Ghrelin, the gonadal axis and the onset of puberty

The Ghrelin System

Volumn 25, Issue , 2013, Pages 69-82

  Tena Sempere, Manuel ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84925844514     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1159/000346055     Document Type: Chapter

References (76)

1. Schwartz NB:Neuroendocrine regulation of reproductive cyclicity;in Conn PM, Freeman ME (eds):Neuroendocrinology in Physiology and Medicine. Totowa, Humana Press, 2000, pp 135-146.
2. Tena-Sempere M, Huhtaniemi I:Gonadotropins and gonadotropin receptors;in Fauser BCJM (ed):Reproductive Medicine-Molecular, Cellular and Genetic Fundamentals. New York, Partenon Publishing, 2003, pp 225-244.
3. Fink G:In Conn PM, Freeman ME (eds):Neuroendocrinology in Physiology and Medicine. Totowa, Humana Press, 2000, pp 107-134.
4. Fernandez-Fernandez R, et al:Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol 2006;254-255:127-132.
5. Navarro VM, Castellano JM, Garcia-Galiano D, Tena-Sempere M:Neuroendocrine factors in the initiation of puberty. The emergent role of kisspeptin. Rev Endocr Metab Disord 2007;8:11-20.
6. Casanueva FF, Dieguez C:Neuroendocrine regulation and actions of leptin. Front Neuroendocrinol 1999;20:317-363.
7. Tena-Sempere M:Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nat Clin Pract Endocrinol Metab 2008;4:666-674.
8. Tena-Sempere M:Roles of ghrelin and leptin in the control of reproductive function. Neuroendocrinology 2007;86:229-241.
9. Cummings DE, Overduin J:Gastrointestinal regulation of food intake. J Clin Invest 2007;117:13-23.
10. van der Lely AJ, Tschop M, Heiman ML, Ghigo E:Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004;25:426-457.
11. Sun Y, Asnicar M, Smith RG:Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology 2007;86:215-228.
12. Zigman JM, Elmquist JK:Minireview:From anorexia to obesity-the yin and yang of body weight control. Endocrinology 2003;144:3749-3756.
13. Roa J, Tena-Sempere M:Energy balance and puberty onset:emerging role of central mTOR signaling. Trends Endocrinol Metab 2010;21:519-528.
14. Roa J, et al:Metabolic control of puberty onset:new players, new mechanisms. Mol Cell Endocrinol 2010;324:87-94.
15. Tena-Sempere M:Ghrelin and reproduction:ghrelin as novel regulator of the gonadotropic axis. Vitam Horm 2008;77:285-300.
16. Fernandez-Fernandez R, et al:Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats:in vivo and in vitro studies. Neuroendocrinology 2005;82:245-255.
17. Martini AC, et al:Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 2006;147:2374-2382.
18. Fernandez-Fernandez R, et al:Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology 2005;146:3018-3025.
19. Soriano-Guillen L, et al:Ghrelin levels from fetal life through early adulthood:relationship with endocrine and metabolic and anthropometric measures. J Pediatr 2004;144:30-35.
20. Kojima M, et al:Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-660.
21. Furuta M, Funabashi T, Kimura F:Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun 2001;288:780-785.
22. Fernandez-Fernandez R, Tena-Sempere M, Aguilar E, Pinilla L:Ghrelin effects on gonadotropin secretion in male and female rats. Neurosci Lett 2004;362:103-107.
23. Vulliemoz NR, et al:Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab 2004;89:5718-5723.
24. Iqbal J, Kurose Y, Canny B, Clarke IJ:Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology 2006;147:510-519.
25. Kluge M, Schussler P, Uhr M, Yassouridis A, Steiger A:Ghrelin suppresses secretion of luteinizing hormone in humans. J Clin Endocrinol Metab 2007;92:3202-3205.
26. Lanfranco F, et al:Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH, in young men. Evidence for a central inhibitory action of ghrelin on the gonadal axis. J Clin Endocrinol Metab 2008;93:3633-3639.
27. Harrison JL, Miller DW, Findlay PA, Adam CL:Photoperiod influences the central effects of ghrelin on food intake, GH and LH secretion in sheep. Neuroendocrinology 2008;87:182-192.
28. Lanfranco F, et al:Ghrelin and anterior pituitary function. Front Horm Res 2010;38:206-211.
29. Fang F, et al:Role of ghrelin on estrogen and progesterone secretion in the adult rat ovary during estrous cycle. Syst Biol Reprod Med 2012;58:116-119.
30. Sirotkin AV, et al:Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats. Peptides 2008;29:1362-1368.
31. Moshtaghi-Kashanian GR, Razavi F:Ghrelin and leptin levels in relation to puberty and reproductive function in patients with beta-thalassemia. Hormones (Athens) 2009;8:207-213.
32. Messini CI, Dafopoulos K, Chalvatzas N, Georgoulias P, Messinis IE:Effect of ghrelin on gonadotrophin secretion in women during the menstrual cycle. Hum Reprod 2009;24:976-981.
33. Kluge M, Uhr M, Bleninger P, Yassouridis A, Steiger A:Ghrelin suppresses secretion of FSH in males. Clin Endocrinol (Oxf) 2009;70:920-923.
34. Lebrethon MC, et al:Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty. J Neuroendocrinol 2007;19:181-188.
35. Vulliemoz NR, Xiao E, Xia-Zhang L, Rivier J, Ferin M:Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey. Endocrinology 2008;149:869-874.
36. Forbes S, Li XF, Kinsey-Jones J, O'Byrne K:Effects of ghrelin on kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat. Neurosci Lett 2009;460:143-147.
37. Roa J, et al:Kisspeptins and the control of gonadotropin secretion in male and female rodents. Peptides 2009;30:57-66.
38. Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M:New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Front Neuroendocrinol 2008;29:48-69.
39. Fernandez-Fernandez R, et al:Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen. Reproduction 2007;133:1223-1232.
40. Unniappan S, Peter RE:In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish. Am J Physiol Regul Integr Comp Physiol 2004;286:R1093-R1101.
41. Kaiya H, Miyazato M, Kangawa K, Peter RE, Unniappan S:Ghrelin:a multifunctional hormone in non-mammalian vertebrates. Comp Biochem Physiol A Mol Integr Physiol 2008;149:109-128.
42. Caminos JE, et al:Novel expression and direct effects of adiponectin in the rat testis. Endocrinology 2008;149:3390-3402.
43. Nogueiras R, et al:Novel expression of resistin in rat testis:functional role and regulation by nutritional status and hormonal factors. J Cell Sci 2004;117:3247-3257.
44. Barreiro ML, et al:Pattern of orexin expression and direct biological actions of orexin-A in rat testis. Endocrinology 2005;146:5164-5175.
45. Garcia-Galiano D, et al:Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Endocrinology 2012;153:1959-1971.
46. Tena-Sempere M, et al:Novel expression and functional role of ghrelin in rat testis. Endocrinology 2002;143:717-725.
47. Barreiro ML, et al:Cellular location and hormonal regulation of ghrelin expression in rat testis. Biol Reprod 2002;67:1768-1776.
48. Gaytan F, et al:Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. J Clin Endocrinol Metab 2004;89:400-409.
49. Tanaka M, Hayashida Y, Nakao N, Nakai N, Nakashima K:Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochim Biophys Acta 2001;1522:62-65.
50. Barreiro ML, et al:Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis. Biol Reprod 2003;68:1631-1640.
51. Caminos JE, et al:Expression of ghrelin in the cyclic and pregnant rat ovary. Endocrinology 2003;144:1594-1602.
52. Gaytan F, et al:Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. J Clin Endocrinol Metab 2003;88:879-887.
53. Gaytan F, et al:Expression of growth hormone secretagogue receptor type 1a, the functional ghrelin receptor, in human ovarian surface epithelium, mullerian duct derivatives, and ovarian tumors. J Clin Endocrinol Metab 2005;90:1798-1804.
54. Zhang W, Lei Z, Su J, Chen S:Expression of ghrelin in the porcine hypothalamo-pituitary-ovary axis during the estrous cycle. Anim Reprod Sci 2008;109:356-367.
55. Sirotkin AV, et al:Novel expression and functional role of ghrelin in chicken ovary. Mol Cell Endocrinol 2006;257-258:15-25.
56. Manning AJ, et al:Ontogenetic and tissue-specific expression of preproghrelin in the Atlantic halibut, Hippoglossus hippoglossus L. J Endocrinol 2008;196:181-192.
57. Dun SL, et al:Distribution and biological activity of obestatin in the rat. J Endocrinol 2006;191:481-489.
58. Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL:Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008;132:387-396.
59. Lim CT, Kola B, Grossman A, Korbonits M:The expression of ghrelin O-acyltransferase (GOAT) in human tissues. Endocr J 2011;58:707-710.
60. Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M:Ghrelin expression in human testis and serum testosterone level. J Androl 2007;28:320-324.
61. Barreiro ML, et al:Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis. Endocrinology 2004;145:4825-4834.
62. Viani I, et al:Ghrelin inhibits steroid biosynthesis by cultured granulosa-lutein cells. J Clin Endocrinol Metab 2008;93:1476-1481.
63. Tropea A, et al:Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells. J Clin Endocrinol Metab 2007;92:3239-3245.
64. Rak-Mardyla A, Gregoraszczuk EL, Karpeta A, Duda M:Expression of ghrelin and the ghrelin receptor in different stages of porcine corpus luteum development and the inhibitory effects of ghrelin on progesterone secretion, 3-beta-hydroxysteroid dehydrogenase activity and protein expression. Theriogenology 2012;77:1505-1512.
65. Romani F, et al:In vitro effect of unacylated ghrelin and obestatin on human luteal cell function. Fertil Steril 2012;97:991-996.
66. Sirotkin AV, Meszarosova M, Grossmann R, Benco A, Valenzuela F:Effect of inhibitor and activator of ghrelin receptor (GHS-R1a) on porcine ovarian granulosa cell functions. Gen Comp Endocrinol 2011;173:105-110.
67. Sirotkin AV, Rafay J, Kotwica J, Darlak K, Valenzuela F:Role of ghrelin in regulating rabbit ovarian function and the response to LH and IGF-1. Domest Anim Endocrinol 2009;36:162-172.
68. Moran LJ, et al:Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. J Clin Endocrinol Metab 2004;89:3337-3344.
69. Schofl C, et al:Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2002;87:4607-4610.
70. Pagotto U, et al:Plasma ghrelin, obesity, and the polycystic ovary syndrome:correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 2002;87:5625-5629.
71. Gambineri A, et al:Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome. J Endocrinol Invest 2003;26:629-634.
72. Komarowska H, et al:Ghrelin ovarian cell expression in patients with polycystic ovary syndrome:an immunohistochemical evaluation. Horm Metab Res 2006;38:783-788.
73. Repaci A, Gambineri A, Pagotto U, Pasquali R:Ghrelin and reproductive disorders. Mol Cell Endocrinol 2011;340:70-79.
74. Panidis D, et al:Serum and seminal plasma ghrelin levels in men with normospermia and dyspermia. Gynecol Endocrinol 2008;24:320-325.
75. Lukaszyk A, et al:Immunohistochemical and hybridocytochemical study on ghrelin signalling in the rat seminiferous epithelium. Folia Histochem Cytobiol 2009;47:415-423.
76. Bertoldi ML, et al:Inhibitory effects of ghrelin on sexual behavior:role of the peptide in the receptivity reduction induced by food restriction in mice. Horm Metab Res 2011;43:494-499.