Acylated ghrelin inhibits spontaneous luteinizing hormone pulsatility and responsiveness to naloxone but not that to gonadotropin-releasing hormone in young men: Evidence for a central inhibitory action of ghrelin on the gonadal axis

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 9, 2008, Pages 3633-3639

  Lanfranco, Fabio ^a   Bonelli, Lorenza ^a   Baldi, Matteo ^a   Me, Elisa ^a   Broglio, Fabio ^a   Ghigo, Ezio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GHRELIN; GONADORELIN; GONADOTROPIN; LUTEINIZING HORMONE; NALOXONE; SODIUM CHLORIDE;

ABSENCE OF SIDE EFFECTS; ADULT; AREA UNDER THE CURVE; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG EFFECT; FOLLITROPIN BLOOD LEVEL; GONAD; HORMONE INHIBITION; HUMAN; HUMAN EXPERIMENT; INHIBITION KINETICS; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NEUROMODULATION; NORMAL HUMAN; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; TREATMENT RESPONSE; VOLUNTEER;

ANIMALIA;

EID: 51649085619     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-0049     Document Type: Article

References (48)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone acylated peptide from stomach. Nature 402:656-660
2. Tena-Sempere M 2005 Exploring the role of ghrelin as novel regulator of gonadal function. Growth Horm IGF Res 15:83-88
3. Smith RG, Van der Ploeg LH, Howard AD, Feighner SD, Cheng K, Hickey GJ, Wyvratt Jr MJ, Fisher MH, Nargund RP, Patchett AA 1997 Peptidomimetic regulation of growth hormone secretion. Endocr Rev 18:621-645
4. van der Lely AJ, Tschop M, Heiman ML, Ghigo E 2004 Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25:426-457
5. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB 2004 Ghrelin - a hormone with multiple functions. Front Neuroendocrinol 25:27-68
6. Muccioli G, Baragli A, Granata R, Papotti M, Ghigo E 2007 Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors. Neuroendocrinology 86:147-164
7. Tschoep M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
8. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328
9. Hosoda H, Kojima M, Kangawa K 2006 Biological, physiological, and pharmacological aspects of ghrelin. J Pharmacol Sci 100:398-410
10. Sun Y, Asnicar M, Smith RG 2007 Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology 86:215-228
11. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, Kangawa K, Matsukura S 2001 Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 281:1220-1225
12. Warren MP 1983 Effects of undernutrition on reproductive function in the human. Endocr Rev 4:363-377
13. I'Anson H, Foster DL, Foxcroft GR, Booth PJ 1991 Nutrition and reproduction. Oxf Rev Reprod Biol 13:239-311
14. Loucks AB, Thuma JR 2003 Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women. J Clin Endocrinol Metab 88:297-311
15. Broglio F, Gianotti L, Destefanis S, Fassino S, Abbate Daga G, Mondelli V, Lanfranco F, Gottero C, Gauna C, Hofland L, Van der Lely AJ, Ghigo E 2004 The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state. Clin Endocrinol (Oxf) 60:592-599
16. Loucks AB 2007 Energy availability and infertility. Curr Opin Endocrinol Diabetes Obes 14:470-474
17. Furuta M, Funabashi T, Rimura F 2001 Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun 288:780-785
18. Tena-Sempere M, Barreiro ML, Gonzalez LC, Gaytan F, Zhang FP, Caminos JE, Pinilla L, Casanueva FF, Dieguez C, Aguilar E 2002 Novel expression and functional role of ghrelin in rat testis. Endocrinology 143:717-725
19. Kawamura K, Sato N, Fukuda J, Kodama H, Kumegai J, Tanikawa H, Nakamura A, Honda Y, Sato T, Tanaka T 2003 Ghrelin inhibits the development of mouse preimplantation embryos in vitro. Endocrinology 144:2623-2633
20. Barreiro ML, Tena-Sempere M 2004 Ghrelin and reproduction: a novel signal linking energy status and fertility? Mol Cell Endocrinol 226:1-9
21. Fernández-Fernández R, Tena-Sempere M, Aguilar E, Pinilla L 2004 Ghrelin effects on gonadotropin secretion in male and female rats. Neurosci Lett 362:103-107
22. Vulliémoz NR, Xiao E, Xia-Zhang L, Wardlaw SL, Ferin M 2005 Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey. Endocrinology 146:784-789
23. Fernández-Fernández R, Tena-Sempere M, Navarro VM, Barreiro ML, Castellano JM, Aguilar E, Pinilla L 2005 Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies. Neuroendocrinology 82:245-255
24. Iqbal J, Kurose Y, Canny B, Clarke IJ 2006 Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology 147:510-519
25. Vulliémoz NR, Xiao E, Xia-Zhang L, Germond M, Rivier J, Ferin M 2004 Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab 89:5718-5723
26. Fernández-Fernández R, Navarro VM, Barreiro ML, Vigo EM, Tovar S, Sirotkin AV, Casanueva FF, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M 2005 Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology 146:3018-3025
27. Kluge M, Schüssler P, Uhr M, Yassouridis A, Steiger A 2007 Ghrelin suppresses secretion of luteinizing hormone in humans. J Clin Endocrinol Metab 92:3202-3205
28. Veldhuis JD, Carlson ML, Johnson ML 1987 The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84:7686-7690
29. Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, Hayashi Y, Kangawa K 2001 Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Regul Integr Comp Physiol 280:R1483-R1487
30. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K 2000 Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85:4908-4911
31. Grossman A, Moult PJ, Gaillard RC, Delitala G, Toff WD, Rees LH, Besser GM 1981 The opioid control of LH and FSH release: effects of a met-enkephalin analogue and naloxone. Clin Endocrinol (Oxf) 14:41-47
32. Bruni JF, Van Vugt D, Marshall S, Meites J 1977 Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone. Life Sci 21:461-466
33. Morley JE, Baranetsky NG, Wingert TD, Carlson HE, Hershman JM, Melmed S, Levin SR, Jamison KR, Weitzman R, Chang RJ, Varner AA 1980 Endocrine effects of naloxone-induced opiate receptor blockade. J Clin Endocrinol Metab 50:251-257
34. Delitala G, Devilla L, Arata L 1981 Opiate receptors and anterior pituitary hormone secretion in man. Effect of naloxone infusion. Acta Endocrinol 97:150-156
35. Abs R, Verhelst J, Maeyaert J, Van Buyten JP, Opsomer F, Adriaensen H, Verlooy J, Van Havenbergh T, Smet M, Van Acker K 2000 Endocrine consequences of long-term intrathecal administration of opioids. J Clin Endocrinol Metab 85:2215-2222
36. Daniell HW, Lentz R, Mazer NA 2006 Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency. J Pain 7:200-210
37. Muccioli G, Tschoep M, Papotti M, Deghenghi R, Heiman M, Ghigo E 2002 Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 440:235-254
38. Tannenbaum GS, Epelbaum J, Bowers CY 2003 Interrelationship between the novel peptide ghrelin and somatostatin/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion. Endocrinology 144:967-974
39. Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL 2003 The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661
40. Kaynard AH, Pau KY, Hess DL, Spies HG 1990 Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus macaques. Endocrinology 127:2437-2444
41. Tamura T, Irahara M, Tezuka M, Kiyokawa M, Aono T 1999 Orexins, orexigenic hypothalamic neuropeptides, suppress the pulsatile secretion of luteinizing hormone in ovariectomized female rats. Biochem Biophys Res Commun 264:759-762
42. Vulliémoz NR, Xiao E, Xia-Zhang L, Rivier J, Ferin M 2008 Astressin B, a nonselective CRH receptor antagonist, prevents the inhibitory effect of ghrelin on LH pulse frequency in the ovariectomized rhesus monkey. Endocrinology 149:869-874
43. Kimura F, Funabashi T 1998 Two subgroups of gonadotropin releasing hormone neurons control gonadotropin secretion in rats. News Physiol Sci 13:225-231
44. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, Van der Ploeg LH, Howard AD 1997 Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 48:23-29
45. Vanhorebeek I, Langouche L, Van den Berghe G 2006 Endocrine aspects of acute and prolonged critical illness. Nat Clin Pract Endocrinol Metab 2:20-31
46. Shimizu Y, Nagaya N, Isobe T, Imazu M, Okumura H, Hosoda H, Kojima M, Kangawa K, Kohno N 2003 Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res 9:774-778
47. Sun Y, Ahmed S, Smith RG 2003 Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 23:7973-7981
48. Esler WP, Rudolph J, Claus TH, Tang W, Barucci N, Brown SE, Bullock W, Daly M, Decarr L, Li Y, Milardo L, Molstad D, Zhu J, Gardell SJ, Livingston JN, Sweet LJ 2007 Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148:5175-5185