Alarin stimulates food intake and gonadotrophin release in male rats

British Journal of Pharmacology

Volumn 161, Issue 3, 2010, Pages 601-613

  Boughton, C K ^a   Patterson, M ^a   Bewick, G A ^a   Tadross, J A ^a   Gardiner, J V ^a   Beale, K E L ^a   Chaudery, F ^a   Hunter, G ^a   Busbridge, M ^a   Leavy, E M ^a   Ghatei, M A ^a   Bloom, S R ^a   Murphy, K G ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

alarin; galanin; GALP; hypothalamo pituitary gonadal axis

Indexed keywords

ALARIN; APPETITE STIMULANT; CETRORELIX; GALANIN RECEPTOR; GONADORELIN; GONADOTROPIN; LUTEINIZING HORMONE; NEUROPEPTIDE Y; SODIUM CHLORIDE; TESTOSTERONE; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFECT; DRUG RECEPTOR BINDING; EXPLANT; FOOD INTAKE; GONADOTROPIN RELEASE; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IN VITRO STUDY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TESTOSTERONE BLOOD LEVEL;

ANIMALS; BEHAVIOR, ANIMAL; CELL LINE; EATING; GALANIN-LIKE PEPTIDE; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; LUTEINIZING HORMONE; MALE; NEUROPEPTIDE Y; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GALANIN; TESTOSTERONE;

EID: 77956335324     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00893.x     Document Type: Article

References (64)

1. Alarid ET, Windle JJ, Whyte DB, Mellon PL (1996). Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development 122 : 3319 3329.
2. Alexander SPH, Mathie A, Peters JA (2009). Guide to Receptors and Channels (GRAC), 4th edn. Br J Pharmacol 158 (Suppl. 1 S1 S254.
3. Allen JM, Yeats JC, Adrian TE, Bloom SR (1984). Radioimmunoassay of neuropeptide Y. Regul Pept 8 : 61 70.
4. Beak SA, Heath MM, Small CJ, Morgan DG, Ghatei MA, Taylor AD et al. (1998). Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line. J Clin Invest 101 : 1334 1341.
5. Berthoud HR (2006). Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance. Obesity 14 (Suppl 5) 197S-200S.
6. Bhogal R, Smith DM, Purkiss P, Bloom SR (1993). Molecular identification of binding sites for calcitonin gene-related peptide (CGRP) and islet amyloid polypeptide (IAPP) in mammalian lung: species variation and binding of truncated CGRP and IAPP. Endocrinology 133 : 2351 2361.
7. Bloomquist BT, Beauchamp MR, Zhelnin L, Brown SE, Gore-Willse AR, Gregor P et al. (1998). Cloning and expression of the human galanin receptor GalR2. Biochem Biophys Res Commun 243 : 474 479.
8. Branchek TA, Smith KE, Gerald C, Walker MW (2000). Galanin receptor subtypes. Trends Pharmacol Sci 21 : 109 117.
9. Brown KS (1998). Central injection in rats of alpha-melanocyte- stimulating hormone analog: effects on food intake and brain Fos. Regul Pept 78 : 89 94.
10. Castellano JM, Navarro VM, Fernandez-Fernandez R, Roa J, Vigo E, Pineda R et al. (2006). Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty. Am J Physiol Endocrinol Metab 291 : E1281 E1289.
11. Coppock HA, Owji AA, Austin C, Upton PD, Jackson ML, Gardiner JV et al. (1999). Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem J 338 (Pt 1 15 22.
12. Crawley JN, Austin MC, Fiske SM, Martin B, Consolo S, Berthold M et al. (1990). Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. J Neurosci 10 : 3695 3700.
13. Cunningham MJ (2004). Galanin-like peptide as a link between metabolism and reproduction. J Neuroendocrinol 16 : 717 723.
14. Eberhard N, Schmidhuber SM, Rauch I, Sperk G, Kofler B (2007). Immunohistochemical distribution of the novel peptide alarin in the adult rat brain. FEBS J 274 : 204.
15. Fray PJ, Sahakian BJ, Robbins TW, Koob GF, Iversen SD (1980). An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine. Psychopharmacology (Berl) 69 : 253 259.
16. Gornall AG, Bardawill CJ, David MM (1949). Determination of serum proteins by means of the biuret reaction. J Biol Chem 177 : 751 766.
17. Gottsch ML, Clifton DK, Steiner RA (2004). Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends Endocrinol Metab 15 : 215 221.
18. Gundlach AL (2002). Galanin/GALP and galanin receptors: role in central control of feeding, body weight/obesity and reproduction? Eur J Pharmacol 440 : 255 268.
19. Jureus A, Cunningham MJ, McClain ME, Clifton DK, Steiner RA (2000). Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat. Endocrinology 141 : 2703 2706.
20. Kelley A (2004). Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev 27 : 765 776.
21. Kerr NC, Holmes FE, Wynick D (2000). Galanin-like peptide (GALP) is expressed in rat hypothalamus and pituitary, but not in DRG. Neuroreport 11 : 3909 3913.
22. Kofler B, Liu ML, Jacoby AS, Shine J, Iismaa TP (1996). Molecular cloning and characterisation of the mouse preprogalanin gene. Gene 182 : 71 75.
23. Krasnow SM, Hohmann JG, Gragerov A, Clifton DK, Steiner RA (2004). Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide. Neuroendocrinology 79 : 268 277.
24. Kuramochi M, Onaka T, Kohno D, Kato S, Yada T (2006). Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat. Endocrinology 147 : 1744 1752.
25. Land T, Langel U, Low M, Berthold M, Unden A, Bartfai T (1991). Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor. Int J Pept Protein Res 38 : 267 272.
26. Lang R, Berger A, Santic R, Geisberger R, Hermann A, Herzog H et al. (2005). Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists. Neuropeptides 39 : 179 184.
27. Lang R, Gundlach AL, Kofler B (2007). The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol Ther 115 : 177 207.
28. Larm JA, Gundlach AL (2000). Galanin-like peptide (GALP) mRNA expression is restricted to arcuate nucleus of hypothalamus in adult male rat brain. Neuroendocrinology 72 : 67 71.
29. Lawrence CB, Williams T, Luckman SM (2003). Intracerebroventricular galanin-like peptide induces different brain activation compared with galanin. Endocrinology 144 : 3977 3984.
30. Levine AS, Morley JE (1984). Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5 : 1025 1029.
31. Li XF, Edward J, Mitchell JC, Shao B, Bowes JE, Coen CW et al. (2004). Differential effects of repeated restraint stress on pulsatile lutenizing hormone secretion in female Fischer, Lewis and Wistar rats. J Neuroendocrinol 16 : 620 627.
32. Lopez FJ, Merchenthaler I, Ching M, Wisniewski MG, Negro-Vilar A (1991). Galanin: a hypothalamic-hypophysiotropic hormone modulating reproductive functions. Proc Natl Acad Sci U S A 88 : 4508 4512.
33. Lundkvist J (1995). cDNA sequence, ligand biding, and regulation of galanin/GMAP in mouse brain. Neurosci Lett 200 : 121 124.
34. Matsumoto H, Noguchi J, Takatsu Y, Horikoshi Y, Kumano S, Ohtaki T et al. (2001). Stimulation effect of galanin-like peptide (GALP) on luteinizing hormone-releasing hormone-mediated luteinizing hormone (LH) secretion in male rats. Endocrinology 142 : 3693 3696.
35. Matsumoto Y, Watanabe T, Adachi Y, Itoh T, Ohtaki T, Onda H et al. (2002). Galanin-like peptide stimulates food intake in the rat. Neurosci Lett 322 : 67 69.
36. Melander T, Hokfelt T, Rokaeus A, Fahrenkrug J, Tatemoto K, Mutt V (1985). Distribution of galanin-like immunoreactivity in the gastro-intestinal tract of several mammalian species. Cell Tissue Res 239 : 253 270.
37. Melander T, Hokfelt T, Rokaeus A (1986). Distribution of galaninlike immunoreactivity in the rat central nervous system. J Comp Neurol 248 : 475 517.
38. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI (1990). Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5 : 1 10.
39. Merchenthaler I (2008). Galanin and the neuroendocrine axes. Cell Mol Life Sci 65 : 1826 1835.
40. Mitchell V, Bouret S, Prevot V, Jennes L, Beauvillain JC (1999). Evidence for expression of galanin receptor Gal-R1 mRNA in certain gonadotropin releasing hormone neurones of the rostral preoptic area. J Neuroendocrinol 11 : 805 812.
41. Nonaka N, Farr SA, Kageyama H, Shioda S, Banks WA (2008). Delivery of galanin-like peptide to the brain: targeting with intranasal delivery and cyclodextrins. J Pharmacol Exp Ther 325 : 513 519.
42. Ohtaki T, Kumano S, Ishibashi Y, Ogi K, Matsui H, Harada M et al. (1999). Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J Biol Chem 274 : 37041 37045.
43. Patel SR, Murphy KG, Thompson EL, Patterson M, Curtis AE, Ghatei MA et al. (2008). Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats. Endocrinology 149 : 4747 4754.
44. Paxinos G, Watson C (2007). The Rat Brain in Stereotaxic Coordinates. Academic Press : San Diego, CA.
45. Sahu A, Crowley WR, Tatemoto K, Balasubramaniam A, Kalra SP (1987). Effects of neuropeptide Y, NPY analog (norleucine4-NPY), galanin and neuropeptide K on LH release in ovariectomized (ovx) and ovx estrogen, progesterone-treated rats. Peptides 8 : 921 926.
46. Santic R, Fenninger K, Graf K, Schneider R, Hauser-Kronberger C, Schilling FH et al. (2006). Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene. J Mol Neurosci 29 : 145 152.
47. Santic R, Schmidhuber SM, Lang R, Rauch I, Voglas E, Eberhard N et al. (2007). Alarin is a vasoactive peptide. Proc Natl Acad Sci U S A 104 : 10217 10222.
48. Schmidt WE (1991). Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide. Proc Natl Acad Sci U S A 88 : 11435 11439.
49. Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom S (2003). Effects of galanin-like peptide on food intake and the hypothalamo-pituitary-thyroid axis. Neuroendocrinology 77 : 125 131.
50. Seth A, Stanley S, Jethwa P, Gardiner J, Ghatei M, Bloom S (2004). Galanin-like peptide stimulates the release of gonadotropin-releasing hormone in vitro and may mediate the effects of leptin on the hypothalamo-pituitary- gonadal axis. Endocrinology 145 : 743 750.
51. Smith KL (2006). Neuropeptide S stimulates the hypothalamo-pituitary- adrenal axis and inhibits food intake. Endocrinology 147 : 3510.
52. + channels. J Biol Chem 273 : 23321 23326.
53. Stanley SA, Small CJ, Kim MS, Heath MM, Seal LJ, Russell SH et al. (1999). Agouti related peptide (Agrp) stimulates the hypothalamo pituitary gonadal axis in vivo& in vitro in male rats. Endocrinology 140 : 5459 5462.
54. Stanley SA, Murphy KG, Bewick GA, Kong WM, Opacka-Juffry J, Gardiner JV et al. (2004). Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids. Am J Physiol Endocrinol Metab 287 : E583 E590.
55. Takatsu Y, Matsumoto H, Ohtaki T, Kumano S, Kitada C, Onda H et al. (2001). Distribution of galanin-like peptide in the rat brain. Endocrinology 142 : 1626 1634.
56. Tatemoto K, Rokaeus A, Jornvall H, McDonald TJ, Mutt V (1983). Galanin - a novel biologically active peptide from porcine intestine. FEBS Lett 164 : 124 128.
57. Thomas P, Mellon PL, Turgeon J, Waring DW (1996). The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion. Endocrinology 137 : 2979 2989.
58. Thompson EL, Patterson M, Murphy KG, Smith KL, Dhillo WS, Todd JF et al. (2004). Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J Neuroendocrinol 16 : 850 858.
59. Turgeon JL, Kimura Y, Waring DW, Mellon PL (1996). Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol 10 : 439 450.
60. Vrontakis ME (1987). Isolation and characterization of a complementary DNA (galanin) clone from estrogen-induced pituitary tumor messenger RNA. J Biol Chem 262 : 16755 16758.
61. Wood WG, Wachter C, Scriba PC (1981). Experiences using chloramine-T and 1, 3, 4, 6-tetrachloro-3 alpha, 6 alpha-diphenylglycoluril (Iodogen) for radioiodination of materials for radioimmunoassay. J Clin Chem Clin Biochem 19 : 1051 1056.
62. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA et al. (2001). Ghrelin causes hyperphagia and obesity in rats. Diabetes 50 : 2540 2547.
63. Wren AM, Small CJ, Abbott CR, Jethwa PH, Kennedy AR, Murphy KG et al. (2002). Hypothalamic actions of neuromedin U. Endocrinology 143 : 4227 4234.
64. Wynick D, Smith DM, Ghatei M, Akinsanya K, Bhogal R, Purkiss P et al. (1993). Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor. Proc Natl Acad Sci U S A 90 : 4231 4235.