Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide

American Journal of Physiology - Endocrinology and Metabolism

Volumn 295, Issue 3, 2008, Pages

  Dungan Lemko, Heather M ^a   Clifton, Donald K ^b   Steiner, Robert A ^a,b   Fraley, Gregory S ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c HOPE COLLEGE   (United States)

Author keywords

Body weight; Knockout; Metabolism; Obesity; Reproduction

Indexed keywords

CORTICOSTERONE; FAT; GALANIN LIKE PEPTIDE; WATER; ANTIMETABOLITE; DEOXYGLUCOSE; GLUCOSE; LUTEINIZING HORMONE; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY GROWTH; BODY TEMPERATURE; BODY WEIGHT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENERGY BALANCE; EVOLUTIONARY ADAPTATION; FLUID INTAKE; FOOD INTAKE; GENE DELETION; GENOTYPE; GONAD; HOMEOSTASIS; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; LIPID DIET; LOCOMOTION; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; NUTRITION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; REFEEDING; REPRODUCTION; RODENT; SEXUAL DEVELOPMENT; STEADY STATE; WATER DEPRIVATION; WEIGHT GAIN; WILD TYPE; ANIMAL; BLOOD; DIET; DIET RESTRICTION; DRINKING; EATING; ENERGY METABOLISM; FAT INTAKE; FEMALE; FERTILITY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOUSE MUTANT; OVARY; PHYSIOLOGY; SEXUAL MATURATION; TESTIS;

ANIMALS; ANTIMETABOLITES; DEOXYGLUCOSE; DIET; DIETARY FATS; DRINKING; EATING; ENERGY METABOLISM; FASTING; FEMALE; FERTILITY; GALANIN-LIKE PEPTIDE; GLUCOSE; IN SITU HYBRIDIZATION; LUTEINIZING HORMONE; MALE; METABOLISM; MICE; MICE, KNOCKOUT; NEUROPEPTIDE Y; OVARY; PHENOTYPE; PRO-OPIOMELANOCORTIN; REPRODUCTION; SEXUAL MATURATION; TESTIS; WEIGHT GAIN;

EID: 53149092080     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90425.2008     Document Type: Article

References (38)

1. Castellano JM, Navarro VM, Fernandez-Fernandez R, Roa J, Vigo E, Pineda R, Steiner RA, Aguilar E, Pinilla L, Tena-Sempere M. Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty. Am J Physiol Endocrinol Metab 291: E1281-E1289, 2006.
2. Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138: 4489-4492, 1997.
3. Clegg DJ, Brown LM, Zigman JM, Kemp CJ, Strader AD, Benoit SC, Woods SC, Mangiaracina M, Geary N. Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes 56: 1051-1058, 2007.
4. Cunningham MJ. Galanin-like peptide as a link between metabolism and reproduction. J Neuroendocrinol 16: 717-723, 2004.
5. Cunningham MJ, Clifton DK, Steiner RA. Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 60: 216-222, 1999.
6. Cunningham MJ, Krasnow SM, Gevers EF, Chen P, Thompson CK, Robinson IC, Smith MS, Clifton DK, Steiner RA. Regulation of galanin-like peptide gene expression by pituitary hormones and their downstream targets. J Neuroendocrinol 16: 10-18, 2004.
7. Cunningham MJ, Scarlett JM, Steiner RA. Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque. Endocrinology 143: 755-763, 2002.
8. Cunningham MJ, Shahab M, Grove KL, Scarlett JM, Plant TM, Cameron JL, Smith MS, Clifton DK, Steiner RA. Galanin-like peptide as a possible link between metabolism and reproduction in the macaque. J Clin Endocrinol Metab 89: 1760-1766, 2004.
9. Fraley GS. Immunolesions of glucoresponsive projections to the arcuate nucleus alter glucoprivic-induced alterations in food intake, luteinizing hormone secretion, and GALP mRNA, but not sex behavior, in adult male rats. Neuroendocrinology 83: 97-105, 2006.
10. Fraley GS, Scarlett JM, Shimada I, Teklemichael DN, Acohido BV, Clifton DK, Steiner RA. Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat. Diabetes 53: 1237-1242, 2004.
11. Fraley GS, Shimada I, Baumgartner JW, Clifton DK, Steiner RA. Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin. Endocrinology 144: 1143-1146, 2003.
12. Gottsch ML, Clifton DK, Steiner RA. Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends Endocrinol Metab 15: 215-221, 2004.
13. Hansen KR, Krasnow SM, Nolan MA, Fraley GS, Baumgartner JW, Clifton DK, Steiner RA. Activation of the sympathetic nervous system by galanin-like peptide - a possible link between leptin and metabolism. Endocrinology 144: 4709-4717, 2003.
14. Herbison AE. Physiology of the gonadotropin-releasing hormone neuronal network. Physiol Reprod 1: 1415-1482, 2006.
15. Hohmann JG, Teklemichael DN, Weinshenker D, Wynick D, Clifton DK, Steiner RA. Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Mol Cell Biol 24: 2978-2985, 2004.
16. Holzwarth-McBride MA, Hurst EM, Knigge KM. Monosodium glutamate induced lesions of the arcuate nucleus. I. Endocrine deficiency and ultrastructure of the median eminence. Anat Rec 186: 185-205, 1976.
17. Jureus A, Cunningham MJ, Li D, Johnson LL, Krasnow SM, Teklemichael DN, Clifton DK, Steiner RA. Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse. Endocrinology 142: 5140-5144, 2001.
18. Jureus A, Cunningham MJ, McClain ME, Clifton DK, Steiner RA. Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat. Endocrinology 141: 2703-2706, 2000.
19. Kauffman AS, Buenzle J, Fraley GS, Rissman EF. Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice. Horm Behav 48: 141-151, 2005.
20. Kawasaki M, Saito J, Hashimoto H, Suzuki H, Otsubo H, Fujihara H, Ohnishi H, Nakamura T, Ueta Y. Induction of the galanin-like peptide gene expression in the posterior pituitary gland after acute osmotic stimulus in rats. Neurosci Lett 419: 125-130, 2007.
21. Krasnow SM, Fraley GS, Schuh SM, Baumgartner JW, Clifton DK, Steiner RA. A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse. Endocrinology 144: 813-822, 2003.
22. Krasnow SM, Hohmann JG, Gragerov A, Clifton DK, Steiner RA. Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide. Neuroendocrinology 79: 268-277, 2004.
23. Kumano S, Matsumoto H, Takatsu Y, Noguchi J, Kitada C, Ohtaki T. Changes in hypothalamic expression levels of galanin-like peptide in rat and mouse models support that it is a leptin-target peptide. Endocrinology 144: 2634-2643, 2003.
24. Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310: 683-685, 2005.
25. Magni P, Motta M, Martini L. Leptin: a possible link between food intake, energy expenditure, and reproductive function. Regul Pept 92: 51-56, 2000.
26. Man PS, Lawrence CB. The effects of galanin-like peptide on energy balance, body temperature and brain activity in the mouse and rat are independent of the GALR2/3 receptor. J Neuroendocrinol 20: 128-137, 2008.
27. Navarro VM, Castellano JM, Fernandez-Fernandez R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145: 4565-4574, 2004.
28. Ohtaki T, Kumano S, Ishibashi Y, Ogi K, Matsui H, Harada M, Kitada C, Kurokawa T, Onda H, Fujino M. Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J Biol Chem 274: 37041-37045, 1999.
29. Onaka T, Kuramochi M, Saito J, Ueta Y, Yada T. Galanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats. Neuroreport 16: 243-247, 2005.
30. Rich N, Reyes P, Reap L, Goswami R, Fraley GS. Sex differences in the effect of prepubertal GALP infusion on growth, metabolism and LH secretion. Physiol Behav 92: 814-823, 2007.
31. Shen J, Gundlach AL. Galanin-like peptide mRNA alterations in arcuate nucleus and neural lobe of streptozotocin-diabetic and obese Zucker rats. Further evidence for leptin-dependent and independent regulation. Neuroendocrinology 79: 327-337, 2004.
32. Shen J, Larm JA, Gundlach AL. Galanin-like peptide mRNA in neural lobe of rat pituitary. Increased expression after osmotic stimulation suggests a role for galanin-like peptide in neuron-glial interactions and/or neurosecretion. Neuroendocrinology 73: 2-11, 2001.
33. Stoyanovitch AG, Johnson MA, Clifton DK, Steiner RA, Fraley GS. Galanin-like peptide rescues reproductive function in the diabetic rat. Diabetes 54: 2471-2476, 2005.
34. Takatsu Y, Matsumoto H, Ohtaki T, Kumano S, Kitada C, Onda H, Nishimura O, Fujino M. Distribution of galanin-like peptide in the rat brain. Endocrinology 142: 1626-1634, 2001.
35. Ueta Y, Ozaki Y, Saito J. Novel G-protein-coupled receptor ligands and neurohypophysial hormones. J Neuroendocrinol 16: 378-382, 2004.
36. Williams G, Bing C, Cai XJ, Harrold JA, King PJ, Liu XH. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav 74: 683-701, 2001.
37. Wortley KE, del Rincon JP, Murray JD, Garcia K, Iida K, Thorner MO, Sleeman MW. Absence of ghrelin protects against early-onset obesity. J Clin Invest 115: 3573-3578, 2005.
38. Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 115: 3564-3572, 2005.