 1993 Progesterone inhibits the estrogen-induced prolactin gene expression in the rat pituitary. Mol Cell Endocrinol 93:47-52
54. Nishikawa S, Moore RC, Nonomura N, Oka T 1994 Progesterone and EGF inhibit mouse mammary gland prolactin receptor and β-casein gene expression. Am J Physiol 267:C1467-C1472
55. Sobrinho LG 2003 Prolactin, psychological stress and environment in humans: adaptation and maladaptation. Pituitary 6:35-39
56. Goldman JM, Murr AS, Cooper RL 2007 The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res B Dev Reprod Toxicol 80:84-97
57. Stanislaus D, Janovick JA, Ji T, Wilkie TM, Offermanns S, Conn PM 1998 Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqα and G11α knockout mice. Endocrinology 139:2710-2717
58. Ogawa S, Chan J, Chester AE, Gustafsson JA, Korach KS, Pfaff DW 1999 Survival of reproductive behaviors in estrogen receptor β gene-deficient (βERKO) male and female mice. Proc Natl Acad Sci USA 96:12887-12892
59. Sisk CL, Meek LR 2001 Sexual and reproductive behaviors. Curr Protoc Neurosci Chapter 8:Unit 8.2
60. Meredith JM, Moffatt CA, Auger AP, Snyder GL, Greengard P, Blaustein JD 1998 Mating-related stimulation induces phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in progestin receptor-containing areas in the female rat brain. J Neurosci 18:10189-10195