Kisspeptin signaling in the brain

Endocrine Reviews

Volumn 30, Issue 6, 2009, Pages 713-743

  Oakley, Amy E ^a   Clifton, Donald K ^b   Steiner, Robert A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CALCIUM ION; DYNORPHIN; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; GONADOTROPIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE ANTAGONIST; INTERLEUKIN 2; INWARDLY RECTIFYING POTASSIUM CHANNEL; ISOPROTEIN; KISSPEPTIN; KISSPEPTIN 10; KISSPEPTIN ANTAGONIST; MEMBRANE PROTEIN; MESSENGER RNA; METABOTROPIC RECEPTOR; METASTIN; MONOCLONAL ANTIBODY; MUTANT PROTEIN; NEUROKININ B; NEUROTRANSMITTER; PHOSPHOLIPASE C; PROTEIN KINASE C; RHODOPSIN; SECRETIN; SEX HORMONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AGING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BRAIN; BRAIN NUCLEUS; BRAIN REGION; CELL COUNT; CELL DIFFERENTIATION; CELL FUNCTION; CELL STIMULATION; CIRCADIAN RHYTHM; COMPARATIVE ANATOMY; FEEDBACK SYSTEM; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; HORMONE ACTION; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LACTATION; METABOLIC REGULATION; NEGATIVE FEEDBACK; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PREGNANCY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PUBERTY; REPRODUCTION; REVIEW; SEASONAL VARIATION; SEQUENCE HOMOLOGY; SEX DIFFERENTIATION; SEXUAL MATURATION; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; VERTEBRATE;

ANIMALS; BRAIN; FISHES; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MAMMALS; NEURONS; PROTEINS; REPRODUCTION; SIGNAL TRANSDUCTION; TERMINOLOGY AS TOPIC; TUMOR SUPPRESSOR PROTEINS; ZEBRAFISH PROTEINS;

EID: 70849092893     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.2009-0005     Document Type: Review

References (206)

1. Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR 1996 KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst 88:1731-1737
2. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M 2001 The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 276:34631-34636 (Pubitemid 37384458)
3. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC 2001 AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem 276:28969-28975
4. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M 2001 Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411:613-617
5. Clements MK, McDonald TP, Wang R, Xie G, O'Dowd BF, George SR, Austin CP, Liu Q 2001 FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun 284:1189-1193 (Pubitemid 32917964)
6. Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF 1999 Discovery of a receptor related to the galanin receptors. FEBS Lett 446:103-107 (Pubitemid 29127258)
7. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E 2003 Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100:10972-10976 (Pubitemid 37140137)
8. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno Jr JS, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley Jr WF, Aparicio SA, Colledge WH 2003 The GPR54 gene as a regulator of puberty. N Engl J Med 349:1614-1627
9. Funes S, Hedrick JA, Vassileva G, Markowitz L, Abbondanzo S, Golovko A, Yang S, Monsma FJ, Gustafson EL 2003 The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun 312:1357-1363 (Pubitemid 37490966)
10. Harms JF, Welch DR, Miele ME 2003 KISS1 metastasis suppression and emergent pathways. Clin Exp Metastasis 20:11-18
11. Gottsch ML, Clifton DK, Steiner RA 2009 From KISS1 to kisspeptins: an historical perspective and suggested nomenclature. Peptides 30:4-9
12. Ringel MD, Hardy E, Bernet VJ, Burch HB, Schuppert F, Burman KD, Saji M 2002 Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. J Clin Endocrinol Metab 87:2399 (Pubitemid 34521537)
13. Marchese A, George SR, Kolakowski Jr LF, Lynch KR, O'Dowd BF 1999 Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends Pharmacol Sci 20:370-375 (Pubitemid 29421618)
14. Greenberg MJ, Price DA 1992 Relationships among the FMRFamide-like peptides. Prog Brain Res 92:25-37
15. Li C, Kim K, Nelson LS 1999 FMRFamide-related neuropeptide gene family in Caenorhabditis elegans. Brain Res 848:26-34
16. Stafford LJ, Xia C, Ma W, Cai Y, Liu M 2002 Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res 62:5399-5404
17. Liu X, Lee K, Herbison AE 2008 Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology 149:4605-4614
18. Constantin S, Caligioni CS, Stojilkovic S, Wray S 2009 Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin- releasing hormone-1 neurons. Endocrinology 150:1400-1412
19. Zhang C, Roepke TA, Kelly MJ, Rønnekleiv OK 2008 Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels. J Neurosci 28:4423-4434
20. Castellano JM, Navarro VM, Fernández-Fernández R, Castaño JP, Malagón MM, Aguilar E, Dieguez C, Magni P, Pinilla L, Tena-Sempere M 2006 Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat. Mol Cell Endocrinol 257-258:75-83 (Pubitemid 44292423)
21. Lee JY, Moon JS, Eu YJ, Lee CW, Yang ST, Lee SK, Jung HH, Kim HH, Rhim H, Seong JY, Kim JI 2009 Molecular interaction between kisspeptin decapeptide analogs and a lipid membrane. Arch Biochem Biophys 485:109-114
22. Wacker JL, Feller DB, Tang XB, Defino MC, Namkung Y, Lyssand JS, Mhyre AJ, Tan X, Jensen JB, Hague C 2008 Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. J Biol Chem 283:31068-31078
23. Cerrato F, Seminara SB 2007 Human genetics of GPR54. Rev Endocr Metab Disord 8:47-55
24. Colledge WH 2009 Transgenic mouse models to study Gpr54/kisspeptin physiology. Peptides 30:34-41
25. Gianetti E, Seminara S 2008 Kisspeptin and KISS1R: a critical pathway in the reproductive system. Reproduction 136:295-301
26. Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, Latronico AC 2008 A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med 358:709-715 (Pubitemid 351240750)
27. West A, Vojta PJ, Welch DR, Weissman BE 1998 Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). Genomics 54:145-148 (Pubitemid 28536204)
28. Mikkelsen JD, Ansel L, Bentsen A, Simonneaux V, Mapping of kisspeptin neurons in the adult male rat brain. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 42
29. Fukusumi S, Habata Y, Yoshida H, Iijima N, Kawamata Y, Hosoya M, Fujii R, Hinuma S, Kitada C, Shintani Y, Suenaga M, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M 2001 Characteristics and distribution of endogenous RFamide-related peptide-1. Biochim Biophys Acta 1540:221-232
30. Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, Fujii R, Watanabe T, Kikuchi K, Terao Y, Yano T, Yamamoto T, Kawamata Y, Habata Y, Asada M, Kitada C, Kurokawa T, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M 2000 New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol 2:703-708
31. Ukena K, Iwakoshi E, Minakata H, Tsutsui K 2002 A novel rat hypothalamic RFamide-related peptide identified by immunoaffinity chromatography and mass spectrometry. FEBS Lett 512:255-258 (Pubitemid 34164490)
32. Ukena K, Tsutsui K 2001 Distribution of novel RFamide-related peptide-like immunoreactivity in the mouse central nervous system. Neurosci Lett 300:153-156 (Pubitemid 32168210)
33. Yano T, Iijima N, Kakihara K, Hinuma S, Tanaka M, Ibata Y 2003 Localization and neuronal response of RFamide related peptides in the rat central nervous system. Brain Res 982:156-167 (Pubitemid 37281413)
34. Yoshida H, Habata Y, Hosoya M, Kawamata Y, Kitada C, Hinuma S 2003 Molecular properties of endogenous RFamide-related peptide-3 and its interaction with receptors. Biochim Biophys Acta 1593:151-157
35. Orsini MJ, Klein MA, Beavers MP, Connolly PJ, Middleton SA, Mayo KH 2007 Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening. J Med Chem 50:462-471
36. Gutiérrez-Pascual E, Leprince J, Martínez-Fuentes AJ, Ségalas-Milazzo I, Pineda R, Roa J, Duran-Prado M, Guilhaudis L, Desperrois E, Lebreton A, Pinilla L, Tonon MC, Malagón MM, Vaudry H, Tena-Sempere M, Castaño JP 2009 In vivo and in vitro structure-activity relationships and structural conformation of kisspeptin-10-related peptides. Mol Pharmacol 76:58-67
37. Niida A, Wang Z, Tomita K, Oishi S, Tamamura H, Otaka A, Navenot JM, Broach JR, Peiper SC, Fujii N 2006 Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity. Bioorg Med Chem Lett 16:134-137 (Pubitemid 41625658)
38. Tomita K, Niida A, Oishi S, Ohno H, Cluzeau J, Navenot JM, Wang ZX, Peiper SC, Fujii N 2006 Structure-activity relationship study on small peptidic GPR54 agonists. Bioorg Med Chem 14:7595-7603 (Pubitemid 44486792)
39. Tomita K, Narumi T, Niida A, Oishi S, Ohno H, Fujii N 2007 Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres. Biopolymers 88:272-278 (Pubitemid 46657993)
40. Tomita K, Oishi S, Cluzeau J, Ohno H, Navenot JM, Wang ZX, Peiper SC, Akamatsu M, Fujii N 2007 SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54. J Med Chem 50:3222-3228 (Pubitemid 47065971)
41. Tomita K, Oishi S, Ohno H, Fujii N 2008 Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists. Biopolymers 90:503-511
42. Kinoshita M, Tsukamura H, Adachi S, Matsui H, Uenoyama Y, Iwata K, Yamada S, Inoue K, Ohtaki T, Matsumoto H, Maeda K 2005 Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. Endocrinology 146:4431-4436 (Pubitemid 41324041)
43. Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP 2009 Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci 29:3920-3929
44. Elizur A 2009 The KiSS1/GPR54 system in fish. Peptides 30:164-170
45. Zohar Y, Munoz-Cueto JA, Elizur A, Kah O 23 April 2009 Neuroendocrinology of reproduction in teleost fish. Gen Comp Endocrinol 10.1016/j.ygcen.2009.04. 017
46. Parhar IS, Ogawa S, Sakuma Y 2004 Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish. Endocrinology 145:3613-3618 (Pubitemid 39037544)
47. Mohamed JS, Benninghoff AD, Holt GJ, Khan IA 2007 Developmental expression of the G protein-coupled receptor 54 and three GnRH mRNAs in the teleost fish cobia. J Mol Endocrinol 38:235-244
48. Martinez-Chavez CC, Minghetti M, Migaud H 2008 GPR54 and rGnRH I gene expression during the onset of puberty in Nile tilapia. Gen Comp Endocrinol 156:224-233
49. Nocillado JN, Levavi-Sivan B, Carrick F, Elizur A 2007 Temporal expression of G-protein-coupled receptor 54 (GPR54), gonadotropin-releasing hormones (GnRH), and dopamine receptor D2 (drd2) in pubertal female grey mullet, Mugil cephalus. Gen Comp Endocrinol 150:278-287 (Pubitemid 44909158)
50. Mechaly AS, Viñas J, Piferrer F 2009 Identification of two isoforms of the Kisspeptin-1 receptor (kiss1r) generated by alternative splicing in a modern teleost, the Senegalese sole (Solea senegalensis). Biol Reprod 80:60-69
51. Filby AL, van Aerle R, Duitman J, Tyler CR 2008 The kisspeptin/ gonadotropin-releasing hormone pathway and molecular signaling of puberty in fish. Biol Reprod 78:278-289 (Pubitemid 351159983)
52. Kanda S, Akazome Y, Matsunaga T, Yamamoto N, Yamada S, Tsukamura H, Maeda K, Oka Y 2008 Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (Oryzias latipes). Endocrinology 149:2467-2476
53. Okubo K, Kanda S, Oka Y, Quantitative expression profiling of Kiss1 and its receptor in the teleost medaka. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 108
54. Kitahashi T, Ogawa S, Parhar IS 2009 Cloning and expression of kiss2 in the zebrafish and medaka. Endocrinology 150:821-831
55. Li S, Zhang Y, Liu Y, Huang X, Huang W, Lu D, Zhu P, Shi Y, Cheng CH, Liu X, Lin H 2009 Structural and functional multiplicity of the kisspeptin/GPR54 system in goldfish (Carassius auratus). J Endocrinol 201:407-418
56. Yang B, Jiang Q, Chan T, Ko WK, Wong AO 9 June 2009 Goldfish kisspeptin: molecular cloning, tissue distribution of transcript expression, and stimulatory effects on prolactin, growth hormone and luteinizing hormone secretion and gene expression via direct actions at the pituitary level. Gen Comp Endocrinol 10.1016/j.ygcen.2009.06.001
57. Biran J, Ben-Dor S, Levavi-Sivan B 2008 Molecular identification and functional characterization of the kisspeptin/kisspeptin receptor system in lower vertebrates. Biol Reprod 79:776-786
58. van Aerle R, Kille P, Lange A, Tyler CR 2008 Evidence for the existence of a functional Kiss1/Kiss1 receptor pathway in fish. Peptides 29:57-64 (Pubitemid 350266117)
59. Felip A, Zanuy S, Carrillo M, Gomez A, Molecular characterization of two sea bass G-protein-coupled receptor 54 (GPR54): cDNA cloning and expression analysis. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 109
60. Felip A, Zanuy S, Carrillo M, Gomez A, Evidence for two kisspeptins in vertebrate non-mammalian species: a particular study of kiss-1 system in the European sea bass, Dicentrarchus labrax. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 47
61. Felip A, Zanuy S, Pineda R, Pinilla L, Carrillo M, Tena-Sempere M, Gomez A 25 Nov 2008 Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals. Mol Cell Endocrinol 10.1016/j.mce.2008.11.017
62. Carrillo M, Zanuy S, Felip A, Bayarri MJ, Molés G, Gómez A 2009 Hormonal and environmental control of puberty in perciform fish: the case of sea bass. Ann NY Acad Sci 1163:49-59
63. Kah O, Zanuy S, Felip A, Caraty A, Carrillo M, Characterization of a kisspeptin-10 system and relationship with the 3 GnRH systems in the brain of a perciform fish, the European sea bass (Dicentrachus labrax). Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 113
64. Lee YR, Tsunekawa K, Moon MJ, Um HN, Hwang JI, Osugi T, Otaki N, Sunakawa Y, Kim K, Vaudry H, Kwon HB, Seong JY, Tsutsui K 2009 Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. Endocrinology 150:2837-2846
65. Moon JS, Lee YR, Oh da Y, Hwang JI, Lee JY, Kim JI, Vaudry H, Kwon HB, Seong JY 2009 Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin. Peptides 30:171-179
66. Tobari Y, Iijima N, Matsumoto K, Okanoya K, Ozawa H, Distribution of kisspeptin-like immunoreactivity in the brain of the bird, Taeniopygia guttata. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 115
67. Akazome Y, Shinji K, Mitani Y, Okubo K, Oka Y, Possible novel form of kisspeptin and kisspeptin receptors in the medaka, Oryzias latipes. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 110
68. Lapatto R, Pallais JC, Zhang D, Chan YM, Mahan A, Cerrato F, Le WW, Hoffman GE, Seminara SB 2007 Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology 148:4927-4936
69. d'Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, Zahn D, Franceschini I, Caraty A, Carlton MB, Aparicio SA, Colledge WH 2007 Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci USA 104:10714-10719
70. Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, Herbison AE 2005 Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci 25:11349-11356
71. Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA 2005 Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci USA 102:1761-1766 (Pubitemid 40209241)
72. Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA 2004 A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145:4073-4077 (Pubitemid 39120554)
73. Clarkson J, Herbison AE 2006 Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin- releasing hormone neurons. Endocrinology 147:5817-5825 (Pubitemid 44833498)
74. Clarkson J, d'Anglemont de Tassigny X, Colledge WH, Caraty A, Herbison AE 2009 Distribution of kisspeptin neurons in the adult female mouse brain. J Neuroendocrinol 21:673-682
75. Kauffman AS, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA, Tena-Sempere M 2007 Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology 148:1774-1783 (Pubitemid 46457121)
76. Revel FG, Saboureau M, Masson-Pévet M, Pévet P, Mikkelsen JD, Simonneaux V 2006 Kisspeptin mediates the photoperiodic control of reproduction in hamsters. Curr Biol 16:1730-1735 (Pubitemid 44767530)
77. Mason AO, Greives TJ, Scotti MA, Levine J, Frommeyer S, Ketterson ED, Demas GE, Kriegsfeld LJ 2007 Suppression of kisspeptin expression and gonadotropic axis sensitivity following exposure to inhibitory day lengths in female Siberian hamsters. Horm Behav 52:492-498 (Pubitemid 47488260)
78. Greives TJ, Mason AO, Scotti MA, Levine J, Ketterson ED, Kriegsfeld LJ, Demas GE 2007 Environmental control of kisspeptin: implications for seasonal reproduction. Endocrinology 148:1158-1166 (Pubitemid 46272807)
79. Adachi S, Yamada S, Takatsu Y, Matsui H, Kinoshita M, Takase K, Sugiura H, Ohtaki T, Matsumoto H, Uenoyama Y, Tsukamura H, Inoue K, Maeda K 2007 Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. J Reprod Dev 53:367-378 (Pubitemid 46743563)
80. Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA 2004 Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 80:264-272
81. Kalamatianos T, Grimshaw SE, Poorun R, Hahn JD, Coen CW 2008 Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats. J Neuroendocrinol 20:1089-1097
82. Smith JT, Popa SM, Clifton DK, Hoffman GE, Steiner RA 2006 Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci 26:6687-6694
83. Brailoiu GC, Dun SL, Ohsawa M, Yin D, Yang J, Chang JK, Brailoiu E, Dun NJ 2005 KiSS-1 expression and metastin-like immunoreactivity in the rat brain. J Comp Neurol 481:314-329 (Pubitemid 40023540)
84. Dun SL, Brailoiu GC, Parsons A, Yang J, Zeng Q, Chen X, Chang JK, Dun NJ 2003 Metastin-like immunoreactivity in the rat medulla oblongata and spinal cord. Neurosci Lett 335:197-201 (Pubitemid 36071633)
85. Inoue N, Pheng V, Inamoto Y, Uenoyama Y, Tsukamura H, Ichikawa M, Maeda KI, Kisspeptin fibers directly contact with gonadotropin-releasing hormone fibers in the median eminence of female rats. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 74
86. Richard N, Galmiche G, Corvaisier S, Caraty A, Kottler ML 2008 KiSS-1 and GPR54 genes are co-expressed in rat gonadotrophs and differentially regulated in vivo by oestradiol and gonadotrophin-releasing hormone. J Neuroendocrinol 20:381-393 (Pubitemid 351280102)
87. Caraty A, Locatelli A, Moenter SM, Karsch FJ, Sampling of hypophyseal portal blood of conscious sheep for direct monitoring of hypothalamic neurosecretory substances. Methods Neurosci 20:162-183
88. Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda KI, Okamura H 12 August 2009 Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. J Neuroendocrinol 10.1111/j.1365-2826.2009.01909.x
89. Keen KL, Wegner FH, Bloom SR, Ghatei MA, Terasawa E 2008 An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo. Endocrinology 149:4151-4157
90. Li S, Ren J, Yang G, Guo Y, Huang L 2008 Characterization of the porcine kisspeptins receptor gene and evaluation as candidate for timing of puberty in sows. J Anim Breed Genet 125:219-227 (Pubitemid 352019653)
91. Pompolo S, Pereira A, Estrada KM, Clarke IJ 2006 Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain. Endocrinology 147:804-810 (Pubitemid 43112997)
92. Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A 2006 Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett 401:225-230 (Pubitemid 43729526)
93. Caldani M, Batailler M, Thiéry JC, Dubois MP 1988 LHRH-immunoreactive structures in the sheep brain. Histochemistry 89:129-139
94. Smith JT, Coolen LM, Kriegsfeld LJ, Sari IP, Jaafarzadehshirazi MR, Maltby M, Bateman K, Goodman RL, Tilbrook AJ, Ubuka T, Bentley GE, Clarke IJ, Lehman MN 2008 Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology 149:5770-5782
95. Smith JT, Rao A, Pereira A, Caraty A, Millar RP, Clarke IJ 2008 Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. Endocrinology 149:1951-1959
96. Decourt C, Tillet Y, Caraty A, Franceschini I, Briant C 2008 Kisspeptin immunoreactive neurons in the equine hypothalamus interactions with GnRH neuronal system. J Chem Neuroanat 36:131-137
97. Magee C, Foradori CD, Bruemmer JE, Arreguin-Arevalo JA, McCue PM, Handa RJ, Squires EL, Clay CM 2009 Biological and anatomical evidence for kisspeptin regulation of the hypothalamic-pituitary-gonadal axis of estrous horse mares. Endocrinology 150:2813-2821
98. de Roux N 2005 Isolated gonadotropic deficiency with and without anosmia: a developmental defect or a neuroendocrine regulation abnormality of the gonadotropic axis. Horm Res 64(Suppl 2):48-55
99. Ramaswamy S, Guerriero KA, Gibbs RB, Plant TM 2008 Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy. Endocrinology 149:4387-4395
100. Shibata M, Friedman RL, Ramaswamy S, Plant TM 2007 Evidence that down regulation of hypothalamic KiSS-1 expression is involved in the negative feedback action of testosterone to regulate luteinising hormone secretion in the adult male rhesus monkey (Macaca mulatta). J Neuroendocrinol 19:432-438 (Pubitemid 46774035)
101. Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM 2005 Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci USA 102:2129-2134 (Pubitemid 40262023)
102. Rometo AM, Krajewski SJ, Voytko ML, Rance NE 2007 Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab 92:2744-2750
103. Hrabovszky E, Vida B, Horvath B, Keller E, Caraty A, Coen CW, Liposits Z, Kallo I, Distribution of kisspeptin-like immunoreactivity in the human hypothalamus: demonstration of neuronal contacts with type-I gonadotropin-releasing hormone neurons. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 73
104. Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA 2005 Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146:3686-3692 (Pubitemid 41175732)
105. Smith JT, Dungan HM, Stoll EA, Gottsch ML, Braun RE, Eacker SM, Clifton DK, Steiner RA 2005 Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology 146:2976-2984
106. Clarkson J, d'Anglemont de Tassigny X, Moreno AS, Colledge WH, Herbison AE 2008 Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci 28:8691-8697
107. Smith JT, Clay CM, Caraty A, Clarke IJ 2007 KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology 148:1150-1157 (Pubitemid 46272806)
108. Smith JT, Acohido BV, Clifton DK, Steiner RA 2006 KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol 18:298-303
109. Gingerich S, Wang X, Lee PK, Dhillon SS, Chalmers JA, Koletar MM, Belsham DD 2009 The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin inhibitory hormone neurons. Neuroscience 162:1134-1140
110. Goodman RL, Lehman MN, Smith JT, Coolen LM, de Oliveira CV, Jafarzadehshirazi MR, Pereira A, Iqbal J, Caraty A, Ciofi P, Clarke IJ 2007 Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology 148:5752-5760 (Pubitemid 350146171)
111. Foradori CD, Coolen LM, Fitzgerald ME, Skinner DC, Goodman RL, Lehman MN 2002 Colocalization of progesterone receptors in parvicellular dynorphin neurons of the ovine preoptic area and hypothalamus. Endocrinology 143:4366-4374
112. Goubillon ML, Forsdike RA, Robinson JE, Ciofi P, Caraty A, Herbison AE 2000 Identification of neurokinin B-expressing neurons as an highly estrogen-receptive, sexually dimorphic cell group in the ovine arcuate nucleus. Endocrinology 141:4218-4225 (Pubitemid 30953537)
113. Burke MC, Letts PA, Krajewski SJ, Rance NE 2006 Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function within the arcuate nucleus. J Comp Neurol 498:712-726
114. Pompolo S, Pereira A, Scott CJ, Fujiyma F, Clarke IJ 2003 Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: an immunohistochemical study using an antibody against vesicular glutamate transporter-2. J Comp Neurol 465:136-144 (Pubitemid 37075685)
115. Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA, Regulation of GnRH secretion by Kiss1/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci 10.1523/JNEUROSCI.1569-09.2009
116. Inyushkin AN, Kallo I, Deli L, Kalamatianos T, Mikkelsen JD, Liposits Z, Coen CW, Dyball REJ, Kisspeptin is present presynaptically in the rat arcuate nucleus and modulates neuronal activity at that site. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 72
117. Clarkson J, Herbison AE 2006 Development of GABA and glutamate signaling at the GnRH neuron in relation to puberty. Mol Cell Endocrinol 254-255:32-38
118. Lee KJ, Maizlin II, Clifton DK, Steiner RA 2005 Coexpression of tyrosine hydroxylase and KiSS-1 mRNA in the anteroventral periventricular nucleus of the female mouse. Proc 35th Annual Meeting of the Society for Neuroscience, Washington, DC, 2005 (Abstract 758.19)
119. Watson Jr RE, Langub Jr MC, Engle MG, Maley BE 1995 Estrogen-receptive neurons in the anteroventral periventricular nucleus are synaptic targets of the suprachiasmatic nucleus and peri-suprachiasmatic region. Brain Res 689:254-264
120. Kalsbeek A, Palm IF, La Fleur SE, Scheer FA, Perreau-Lenz S, Ruiter M, Kreier F, Cailotto C, Buijs RM 2006 SCN outputs and the hypothalamic balance of life. J Biol Rhythms 21:458-469 (Pubitemid 44706827)
121. Colledge WH 2009 Kisspeptins and GnRH neuronal signalling. Trends Endocrinol Metab 20:115-121
122. Liu X, Herbison AE 2008 Small-conductance calcium-activated potassium channels control excitability and firing dynamics in gonadotropin-releasing hormone (GnRH) neurons. Endocrinology 149:3598-3604 (Pubitemid 351919606)
123. Pielecka-Fortuna J, Chu Z, Moenter SM 2008 Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology 149:1979-1986
124. Quaynor S, Hu L, Leung PK, Feng H, Mores N, Krsmanovic LZ, Catt KJ 2007 Expression of a functional G protein-coupled receptor 54-kisspeptin autoregulatory system in hypothalamic gonadotropin-releasing hormone neurons. Mol Endocrinol 21:3062-3070 (Pubitemid 350223515)
125. Dumalska I, Wu M, Morozova E, Liu R, van den Pol A, Alreja M 2008 Excitatory effects of the puberty-initiating peptide kisspeptin and group I metabotropic glutamate receptor agonists differentiate two distinct subpopulations of gonadotropin-releasing hormone neurons. J Neurosci 28:8003-8013
126. d'Anglemont de Tassigny X, Fagg LA, Carlton MB, Colledge WH 2008 Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals. Endocrinology 149:3926-3932
127. Zhang C, Bosch MA, Rønnekleiv OK, Kelly MJ 2009 γ-Aminobutyric acid B receptor mediated inhibition of gonadotropin- releasing hormone neurons is suppressed by kisspeptin-G protein-coupled receptor 54 signaling. Endocrinology 150:2388-2394
128. Richard N, Corvaisier S, Camacho E, Kottler ML 2009 KiSS-1 and GPR54 at the pituitary level: overview and recent insights. Peptides 30:123-129
129. Gutiérrez-Pascual E, Martínez-Fuentes AJ, Pinilla L, Tena-Sempere M, Malagón MM, Castaño JP 2007 Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion. J Neuroendocrinol 19:521-530
130. Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Barreiro ML, Casanueva FF, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M 2005 Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology 146:1689-1697
131. Suzuki S, Kadokawa H, Hashizume T 2008 Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells. Anim Reprod Sci 103:360-365 (Pubitemid 350180305)
132. Belchetz PE, Plant TM, Nakai Y, Keogh EJ, Knobil E 1978 Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone. Science 202:631-633 (Pubitemid 9055618)
133. McArdle CA, Gorospe WC, Huckle WR, Conn PM 1987 Homologous down-regulation of gonadotropin-releasing hormone receptors and desensitization of gonadotropes: lack of dependence on protein kinase C. Mol Endocrinol 1:420-429
134. Wu JC, Sealfon SC, Miller WL 1994 Gonadal hormones and gonadotropin-releasing hormone (GnRH) alter messenger ribonucleic acid levels for GnRH receptors in sheep. Endocrinology 134:1846-1850 (Pubitemid 24110746)
135. Vizcarra JA, Wettemann RP, Braden TD, Turzillo AM, Nett TM 1997 Effect of gonadotropin-releasing hormone (GnRH) pulse frequency on serum and pituitary concentrations of luteinizing hormone and follicle-stimulating hormone, GnRH receptors, and messenger ribonucleic acid for gonadotropin subunits in cows. Endocrinology 138:594-601
136. Mason DR, Arora KK, Mertz LM, Catt KJ 1994 Homologous down-regulation of gonadotropin-releasing hormone receptor sites and messenger ribonucleic acid transcripts in α T3-1 cells. Endocrinology 135:1165-1170 (Pubitemid 24271212)
137. Seminara SB, Dipietro MJ, Ramaswamy S, Crowley Jr WF, Plant TM 2006 Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology 147:2122-2126
138. Ramaswamy S, Seminara SB, Pohl CR, DiPietro MJ, Crowley Jr WF, Plant TM 2007 Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta). Endocrinology 148:3364-3370
139. Thompson EL, Murphy KG, Patterson M, Bewick GA, Stamp GW, Curtis AE, Cooke JH, Jethwa PH, Todd JF, Ghatei MA, Bloom SR 2006 Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats. Am J Physiol Endocrinol Metab 291:E1074-E1082 (Pubitemid 44776760)
140. Tovar S, Vázquez MJ, Navarro VM, Fernández-Fernández R, Castellano JM, Vigo E, Roa J, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M 2006 Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats. Endocrinology 147:2696-2704 (Pubitemid 43764606)
141. Plant TM, Ramaswamy S, Dipietro MJ 2006 Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges. Endocrinology 147:1007-1013
142. Caraty A, Smith JT, Lomet D, Ben Saïd S, Morrissey A, Cognie J, Doughton B, Baril G, Briant C, Clarke IJ 2007 Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes. Endocrinology 148:5258-5267 (Pubitemid 350017445)
143. Navarro VM, Castellano JM, Fernández-Fernández R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M 2004 Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145:4565-4574
144. Dungan HM, Gottsch ML, Zeng H, Gragerov A, Bergmann JE, Vassilatis DK, Clifton DK, Steiner RA 2007 The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci 27:12088-12095 (Pubitemid 350072118)
145. Kim W, Jessen HM, Auger AP, Terasawa E 2009 Postmenopausal increase in KiSS-1, GPR54, and luteinizing hormone releasing hormone (LHRH-1) mRNA in the basal hypothalamus of female rhesus monkeys. Peptides 30:103-110
146. Terasawa E, Wiegand SJ, Bridson WE 1980 A role for medial preoptic nucleus on afternoon of proestrus in female rats. Am J Physiol 238:E533-E539
147. Wintermantel TM, Campbell RE, Porteous R, Bock D, Gröne HJ, Todman MG, Korach KS, Greiner E, Pérez CA, Schütz G, Herbison AE 2006 Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron 52:271-280 (Pubitemid 44548337)
148. Simerly RB 1989 Hormonal control of the development and regulation of tyrosine hydroxylase expression within a sexually dimorphic population of dopaminergic cells in the hypothalamus. Brain Res Mol Brain Res 6:297-310
149. Dungan HM, Naderi R, Clifton DK, Steiner RA Role of neurotensin in the positive feedback control of GnRH/LH secretion in the mouse. Society for Neuroscience Meeting, Washington DC, November 2008. 381.5/RR30
150. Robertson JL, Clifton DK, de la Iglesia HO, Steiner RA, Kauffman AS 2009 Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge. Endocrinology 150:3664-3671
151. Chan YM, Broder-Fingert S, Seminara SB 2009 Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men. Peptides 30:42-48
152. Tenenbaum-Rakover Y, Commenges-Ducos M, Iovane A, Aumas C, Admoni O, de Roux N 2007 Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54. J Clin Endocrinol Metab 92:1137-1144 (Pubitemid 46465693)
153. Semple RK, Achermann JC, Ellery J, Farooqi IS, Karet FE, Stanhope RG, O'rahilly S, Aparicio SA 2005 Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. J Clin Endocrinol Metab 90:1849-1855
154. Alexander MJ, Dobner PR, Miller MA, Bullock BP, Dorsa DM, Leeman SE 1989 Estrogen induces neurotensin/neuromedin N messenger ribonucleic acid in a preoptic nucleus essential for the preovulatory surge of luteinizing hormone in the rat. Endocrinology 125:2111-2117
155. Estrada KM, Clay CM, Pompolo S, Smith JT, Clarke IJ 2006 Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback. J Neuroendocrinol 18:806-809 (Pubitemid 44340517)
156. Knobil E, Neill JD, Freeman MF 2006 Neuroendocrine Control of the Ovarian Cycle of the Rat. In: Neill JD, ed. Physiology of reproduction. Chap 43. Vol 2, 3rd ed. San Diego: Academic Press/Elsevier, Inc.; 2327-2510
157. Glidewell-Kenney C, Hurley LA, Pfaff L, Weiss J, Levine JE, Jameson JL 2007 Nonclassical estrogen receptor α signaling mediates negative feedback in the female mouse reproductive axis. Proc Natl Acad Sci USA 104:8173-8177 (Pubitemid 47185894)
158. Gottsch ML, Navarro VM, Zhao Z, Glidewell-Kenney C, Weiss J, Jameson JL, Clifton DK, Levine JE, Steiner RA 2009 Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci 29:9390-9395
159. Roa J, Vigo E, Castellano JM, Navarro VM, Fernández- Fernández R, Casanueva FF, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M 2006 Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat. Endocrinology 147:2864-2878 (Pubitemid 43764622)
160. Horikoshi Y, Matsumoto H, Takatsu Y, Ohtaki T, Kitada C, Usuki S, Fujino M 2003 Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. J Clin Endocrinol Metab 88:914-919 (Pubitemid 36207842)
161. Hori A, Honda S, Asada M, Ohtaki T, Oda K, Watanabe T, Shintani Y, Yamada T, Suenaga M, Kitada C, Onda H, Kurokawa T, Nishimura O, Fujino M 2001 Metastin suppresses the motility and growth of CHO cells transfected with its receptor. Biochem Biophys Res Commun 286:958-963 (Pubitemid 32924865)
162. Yamada S, Uenoyama Y, Kinoshita M, Iwata K, Takase K, Matsui H, Adachi S, Inoue K, Maeda KI, Tsukamura H 2007 Inhibition of metastin (kisspeptin-54)- GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats. Endocrinology 148:2226-2232 (Pubitemid 46997060)
163. Tsukamura H, Maeda KI, Yokoyama A 1988 Effect of the suckling stimulus on daily LH surges induced by chronic oestrogen treatment in ovariectomized lactating rats. J Endocrinol 118:311-316 (Pubitemid 18210695)
164. Downs JL, Wise PM 2009 The role of the brain in female reproductive aging. Mol Cell Endocrinol 299:32-38
165. Downs JL, Wise PM, E2-mediated Kiss1 drive from the AVPV is diminished at the onset of age-related reproductive decline in the female rat. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 54
166. Fernandez-Fernandez R, Martini AC, Navarro VM, Castellano JM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M 2006 Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol 254-255:127-132 (Pubitemid 44041763)
167. Forbes S, Li XF, Kinsey-Jones J, O'Byrne K 2009 Effects of ghrelin on kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat. Neurosci Lett 460:143-147
168. Navarro VM, Fernández-Fernández R, Castellano JM, Roa J, Mayen A, Barreiro ML, Gaytan F, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M 2004 Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol 561:379-386 (Pubitemid 39646528)
169. Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, Pineda R, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M 2006 Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 55:2602-2610 (Pubitemid 44871162)
170. Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, García-Galiano D, Vigo E, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M 2009 Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology 150:784-794
171. Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, Pineda R, Diéguez C, Aguilar E, Pinilla L, Tena-Sempere M 2008 Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. Am J Physiol Endocrinol Metab 294:E1088-E1096
172. Castellano JM, Navarro VM, Fernández-Fernández R, Nogueiras R, Tovar S, Roa J, Vazquez MJ, Vigo E, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M 2005 Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology 146:3917-3925 (Pubitemid 41175762)
173. Simonneaux V, Ansel L, Revel FG, Klosen P, Pévet P, Mikkelsen JD 2009 Kisspeptin and the seasonal control of reproduction in hamsters. Peptides 30:146-153
174. Clarke IJ, Smith JT, Caraty A, Goodman RL, Lehman MN 2009 Kisspeptin and seasonality in sheep. Peptides 30:154-163
175. Revel FG, Ansel L, Klosen P, Saboureau M, Pévet P, Mikkelsen JD, Simonneaux V 2007 Kisspeptin: a key link to seasonal breeding. Rev Endocr Metab Disord 8:57-65 (Pubitemid 46536848)
176. Messager S 2005 Kisspeptin and its receptor: new gatekeepers of puberty. J Neuroendocrinol 17:687-688
177. Tena-Sempere M 2006 The roles of kisspeptins and G protein-coupled receptor-54 in pubertal development. Curr Opin Pediatr 18:442-447 (Pubitemid 44259004)
178. Kuohung W, Kaiser UB 2006 GPR54 and KiSS-1: role in the regulation of puberty and reproduction. Rev Endocr Metab Disord 7:257-263 (Pubitemid 46399311)
179. Seminara SB 2006 Mechanisms of disease: the first kiss-a crucial role for kisspeptin-1 and its receptor, G-protein-coupled receptor 54, in puberty and reproduction. Nat Clin Pract Endocrinol Metab 2:328-334
180. Navarro VM, Castellano JM, García-Galiano D, Tena-Sempere M 2007 Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin. Rev Endocr Metab Disord 8:11-20 (Pubitemid 46536845)
181. Kauffman AS, Clifton DK, Steiner RA 2007 Emerging ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci 30:504-511
182. Smith JT, Clarke IJ 2007 Kisspeptin expression in the brain: catalyst for the initiation of puberty. Rev Endocr Metab Disord 8:1-9 (Pubitemid 46536844)
183. Clarkson J, Boon WC, Simpson ER, Herbison AE 2009 Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology 150:3214-3220
184. Matsui H, Takatsu Y, Kumano S, Matsumoto H, Ohtaki T 2004 Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun 320:383-388 (Pubitemid 38798878)
185. Fisher CR, Graves KH, Parlow AF, Simpson ER 1998 Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 95:6965-6970
186. Caraty A, Fabre-Nys C, Delaleu B, Locatelli A, Bruneau G, Karsch FJ, Herbison A 1998 Evidence that the mediobasal hypothalamus is the primary site of action of estradiol in inducing the preovulatory gonadotropin releasing hormone surge in the ewe. Endocrinology 139:1752-1760 (Pubitemid 28513834)
187. Navarro VM, Sánchez-Garrido MA, Castellano JM, Roa J, García-Galiano D, Pineda R, Aguilar E, Pinilla L, Tena-Sempere M 2009 Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation. Endocrinology 150:2359-2367
188. Kauffman AS, Sex differences in the Kiss1 system of rodents as the basis for generating the GnRH/LH surge and guiding the tempo of pubertal development. Proc First World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain, 2008; p 27
189. Velasco ME, Taleisnik S 1971 Effects of the interruption of amygdaloid and hippocampal afferents to the medial hypothalamus on gonadotrophin release. J Endocrinol 51:41-55
190. Arai AC, Orwig N 2008 Factors that regulate KiSS1 gene expression in the hippocampus. Brain Res 1243:10-18
191. Arai AC, Xia YF, Suzuki E, Kessler M, Civelli O, Nothacker HP 2005 Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells. J Neurophysiol 94:3648-3652 (Pubitemid 41504799)
192. Arai AC 2009 The role of kisspeptin and GPR54 in the hippocampus. Peptides 30:16-25
193. Kauffman AS, Kim JI, Clifton DK, Steiner RA, Regulation of Kiss1 gene expression by sex steroids in the medial amygdala of mice. Proc of 37th Annual Meeting of the Society for Neuroscience, San Diego, 2007 (Abstract 626.10/VV13)
194. Nakamura Y, Aoki S, Xing Y, Sasano H, Rainey WE 2007 Metastin stimulates aldosterone synthesis in human adrenal cells. Reprod Sci 14:836-845 (Pubitemid 351903559)
195. Hauge-Evans AC, Richardson CC, Milne HM, Christie MR, Persaud SJ, Jones PM 2006 A role for kisspeptin in islet function. Diabetologia 49:2131-2135
196. Bowe JE, King AJ, Kinsey-Jones JS, Foot VL, Li XF, O'Byrne KT, Persaud SJ, Jones PM 2009 Kisspeptin stimulation of insulin secretion: mechanisms of action in mouse islets and rats. Diabetologia 52:855-862
197. Castellano JM, Gaytan M, Roa J, Vigo E, Navarro VM, Bellido C, Dieguez C, Aguilar E, Sánchez-Criado JE, Pellicer A, Pinilla L, Gaytan F, Tena-Sempere M 2006 Expression of KiSS-1 in rat ovary: putative local regulator of ovulation? Endocrinology 147:4852-4862
198. Gaytán F, Gaytán M, Castellano JM, Romero M, Roa J, Aparicio B, Garrido N, Sánchez-Criado JE, Millar RP, Pellicer A, Fraser HM, Tena-Sempere M 2009 KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction. Am J Physiol Endocrinol Metab 296:E520-E531
199. Gaytán M, Castellano JM, Roa J, Sánchez-Criado JE, Tena-Sempere M, Gaytán F 2007 Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation? Cell Tissue Res 329:571-579
200. Hiden U, Bilban M, Knöfler M, Desoye G 2007 Kisspeptins and the placenta: regulation of trophoblast invasion. Rev Endocr Metab Disord 8:31-39 (Pubitemid 46536847)
201. Mead EJ, Maguire JJ, Kuc RE, Davenport AP 2007 Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels. Endocrinology 148:140-147
202. Popa SM, Clifton DK, Steiner RA 2008 The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. Annu Rev Physiol 70:213-238 (Pubitemid 351738178)
203. Dungan HM, Clifton DK, Steiner RA 2006 Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology 147:1154-1158
204. Gottsch ML, Clifton DK, Steiner RA 2006 Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis. Mol Cell Endocrinol 254-255:91-96
205. Wu M, Dumalska I, Morozova E, van den Pol A, Alreja M 2009 Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. PNAS 10.1073/Pnas.0908200106
206. Homma T, Sakakibara M, Yamada S, Kinoshita M, Iwata K, Tomikawa J, Kanazawa T, Matsui H, Takatsu Y, Matsumoto H, Uenoyama Y, Maeda K, Tsukamura H 2009 Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats. Biology of Reproduction 10.1095/biolreprod.109.078311