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Volumn 4, Issue 12, 2008, Pages 666-674

Ghrelin as a pleotrophic modulator of gonadal function and reproduction

Author keywords

Ghrelin; Gonadotropin; Ovary; Puberty; Testis

Indexed keywords

GHRELIN; GONADOTROPIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR;

EID: 56649102174     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet1003     Document Type: Review
Times cited : (94)

References (74)
  • 1
    • 0012104541 scopus 로고    scopus 로고
    • Neuroendocrine regulation of pituitary function: General principles
    • Eds Conn PM and Freeman ME Totowa, NJ: Humana Press
    • Fink G (2000) Neuroendocrine regulation of pituitary function: general principles. In Neuroendocrinology in Physiology and Medicine, 107-134 (Eds Conn PM and Freeman ME) Totowa, NJ: Humana Press
    • (2000) Neuroendocrinology in Physiology and Medicine , pp. 107-134
    • Fink, G.1
  • 2
    • 0141844771 scopus 로고    scopus 로고
    • Neuroendocrine regulation of reproductive cyclicity
    • Eds Conn PM and Freeman ME Totowa, NJ: Humana Press
    • Schwartz NB (2000) Neuroendocrine regulation of reproductive cyclicity. In Neuroendocrinology in Physiology and Medicine, 135-146 (Eds Conn PM and Freeman ME) Totowa, NJ: Humana Press
    • (2000) Neuroendocrinology in Physiology and Medicine , pp. 135-146
    • Schwartz, N.B.1
  • 3
    • 33745902547 scopus 로고    scopus 로고
    • Novel signals for the integration of energy balance and reproduction
    • Fernández-Fernández R et al. (2006) Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol 254-255: 127-132
    • (2006) Mol Cell Endocrinol , vol.254-255 , pp. 127-132
    • Fernández-Fernández, R.1
  • 4
    • 0032739022 scopus 로고    scopus 로고
    • Neuroendocrine regulation and actions of leptin
    • Casanueva FF and Dieguez C (1999) Neuroendocrine regulation and actions of leptin. Front Neuroendocrinol 20: 317-363
    • (1999) Front Neuroendocrinol , vol.20 , pp. 317-363
    • Casanueva, F.F.1    Dieguez, C.2
  • 5
    • 33646110761 scopus 로고    scopus 로고
    • Obesity and androgens: Facts and perspectives
    • Pasquali R (2006) Obesity and androgens: facts and perspectives. Fertil Steril 85: 1319-1340
    • (2006) Fertil Steril , vol.85 , pp. 1319-1340
    • Pasquali, R.1
  • 6
    • 38549132322 scopus 로고    scopus 로고
    • Metabolic syndrome and reproduction: I. Testicular function
    • Goulis DG and Tarlatzis BC (2008) Metabolic syndrome and reproduction: I. Testicular function. Gynecol Endocrinol 24: 33-39
    • (2008) Gynecol Endocrinol , vol.24 , pp. 33-39
    • Goulis, D.G.1    Tarlatzis, B.C.2
  • 7
    • 35948995689 scopus 로고    scopus 로고
    • Roles of ghrelin and leptin in the control of reproductive function
    • Tena-Sempere M (2007) Roles of ghrelin and leptin in the control of reproductive function. Neuroendocrinology 86: 229-241
    • (2007) Neuroendocrinology , vol.86 , pp. 229-241
    • Tena-Sempere, M.1
  • 8
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1
  • 9
    • 2942528459 scopus 로고    scopus 로고
    • van der Lely AJ et al. (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25: 426-457
    • van der Lely AJ et al. (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25: 426-457
  • 10
    • 2942530618 scopus 로고    scopus 로고
    • Ghrelin - a hormone with multiple functions
    • Korbonits M et al. (2004) Ghrelin - a hormone with multiple functions. Front Neuroendocrinol 25: 27-68
    • (2004) Front Neuroendocrinol , vol.25 , pp. 27-68
    • Korbonits, M.1
  • 11
    • 33746865283 scopus 로고    scopus 로고
    • One ancestor, several peptides. Post-translational modifications of preproghrelin generate several peptides with antithetical effects
    • Gualillo O et al. (2006) One ancestor, several peptides. Post-translational modifications of preproghrelin generate several peptides with antithetical effects. Mol Cell Endocrinol 256: 1-8
    • (2006) Mol Cell Endocrinol , vol.256 , pp. 1-8
    • Gualillo, O.1
  • 12
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J et al. (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132: 387-396
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1
  • 13
    • 44049094269 scopus 로고    scopus 로고
    • Ghrelin octanoylation mediated by an orphan lipid transferase
    • Gutierrez JA et al. (2008) Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci USA 105: 6320-6325
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6320-6325
    • Gutierrez, J.A.1
  • 14
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • Zhang JV et al. (2005) Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310: 996-999
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.V.1
  • 15
    • 33846958353 scopus 로고    scopus 로고
    • Chartrel N et al. (2007) Comment on Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 315: 766; author reply 766
    • Chartrel N et al. (2007) Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science 315: 766; author reply 766
  • 16
    • 33845911774 scopus 로고    scopus 로고
    • Effects of obestatin on energy balance and growth hormone secretion in rodents
    • Nogueiras R et al. (2007) Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 148: 21-26
    • (2007) Endocrinology , vol.148 , pp. 21-26
    • Nogueiras, R.1
  • 17
    • 33845883349 scopus 로고    scopus 로고
    • GPR39 signaling is stimulated by zinc ions but not by obestatin
    • Holst B et al. (2007) GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 148: 13-20
    • (2007) Endocrinology , vol.148 , pp. 13-20
    • Holst, B.1
  • 18
    • 0034698072 scopus 로고    scopus 로고
    • Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor
    • Hosoda H et al. (2000) Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem 275: 21995-22000
    • (2000) J Biol Chem , vol.275 , pp. 21995-22000
    • Hosoda, H.1
  • 19
    • 11144228935 scopus 로고    scopus 로고
    • Expression of the ghrelin axis in the mouse: An exon 4-deleted mouse proghrelin variant encodes a novel C terminal peptide
    • Jeffery PL et al. (2005) Expression of the ghrelin axis in the mouse: an exon 4-deleted mouse proghrelin variant encodes a novel C terminal peptide. Endocrinology 146: 432-440
    • (2005) Endocrinology , vol.146 , pp. 432-440
    • Jeffery, P.L.1
  • 20
    • 35248827576 scopus 로고    scopus 로고
    • Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts
    • Seim I et al. (2007) Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. BMC Genomics 8: 298
    • (2007) BMC Genomics , vol.8 , pp. 298
    • Seim, I.1
  • 21
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschöp M et al. (2000) Ghrelin induces adiposity in rodents. Nature 407: 908-913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1
  • 22
    • 50349090968 scopus 로고    scopus 로고
    • Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats
    • Strassburg S et al. (2008) Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. Am J Physiol Endocrinol Metab 295: E78-E84
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Strassburg, S.1
  • 23
    • 35948929766 scopus 로고    scopus 로고
    • Central and peripheral roles of ghrelin on glucose homeostasis
    • Sun Y et al. (2007) Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology 86: 215-228
    • (2007) Neuroendocrinology , vol.86 , pp. 215-228
    • Sun, Y.1
  • 24
    • 0043030280 scopus 로고    scopus 로고
    • Minireview: From anorexia to obesity - the yin and yang of body weight control
    • Zigman JM and Elmquist JK (2003) Minireview: from anorexia to obesity - the yin and yang of body weight control. Endocrinology 144: 3749-3756
    • (2003) Endocrinology , vol.144 , pp. 3749-3756
    • Zigman, J.M.1    Elmquist, J.K.2
  • 25
    • 0035834586 scopus 로고    scopus 로고
    • Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats
    • Furuta M et al. (2001) Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun 288: 780-785
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 780-785
    • Furuta, M.1
  • 26
    • 2942536620 scopus 로고    scopus 로고
    • Ghrelin effects on gonadotropin secretion in male and female rats
    • Fernández-Fernández R et al. (2004) Ghrelin effects on gonadotropin secretion in male and female rats. Neurosci Lett 362: 103-107
    • (2004) Neurosci Lett , vol.362 , pp. 103-107
    • Fernández-Fernández, R.1
  • 27
    • 33744459206 scopus 로고    scopus 로고
    • Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: In vivo and in vitro studies
    • Fernández-Fernández R et al. (2005) Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies. Neuroendocrinology 82: 245-255
    • (2005) Neuroendocrinology , vol.82 , pp. 245-255
    • Fernández-Fernández, R.1
  • 28
    • 8744313973 scopus 로고    scopus 로고
    • Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey
    • Vulliémoz NR et al. (2004) Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab 89: 5718-5723
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5718-5723
    • Vulliémoz, N.R.1
  • 29
    • 29344456423 scopus 로고    scopus 로고
    • Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep
    • Iqbal J et al. (2006) Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology 147: 510-519
    • (2006) Endocrinology , vol.147 , pp. 510-519
    • Iqbal, J.1
  • 30
    • 34547796479 scopus 로고    scopus 로고
    • Ghrelin suppresses secretion of luteinizing hormone in humans
    • Kluge M et al. (2007) Ghrelin suppresses secretion of luteinizing hormone in humans. J Clin Endocrinol Metab 92: 3202-3205
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3202-3205
    • Kluge, M.1
  • 31
    • 51649085619 scopus 로고    scopus 로고
    • Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH, in young men: Evidence for a central inhibitory action of ghrelin on the gonadal axis
    • Lanfranco F et al. (2008) Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH, in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. J Clin Endocrinol Metab 93: 3633-3639
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3633-3639
    • Lanfranco, F.1
  • 32
    • 42449138247 scopus 로고    scopus 로고
    • Photoperiod influences the central effects of ghrelin on food intake, GH and LH secretion in sheep
    • Harrison JL et al. (2008) Photoperiod influences the central effects of ghrelin on food intake, GH and LH secretion in sheep. Neuroendocrinology 87: 182-192
    • (2008) Neuroendocrinology , vol.87 , pp. 182-192
    • Harrison, J.L.1
  • 33
    • 22144497185 scopus 로고    scopus 로고
    • Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat
    • Fernández-Fernández R et al. (2005) Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology 146: 3018-3025
    • (2005) Endocrinology , vol.146 , pp. 3018-3025
    • Fernández-Fernández, R.1
  • 34
    • 33645882953 scopus 로고    scopus 로고
    • Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats
    • Martini AC et al. (2006) Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 147: 2374-2382
    • (2006) Endocrinology , vol.147 , pp. 2374-2382
    • Martini, A.C.1
  • 35
    • 47649098401 scopus 로고    scopus 로고
    • Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats
    • Sirotkin AV et al. (2008) Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats. Peptides 29: 1362-1368
    • (2008) Peptides , vol.29 , pp. 1362-1368
    • Sirotkin, A.V.1
  • 36
    • 33846837280 scopus 로고    scopus 로고
    • Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty
    • Lebrethon MC et al. (2007) Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty. J Neuroendocrinol 19: 181-188
    • (2007) J Neuroendocrinol , vol.19 , pp. 181-188
    • Lebrethon, M.C.1
  • 37
    • 40849116453 scopus 로고    scopus 로고
    • A nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey
    • Vulliémoz NR et al. (2008) A nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey. Endocrinology 149: 869-874
    • (2008) Endocrinology , vol.149 , pp. 869-874
    • Vulliémoz, N.R.1
  • 38
    • 34547588537 scopus 로고    scopus 로고
    • Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen
    • Fernández-Fernández R et al. (2007) Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen. Reproduction 133: 1223-1232
    • (2007) Reproduction , vol.133 , pp. 1223-1232
    • Fernández-Fernández, R.1
  • 39
    • 2442697904 scopus 로고    scopus 로고
    • In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish
    • Unniappan S and Peter RE (2004) In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish. Am J Physiol Regul Integr Comp Physiol 286: R1093-R1101
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Unniappan, S.1    Peter, R.E.2
  • 40
    • 38649123322 scopus 로고    scopus 로고
    • Ghrelin: A multifunctional hormone in non-mammalian vertebrates
    • Kaiya H et al. (2008) Ghrelin: a multifunctional hormone in non-mammalian vertebrates. Comp Biochem Physiol A Mol Integr Physiol 149: 109-128
    • (2008) Comp Biochem Physiol A Mol Integr Physiol , vol.149 , pp. 109-128
    • Kaiya, H.1
  • 41
    • 0347755156 scopus 로고    scopus 로고
    • Ghrelin levels from fetal life through early adulthood: Relationship with endocrine and metabolic and anthropometric measures
    • Soriano-Guillén L et al. (2004) Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures. J Pediatr 144: 30-35
    • (2004) J Pediatr , vol.144 , pp. 30-35
    • Soriano-Guillén, L.1
  • 42
    • 46349085720 scopus 로고    scopus 로고
    • Novel expression and direct effects of adiponectin in the rat testis
    • Caminos JE et al. (2008) Novel expression and direct effects of adiponectin in the rat testis. Endocrinology 149: 3390-3402
    • (2008) Endocrinology , vol.149 , pp. 3390-3402
    • Caminos, J.E.1
  • 43
    • 4344649881 scopus 로고    scopus 로고
    • Novel expression of resistin in rat testis: Functional role and regulation by nutritional status and hormonal factors
    • Nogueiras R et al. (2004) Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. J Cell Sci 117: 3247-3257
    • (2004) J Cell Sci , vol.117 , pp. 3247-3257
    • Nogueiras, R.1
  • 44
    • 38549118343 scopus 로고    scopus 로고
    • Functional hypothalamic amenorrhea: Current view on neuroendocrine aberrations
    • Meczekalski B et al. (2008) Functional hypothalamic amenorrhea: current view on neuroendocrine aberrations. Gynecol Endocrinol 24: 4-11
    • (2008) Gynecol Endocrinol , vol.24 , pp. 4-11
    • Meczekalski, B.1
  • 45
    • 42549119378 scopus 로고    scopus 로고
    • Acylated ghrelin and leptin in adolescent athletes with amenorrhea, eumenorrheic athletes and controls: A cross sectional study
    • Christo K et al. (2008) Acylated ghrelin and leptin in adolescent athletes with amenorrhea, eumenorrheic athletes and controls: a cross sectional study. Clin Endocrinol (Oxf) 69: 628-633
    • (2008) Clin Endocrinol (Oxf) , vol.69 , pp. 628-633
    • Christo, K.1
  • 46
    • 3242688588 scopus 로고    scopus 로고
    • Fasting ghrelin levels in physically active women: Relationship with menstrual disturbances and metabolic hormones
    • De Souza MJ et al. (2004) Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones. J Clin Endocrinol Metab 89: 3536-3542
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3536-3542
    • De Souza, M.J.1
  • 47
    • 45849147014 scopus 로고    scopus 로고
    • Elevated ghrelin level in women of normal weight with amenorrhea is related to disordered eating
    • Schneider LF et al. (2008) Elevated ghrelin level in women of normal weight with amenorrhea is related to disordered eating. Fertil Steril 90: 121-128
    • (2008) Fertil Steril , vol.90 , pp. 121-128
    • Schneider, L.F.1
  • 48
    • 3242730062 scopus 로고    scopus 로고
    • Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition
    • Moran LJ et al. (2004) Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. J Clin Endocrinol Metab 89: 3337-3344
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3337-3344
    • Moran, L.J.1
  • 49
    • 0036775168 scopus 로고    scopus 로고
    • Circulating ghrelin levels in patients with polycystic ovary syndrome
    • Schöfl C et al. (2002) Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 87: 4607-4610
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4607-4610
    • Schöfl, C.1
  • 50
    • 0036925201 scopus 로고    scopus 로고
    • Plasma ghrelin, obesity, and the polycystic ovary syndrome: Correlation with insulin resistance and androgen levels
    • Pagotto U et al. (2002) Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 87: 5625-5629
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5625-5629
    • Pagotto, U.1
  • 51
    • 0142025214 scopus 로고    scopus 로고
    • Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome
    • Gambineri A et al. (2003) Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome. J Endocrinol Invest 26: 629-634
    • (2003) J Endocrinol Invest , vol.26 , pp. 629-634
    • Gambineri, A.1
  • 52
    • 33845982604 scopus 로고    scopus 로고
    • Ghrelin ovarian cell expression in patients with polycystic ovary syndrome: An immunohistochemical evaluation
    • Komarowska H et al. (2006) Ghrelin ovarian cell expression in patients with polycystic ovary syndrome: an immunohistochemical evaluation. Horm Metab Res 38: 783-788
    • (2006) Horm Metab Res , vol.38 , pp. 783-788
    • Komarowska, H.1
  • 53
    • 33845595901 scopus 로고    scopus 로고
    • Gut peptides in the regulation of food intake and energy homeostasis
    • Murphy KG et al. (2006) Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev 27: 719-727
    • (2006) Endocr Rev , vol.27 , pp. 719-727
    • Murphy, K.G.1
  • 54
    • 42949146633 scopus 로고    scopus 로고
    • Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin
    • López M et al. (2008) Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab 7: 389-399
    • (2008) Cell Metab , vol.7 , pp. 389-399
    • López, M.1
  • 55
    • 33846032275 scopus 로고    scopus 로고
    • Gastrointestinal regulation of food intake
    • Cummings DE and Overduin J (2007) Gastrointestinal regulation of food intake. J Clin Invest 117: 13-23
    • (2007) J Clin Invest , vol.117 , pp. 13-23
    • Cummings, D.E.1    Overduin, J.2
  • 56
    • 0038804193 scopus 로고    scopus 로고
    • Ghrelin as a potential anti-obesity target
    • Horvath TL et al. (2003) Ghrelin as a potential anti-obesity target. Curr Pharm Des 9: 1383-1395
    • (2003) Curr Pharm Des , vol.9 , pp. 1383-1395
    • Horvath, T.L.1
  • 57
    • 18244390529 scopus 로고    scopus 로고
    • Novel expression and functional role of ghrelin in rat testis
    • Tena-Sempere M et al. (2002) Novel expression and functional role of ghrelin in rat testis. Endocrinology 143: 717-725
    • (2002) Endocrinology , vol.143 , pp. 717-725
    • Tena-Sempere, M.1
  • 58
    • 0036892268 scopus 로고    scopus 로고
    • Cellular location and hormonal regulation of ghrelin expression in rat testis
    • Barreiro ML et al. (2002) Cellular location and hormonal regulation of ghrelin expression in rat testis. Biol Reprod 67: 1768-1776
    • (2002) Biol Reprod , vol.67 , pp. 1768-1776
    • Barreiro, M.L.1
  • 59
    • 10744220319 scopus 로고    scopus 로고
    • Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors
    • Gaytan F et al. (2004) Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. J Clin Endocrinol Metab 89: 400-409
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 400-409
    • Gaytan, F.1
  • 60
    • 0035846447 scopus 로고    scopus 로고
    • Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse
    • Tanaka M et al. (2001) Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochim Biophys Acta 1522: 62-65
    • (2001) Biochim Biophys Acta , vol.1522 , pp. 62-65
    • Tanaka, M.1
  • 61
    • 0242432330 scopus 로고    scopus 로고
    • Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis
    • Barreiro ML et al. (2003) Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis. Biol Reprod 68: 1631-1640
    • (2003) Biol Reprod , vol.68 , pp. 1631-1640
    • Barreiro, M.L.1
  • 62
    • 0037387132 scopus 로고    scopus 로고
    • Expression of ghrelin in the cyclic and pregnant rat ovary
    • Caminos JE et al. (2003) Expression of ghrelin in the cyclic and pregnant rat ovary. Endocrinology 144: 1594-1602
    • (2003) Endocrinology , vol.144 , pp. 1594-1602
    • Caminos, J.E.1
  • 63
    • 0037329049 scopus 로고    scopus 로고
    • Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary
    • Gaytan F et al. (2003) Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. J Clin Endocrinol Metab 88: 879-887
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 879-887
    • Gaytan, F.1
  • 64
    • 15944364270 scopus 로고    scopus 로고
    • Expression of growth hormone secretagogue receptor type 1a, the functional ghrelin receptor, in human ovarian surface epithelium, mullerian duct derivatives, and ovarian tumors
    • Gaytan F et al. (2005) Expression of growth hormone secretagogue receptor type 1a, the functional ghrelin receptor, in human ovarian surface epithelium, mullerian duct derivatives, and ovarian tumors. J Clin Endocrinol Metab 90: 1798-1804
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1798-1804
    • Gaytan, F.1
  • 65
    • 54149116288 scopus 로고    scopus 로고
    • Expression of ghrelin in the porcine hypothalamo-pituitary-ovary axis during the estrous cycle
    • doi:10.1016/j.anireprosci.2007.12.020
    • Zhang W et al. (2008) Expression of ghrelin in the porcine hypothalamo-pituitary-ovary axis during the estrous cycle. Anim Reprod Sci [doi:10.1016/j.anireprosci.2007.12.020]
    • (2008) Anim Reprod Sci
    • Zhang, W.1
  • 66
    • 33748131811 scopus 로고    scopus 로고
    • Novel expression and functional role of ghrelin in chicken ovary
    • Sirotkin AV et al. (2006) Novel expression and functional role of ghrelin in chicken ovary. Mol Cell Endocrinol 257-258: 15-25
    • (2006) Mol Cell Endocrinol , vol.257-258 , pp. 15-25
    • Sirotkin, A.V.1
  • 67
    • 38849147226 scopus 로고    scopus 로고
    • Ontogenetic and tissue-specific expression of preproghrelin in the Atlantic halibut, Hippoglossus hippoglossus L
    • Manning AJ et al. (2008) Ontogenetic and tissue-specific expression of preproghrelin in the Atlantic halibut, Hippoglossus hippoglossus L. J Endocrinol 196: 181-192
    • (2008) J Endocrinol , vol.196 , pp. 181-192
    • Manning, A.J.1
  • 68
    • 33947245127 scopus 로고    scopus 로고
    • Ghrelin expression in human testis and serum testosterone level
    • Ishikawa T et al. (2007) Ghrelin expression in human testis and serum testosterone level. J Androl 28: 320-324
    • (2007) J Androl , vol.28 , pp. 320-324
    • Ishikawa, T.1
  • 69
    • 42049092078 scopus 로고    scopus 로고
    • Ghrelin inhibits steroid biosynthesis by cultured granulosa-lutein cells
    • Viani I et al. (2008) Ghrelin inhibits steroid biosynthesis by cultured granulosa-lutein cells. J Clin Endocrinol Metab 93: 1476-1481
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1476-1481
    • Viani, I.1
  • 70
    • 34547801816 scopus 로고    scopus 로고
    • Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells
    • Tropea A et al. (2007) Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells. J Clin Endocrinol Metab 92: 3239-3245
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3239-3245
    • Tropea, A.1
  • 71
    • 9244247597 scopus 로고    scopus 로고
    • Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis
    • Barreiro ML et al. (2004) Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis. Endocrinology 145: 4825-4834
    • (2004) Endocrinology , vol.145 , pp. 4825-4834
    • Barreiro, M.L.1
  • 72
    • 0042525955 scopus 로고    scopus 로고
    • Circulating levels of ghrelin in human fetuses
    • Cortelazzi D et al. (2003) Circulating levels of ghrelin in human fetuses. Eur J Endocrinol 149: 111-116
    • (2003) Eur J Endocrinol , vol.149 , pp. 111-116
    • Cortelazzi, D.1
  • 73
    • 0038707318 scopus 로고    scopus 로고
    • Ghrelin is involved in the decidualization of human endometrial stromal cells
    • Tanaka K et al. (2003) Ghrelin is involved in the decidualization of human endometrial stromal cells. J Clin Endocrinol Metab 88: 2335-2340
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2335-2340
    • Tanaka, K.1
  • 74
    • 0038522633 scopus 로고    scopus 로고
    • Ghrelin inhibits the development of mouse preimplantation embryos in vitro
    • Kawamura K et al. (2003) Ghrelin inhibits the development of mouse preimplantation embryos in vitro. Endocrinology 144: 2623-2633
    • (2003) Endocrinology , vol.144 , pp. 2623-2633
    • Kawamura, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.