Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects

American Journal of Physiology - Endocrinology and Metabolism

Volumn 299, Issue 1, 2010, Pages

  Castellano, J M ^a,b   Bentsen, A H ^d   Romero, M ^a   Pineda, R ^a,b   Ruiz Pino, F ^a,b   Garcia Galiano, D ^a,b   Sanchez Garrido M A ^a,b   Pinilla, L ^a,b   Mikkelsen, J D ^d   Tena Sempere, M ^a,b,c  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c Instituto de Salud Carlos III   (Spain)

^d Mental Health Services CPH   (Denmark)

Author keywords

Gonadotropin releasing hormone; Gonadotropins; Kiss1 kisspeptins; Lipopolysaccharide S

Indexed keywords

KISSPEPTIN; KISSPEPTIN 10; LIPOPOLYSACCHARIDE; LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; FOOD INTAKE; HYPOTHALAMUS; IMMUNOREACTIVITY; INFLAMMATION; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; MALE; METABOLIC STRESS; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; REPRODUCTION; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE RELEASE;

ANIMALS; ARCUATE NUCLEUS; AREA UNDER CURVE; EATING; HYPOGONADISM; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUTEINIZING HORMONE; MALE; OLIGOPEPTIDES; RATS; RATS, WISTAR; TESTOSTERONE;

EID: 77953434412     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00081.2010     Document Type: Article

References (39)

1. Akema T, He D, Sugiyama H. Lipopolysaccharide increases gamma-aminobutyric acid synthesis in medial preoptic neurones in association with inhibition of steroid-induced luteinising hormone surge in female rats. J Neuroendocrinol 17: 672-678, 2005. (Pubitemid 41341645)
2. Becskei C, Riediger T, Hernadfalvy N, Arsenijevic D, Lutz TA, Langhans W. Inhibitory effects of lipopolysaccharide on hypothalamic nuclei implicated in the control of food intake. Brain Behav Immun 22: 56-64, 2008. (Pubitemid 350216359)
3. Bentsen AH, Ansel L, Simonneaux V, Tena-Sempere M, Juul A, Mikkelsen JD. Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides 31: 275-283, 2010.
4. Castellano JM, Navarro VM, Fernández-Fernández R, Nogueiras R, Tovar S, Roa J, Vazquez MJ, Vigo E, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M. Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology 146: 3917-3925, 2005.
5. Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, Pineda R, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 55: 2602-2610, 2006.
6. Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, García-Galiano D, Vigo E, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M. Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology 150: 784-794, 2009.
7. Castellano JM, Roa J, Luque RM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M. KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications. Peptides 30: 139-145, 2009.
8. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100: 10972-10976, 2003.
9. Guijarro A, Laviano A, Meguid MM. Hypothalamic integration of immune function and metabolism. Prog Brain Res 153: 367-405, 2006.
10. He D, Akema T. Inhibition by lipopolysaccharide of naloxone-induced luteinising hormone secretion is accompanied by increases in corticotropin-releasing factor immunoreactivity in hypothalamic paraventricular neurones in female rats. J Neuroendocrinol 17: 67-72, 2005.
11. Herbison AE. Physiology of the gonadotropin-releasing hormone neuronal network. In: The Physiology of Reproduction, edited by Neill JD. San Diego, CA: Elsevier, 2006, p. 1415-1482.
12. Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Ogata R, Kuwahara A, Yasui T, Irahara M. Neonatal lipopolysaccharide exposure attenuates the homotypic stress-induced suppression of LH secretion in adulthood in male rat. Int J Dev Neurosci 27: 345-349, 2009.
13. Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Shimizu F, Kuwahara A, Yasui T, Irahara M. Neonatal immune challenge affects the regulation of estrus cyclicity and feeding behavior in female rats. Int J Dev Neurosci 27: 111-114, 2009.
14. Iwasa T, Matsuzaki T, Murakami M, Shimizu F, Kuwahara A, Yasui T, Irahara M. Decreased expression of kisspeptin mediates acute immune/inflammatory stress-induced suppression of gonadotropin secretion in female rat. J Endocrinol Invest 31: 656-659, 2008.
15. Kalamatianos T, Grimshaw SE, Poorun R, Hahn JD, Coen CW. Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats. J Neuroendocrinol 20: 1089-1097, 2008.
16. Kalra PS, Edwards TG, Xu B, Jain M, Kalra SP. The anti-gonadotropic effects of cytokines: the role of neuropeptides. Domest Anim Endocrinol 15: 321-332, 1998.
17. Kinsey-Jones JS, Li XF, Knox AM, Wilkinson ES, Zhu XL, Chaudhary AA, Milligan SR, Lightman SL, O'Byrne KT. Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat. J Neuroendocrinol 21: 20-29, 2009.
18. Knox AM, Li XF, Kinsey-Jones JS, Wilkinson ES, Wu XQ, Cheng YS, Milligan SR, Lightman SL, O'Byrne KT. Neonatal lipopolysaccharide exposure delays puberty and alters hypothalamic Kiss1 and Kiss1r mRNA expression in the female rat. J Neuroendocrinol 21: 683-689, 2009.
19. Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW, Hong JT. Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J Neuroinflammation 5: 37, 2008.
20. Luque RM, Kineman RD, Tena-Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 148: 4601-4611, 2007.
21. Mikkelsen JD, Simonneaux V. The neuroanatomy of the kisspeptin system in the mammalian brain. Peptides 30: 26-33, 2009.
22. Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Nogueiras R, Vazquez MJ, Barreiro ML, Magni P, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology 146: 156-163, 2005.
23. Oakley AE, Clifton DK, Steiner RA. Kisspeptin signaling in the brain. Endocr Rev 30: 713-743, 2009.
24. Plata-Salaman CR. Anorexia during acute and chronic disease. Nutrition 12: 69-78, 1996.
25. Popa SM, Clifton DK, Steiner RA. The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. Annu Rev Physiol 70: 213-238, 2008.
26. Priego T, Granado M, Ibáñez de Cáceres I, Martín AI, Villanúa MA, López-Calderón A. Endotoxin at low doses stimulates pituitary GH whereas it decreases IGF-I and IGF-binding protein-3 in rats. J Endocrinol 179: 107-117, 2003.
27. Priego T, Ibáñez de Cáceres I, Martín AI, Villanúa MA, López-Calderón A. Endotoxin decreases serum IGFBP-3 and liver IGFBP-3 mRNA: comparison between Lewis and Wistar rats. Mol Cell Endocrinol 199: 23-28, 2003.
28. Rivest S, Rivier C. The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controlling reproductive functions. Endocr Rev 16: 177-199, 1995.
29. Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Front Neuroendocrinol 29: 48-69, 2008.
30. Roa J, Vigo E, Castellano JM, Gaytan F, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, Tena-Sempere M. Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge. Endocrinology 149: 1627-1637, 2008.
31. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH. The GPR54 gene as a regulator of puberty. N Engl J Med 349: 1614-1627, 2003.
32. Simonneaux V, Ansel L, Revel FG, Klosen P, Pevet P, Mikkelsen JD. Kisspeptin and the seasonal control of reproduction in hamsters. Peptides 30: 146-153, 2009.
33. Sirivelu MP, Shin AC, Perez GI, MohanKumar PS, MohanKumar SM. Effect of L-dopa on interleukin-1 beta-induced suppression of luteinizing hormone secretion in intact female rats. Hum Reprod 24: 718-725, 2009.
34. Soto L, Martín AI, Millán S, Vara E, López- Calderón A. Effects of endotoxin lipopolysaccharide administration on the somatotropic axis. J Endocrinol 159: 239-246, 1998.
35. Takeuchi Y, Nagabukuro H, Kizumi O, Mori Y. Lipopolysaccharide-induced suppression of the hypothalamic gonadotropin-releasing hormone pulse generator in ovariectomized goats. J Vet Med Sci 59: 93-96, 1997.
36. Tena-Sempere M. KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility. Neuroendocrinology 83: 275-281, 2006.
37. Tomaszewska-Zaremba D, Herman A. The role of immunological system in the regulation of gonadoliberin and gonadotropin secretion. Reprod Biol 9: 11-23, 2009.
38. Vonlaufen A, Xu Z, Daniel B, Kumar RK, Pirola R, Wilson J, Apte MV. Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model. Gastroenterology 133: 1293-1303, 2007.
39. Watanobe H, Hayakawa Y. Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats. Endocrinology 144: 4868-4875, 2003. (Pubitemid 37378401)