Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients

Neuroendocrinology

Volumn 89, Issue 2, 2009, Pages 131-139

  Moret, Mallory ^a   Stettler, Rodrigue ^b   Rodieux, Frederique ^b   Gaillard, Rolf C ^a   Waeber, Gérard ^a   Wirthner, Daniel ^d   Giusti, Vittorio ^a   Tappy, Luc ^a,b   Pralong, Francois P ^a,c  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY HOSPITAL   (Switzerland)

^d Centre de Procreation Medicalement Assistee et d'Endocrinologie Gynecologique Lausanne   (Switzerland)

Author keywords

Clinical neuroendocrinology; Gonadotropin; Hypothalamus; Insulin; Pituitary; Polycystic ovary; Pulsatility

Indexed keywords

FOLLITROPIN; INSULIN; LUTEINIZING HORMONE;

ADULT; AMENORRHEA; ANTHROPOMETRY; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLICULAR PHASE; FOLLITROPIN BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; HYPERINSULINEMIA; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INSULIN RELEASE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; OVARY POLYCYSTIC DISEASE; PHENOTYPE; PRIORITY JOURNAL; TRANSVAGINAL ECHOGRAPHY; VOLUNTEER;

ADULT; FEMALE; GLUCOSE CLAMP TECHNIQUE; GONADOTROPIN-RELEASING HORMONE; HUMANS; HYPOTHALAMUS; INSULIN; LUTEINIZING HORMONE; POLYCYSTIC OVARY SYNDROME; THINNESS;

EID: 61749097633     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000160911     Document Type: Article

References (26)

1. Stein IF, Leventhal ML: Amenorrhoea associated with bilateral polycystic ovaries. Am J Obstet Gynecol 1935;29:181-191.
2. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
3. Ehrmann DA: Polycystic ovary syndrome. N Engl J Med 2005;352:1223-1236.
4. Legro RS, Kunselman AR, Dodson WC, Dunaif A: Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 1999;84:165-169.
5. Gilling-Smith C, Story H, Rogers V, Franks S: Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin Endocrinol (Oxf) 1997;47:93-99.
6. Ibanez L, Hall JE, Potau N, Carrascosa A, Prat N, Taylor AE: Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorionic gonadotropin stimulation testing. J Clin Endocrinol Metab 1996;81:4103-4107.
7. Gilling-Smith C, Willis DS, Beard RW, Franks S: Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries. J Clin Endocrinol Metab 1994;79:1158-1165.
8. Nelson VL, Legro RS, Strauss JF 3rd, McAllister JM: Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Mol Endocrinol 1999;13:946-957.
9. Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ: Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 1986;62:904-910.
10. Nestler JE, Jakubowicz DJ, de Vargas AF, Brik C, Quintero N, Medina F: Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositol glycan mediators as the signal transduction system. J Clin Endocrinol Metab 1998;83:2001-2005.
11. Blank SK, McCartney CR, Marshall JC: The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome. Hum Reprod Update 2006;12:351-361.
12. Franks S: Polycystic ovary syndrome. N Engl J Med 1995;333:853-861.
13. Evans WS, Taylor AE, Boyd DG, Johnson ML, Matt DW, Jimenez Y, Nestler JE: Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome. Fertil Steril 2007;88:118-124.
14. Morales AJ, Laughlin GA, Butzow T, Maheshwari H, Baumann G, Yen SS: Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features. J Clin Endocrinol Metab 1996;81:2854-2864.
15. Rebar R, Judd HL, Yen SS, Rakoff J, Vandenberg G, Naftolin F: Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest 1976;57:1320-1329.
16. Waldstreicher J, Santoro NF, Hall JE, Filicori M, Crowley WF Jr: Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization. J Clin Endocrinol Metab 1988;66:165-172.
17. Gamba M, Pralong FP: Control of GnRH neuronal activity by metabolic factors: the role of leptin and insulin. Mol Cell Endocrinol 2006;254-255:133-139.
18. Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR: Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125.
19. Burcelin R, Thorens B, Glauser M, Gaillard RC, Pralong FP: Gonadotropin-releasing hormone secretion from hypothalamic neurons: stimulation by insulin and potentiation by leptin. Endocrinology 2003;144:4484-4491.
20. Salvi R, Castillo E, Voirol MJ, Glauser M, Rey JP, Gaillard RC, Vollenweider P, Pralong FP: Gonadotropin-releasing hormone-expressing neurons immortalized conditionally are activated by insulin: implication of the mitogen-activated protein kinase pathway. Endocrinology 2006;147:816-826.
21. Mehta RV, Patel KS, Coffler MS, Dahan MH, Yoo RY, Archer JS, Malcom PJ, Chang RJ: Luteinizing hormone secretion is not influenced by insulin infusion in women with polycystic ovary syndrome despite improved insulin sensitivity during pioglitazone treatment. J Clin Endocrinol Metab 2005;90:2136-2141.
22. Patel K, Coffler MS, Dahan MH, Yoo RY, Lawson MA, Malcom PJ, Chang RJ: Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. J Clin Endocrinol Metab 2003;88:5456-5461.
23. Taylor AE, McCourt B, Martin KA, Anderson EJ, Adams JM, Schoenfeld D, Hall JE: Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997;82:2248-2256.
24. Weiss LW, Clark FC: Three protocols for measuring subcutaneous fat thickness on the upper extremities. Eur J Appl Physiol Occup Physiol 1987;56:217-221.
25. Durnin JV, Womersley J: Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 1974;32:77-97.
26. Veldhuis JD, Johnson ML: Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol 1986;250:E486-E493.