Ghrelin levels from fetal life through early adulthood: Relationship with endocrine and metabolic and anthropometric measures

Journal of Pediatrics

Volumn 144, Issue 1, 2004, Pages 30-35

  Soriano Guillén, Leandro ^b   Barrios, Vicente ^b   Chowen, Julie A ^b   Sánchez, Ignacio ^b   Vila, Santiago ^b   Quero, José ^b   Argente, Jesús ^a  

^a HOSPITAL INFANTIL UNIVERSITARIO NIÑO JESÚS   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCOSE; INSULIN; LEPTIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULTHOOD; ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD LEVEL; BODY MASS; CHILDHOOD; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; ENDOCRINOLOGY; FEMALE; FETUS DEVELOPMENT; HUMAN; MALE; MEASUREMENT; METABOLISM; NEWBORN; NEWBORN PERIOD; NORMAL HUMAN; POSTNATAL DEVELOPMENT; PREMATURITY; PRIORITY JOURNAL; PUBERTY; SEX; UMBILICAL CORD BLOOD;

EID: 0347755156     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2003.08.050     Document Type: Article

References (38)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from the stomach. Nature 1999;402:656-60.
2. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairlough P, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002;87:2988-91.
3. Wierup N, Svensson H, Mudler H, Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002;107:63-9.
4. Rindi G, Necchi V, Savio A, Torsello A, Zoli M, Locatelli V, et al. Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochem Cell Biol 2002;117:511-9.
5. Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 2001;86:1169-74.
6. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407:908-13.
7. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-8.
8. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, et al. Ghrelin enhances appetite and increase food intake in humans. J Clin Endocrinol Metab 2001;86:5992-5.
9. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, et al. Ghrelin, natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 2001;86:5083-6.
10. Muller AF, Lamberts SWJ, Janssen JA, Hofland LJ, Koetsveld PV, Bidlingmaier M, et al. Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol 2002;146:203-7.
11. English PJ, Ghatei MA, Malik IA, Bloom SR, Wilding JPH. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 2002;87:2984-7.
12. Tschöp M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, et al. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 2001;24:RC19-21.
13. Baker J, Lui JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993;75:73-82.
14. 14; LeRoith D. Insulin-like growth factors. N Engl J Med 1997;336:633-40.
15. Argente J, Barrios V, Pozo J, Muñoz MT, Hervás F, Stene M, et al. Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age-and sex-related changes. J Clin Endocrinol Metab 1993;77:1522-8.
16. Argente J, Caballo N, Barrios V, Pozo J, Muñoz MT, Chowen JA, et al. Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepuberal children with exogenous obesity: effect of short and long-term weight reduction. J Clin Endocrinol Metab 1997;82:2076-83.
17. Argente J, Caballo N, Barrios V, Muñoz MT, Pozo J, Chowen JA, et al. Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in patients with anorexia nervosa: effect of short-and long-term weight recuperation. J Clin Endocrinol Metab 1997;82:2084-92.
18. Christou H, Conors JM, Ziotopoulou M, Hatzidakis V, Papathanassoglou E, Ringer SA, et al. Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth. J Clin Endocrinol Metab 2001;86:935-8.
19. Argente J, Barrios V, Chowen JA, Sinha MK, Considine RV. Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimic nervosa. J Pediatr 1997;131:833-8.
20. Chanoine JP, Yeung LP, Wong AC, Birmingham CL. Immunoreactive ghrelin in human cord blood: relation to anthropometry, leptin and growth hormone. J Pediatr Gastroenterol Nutr 2002;35:282-6.
21. Bellone S, Rapa A, Vivenza D, Castellino N, Petri A, Bellone J, et al. Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood. J Endocrinol Invest 2002;25:RC13-15.
22. Delgado Beltran P, Melchor Marros JC, Rodriguez-Alarcon J, Linares Uribe A, Fernandez-Llebrez del Rey L, Barbazan Cortes MJ, et al. Intrauterine growth curves of Hospital de Cruces (Vizcaya), II: length, head circumference, and ponderal index. An Esp Pediatr 1996;44:55-9.
23. Delgado Beltran P, Melchor Marros JC, Rodriguez-Alarcon J, Linares Uribe A, Fernandez-Llebrez del Rey L, Barbazan Cortes MJ, et al. Intrauterine growth curves of Hospital de Cruces (Vizcaya), I: birth weight. An Esp Pediatr 1996;44:50-4.
24. Hernández M, Castellet J, Narvaiza JL, Rincón JM, Ruiz I, Sánchez E, et al. Curvas y tablas de crecimiento, 1988. Madrid: Garsi; 1988.
25. Lee HM, Wang G, Englander EW, Kojima M, Greeley GH Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 2002;143:185-90.
26. Hayashida T, Nakahara K, Mondai MS, Date Y, Nakazato M, Kojima M, et al. Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol 2002;173:239-45.
27. Gualillo O, Caminos J, Blanco M, García-Caballero T, Kojima M, Kangawa K, et al. Ghrelin, a novel placental-derived hormone. Endocrinology 2001;142:788-94.
28. Kamegai J, Wakabayashi I, Kineman RD, Frohman LA. Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats. J Neuroendocrinol 1999;11:299-306.
29. Papotti M, Ghe C, Cassoni P, Catapano F, Deghenghi R, Ghigo E, et al. Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 2000;85:3803-7.
30. Tena-Sempere M, Barreiro ML, Gonzalez LC, Gaytan F, Zhang FP, Caminos JE, et al. Novel expression and functional role of ghrelin in rat testis. Endocrinology 2002;143:717-25.
31. Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschöp M, Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 2002;87:5625-9.
32. Cotterill AM, Cowell CT, Baxter RC, McNeill D, Silink M. Regulation of the growth hormone-independent growth factor in human plasma. J Clin Endocrinol Metab 1988;67:882-7.
33. Schaller G, Schmidt A, Pleiner J, Woloszczuk W, Wolzt M, Luger A. Plasma ghrelin concentrations are not regulated by glucose or insulin: a double-blind, placebo-controlled crossover clamp study. Diabetes 2003; 52:16-20.
34. Caixas A, Bashore C, Nasw W, Pi-Sunyer F, Laferre B. Insulin, unlike food intake, does not suppress ghrelin in human subjects. J Clin Endocrinol Metab 2002;87:1902-6.
35. Saad MF, Bernaba B, Hwu CM, Jinagouda S, Fahmi S, Kogosov E, et al. Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 2002;87:3997-4000.
36. Reimer MK, Pacini G, Ahren B. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology 2003;144:916-21.
37. Ukkola O. Ghrelin and insulin metabolism. Eur J Clin Invest 2003; 33:183-5.
38. Ikezaki A, Hosoda H, Ito K, Iwama S, Miura N, Matsuoka H, et al. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-I, but not with leptin, in obese children and adolescents. Diabetes 2002;51:3408-11.