메뉴 건너뛰기




Volumn 324, Issue 1-2, 2010, Pages 82-86

Insulin and NPY pathways and the control of GnRH function and puberty onset

Author keywords

GnRH; Hypothalamus; Insulin; Leptin; Neuropeptide Y

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; GONADORELIN; INSULIN; LUTEINIZING HORMONE; NEUROPEPTIDE Y; SUPPRESSOR OF CYTOKINE SIGNALING 3; LEPTIN;

EID: 77953915672     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.01.037     Document Type: Review
Times cited : (60)

References (68)
  • 1
    • 75449148131 scopus 로고
    • Body weight and food intake as initiating factors for puberty in the rat
    • Kennedy G.C., Mitra J. Body weight and food intake as initiating factors for puberty in the rat. J. Physiol. 1963, 166:408-448.
    • (1963) J. Physiol. , vol.166 , pp. 408-448
    • Kennedy, G.C.1    Mitra, J.2
  • 2
    • 0016149002 scopus 로고
    • Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset
    • Frisch R.E., McArthur J.W. Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 1974, 185:949-951.
    • (1974) Science , vol.185 , pp. 949-951
    • Frisch, R.E.1    McArthur, J.W.2
  • 3
    • 0022510792 scopus 로고
    • Food-restricted, prepubertal female rats: rapid recovery of luteinizing hormone pulsing with excess food, and full recovery of pubertal development with gonadotropin-releasing hormone
    • Bronson F.H. Food-restricted, prepubertal female rats: rapid recovery of luteinizing hormone pulsing with excess food, and full recovery of pubertal development with gonadotropin-releasing hormone. Endocrinology 1986, 118:2483-2487.
    • (1986) Endocrinology , vol.118 , pp. 2483-2487
    • Bronson, F.H.1
  • 4
    • 0032919990 scopus 로고    scopus 로고
    • Leptin's actions on the reproductive axis: perspectives and mechanisms
    • Cunningham M.J, Clifton D.K., Steiner R.A. Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol. Reprod. 1999, 60:216-222.
    • (1999) Biol. Reprod. , vol.60 , pp. 216-222
    • Cunningham, M.J.1    Clifton, D.K.2    Steiner, R.A.3
  • 5
    • 0032917804 scopus 로고    scopus 로고
    • Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty
    • Foster D.L., Nagatani S. Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty. Biol. Reprod. 1999, 60:205-215.
    • (1999) Biol. Reprod. , vol.60 , pp. 205-215
    • Foster, D.L.1    Nagatani, S.2
  • 6
    • 0022499326 scopus 로고
    • Food restriction and reproductive development: male and female mice and male rats
    • Hamilton G.D., Bronson F.H. Food restriction and reproductive development: male and female mice and male rats. Am. J. Physiol. 1986, 250:R370-R376.
    • (1986) Am. J. Physiol. , vol.250
    • Hamilton, G.D.1    Bronson, F.H.2
  • 8
    • 0033608404 scopus 로고    scopus 로고
    • Effects of glucose and related substrates on the recovery of the electrical activity of gonadotropin-releasing hormone pulse generator which is decreased by insulin-induced hypoglycemia in the estrogen-primed ovariectomized rat
    • He D., Funabashi T., Sano A., Uemura T., Minaguchi H., Kimura F. Effects of glucose and related substrates on the recovery of the electrical activity of gonadotropin-releasing hormone pulse generator which is decreased by insulin-induced hypoglycemia in the estrogen-primed ovariectomized rat. Brain Res. 1999, 820:71-76.
    • (1999) Brain Res. , vol.820 , pp. 71-76
    • He, D.1    Funabashi, T.2    Sano, A.3    Uemura, T.4    Minaguchi, H.5    Kimura, F.6
  • 9
    • 0029791821 scopus 로고    scopus 로고
    • Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty
    • Hiney J.K., Srivastava V., Nyberg C.L., Ojeda S.R., Dees W.L. Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty. Endocrinology 1996, 137:3717-3728.
    • (1996) Endocrinology , vol.137 , pp. 3717-3728
    • Hiney, J.K.1    Srivastava, V.2    Nyberg, C.L.3    Ojeda, S.R.4    Dees, W.L.5
  • 10
    • 0031769325 scopus 로고    scopus 로고
    • Insulin-like growth factor-I effects on gonadotropin-releasing hormone biosynthesis in GT1-7 cells
    • Longo K.M., Sun Y., Gore A.C. Insulin-like growth factor-I effects on gonadotropin-releasing hormone biosynthesis in GT1-7 cells. Endocrinology 1998, 139:1125-1132.
    • (1998) Endocrinology , vol.139 , pp. 1125-1132
    • Longo, K.M.1    Sun, Y.2    Gore, A.C.3
  • 11
    • 0024324195 scopus 로고
    • Availability of metabolic fuels controls estrous cyclicity of Syrian hamsters
    • Schneider J.E., Wade G.N. Availability of metabolic fuels controls estrous cyclicity of Syrian hamsters. Science 1989, 244:1326-1328.
    • (1989) Science , vol.244 , pp. 1326-1328
    • Schneider, J.E.1    Wade, G.N.2
  • 14
    • 0026915602 scopus 로고
    • Remembrance: the discovery of the hypothalamic gonadotropin-releasing hormone pulse generator and of its physiological significance
    • Knobil E. Remembrance: the discovery of the hypothalamic gonadotropin-releasing hormone pulse generator and of its physiological significance. Endocrinology 1992, 131:1005-1006.
    • (1992) Endocrinology , vol.131 , pp. 1005-1006
    • Knobil, E.1
  • 15
    • 0022918970 scopus 로고
    • Gonadotropin-releasing hormone: role of pulsatile secretion in the regulation of reproduction
    • Marshall J.C., Kelch R.P. Gonadotropin-releasing hormone: role of pulsatile secretion in the regulation of reproduction. New Engl. J. Med. 1986, 315:1459-1468.
    • (1986) New Engl. J. Med. , vol.315 , pp. 1459-1468
    • Marshall, J.C.1    Kelch, R.P.2
  • 16
    • 33745976149 scopus 로고    scopus 로고
    • Control of GnRH neuronal activity by metabolic factors: the role of leptin and insulin
    • Gamba M., Pralong F.P. Control of GnRH neuronal activity by metabolic factors: the role of leptin and insulin. Mol. Cell. Endocrinol. 2006, 254-255:133-139.
    • (2006) Mol. Cell. Endocrinol. , pp. 133-139
    • Gamba, M.1    Pralong, F.P.2
  • 20
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural network
    • Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural network. Science 1995, 269:546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 22
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab F.F, Lim M.E., Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 1996, 12:318-320.
    • (1996) Nat. Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 23
    • 0031051499 scopus 로고    scopus 로고
    • Leptin treatment rescues the sterility of genetically obese ob/ob males
    • Mounzih K., Lu R., Chehab F.F. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 1997, 138:1190-1193.
    • (1997) Endocrinology , vol.138 , pp. 1190-1193
    • Mounzih, K.1    Lu, R.2    Chehab, F.F.3
  • 27
    • 0032998652 scopus 로고    scopus 로고
    • Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus
    • Baskin D.G., Breininger J.F., Schwartz M.W. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 1999, 48:828-833.
    • (1999) Diabetes , vol.48 , pp. 828-833
    • Baskin, D.G.1    Breininger, J.F.2    Schwartz, M.W.3
  • 29
    • 0021264217 scopus 로고
    • Differential effects of pancreatic polypeptide on luteinizing hormone release in female rats
    • Kalra S.P., Crowley W.R. Differential effects of pancreatic polypeptide on luteinizing hormone release in female rats. Neuroendocrinology 1984, 38:511-513.
    • (1984) Neuroendocrinology , vol.38 , pp. 511-513
    • Kalra, S.P.1    Crowley, W.R.2
  • 30
    • 0021264777 scopus 로고
    • Norepinephrine-like effects of neuropeptide Y in the rat
    • Kalra S.P., Crowley W.R. Norepinephrine-like effects of neuropeptide Y in the rat. Life Sci. 1984, 35:1173-1176.
    • (1984) Life Sci. , vol.35 , pp. 1173-1176
    • Kalra, S.P.1    Crowley, W.R.2
  • 31
    • 0024994253 scopus 로고
    • Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus monkeys
    • Kaynard A.H., Pau K.Y.F., Spies A.G. Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus monkeys. Endocrinology 1990, 45:2437-2444.
    • (1990) Endocrinology , vol.45 , pp. 2437-2444
    • Kaynard, A.H.1    Pau, K.Y.F.2    Spies, A.G.3
  • 32
    • 0023114303 scopus 로고
    • Bimodal effects of neuropeptide Y on hypothalamic release of gonadotropin-releasing hormone in conscious rabbits
    • Khorram O., Pau K.Y.F., Spies H.G. Bimodal effects of neuropeptide Y on hypothalamic release of gonadotropin-releasing hormone in conscious rabbits. Neuroendocrinology 1987, 45:290-297.
    • (1987) Neuroendocrinology , vol.45 , pp. 290-297
    • Khorram, O.1    Pau, K.Y.F.2    Spies, H.G.3
  • 33
    • 0024413592 scopus 로고
    • Neuropeptide Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: possible site of action
    • McDonald J.K., Lumpkin M.D., DePaolo L.V. Neuropeptide Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: possible site of action. Endocrinology 1989, 125:186-191.
    • (1989) Endocrinology , vol.125 , pp. 186-191
    • McDonald, J.K.1    Lumpkin, M.D.2    DePaolo, L.V.3
  • 34
    • 0027475201 scopus 로고
    • Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in the intact adult female rats
    • Catzeflis C., Pierroz D.D., Rohner-Jeanrenaud F., Rivier J.E., Sizonenko P.C., Aubert M.L. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in the intact adult female rats. Endocrinology 1993, 224-234.
    • (1993) Endocrinology , pp. 224-234
    • Catzeflis, C.1    Pierroz, D.D.2    Rohner-Jeanrenaud, F.3    Rivier, J.E.4    Sizonenko, P.C.5    Aubert, M.L.6
  • 35
    • 0030041430 scopus 로고    scopus 로고
    • Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in adult male rats
    • Pierroz D.D., Catzeflis C., Aebi A.C., Rivier J.E., Aubert M.L. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in adult male rats. Endocrinology 1996, 137:3-12.
    • (1996) Endocrinology , vol.137 , pp. 3-12
    • Pierroz, D.D.1    Catzeflis, C.2    Aebi, A.C.3    Rivier, J.E.4    Aubert, M.L.5
  • 36
    • 0028925181 scopus 로고
    • Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the femal rat
    • Pierroz D.D., Gruaz N.M., D'Allèves V., Aubert M.L. Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the femal rat. Neuroendocrinology 1995, 61:293-300.
    • (1995) Neuroendocrinology , vol.61 , pp. 293-300
    • Pierroz, D.D.1    Gruaz, N.M.2    D'Allèves, V.3    Aubert, M.L.4
  • 37
    • 0025721025 scopus 로고
    • Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
    • Kalra S.P., Dube M.G., Sahu A., Phelps C.P., Kalra P.S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:10931-10935.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 10931-10935
    • Kalra, S.P.1    Dube, M.G.2    Sahu, A.3    Phelps, C.P.4    Kalra, P.S.5
  • 40
    • 0031957139 scopus 로고    scopus 로고
    • Multiple receptors for the pancreatic polypeptide (PP-fold) family: physiological implications
    • Gehlert D.R. Multiple receptors for the pancreatic polypeptide (PP-fold) family: physiological implications. Proc. Soc. Exp. Biol. Med. 1998, 218:7-22.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.218 , pp. 7-22
    • Gehlert, D.R.1
  • 43
    • 0026663603 scopus 로고
    • Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats
    • Kalra S.P., Fuentes M., Fournier A., Parker S.L., Crowley W.R. Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats. Endocrinology 1992, 130:3323-3330.
    • (1992) Endocrinology , vol.130 , pp. 3323-3330
    • Kalra, S.P.1    Fuentes, M.2    Fournier, A.3    Parker, S.L.4    Crowley, W.R.5
  • 44
    • 0033305479 scopus 로고    scopus 로고
    • Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype
    • Raposinho P.D., Broqua P., Pierroz D.D., Hayward A., Dumont Y., Quirion R., Junien J.L., Aubert M.L. Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype. Endocrinology 1999, 140:4046-4055.
    • (1999) Endocrinology , vol.140 , pp. 4046-4055
    • Raposinho, P.D.1    Broqua, P.2    Pierroz, D.D.3    Hayward, A.4    Dumont, Y.5    Quirion, R.6    Junien, J.L.7    Aubert, M.L.8
  • 45
    • 0034705033 scopus 로고    scopus 로고
    • Neuropeptide Y: a hypothalamic brake restraining the onset of puberty in primates
    • El Majdoubi M., Sahu A., Ramaswamy S., Plant T.M. Neuropeptide Y: a hypothalamic brake restraining the onset of puberty in primates. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:6179-6184.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 6179-6184
    • El Majdoubi, M.1    Sahu, A.2    Ramaswamy, S.3    Plant, T.M.4
  • 46
    • 0034711589 scopus 로고    scopus 로고
    • Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors
    • Pralong F.P., Voirol M., Giacomini M., Gaillard R.C., Grouzmann E. Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors. Regul. Pept. 2000, 95:47-52.
    • (2000) Regul. Pept. , vol.95 , pp. 47-52
    • Pralong, F.P.1    Voirol, M.2    Giacomini, M.3    Gaillard, R.C.4    Grouzmann, E.5
  • 47
    • 1342332152 scopus 로고    scopus 로고
    • The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions
    • Epub 2003 Nov 2004
    • Gonzales C., Voirol M.J., Giacomini M., Gaillard R.C., Pedrazzini T., Pralong F.P. The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions. FASEB J. 2003, 18:137-139. Epub 2003 Nov 2004.
    • (2003) FASEB J. , vol.18 , pp. 137-139
    • Gonzales, C.1    Voirol, M.J.2    Giacomini, M.3    Gaillard, R.C.4    Pedrazzini, T.5    Pralong, F.P.6
  • 51
    • 57849148921 scopus 로고    scopus 로고
    • KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications
    • Castellano J.M., Roa J., Luque R.M., Dieguez C., Aguilar E., Pinilla L., Tena-Sempere M. KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications. Peptides 2009, 30:139-145.
    • (2009) Peptides , vol.30 , pp. 139-145
    • Castellano, J.M.1    Roa, J.2    Luque, R.M.3    Dieguez, C.4    Aguilar, E.5    Pinilla, L.6    Tena-Sempere, M.7
  • 52
    • 0033303823 scopus 로고    scopus 로고
    • Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin-releasing hormone neurons and the possible involvement of NPY Y1 receptors
    • Li C., Chen P., Smith M.S. Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin-releasing hormone neurons and the possible involvement of NPY Y1 receptors. Endocrinology 1999, 140:5382-5390.
    • (1999) Endocrinology , vol.140 , pp. 5382-5390
    • Li, C.1    Chen, P.2    Smith, M.S.3
  • 53
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • Woods S.C., Lotter E.C., McKay L.D., Porte D. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979, 282:503-505.
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, L.D.3    Porte, D.4
  • 54
    • 0034703107 scopus 로고    scopus 로고
    • Staying slim with insulin in mind
    • Schwartz M.W. Staying slim with insulin in mind. Science 2000, 289:2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Schwartz, M.W.1
  • 55
    • 4544306391 scopus 로고    scopus 로고
    • Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis
    • Niswender K.D., Baskin D.G., Schwartz M.W. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol. Metab. 2004, 15:362-369.
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 362-369
    • Niswender, K.D.1    Baskin, D.G.2    Schwartz, M.W.3
  • 56
    • 0027361094 scopus 로고
    • Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain
    • Baura G.D., Foster D.M., Porte D., Kahn S.E., Bergman R.N., Cobelli C., Schwartz M.W. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J. Clin. Invest. 1993, 92:1824-1830.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1824-1830
    • Baura, G.D.1    Foster, D.M.2    Porte, D.3    Kahn, S.E.4    Bergman, R.N.5    Cobelli, C.6    Schwartz, M.W.7
  • 57
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans
    • Schwartz M.W., Peskind E., Raskind M., Boyko E.J., Porte D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 1996, 2:589-593.
    • (1996) Nat. Med. , vol.2 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte, D.5
  • 59
    • 0025359018 scopus 로고
    • Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat
    • McGowan M.K., Andrews K.M., Kelly J., Grossman S.P. Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat. Behav. Neurosci. 1990, 104:373-385.
    • (1990) Behav. Neurosci. , vol.104 , pp. 373-385
    • McGowan, M.K.1    Andrews, K.M.2    Kelly, J.3    Grossman, S.P.4
  • 61
    • 0141673466 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone secretion from hypothalamic neurons: stimulation by insulin and potentiation by leptin
    • Burcelin R., Thorens B., Glauser M., Gaillard R.C., Pralong F.P. Gonadotropin-releasing hormone secretion from hypothalamic neurons: stimulation by insulin and potentiation by leptin. Endocrinology 2003, 144:4484-4491.
    • (2003) Endocrinology , vol.144 , pp. 4484-4491
    • Burcelin, R.1    Thorens, B.2    Glauser, M.3    Gaillard, R.C.4    Pralong, F.P.5
  • 62
    • 30944447860 scopus 로고    scopus 로고
    • Effects of cytokines on gonadotropin-releasing hormone (GnRH) gene expression in primary hypothalamic neurons and in GnRH neurons immortalized conditionally
    • Igaz P., Salvi R., Rey J.P., Glauser M., Pralong F.P., Gaillard R.C. Effects of cytokines on gonadotropin-releasing hormone (GnRH) gene expression in primary hypothalamic neurons and in GnRH neurons immortalized conditionally. Endocrinology 2006, 147:1037-1043.
    • (2006) Endocrinology , vol.147 , pp. 1037-1043
    • Igaz, P.1    Salvi, R.2    Rey, J.P.3    Glauser, M.4    Pralong, F.P.5    Gaillard, R.C.6
  • 63
    • 30944466103 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone-expressing neurons immortalized conditionally are activated by insulin: implication of the mitogen-activated protein kinase pathway
    • Salvi R., Castillo E., Voirol M.J., Glauser M., Rey J.P., Gaillard R.C., Vollenweider P., Pralong F.P. Gonadotropin-releasing hormone-expressing neurons immortalized conditionally are activated by insulin: implication of the mitogen-activated protein kinase pathway. Endocrinology 2006, 147:816-826.
    • (2006) Endocrinology , vol.147 , pp. 816-826
    • Salvi, R.1    Castillo, E.2    Voirol, M.J.3    Glauser, M.4    Rey, J.P.5    Gaillard, R.C.6    Vollenweider, P.7    Pralong, F.P.8
  • 64
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick D., Smith M.A., Groppi V.E., Logan S.D., Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 1997, 390:521-525.
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 65
    • 34247622216 scopus 로고    scopus 로고
    • Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin
    • DiVall S.A., Radovick S., Wolfe A. Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin. Mol. Cell. Endocrinol. 2007, 270:64-72.
    • (2007) Mol. Cell. Endocrinol. , vol.270 , pp. 64-72
    • DiVall, S.A.1    Radovick, S.2    Wolfe, A.3
  • 67
    • 0037315042 scopus 로고    scopus 로고
    • Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
    • Niswender K.D., Morrison C.D., Clegg D.J., Olson R., Baskin D.G., Myers M.G., Seeley R.J., Schwartz M.W. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 2003, 52:227-231.
    • (2003) Diabetes , vol.52 , pp. 227-231
    • Niswender, K.D.1    Morrison, C.D.2    Clegg, D.J.3    Olson, R.4    Baskin, D.G.5    Myers, M.G.6    Seeley, R.J.7    Schwartz, M.W.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.