Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem

British Journal of Pharmacology

Volumn 168, Issue 2, 2013, Pages 403-410

  Beale, K E L ^a   Gardiner, J V ^a   Bewick, G A ^a   Hostomska, K ^a   Patel, N A ^a   Hussain, S S ^a   Jayasena, C N ^a   Ebling, F J P ^b   Jethwa, P H ^b   Prosser, H M ^c   Lattanzi, R ^d   Negri, L ^d   Ghatei, M A ^a   Bloom, Stephen R ^a   Dhillo, W S ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

body weight; brainstem; food intake; hypothalamus; mice; obesity; PK2; prokineticin 2

Indexed keywords

ANTIOBESITY AGENT; INSULIN; MEMBRANE PROTEIN; PROKINETICIN 2; PROKINETICIN RECEPTOR 1; PROKINETICIN RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANORECTIC ACTIVITY; ARTICLE; BODY WEIGHT; BRAIN STEM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; ENERGY HOMEOSTASIS; FEMALE; FOOD INTAKE; GLUCOSE HOMEOSTASIS; HETEROZYGOSITY; HOMEOSTASIS; IMMUNOREACTIVITY; MALE; MOTONEURON NUCLEUS; MOUSE; NONHUMAN; OBESITY; OSMOTIC MINIPUMP; PRIORITY JOURNAL;

ANIMALS; ANTI-OBESITY AGENTS; BLOOD GLUCOSE; BODY WEIGHT; BRAIN STEM; EATING; FEMALE; GASTROINTESTINAL HORMONES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEUROPEPTIDES; OBESITY; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84871602246     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02191.x     Document Type: Article

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