메뉴 건너뛰기




Volumn 16, Issue 8, 2015, Pages 17048-17087

Milk—a nutrient system of mammalian evolution promoting mTORC1-dependent translation

Author keywords

Aging; Amino acids; Diseases of civilization; ER stress; Exosomes; MicroRNAs; Milk signaling; mTORC1; Quasi program; Translation

Indexed keywords

ARGININE; BRANCHED CHAIN AMINO ACID; GLUTAMINE; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICRORNA 21; MICRORNA 29B; PALMITIC ACID; TRYPTOPHAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

EID: 84938152196     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160817048     Document Type: Review
Times cited : (87)

References (316)
  • 1
    • 84860398169 scopus 로고    scopus 로고
    • Food as exposure: Nutritional epigenetics and the new metabolism
    • Landecker, H. Food as exposure: Nutritional epigenetics and the new metabolism. Biosocieties 2011, 6, 167–194
    • (2011) Biosocieties , vol.6 , pp. 167-194
    • Landecker, H.1
  • 3
    • 84884185205 scopus 로고    scopus 로고
    • The milk revolution
    • Curry, A. The milk revolution. Nature 2013, 500, 20–22
    • (2013) Nature , vol.500 , pp. 20-22
    • Curry, A.1
  • 4
    • 60649108370 scopus 로고    scopus 로고
    • Food and Agriculture Organization of the United Nations, Food and Agriculture Organization of the United Nations: Roma, Italy
    • Food and Agriculture Organization of the United Nations. Food Outlook-Global Market Analysis; Food and Agriculture Organization of the United Nations: Roma, Italy, 2012; pp. 51–54
    • (2012) Food Outlook-Global Market Analysis , pp. 51-54
  • 5
    • 84938131796 scopus 로고    scopus 로고
    • Agriculture and Horticulture Development Board
    • Agriculture and Horticulture Development Board. Dairy Co. World dairy cow numbers. Available online: http://www.dairyco.org.uk/market-information/farming-data/cow-numbers/world-cownumbers/#. VTfift7-BW_ (assessed on 15 April 2015).
    • (2015) Dairy Co. World Dairy Cow Numbers
  • 6
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante, M.; Sabatini, D.M. mTOR signaling in growth control and disease. Cell 2012, 149, 274–293
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 8
    • 84922789990 scopus 로고    scopus 로고
    • Nutrient-sensing mechanisms and pathways
    • Efeyan, A.; Comb, W.C.; Sabatini, D.M. Nutrient-sensing mechanisms and pathways. Nature 2015, 517, 302–310
    • (2015) Nature , vol.517 , pp. 302-310
    • Efeyan, A.1    Comb, W.C.2    Sabatini, D.M.3
  • 9
    • 84880912548 scopus 로고    scopus 로고
    • Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
    • Melnik, B.C.; John, S.M.; Schmitz, G. Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr. J. 2013, 12, 103
    • (2013) Nutr. J , vol.12 , pp. 103
    • Melnik, B.C.1    John, S.M.2    Schmitz, G.3
  • 10
    • 84856716614 scopus 로고    scopus 로고
    • Cow milk consumption, insulin-like growth factor-I, and human biology: A life history approach
    • Wiley, A.S. Cow milk consumption, insulin-like growth factor-I, and human biology: A life history approach. Am. J. Hum. Biol. 2012, 24, 130–138
    • (2012) Am. J. Hum. Biol , vol.24 , pp. 130-138
    • Wiley, A.S.1
  • 11
    • 84907255137 scopus 로고    scopus 로고
    • MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers
    • Baier, S.R.; Nguyen, C.; Xie, F.; Wood, J.R.; Zempleni, J. MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. J. Nutr. 2014, 144, 1495–1500
    • (2014) J. Nutr , vol.144 , pp. 1495-1500
    • Baier, S.R.1    Nguyen, C.2    Xie, F.3    Wood, J.R.4    Zempleni, J.5
  • 12
    • 84863460204 scopus 로고    scopus 로고
    • Dissecting mammalian target of rapamycin to promote longevity
    • Mendelsohn, A.R.; Larrick, J.W. Dissecting mammalian target of rapamycin to promote longevity. Rejuvenation Res. 2012, 15, 334–337
    • (2012) Rejuvenation Res , vol.15 , pp. 334-337
    • Mendelsohn, A.R.1    Larrick, J.W.2
  • 13
    • 84916925703 scopus 로고    scopus 로고
    • MTOR signaling from cellular senescence to organismal aging
    • Xu, S.; Cai, Y.; Wie, Y. mTOR signaling from cellular senescence to organismal aging. Aging Dis. 2014, 5, 263–273
    • (2014) Aging Dis , vol.5 , pp. 263-273
    • Xu, S.1    Cai, Y.2    Wie, Y.3
  • 14
    • 84872527628 scopus 로고    scopus 로고
    • MTOR is a key modulator of ageing and age-related disease
    • Johnson, S.C.; Rabinovitch, P.S.; Kaeberlein, M. mTOR is a key modulator of ageing and age-related disease. Nature 2013, 493, 338–345
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 15
    • 84876869702 scopus 로고    scopus 로고
    • Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne
    • Melnik, B.C.; Zouboulis, C.C. Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Exp. Dermatol. 2013, 22, 311–315
    • (2013) Exp. Dermatol , vol.22 , pp. 311-315
    • Melnik, B.C.1    Zouboulis, C.C.2
  • 16
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu, R.; Efeyan, A.; Sabatini, D.M. mTOR: From growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2011, 12, 21–35
    • (2011) Nat. Rev. Mol. Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 18
    • 84869413374 scopus 로고    scopus 로고
    • The role of mTOR signaling in Alzheimer disease
    • Oddo, S. The role of mTOR signaling in Alzheimer disease. Front. Biosci.2012, 4, 941–952
    • (2012) Front. Biosci , vol.4 , pp. 941-952
    • Oddo, S.1
  • 19
    • 84878422744 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (MTor) mediates tau protein dyshomeostasis: Implication for Alzheimer disease
    • Tang, Z.; Bereczki, E.; Zhang, H.; Wang, S.; Li, C.; Ji, X.; Branca, R.M.; Lehtiö, J.; Guan, Z.; Filipcik, P.; et al. Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: Implication for Alzheimer disease. J. Biol. Chem. 2013, 288, 15556–15570
    • (2013) J. Biol. Chem , vol.288 , pp. 15556-15570
    • Tang, Z.1    Bereczki, E.2    Zhang, H.3    Wang, S.4    Li, C.5    Ji, X.6    Branca, R.M.7    Lehtiö, J.8    Guan, Z.9    Filipcik, P.10
  • 21
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (MTOR): Conducting the cellular signaling symphony
    • Foster, K.G.; Fingar, D.C. Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony. J. Biol. Chem. 2010, 285, 14071–14077
    • (2010) J. Biol. Chem , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 22
    • 14844363721 scopus 로고    scopus 로고
    • Signaling by target of rapamycin proteins in cell growth control
    • Inoki, K.; Ouyang, H.; Li, Y.; Guan, K.L. Signaling by target of rapamycin proteins in cell growth control. Microbiol. Mol. Biol. Rev. 2005, 69, 79–100
    • (2005) Microbiol. Mol. Biol. Rev , vol.69 , pp. 79-100
    • Inoki, K.1    Ouyang, H.2    Li, Y.3    Guan, K.L.4
  • 24
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta, S.; Peterson, T.; Sabatini, D.M. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 2010, 40, 310–322
    • (2010) Mol. Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.2    Sabatini, D.M.3
  • 26
    • 79959409830 scopus 로고    scopus 로고
    • Amino acid signaling in TOR activation
    • Kim, J.; Guan, K.L. Amino acid signaling in TOR activation. Annu. Rev. Biochem. 2011, 80, 1001–1032
    • (2011) Annu. Rev. Biochem , vol.80 , pp. 1001-1032
    • Kim, J.1    Guan, K.L.2
  • 27
    • 84894486696 scopus 로고    scopus 로고
    • Nutrient regulation of the mTOR complex 1 signaling pathway
    • Kim, S.; Buel, G.R.; Blenis, J. Nutrient regulation of the mTOR complex 1 signaling pathway. Mol. Cells 2013, 35, 463–473
    • (2013) Mol. Cells , vol.35 , pp. 463-473
    • Kim, S.1    Buel, G.R.2    Blenis, J.3
  • 28
    • 84884676252 scopus 로고    scopus 로고
    • Nutrient signaling to mTOR and cell growth
    • Jewell, J.L.; Guan, K.L. Nutrient signaling to mTOR and cell growth. Trends Biochem. Sci. 2013, 38, 233–242
    • (2013) Trends Biochem. Sci , vol.38 , pp. 233-242
    • Jewell, J.L.1    Guan, K.L.2
  • 29
    • 84880544460 scopus 로고    scopus 로고
    • Nutrients and growth factors in mTORC1 activation
    • Efeyan, A.; Sabatini, D.M. Nutrients and growth factors in mTORC1 activation. Biochem. Soc. Trans. 2013, 41, 902–905
    • (2013) Biochem. Soc. Trans , vol.41 , pp. 902-905
    • Efeyan, A.1    Sabatini, D.M.2
  • 30
    • 84877965001 scopus 로고    scopus 로고
    • Regulation of mTORC1 and its impact on gene expression at a glance
    • Laplante, M.; Sabatini, D.M. Regulation of mTORC1 and its impact on gene expression at a glance. J. Cell Sci. 2013, 126, 1713–1719
    • (2013) J. Cell Sci , vol.126 , pp. 1713-1719
    • Laplante, M.1    Sabatini, D.M.2
  • 31
    • 66349138676 scopus 로고    scopus 로고
    • Nutrient control of mTORC1, a cell-cycle regulator
    • Wang, X.; Proud, C.G. Nutrient control of mTORC1, a cell-cycle regulator. Trends Cell Biol. 2009, 19, 260–267
    • (2009) Trends Cell Biol , vol.19 , pp. 260-267
    • Wang, X.1    Proud, C.G.2
  • 32
    • 77951166692 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
    • Chakrabarti, P.; English, T.; Shi, J.; Smas, C.M.; Kandror, K.V. Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Diabetes 2010, 59, 775–781
    • (2010) Diabetes , vol.59 , pp. 775-781
    • Chakrabarti, P.1    English, T.2    Shi, J.3    Smas, C.M.4    Kandror, K.V.5
  • 33
    • 84874655800 scopus 로고    scopus 로고
    • The multifaceted role of mTORC1 in the control of lipid metabolism
    • Ricoult, S.J.; Manning, B.D. The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep. 2013, 14, 242–251
    • (2013) EMBO Rep , vol.14 , pp. 242-251
    • Ricoult, S.J.1    Manning, B.D.2
  • 34
    • 84899003225 scopus 로고    scopus 로고
    • Long-term commercial cow’s milk consumption and its effects on metabolic parameters associated with obesity in young mice
    • Yamin, H.B.; Barnea, M.; Genzer, Y.; Chapnik, N.; Froy, O. Long-term commercial cow’s milk consumption and its effects on metabolic parameters associated with obesity in young mice. Mol. Nutr. Food Res. 2014, 58, 1061–1068
    • (2014) Mol. Nutr. Food Res , vol.58 , pp. 1061-1068
    • Yamin, H.B.1    Barnea, M.2    Genzer, Y.3    Chapnik, N.4    Froy, O.5
  • 36
    • 84880906852 scopus 로고    scopus 로고
    • Mechanistic target of rapamycin controls homeostasis of adipogenesis
    • Yoon, M.S.; Zhang, C.; Sun, Y.; Schoenherr, C.J.; Chen, J. Mechanistic target of rapamycin controls homeostasis of adipogenesis. J. Lipid Res. 2013, 54, 2166–2173
    • (2013) J. Lipid Res , vol.54 , pp. 2166-2173
    • Yoon, M.S.1    Zhang, C.2    Sun, Y.3    Schoenherr, C.J.4    Chen, J.5
  • 37
    • 84899709626 scopus 로고    scopus 로고
    • The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli
    • Goodman, C.A. The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli. Rev. Physiol. Biochem. Pharmacol. 2014, 166, 43–95
    • (2014) Rev. Physiol. Biochem. Pharmacol , vol.166 , pp. 43-95
    • Goodman, C.A.1
  • 39
    • 84886628911 scopus 로고    scopus 로고
    • EIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation
    • Yogev, O.; Williams, V.C.; Hinits, Y.; Hughes, S.M. eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation. PLoS Biol. 2013, 11, e1001679
    • (2013) Plos Biol , vol.11
    • Yogev, O.1    Williams, V.C.2    Hinits, Y.3    Hughes, S.M.4
  • 40
    • 84862083354 scopus 로고    scopus 로고
    • Cross-talk between AMPK and mTOR in regulating energy balance
    • Xu, J.; Ji, J.; Yan, X.H. Cross-talk between AMPK and mTOR in regulating energy balance. Crit. Rev. Food Sci. Nutr. 2012, 52, 373–381
    • (2012) Crit. Rev. Food Sci. Nutr , vol.52 , pp. 373-381
    • Xu, J.1    Ji, J.2    Yan, X.H.3
  • 41
    • 84862286951 scopus 로고    scopus 로고
    • Translational regulation in nutrigenomics
    • Liu, B.; Qian, S.B. Translational regulation in nutrigenomics. Adv. Nutr. 2011, 2, 511–519
    • (2011) Adv. Nutr , vol.2 , pp. 511-519
    • Liu, B.1    Qian, S.B.2
  • 42
    • 84893477830 scopus 로고    scopus 로고
    • Amino acids activate mammalian target of rapamycin (MTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging
    • Oshiro, N.; Rapley, J.; Avruch, J. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J. Biol. Chem.2014, 289, 2658–2674
    • (2014) J. Biol. Chem , vol.289 , pp. 2658-2674
    • Oshiro, N.1    Rapley, J.2    Avruch, J.3
  • 45
    • 43549114054 scopus 로고    scopus 로고
    • Protein quality assessment: Impact of expanding understanding of protein and amino acid needs for optimal health
    • Millward, D.J.; Layman, D.K.; Tomé, D.; Schaafsma, G. Protein quality assessment: Impact of expanding understanding of protein and amino acid needs for optimal health. Am. J. Clin. Nutr. 2008, 87, 1576S–1581S.
    • (2008) Am. J. Clin. Nutr , vol.87
    • Millward, D.J.1    Layman, D.K.2    Tomé, D.3    Schaafsma, G.4
  • 47
    • 84898470784 scopus 로고    scopus 로고
    • Slow and fast dietary proteins differentially modulate postprandial metabolism
    • He, T.; Giuseppin, M.L. Slow and fast dietary proteins differentially modulate postprandial metabolism. Int. J. Food Sci. Nutr. 2014, 65, 386–390
    • (2014) Int. J. Food Sci. Nutr , vol.65 , pp. 386-390
    • He, T.1    Giuseppin, M.L.2
  • 49
    • 0030010165 scopus 로고    scopus 로고
    • Gastrojejunal kinetics and the digestion of [15N]β-lactoglobulin and casein in humans: The influence of the nature and quantity of the protein
    • Mahé, S.; Roos, N.; Benamouzig, R.; Davin, L.; Luengo, C.; Gagnon, L.; Gaussergès, N.; Rautureau, J.; Tomé, D. Gastrojejunal kinetics and the digestion of [15N]β-lactoglobulin and casein in humans: The influence of the nature and quantity of the protein. Am. J. Clin. Nutr. 1996, 63, 546–552
    • (1996) Am. J. Clin. Nutr , vol.63 , pp. 546-552
    • Mahé, S.1    Roos, N.2    Benamouzig, R.3    Davin, L.4    Luengo, C.5    Gagnon, L.6    Gaussergès, N.7    Rautureau, J.8    Tomé, D.9
  • 53
    • 59049100116 scopus 로고    scopus 로고
    • An amino acid shuffle activates mTORC1
    • Cohen, A.; Hall, M.N. An amino acid shuffle activates mTORC1. Cell 2009, 136, 399–400
    • (2009) Cell , vol.136 , pp. 399-400
    • Cohen, A.1    Hall, M.N.2
  • 55
    • 84857804808 scopus 로고    scopus 로고
    • The structure and allosteric regulation of mammalian glutamate dehydrogenase
    • Li, M.; Li, C.; Allen, A.; Stanley, C.A.; Smith, T.J. The structure and allosteric regulation of mammalian glutamate dehydrogenase. Arch. Biochem. Biophys. 2012, 519, 69–80
    • (2012) Arch. Biochem. Biophys , vol.519 , pp. 69-80
    • Li, M.1    Li, C.2    Allen, A.3    Stanley, C.A.4    Smith, T.J.5
  • 57
    • 0036787462 scopus 로고    scopus 로고
    • Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic β-cells
    • McDaniel, M.L.; Marshall, C.A.; Pappan, K.L.; Kwon, G. Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic β-cells. Diabetes 2002, 51, 2877–2885
    • (2002) Diabetes , vol.51 , pp. 2877-2885
    • McDaniel, M.L.1    Marshall, C.A.2    Pappan, K.L.3    Kwon, G.4
  • 58
    • 0035145602 scopus 로고    scopus 로고
    • Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic β-cells
    • Xu, G.; Kwon, G.; Cruz, W.S.; Marshall, C.A.; McDaniel, M.L. Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic β-cells. Diabetes 2001, 50, 353–360
    • (2001) Diabetes , vol.50 , pp. 353-360
    • Xu, G.1    Kwon, G.2    Cruz, W.S.3    Marshall, C.A.4    McDaniel, M.L.5
  • 59
    • 75049083587 scopus 로고    scopus 로고
    • Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data
    • Lenders, C.M.; Liu, S.; Wilmore, D.W.; Sampson, L.; Dougherty, L.W.; Spiegelman, D.; Willett, W.C. Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data. Eur. J. Clin. Nutr. 2009, 63, 1433–1439
    • (2009) Eur. J. Clin. Nutr , vol.63 , pp. 1433-1439
    • Lenders, C.M.1    Liu, S.2    Wilmore, D.W.3    Sampson, L.4    Dougherty, L.W.5    Spiegelman, D.6    Willett, W.C.7
  • 60
    • 84922743269 scopus 로고    scopus 로고
    • The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1
    • Wang, S.; Tsun, Z.Y.; Wolfson, R.; Shen, K.; Wyant, G.A.; Plovanich, M.E.; Yuan, E.D.; Jones, T.D.; Chantranupong, L.; Comb, W.; et al. The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1. Science 2015, 347, 188–194
    • (2015) Science , vol.347 , pp. 188-194
    • Wang, S.1    Tsun, Z.Y.2    Wolfson, R.3    Shen, K.4    Wyant, G.A.5    Plovanich, M.E.6    Yuan, E.D.7    Jones, T.D.8    Chantranupong, L.9    Comb, W.10
  • 61
    • 53549129190 scopus 로고    scopus 로고
    • The role of mTOR in the adaptation and failure of β-cells in type 2 diabetes
    • Leibowitz, G.; Cerasi, E.; Ketzinel-Gilad, M. The role of mTOR in the adaptation and failure of β-cells in type 2 diabetes. Diabetes Obes. Metab. 2008, 10, 157–169
    • (2008) Diabetes Obes. Metab , vol.10 , pp. 157-169
    • Leibowitz, G.1    Cerasi, E.2    Ketzinel-Gilad, M.3
  • 62
    • 77955890920 scopus 로고    scopus 로고
    • Leucine metabolism in regulation of insulin secretion from pancreatic β cells
    • Yang, J.; Chi, Y.; Burkhardt, B.R.; Guan, Y.; Wolf, B.A. Leucine metabolism in regulation of insulin secretion from pancreatic β cells. Nutr. Rev. 2010, 68, 270–279
    • (2010) Nutr. Rev , vol.68 , pp. 270-279
    • Yang, J.1    Chi, Y.2    Burkhardt, B.R.3    Guan, Y.4    Wolf, B.A.5
  • 64
    • 0024388360 scopus 로고
    • Protein intake in early infancy: Effects on plasma amino acid concentrations, insulin metabolism, and growth
    • Axelsson, I.E.; Ivarsson, S.A.; Räihä, N.C. Protein intake in early infancy: Effects on plasma amino acid concentrations, insulin metabolism, and growth. Pediatr. Res. 1989, 26, 614–617
    • (1989) Pediatr. Res , vol.26 , pp. 614-617
    • Axelsson, I.E.1    Ivarsson, S.A.2    Räihä, N.C.3
  • 67
    • 84926285465 scopus 로고    scopus 로고
    • The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus
    • Melnik, B.C. The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus. Curr. Diabetes Rev. 2015, 11, 46–62
    • (2015) Curr. Diabetes Rev , vol.11 , pp. 46-62
    • Melnik, B.C.1
  • 68
    • 1842301673 scopus 로고    scopus 로고
    • An insulin index of foods. The insulin demand generated by 1000-kK portions of common foods
    • Holt, S.; Brand Miller, J.; Petocz, P. An insulin index of foods. The insulin demand generated by 1000-kK portions of common foods. Am. J. Clin. Nutr. 1997, 66, 1264–1276
    • (1997) Am. J. Clin. Nutr , vol.66 , pp. 1264-1276
    • Holt, S.1    Brand Miller, J.2    Petocz, P.3
  • 69
    • 15944404633 scopus 로고    scopus 로고
    • Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk
    • Hoyt, G.; Hickey, M.S.; Cordain, L. Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk. Br. J. Nutr. 2005, 93, 175–177
    • (2005) Br. J. Nutr , vol.93 , pp. 175-177
    • Hoyt, G.1    Hickey, M.S.2    Cordain, L.3
  • 70
    • 15544362097 scopus 로고    scopus 로고
    • High intakes of milk, but not meat, increases s-insulin and insulin resistance in 8-year-old boys
    • Hoppe, C.; Mølgaard, C.; Vaag, A.; Barkholt, V.; Michaelsen, K.F. High intakes of milk, but not meat, increases s-insulin and insulin resistance in 8-year-old boys. Eur. J. Clin. Nutr. 2005, 59, 393–398
    • (2005) Eur. J. Clin. Nutr , vol.59 , pp. 393-398
    • Hoppe, C.1    Mølgaard, C.2    Vaag, A.3    Barkholt, V.4    Michaelsen, K.F.5
  • 71
    • 70249098802 scopus 로고    scopus 로고
    • Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: Results from a randomized 7-day supplementation study in prepubertal boys
    • Hoppe, C.; Mølgaard, C.; Dalum, C.; Vaag, A.; Michaelsen, K.F. Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: Results from a randomized 7-day supplementation study in prepubertal boys. Eur. J. Clin. Nutr. 2009, 63, 1076–1083
    • (2009) Eur. J. Clin. Nutr , vol.63 , pp. 1076-1083
    • Hoppe, C.1    Mølgaard, C.2    Dalum, C.3    Vaag, A.4    Michaelsen, K.F.5
  • 73
    • 60149100105 scopus 로고    scopus 로고
    • Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro
    • Chen, Q.; Reimer, R.A. Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro. Nutrition 2009, 25, 340–349
    • (2009) Nutrition , vol.25 , pp. 340-349
    • Chen, Q.1    Reimer, R.A.2
  • 74
    • 16544362066 scopus 로고    scopus 로고
    • Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: The role of plasma amino acids and incretins
    • Nilsson, M.; Stenberg, M.; Frid, A.H.; Holst, J.J.; Björck, I.M. Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: The role of plasma amino acids and incretins. Am. J. Clin. Nutr. 2004, 80, 1246–2353
    • (2004) Am. J. Clin. Nutr , vol.80 , pp. 1246-2353
    • Nilsson, M.1    Stenberg, M.2    Frid, A.H.3    Holst, J.J.4    Björck, I.M.5
  • 75
    • 34147133191 scopus 로고    scopus 로고
    • Metabolic effects of amino acid mixtures and whey protein in healthy subjects: Studies using glucose-equivalent drinks
    • Nilsson, M.; Holst, J.J.; Björck, I.M. Metabolic effects of amino acid mixtures and whey protein in healthy subjects: Studies using glucose-equivalent drinks. Am. J. Clin. Nutr. 2007, 85, 996–1004
    • (2007) Am. J. Clin. Nutr , vol.85 , pp. 996-1004
    • Nilsson, M.1    Holst, J.J.2    Björck, I.M.3
  • 76
    • 84861536072 scopus 로고    scopus 로고
    • The insulinogenic effects of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells
    • Salehi, A.; Gunnerud, U.; Muhammed, S.J.; Ostman, E.; Holst, J.J.; Björck, I.; Rorsman, P. The insulinogenic effects of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells. Nutr. Metab. 2012, 9, doi:10.1186/1743-7075-9-48
    • (2012) Nutr. Metab
    • Salehi, A.1    Gunnerud, U.2    Muhammed, S.J.3    Ostman, E.4    Holst, J.J.5    Björck, I.6    Rorsman, P.7
  • 77
    • 84903980696 scopus 로고    scopus 로고
    • Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1
    • Xie, J.; El Sayed, N.M.; Qi, C.; Zhao, X.; Moore, C.E.; Herbert, T.P. Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1. J. Mol. Endocrinol. 2014, 53, 105–115
    • (2014) J. Mol. Endocrinol , vol.53 , pp. 105-115
    • Xie, J.1    El Sayed, N.M.2    Qi, C.3    Zhao, X.4    Moore, C.E.5    Herbert, T.P.6
  • 80
    • 84903287572 scopus 로고    scopus 로고
    • Analysis of free ACh and 5-HT in milk from four different species and their bioactivity on 5-HT(3) and nACh receptors
    • Gallegos-Perez, J.L.; Limon, A.; Reyes-Ruiz, J.M.; Alshanqeeti, A.S.; Aljohi, M.A.; Miledi, R. Analysis of free ACh and 5-HT in milk from four different species and their bioactivity on 5-HT(3) and nACh receptors. Food Funct. 2014, 5, 1489–1494
    • (2014) Food Funct , vol.5 , pp. 1489-1494
    • Gallegos-Perez, J.L.1    Limon, A.2    Reyes-Ruiz, J.M.3    Alshanqeeti, A.S.4    Aljohi, M.A.5    Miledi, R.6
  • 81
    • 0032740212 scopus 로고    scopus 로고
    • Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes
    • Wheelhouse, N.M.; Stubbs, A.K.; Lomax, M.A.; MacRae, J.C.; Hazlerigg, D.G. Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes. J. Endocrinol. 1999, 163, 353–361
    • (1999) J. Endocrinol , vol.163 , pp. 353-361
    • Wheelhouse, N.M.1    Stubbs, A.K.2    Lomax, M.A.3    Macrae, J.C.4    Hazlerigg, D.G.5
  • 82
    • 0026085228 scopus 로고
    • Nutrition and somatomedin. XXIII. Molecular regulation of IGF-I by amino acid availability in cultured hepatocytes
    • Harp, J.B.; Goldstein, S.; Phillips, L.S. Nutrition and somatomedin. XXIII. Molecular regulation of IGF-I by amino acid availability in cultured hepatocytes. Diabetes 1991, 40, 95–101
    • (1991) Diabetes , vol.40 , pp. 95-101
    • Harp, J.B.1    Goldstein, S.2    Phillips, L.S.3
  • 83
    • 0029745560 scopus 로고    scopus 로고
    • α-lactalbumin enriched low-protein infant formulas: A comparison to breast milk feeding
    • Heine, W.; Radke M.; Wutzke, K.D.; Peters, E.; Kundt, G. α-lactalbumin enriched low-protein infant formulas: A comparison to breast milk feeding. Acta Paediatr. 1996, 85, 1024–1028
    • (1996) Acta Paediatr , vol.85 , pp. 1024-1028
    • Heine, W.1    Radke, M.2    Wutzke, K.D.3    Peters, E.4    Kundt, G.5
  • 84
    • 0034085615 scopus 로고    scopus 로고
    • The bovine protein α-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress
    • Markus, C.R.; Olivier, B.; Panhuysen, G.E.; van der Gugten, J.; Alles, M.S.; Tuiten, A.; Westenberg, H.G.; Fekkes, D.; Koppeschaar, H.F.; de Haan, E.E. The bovine protein α-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am. J. Clin. Nutr. 2000, 71, 1536–1544
    • (2000) Am. J. Clin. Nutr , vol.71 , pp. 1536-1544
    • Markus, C.R.1    Olivier, B.2    Panhuysen, G.E.3    Van Der Gugten, J.4    Alles, M.S.5    Tuiten, A.6    Westenberg, H.G.7    Fekkes, D.8    Koppeschaar, H.F.9    De Haan, E.E.10
  • 85
    • 77951453523 scopus 로고    scopus 로고
    • Milk consumption and circulating insulin-like growth factor-I level: A systematic literature review
    • Qin, L.Q.; He, K.; Xu, J.Y. Milk consumption and circulating insulin-like growth factor-I level: A systematic literature review. Int. J. Food Sci. Nutr. 2009, 60, 330–340
    • (2009) Int. J. Food Sci. Nutr , vol.60 , pp. 330-340
    • Qin, L.Q.1    He, K.2    Xu, J.Y.3
  • 89
    • 84866128888 scopus 로고    scopus 로고
    • Leucine signaling in the pathogenesis of type 2 diabetes and obesity
    • Melnik, B.C. Leucine signaling in the pathogenesis of type 2 diabetes and obesity. World J. Diabetes 2012, 3, 38–53
    • (2012) World J. Diabetes , vol.3 , pp. 38-53
    • Melnik, B.C.1
  • 90
    • 84911090935 scopus 로고    scopus 로고
    • Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of β cell mass and function
    • Modi, H.; Cornu, M.; Thorens, B. Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of β cell mass and function. J. Biol. Chem. 2014, 289, 31972–31982
    • (2014) J. Biol. Chem , vol.289 , pp. 31972-31982
    • Modi, H.1    Cornu, M.2    Thorens, B.3
  • 91
    • 84908192544 scopus 로고    scopus 로고
    • The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation
    • Csibi, A.; Lee, G.; Yoon, S.O.; Tong, H.; Ilter, D.; Elia, I.; Fendt, S.M.; Roberts, T.M.; Blenis, J. The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. J. Curr. Biol. 2014, 24, 2274–2280
    • (2014) J. Curr. Biol , vol.24 , pp. 2274-2280
    • Csibi, A.1    Lee, G.2    Yoon, S.O.3    Tong, H.4    Ilter, D.5    Elia, I.6    Fendt, S.M.7    Roberts, T.M.8    Blenis, J.9
  • 93
    • 34548092167 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
    • Mordier, S.; Iynedjian, P.B. Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. Biochem. Biophys. Res. Commun. 2007, 362, 206–211
    • (2007) Biochem. Biophys. Res. Commun , vol.362 , pp. 206-211
    • Mordier, S.1    Iynedjian, P.B.2
  • 94
    • 77958149976 scopus 로고    scopus 로고
    • Palmitate induced insulin resistance by PKCtheta-dependent activation of mTOR/S6K pathway in C2C12 myotubes
    • Wang, X.; Yu, W.; Nawaz, A.; Guan, F.; Sun, S.; Wang, C. Palmitate induced insulin resistance by PKCtheta-dependent activation of mTOR/S6K pathway in C2C12 myotubes. Exp. Clin. Endocrinol. Diabetes 2010, 118, 657–661
    • (2010) Exp. Clin. Endocrinol. Diabetes , vol.118 , pp. 657-661
    • Wang, X.1    Yu, W.2    Nawaz, A.3    Guan, F.4    Sun, S.5    Wang, C.6
  • 95
    • 84907485622 scopus 로고    scopus 로고
    • Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway
    • Hatanaka, M.; Maier, B.; Sims, E.K.; Templin, A.T.; Kulkarni, R.N.; Evans-Molina, C.; Mirmira, R.G. Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway. Diabetes 2014, 63, 3404–3415
    • (2014) Diabetes , vol.63 , pp. 3404-3415
    • Hatanaka, M.1    Maier, B.2    Sims, E.K.3    Templin, A.T.4    Kulkarni, R.N.5    Evans-Molina, C.6    Mirmira, R.G.7
  • 96
    • 84927636713 scopus 로고    scopus 로고
    • Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection
    • Pardo, V.; González-Rodríguez, Á.; Muntané, J.; Kozma, S.C.; Valverde, Á.M. Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection. Food Chem. Toxicol. 2015, 80, 298–309
    • (2015) Food Chem. Toxicol , vol.80 , pp. 298-309
    • Pardo, V.1    González-Rodríguez, Á.2    Muntané, J.3    Kozma, S.C.4    Valverde, M.5
  • 97
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    • Um, S.H.; D’Alessio, D.; Thomas, G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 2006, 3, 393–402
    • (2006) Cell Metab , vol.3 , pp. 393-402
    • Um, S.H.1    D’Alessio, D.2    Thomas, G.3
  • 99
    • 0025427484 scopus 로고
    • Changes in milk fat phospholipids during lactation
    • Bitman, J.; Wood, D.L. Changes in milk fat phospholipids during lactation. J. Dairy Sci. 1990, 73, 1208–1216
    • (1990) J. Dairy Sci , vol.73 , pp. 1208-1216
    • Bitman, J.1    Wood, D.L.2
  • 100
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNA and microRNAs is novel mechanism of genetic exchange between cells
    • Valadi, H.; Ekstöm, K.; Bossios, A.; Sjöstrand, M.; Lee, J.J.; Lötvall, J.O. Exosome-mediated transfer of mRNA and microRNAs is novel mechanism of genetic exchange between cells. Nat. Cell Biol.2007, 9, 654–659
    • (2007) Nat. Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstöm, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 102
    • 84862777377 scopus 로고    scopus 로고
    • Secreted microRNAs: A new form of intercellular communication
    • Chen, X.; Liang, H.; Zhang, J.; Zen, K.; Thang, C.Y. Secreted microRNAs: A new form of intercellular communication. Trends Cell Biol. 2012, 22, 125–132
    • (2012) Trends Cell Biol , vol.22 , pp. 125-132
    • Chen, X.1    Liang, H.2    Zhang, J.3    Zen, K.4    Thang, C.Y.5
  • 103
    • 83555173384 scopus 로고    scopus 로고
    • Exosomes: Small vesicles participating in intercellular communication
    • Ludwig, A.K.; Giebel, B. Exosomes: Small vesicles participating in intercellular communication. Int. J. Biochem. Cell Biol. 2012, 44, 11–15
    • (2012) Int. J. Biochem. Cell Biol , vol.44 , pp. 11-15
    • Ludwig, A.K.1    Giebel, B.2
  • 104
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros, V. The functions of animal microRNAs. Nature 2004, 431, 350–355
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 105
    • 84862169420 scopus 로고    scopus 로고
    • Horizontal transfer of microRNAs: Molecular mechanism and clinical applications
    • Chen, X.; Liang, H.; Zhang, J.; Zen, K.; Zhang, C.Y. Horizontal transfer of microRNAs: Molecular mechanism and clinical applications. Protein Cell 2012, 3, 28–37
    • (2012) Protein Cell , vol.3 , pp. 28-37
    • Chen, X.1    Liang, H.2    Zhang, J.3    Zen, K.4    Zhang, C.Y.5
  • 110
  • 112
    • 84874819067 scopus 로고    scopus 로고
    • Immune modulatory function of abundant immune-related microRNAs in microvesicles from bovine colostrum
    • Sun, Q.; Chen, X.; Yu, J.; Zen, K.; Zhang, C.Y.; Li, L. Immune modulatory function of abundant immune-related microRNAs in microvesicles from bovine colostrum. Protein Cell 2013, 4, 197–210
    • (2013) Protein Cell , vol.4 , pp. 197-210
    • Sun, Q.1    Chen, X.2    Yu, J.3    Zen, K.4    Zhang, C.Y.5    Li, L.6
  • 113
    • 77957037314 scopus 로고    scopus 로고
    • MicroRNA as a new immune-regulatory agent in breast milk
    • Kosaka, N.; Izumi, H.; Sekine, K.; Ochiya, T. microRNA as a new immune-regulatory agent in breast milk. Silence 2010, 1, doi:10.1186/1758-907X-1-7
    • (2010) Silence
    • Kosaka, N.1    Izumi, H.2    Sekine, K.3    Ochiya, T.4
  • 115
    • 84894246742 scopus 로고    scopus 로고
    • Milk: An exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
    • Melnik, B.C.; John, S.M.; Schmitz, G. Milk: An exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy? J. Transl. Med. 2014, 12, doi:10.1186/1479-5876-12-43
    • (2014) J. Transl. Med
    • Melnik, B.C.1    John, S.M.2    Schmitz, G.3
  • 117
    • 77957567010 scopus 로고    scopus 로고
    • Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products
    • Chen, X.; Gao, C.; Li, H.; Huang, L.; Sun, Q.; Dong, Y.; Guan, D.; Hu, X.; Zhao, S.; Li, L.; et al. Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res. 2010, 20, 1128–1137
    • (2010) Cell Res , vol.20 , pp. 1128-1137
    • Chen, X.1    Gao, C.2    Li, H.3    Huang, L.4    Sun, Q.5    Dong, Y.6    Guan, D.7    Hu, X.8    Zhao, S.9    Li, L.10
  • 118
    • 84865339380 scopus 로고    scopus 로고
    • Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions
    • Izumi, H.; Kosaka, N.; Shimizu, T.; Sekine, K.; Ochiya, T.; Takase, M. Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions. J. Dairy Sci. 2012, 95, 4831–4841
    • (2012) J. Dairy Sci , vol.95 , pp. 4831-4841
    • Izumi, H.1    Kosaka, N.2    Shimizu, T.3    Sekine, K.4    Ochiya, T.5    Takase, M.6
  • 120
    • 31544458134 scopus 로고    scopus 로고
    • Branched-chain amino acids: Enzyme and substrate regulation
    • Brosnan, J.T.; Brosnan, M.E. Branched-chain amino acids: Enzyme and substrate regulation. J. Nutr. 2006, 136, 207S–211S.
    • (2006) J. Nutr , vol.136
    • Brosnan, J.T.1    Brosnan, M.E.2
  • 121
    • 73649126526 scopus 로고    scopus 로고
    • Branched-chain amino acid metabolon: Interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm)
    • Islam, M.M.; Nautiyal, M.; Wynn, R.M.; Mobley, J.A.; Chuang, D.T.; Hutson, S.M. Branched-chain amino acid metabolon: Interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm). J. Biol. Chem.2010, 285, 265–276
    • (2010) J. Biol. Chem , vol.285 , pp. 265-276
    • Islam, M.M.1    Nautiyal, M.2    Wynn, R.M.3    Mobley, J.A.4    Chuang, D.T.5    Hutson, S.M.6
  • 122
    • 0034653468 scopus 로고    scopus 로고
    • Crystal structure of human branched-chain α-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease
    • AEvarsson, A.; Chuang, J.L.; Wynn, R.M.; Turley, S.; Chuang, D.T.; Hol, W.G. Crystal structure of human branched-chain α-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease. Structure 2000, 8, 277–291
    • (2000) Structure , vol.8 , pp. 277-291
    • Aevarsson, A.1    Chuang, J.L.2    Wynn, R.M.3    Turley, S.4    Chuang, D.T.5    Hol, W.G.6
  • 123
    • 27944480498 scopus 로고    scopus 로고
    • Human microRNA (MiR29b) expression controls the amount of branched chain α ketoacid dehydrogenase complex in a cell
    • Mersey, B.D.; Jin, P.; Danner, D.J. Human microRNA (miR29b) expression controls the amount of branched chain α ketoacid dehydrogenase complex in a cell. Hum. Mol. Genet.2005, 14, 3371–3377
    • (2005) Hum. Mol. Genet , vol.14 , pp. 3371-3377
    • Mersey, B.D.1    Jin, P.2    Danner, D.J.3
  • 124
    • 84929773810 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-29s affects the lactation activity of dairy cow mammary epithelial cells
    • Bian, Y.; Lei, Y.; Wang, C.; Wang, J.; Wang, L.; Liu, L.; Liu, L.; Gao, X.; Li, Q. Epigenetic regulation of miR-29s affects the lactation activity of dairy cow mammary epithelial cells. J. Cell. Physiol. 2015, 230, 2152–2163
    • (2015) J. Cell. Physiol , vol.230 , pp. 2152-2163
    • Bian, Y.1    Lei, Y.2    Wang, C.3    Wang, J.4    Wang, L.5    Liu, L.6    Liu, L.7    Gao, X.8    Li, Q.9
  • 125
    • 0029086245 scopus 로고
    • Expression and characterization of branched-chain α-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase?
    • Davie, J.R.; Wynn, R.M.; Meng, M.; Huang, Y.S.; Aalund, G.; Chuang, D.T.; Lau, K.S. Expression and characterization of branched-chain α-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase? J. Biol.Chem. 1995, 270, 19861–19867
    • (1995) J. Biol.Chem , vol.270 , pp. 19861-19867
    • Davie, J.R.1    Wynn, R.M.2    Meng, M.3    Huang, Y.S.4    Aalund, G.5    Chuang, D.T.6    Lau, K.S.7
  • 126
    • 0015914742 scopus 로고
    • Structural and functional role of leucine residues in proteins
    • Chou, P.Y.; Fasman, G.D. Structural and functional role of leucine residues in proteins. J. Mol. Biol. 1973, 74, 263–281
    • (1973) J. Mol. Biol , vol.74 , pp. 263-281
    • Chou, P.Y.1    Fasman, G.D.2
  • 127
    • 0028894384 scopus 로고
    • Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
    • Glover, J.N.; Harrison, S.C. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature 1995, 373, 257–261
    • (1995) Nature , vol.373 , pp. 257-261
    • Glover, J.N.1    Harrison, S.C.2
  • 128
    • 0031796861 scopus 로고    scopus 로고
    • Structure and properties of surfactant protein B
    • Hawgood, S.; Derrick, M.; Poulain, F. Structure and properties of surfactant protein B. Biochim. Biophys. Acta 1998, 1408, 150–160
    • (1998) Biochim. Biophys. Acta , vol.1408 , pp. 150-160
    • Hawgood, S.1    Derrick, M.2    Poulain, F.3
  • 130
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng, F.; Henson, R.; Wehbe-Janek, H.; Ghoshal, K.; Jacob, S.T.; Patel, T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007, 133, 647–658
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 131
    • 84862638243 scopus 로고    scopus 로고
    • Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 incactivation by targeting PTEN
    • Han, M.; Liu, M.; Wang, Y.; Chen, X.; Xu, J.; Sun, Y.; Zhao, L.; Qu, H.; Fan, Y.; Wu, C. Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 incactivation by targeting PTEN. PLoS ONE 2012, 7, e39520
    • (2012) Plos ONE , vol.7
    • Han, M.1    Liu, M.2    Wang, Y.3    Chen, X.4    Xu, J.5    Sun, Y.6    Zhao, L.7    Qu, H.8    Fan, Y.9    Wu, C.10
  • 132
    • 84864541155 scopus 로고    scopus 로고
    • TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion
    • Dey, N.; Ghosh-Choudhury, N.; Kasinath, B.S.; Choudhury, G.G. TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PLoS ONE 2012, 7, e42316
    • (2012) Plos ONE , vol.7
    • Dey, N.1    Ghosh-Choudhury, N.2    Kasinath, B.S.3    Choudhury, G.G.4
  • 133
    • 84873621958 scopus 로고    scopus 로고
    • MiR-21 regulates biological behavior through the PTEN/PI-3K/Akt signaling pathway in human colorectal cancer cells
    • Xiong, B.; Cheng, Y.; Ma, L.; Zhang, C. MiR-21 regulates biological behavior through the PTEN/PI-3K/Akt signaling pathway in human colorectal cancer cells. Int. J. Oncol.2013, 42, 219–228
    • (2013) Int. J. Oncol , vol.42 , pp. 219-228
    • Xiong, B.1    Cheng, Y.2    Ma, L.3    Zhang, C.4
  • 134
    • 59749091850 scopus 로고    scopus 로고
    • Complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang, J.; Manning, B.D. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 2009, 37, 217–222
    • (2009) Biochem. Soc. Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.2
  • 136
    • 80955163793 scopus 로고    scopus 로고
    • Transcriptional and post-transcriptional regulation of Sprouty1, a receptor tyrosine kinase inhibitor in prostate cancer
    • Dariminpourain, M.; Wang, S.; Ittmann, M.; Kwabi-Addo, B. Transcriptional and post-transcriptional regulation of Sprouty1, a receptor tyrosine kinase inhibitor in prostate cancer. Prostate Cancer Prostatic Dis. 2011, 14, 279–285
    • (2011) Prostate Cancer Prostatic Dis , vol.14 , pp. 279-285
    • Dariminpourain, M.1    Wang, S.2    Ittmann, M.3    Kwabi-Addo, B.4
  • 137
    • 78751517914 scopus 로고    scopus 로고
    • Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty
    • Frey, M.R.; Carraro, G.; Batra, R.K.; Polk, D.B.; Warburton, D. Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty. Cancer Biol. Ther. 2011, 11, 122–124
    • (2011) Cancer Biol. Ther , vol.11 , pp. 122-124
    • Frey, M.R.1    Carraro, G.2    Batra, R.K.3    Polk, D.B.4    Warburton, D.5
  • 138
    • 2942726155 scopus 로고    scopus 로고
    • The ins and outs of FoxO shuttling: Mechanisms of FoxO translocation and transcriptional regulation
    • Van der Heide, L.P.; Hoekman, M.F.; Smidt, M.P. The ins and outs of FoxO shuttling: Mechanisms of FoxO translocation and transcriptional regulation. Biochem. J. 2004, 380, 297–309
    • (2004) Biochem. J , vol.380 , pp. 297-309
    • Van Der Heide, L.P.1    Hoekman, M.F.2    Smidt, M.P.3
  • 139
    • 34548289502 scopus 로고    scopus 로고
    • Dynamic FoxO transcription factors
    • Huang, H.; Tindall, D.J. Dynamic FoxO transcription factors. J. Cell Sci.2007, 120, 2479–2487
    • (2007) J. Cell Sci , vol.120 , pp. 2479-2487
    • Huang, H.1    Tindall, D.J.2
  • 140
    • 84907189522 scopus 로고    scopus 로고
    • MiR-21 induces cell proliferation and suppresses the chemosensitivity in glioblastoma cells via downregulation of FOXO1
    • Lei, B.X.; Liu, Z.H.; Li, Z.J.; Li, C.; Deng, Y.F. miR-21 induces cell proliferation and suppresses the chemosensitivity in glioblastoma cells via downregulation of FOXO1. Int. J. Clin. Exp. Med. 2014, 7, 2060–2066
    • (2014) Int. J. Clin. Exp. Med , vol.7 , pp. 2060-2066
    • Lei, B.X.1    Liu, Z.H.2    Li, Z.J.3    Li, C.4    Deng, Y.F.5
  • 141
    • 84938997840 scopus 로고    scopus 로고
    • Interplay of miR-21 and FoxO1 modulates growth of pancreatic ductal adenocarcinoma
    • Song, W.; Wang, L.; Wang, L.; Li, Q. Interplay of miR-21 and FoxO1 modulates growth of pancreatic ductal adenocarcinoma. Tumour Biol. 2015, doi:10.1007/s13277-015-3123-x.
    • (2015) Tumour Biol
    • Song, W.1    Wang, L.2    Wang, L.3    Li, Q.4
  • 142
    • 84921350297 scopus 로고    scopus 로고
    • Modulation of FoxO1 expression by miR-21 to promote growth of pancreatic ductal adenocarcinoma
    • Song, W.; Li, Q.; Wang, L.; Wang, L. Modulation of FoxO1 expression by miR-21 to promote growth of pancreatic ductal adenocarcinoma. Cell. Physiol. Biochem. 2015, 35, 184–190
    • (2015) Cell. Physiol. Biochem , vol.35 , pp. 184-190
    • Song, W.1    Li, Q.2    Wang, L.3    Wang, L.4
  • 145
    • 80052966977 scopus 로고    scopus 로고
    • Interplay between FOXO, TOR, and Akt
    • Hay, N. Interplay between FOXO, TOR, and Akt. Biochim. Biophys. Acta 2011, 1813, 1965–1970
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1965-1970
    • Hay, N.1
  • 146
    • 0242539698 scopus 로고    scopus 로고
    • Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    • Jünger, M.A.; Rintelen, F. Stocker, H.; Wasserman, J.D.; Végh, M.; Radimerski, T.; Greenberg, M.E.; Hafen, E. Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2003, 2, 20
    • (2003) J. Biol , vol.2
    • Jünger, M.A.1    Rintelen, F.2    Stocker, H.3    Wasserman, J.D.4    Végh, M.5    Radimerski, T.6    Greenberg, M.E.7    Hafen, E.8
  • 147
    • 0042161896 scopus 로고    scopus 로고
    • Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway
    • Puig, O.; Marr, M.T.; Ruhf, M.L.; Tjian, R. Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 2003, 17, 2006–2020
    • (2003) Genes Dev , vol.17 , pp. 2006-2020
    • Puig, O.1    Marr, M.T.2    Ruhf, M.L.3    Tjian, R.4
  • 149
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (MiR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani, I.A.; Rasheed, S.A.; Nikolova, D.A.; Leupold, J.H.; Colburn, N.H.; Post, S.; Allgayer, H. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008, 27, 2128–2136
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3    Leupold, J.H.4    Colburn, N.H.5    Post, S.6    Allgayer, H.7
  • 150
    • 47549109566 scopus 로고    scopus 로고
    • MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
    • Lu, Z.; Liu, M.; Stribinskis, V.; Klinge, C.M.; Ramos, K.S.; Colburn, N.H.; Li, Y. MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 2008, 27, 4373–4379
    • (2008) Oncogene , vol.27 , pp. 4373-4379
    • Lu, Z.1    Liu, M.2    Stribinskis, V.3    Klinge, C.M.4    Ramos, K.S.5    Colburn, N.H.6    Li, Y.7
  • 151
    • 43749110929 scopus 로고    scopus 로고
    • Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway
    • Carayol, N.; Katsoulidis, E.; Sassano, A.; Altman, J.K.; Druker, B.J.; Platanias, L.C. Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway. J. Biol. Chem. 2008, 28, 8601–8610
    • (2008) J. Biol. Chem , vol.28 , pp. 8601-8610
    • Carayol, N.1    Katsoulidis, E.2    Sassano, A.3    Altman, J.K.4    Druker, B.J.5    Platanias, L.C.6
  • 152
    • 84871178729 scopus 로고    scopus 로고
    • Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis
    • Dennis, M.D.; Jefferson, L.S.; Kimball, S.R. Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J. Biol. Chem.2012, 287, 42890–42899
    • (2012) J. Biol. Chem , vol.287 , pp. 42890-42899
    • Dennis, M.D.1    Jefferson, L.S.2    Kimball, S.R.3
  • 153
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis, B.N.; Hilyard, A.C.; Lagna, G.; Hata, A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008, 454, 56–61
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 154
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma, X.M.; Blenis, J. Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 2009, 10, 307–318
    • (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 155
    • 84924365868 scopus 로고    scopus 로고
    • Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1
    • Szymańska, P.; Martin, K.R.; MacKeigan, J.P.; Hlavacek, W.S.; Lipniacki, T. Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1. PLoS ONE 2015, 10, e0116550
    • (2015) Plos ONE , vol.10
    • Szymańska, P.1    Martin, K.R.2    Mackeigan, J.P.3    Hlavacek, W.S.4    Lipniacki, T.5
  • 156
    • 0028786952 scopus 로고
    • Repression of cap-dependent translation by 4E-binding protein 1: Competition with p220 for binding to eukaryotic initiation factor-4E
    • Haghighat, A.; Mader, S.; Pause, A.; Sonenberg, N. Repression of cap-dependent translation by 4E-binding protein 1: Competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J. 1995, 14, 5701–5709
    • (1995) EMBO J , vol.14 , pp. 5701-5709
    • Haghighat, A.1    Mader, S.2    Pause, A.3    Sonenberg, N.4
  • 157
  • 160
    • 62849126891 scopus 로고    scopus 로고
    • Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (EIF4GI) for efficient interaction of eIF4E with the mRNA cap
    • Yanagiya, A.; Svitkin, Y.V.; Shibata, S.; Mikami, S.; Imataka, H.; Sonenberg, N. Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap. Mol. Cell. Biol. 2009, 29, 1661–1669
    • (2009) Mol. Cell. Biol , vol.29 , pp. 1661-1669
    • Yanagiya, A.1    Svitkin, Y.V.2    Shibata, S.3    Mikami, S.4    Imataka, H.5    Sonenberg, N.6
  • 163
    • 27744569843 scopus 로고    scopus 로고
    • MTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz, M.K.; Ballif, B.A.; Gygi, S.P.; Blenis, J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005, 123, 569–580
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 166
    • 84917708600 scopus 로고    scopus 로고
    • Crosstalk between Edc4 and mammalian target of rapamycin complex 1 (MTORC1) signaling in mRNA decapping
    • Rahman, H.; Qasim, M.; Oellerich, M.; Asif, A.R. Crosstalk between Edc4 and mammalian target of rapamycin complex 1 (mTORC1) signaling in mRNA decapping. Int. J. Mol. Sci. 2014, 15, 23179–23195
    • (2014) Int. J. Mol. Sci , vol.15 , pp. 23179-23195
    • Rahman, H.1    Qasim, M.2    Oellerich, M.3    Asif, A.R.4
  • 167
    • 28344456221 scopus 로고    scopus 로고
    • Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body
    • Yu, J.H.; Yang, W.H.; Gulick, T.; Bloch, K.D.; Bloch, D.B. Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body. RNA 2005, 11, 1795–1802
    • (2005) RNA , vol.11 , pp. 1795-1802
    • Yu, J.H.1    Yang, W.H.2    Gulick, T.3    Bloch, K.D.4    Bloch, D.B.5
  • 172
    • 84897977386 scopus 로고    scopus 로고
    • Environmental signaling through the mechanistic target of rapamycin complex 1: MTORC1 goes nuclear
    • Workman, J.J.; Chen, H.; Laribee, R.N. Environmental signaling through the mechanistic target of rapamycin complex 1: mTORC1 goes nuclear. Cell Cycle 2014, 13, 714–725
    • (2014) Cell Cycle , vol.13 , pp. 714-725
    • Workman, J.J.1    Chen, H.2    Laribee, R.N.3
  • 173
    • 41949107421 scopus 로고    scopus 로고
    • Cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner
    • Smith, E.M.; Proud, C.G. Cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner. EMBO J. 2008, 27, 1005–1016
    • (2008) EMBO J , vol.27 , pp. 1005-1016
    • Smith, E.M.1    Proud, C.G.2
  • 174
    • 0035225871 scopus 로고    scopus 로고
    • Regulation of translation initiation by amino acids in eukaryotic cells
    • Kimball, S.R. Regulation of translation initiation by amino acids in eukaryotic cells. Prog. Mol. Subcell. Biol. 2001, 26, 155–184
    • (2001) Prog. Mol. Subcell , vol.26 , pp. 155-184
    • Kimball, S.R.1
  • 175
    • 0036440779 scopus 로고    scopus 로고
    • Regulation of mammalian translation factors by nutrients
    • Proud, C.G. Regulation of mammalian translation factors by nutrients. Eur. J. Biochem. 2002, 269, 5338–5349
    • (2002) Eur. J. Biochem , vol.269 , pp. 5338-5349
    • Proud, C.G.1
  • 176
    • 84876782429 scopus 로고    scopus 로고
    • Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism
    • Schriever, S.C.; Deutsch, M.J.; Adamski, J.; Roscher, A.A.; Ensenauer, R. Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism. J. Nutr. Biochem.2013, 24, 824–831
    • (2013) J. Nutr. Biochem , vol.24 , pp. 824-831
    • Schriever, S.C.1    Deutsch, M.J.2    Adamski, J.3    Roscher, A.A.4    Ensenauer, R.5
  • 177
    • 84891438317 scopus 로고    scopus 로고
    • Control of the translational machinery by amino acids
    • Proud, C.G. Control of the translational machinery by amino acids. Am. J. Clin. Nutr. 2014, 99, 231S–236S.
    • (2014) Am. J. Clin. Nutr , vol.99
    • Proud, C.G.1
  • 178
    • 84862758071 scopus 로고    scopus 로고
    • Smad-mediated regulation of microRNA biosynthesis
    • Blahna, M.T.; Hata, A. Smad-mediated regulation of microRNA biosynthesis. FEBS Lett. 2012, 586, 1906–1912
    • (2012) FEBS Lett , vol.586 , pp. 1906-1912
    • Blahna, M.T.1    Hata, A.2
  • 179
    • 34250770436 scopus 로고    scopus 로고
    • Transforming growth factor-β and microRNA:MRNA regulatory networks in epithelial plasticity
    • Zavadil, J.; Narasimhan, M.; Blumenberg, M.; Schneider, R.J. Transforming growth factor-β and microRNA:mRNA regulatory networks in epithelial plasticity. Cells Tissues Organs 2007, 185, 157–161
    • (2007) Cells Tissues Organs , vol.185 , pp. 157-161
    • Zavadil, J.1    Narasimhan, M.2    Blumenberg, M.3    Schneider, R.J.4
  • 182
    • 84908110053 scopus 로고    scopus 로고
    • TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression
    • Das, F.; Bera, A.; Ghosh-Choudhury, N.; Abboud, H.E.; Kasinath, B.S.; Choudhury, G.G. TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression. PLoS ONE 2014, 9, e109608
    • (2014) Plos ONE , vol.9
    • Das, F.1    Bera, A.2    Ghosh-Choudhury, N.3    Abboud, H.E.4    Kasinath, B.S.5    Choudhury, G.G.6
  • 183
    • 84875135419 scopus 로고    scopus 로고
    • Integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy
    • Das, F.; Ghosh-Choudhury, N.; Bera, A.; Dey, N.; Abboud, H.E.; Kasinath, B.S.; Choudhury, G.G. Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy. J. Biol. Chem. 2013, 288, 7756–7768
    • (2013) J. Biol. Chem , vol.288 , pp. 7756-7768
    • Das, F.1    Ghosh-Choudhury, N.2    Bera, A.3    Dey, N.4    Abboud, H.E.5    Kasinath, B.S.6    Choudhury, G.G.7
  • 184
    • 35148819133 scopus 로고    scopus 로고
    • NUTRIX Consortium. Milk consumption during pregnancy is associated with increased infant size at birth: Prospective cohort study
    • Olsen, S.F.; Halldorsson, T.I.; Willett, W.C.; Knudsen, V.K.; Gillman, M.W.; Mikkelsen, T.B.; Olsen, J.; NUTRIX Consortium. Milk consumption during pregnancy is associated with increased infant size at birth: Prospective cohort study. Am. J. Clin. Nutr. 2007, 86, 1104–1110
    • (2007) Am. J. Clin. Nutr , vol.86 , pp. 1104-1110
    • Olsen, S.F.1    Halldorsson, T.I.2    Willett, W.C.3    Knudsen, V.K.4    Gillman, M.W.5    Mikkelsen, T.B.6    Olsen, J.7
  • 186
    • 84926340588 scopus 로고    scopus 로고
    • Milk consumption during pregnancy increases birth weight, a risk factor for the development of diseases of civilization
    • Melnik, B.C.; John, S.M.; Schmitz, G. Milk consumption during pregnancy increases birth weight, a risk factor for the development of diseases of civilization. J. Transl. Med. 2015, 13, doi:10.1186/s12967-014-0377-9
    • (2015) J. Transl. Med , pp. 13
    • Melnik, B.C.1    John, S.M.2    Schmitz, G.3
  • 187
    • 34347211057 scopus 로고    scopus 로고
    • Jansson, T. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted growth
    • Roos, S.; Jansson, N.; Palmberg, I.; Säljö, K.; Powell, T.L.; Jansson, T. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted growth. J. Physiol. 2007, 582, 449–459
    • (2007) J. Physiol , vol.582 , pp. 449-459
    • Roos, S.1    Jansson, N.2    Palmberg, I.3    Säljö, K.4    Powell, T.L.5
  • 188
    • 84869094274 scopus 로고    scopus 로고
    • The emerging role of mTORC1 signaling in placental nutrient-sensing
    • Jansson, T.; Aye, I.L.; Goberdhan, D.C. The emerging role of mTORC1 signaling in placental nutrient-sensing. Placenta 2012, 33, e23–e29
    • (2012) Placenta , vol.33
    • Jansson, T.1    Aye, I.L.2    Goberdhan, D.C.3
  • 189
    • 70349246381 scopus 로고    scopus 로고
    • Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling
    • Roos, S.; Lagerlöf, O.; Wennergren, M.; Powell, T.L.; Jansson, T. Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling. Am. J. Physiol. Cell Physiol. 2009, 297, C723–C731
    • (2009) Am. J. Physiol. Cell Physiol , vol.297
    • Roos, S.1    Lagerlöf, O.2    Wennergren, M.3    Powell, T.L.4    Jansson, T.5
  • 191
    • 84920950261 scopus 로고    scopus 로고
    • Aberrant upregulation of miR-21 in placental tissues of macrosomia
    • Jiang, H.; Wu, W.; Zhang, M.; Li, J.; Peng, Y.; Miao, T.T.; Zhu, H.; Xu, G. Aberrant upregulation of miR-21 in placental tissues of macrosomia. J. Perinatol. 2014, 34, 658–663
    • (2014) J. Perinatol , vol.34 , pp. 658-663
    • Jiang, H.1    Wu, W.2    Zhang, M.3    Li, J.4    Peng, Y.5    Miao, T.T.6    Zhu, H.7    Xu, G.8
  • 192
    • 84899786094 scopus 로고    scopus 로고
    • Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2α signaling and increases fetal growth in rats
    • Gaccioli, F.; White, V.; Capobianco, E.; Powell, T.L.; Jawerbaum, A.; Jansson, T. Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2α signaling and increases fetal growth in rats. Biol. Reprod. 2013, 89, doi:10.1095/biolreprod.113.109702
    • (2013) Biol. Reprod
    • Gaccioli, F.1    White, V.2    Capobianco, E.3    Powell, T.L.4    Jawerbaum, A.5    Jansson, T.6
  • 194
    • 77953555973 scopus 로고    scopus 로고
    • Dairy and milk consumption and child growth: Is BMI involved? An analysis of NHANES 1999–2004
    • Wiley, A.S. Dairy and milk consumption and child growth: Is BMI involved? An analysis of NHANES 1999–2004. Am. J. Hum. Biol.2010, 22, 517–525
    • (2010) Am. J. Hum. Biol , vol.22 , pp. 517-525
    • Wiley, A.S.1
  • 196
    • 79959465223 scopus 로고    scopus 로고
    • The risk of child and adolescent overweight is related to types of food consumed
    • Matthews, V.L.; Wien, M.; Sabaté, J. The risk of child and adolescent overweight is related to types of food consumed. Nutr. J. 2011, 10, 71–74
    • (2011) Nutr. J , vol.10 , pp. 71-74
    • Matthews, V.L.1    Wien, M.2    Sabaté, J.3
  • 197
    • 84872162703 scopus 로고    scopus 로고
    • Skim milk, whey, and casein increase body weight and whey and casein increase plasma C-peptide concentration in overweight adolescents
    • Arnberg, K.; Mølgaard, C.; Michaelsen, K.F.; Jensen, S.M.; Trolle, E.; Larnkjær, A. Skim milk, whey, and casein increase body weight and whey and casein increase plasma C-peptide concentration in overweight adolescents. J. Nutr. 2012, 142, 2083–2090
    • (2012) J. Nutr , vol.142 , pp. 2083-2090
    • Arnberg, K.1    Mølgaard, C.2    Michaelsen, K.F.3    Jensen, S.M.4    Trolle, E.5    Larnkjær, A.6
  • 198
    • 0034222276 scopus 로고    scopus 로고
    • Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults
    • Barr, S.I.; McCarron, D.A.; Heaney, R.P.; Dawson-Hughes, B.; Berga, S.L.; Stern, J.S.; Oparil, S. Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults. Am. J. Diet. Assoc. 2000, 100, 810–817
    • (2000) Am. J. Diet. Assoc , vol.100 , pp. 810-817
    • Barr, S.I.1    McCarron, D.A.2    Heaney, R.P.3    Dawson-Hughes, B.4    Berga, S.L.5    Stern, J.S.6    Oparil, S.7
  • 199
    • 84885401110 scopus 로고    scopus 로고
    • Effects of high and low fat dairy food on cardio-metabolic risk factors: A meta-analysis of randomized studies
    • Benatar, J.R.; Sidhu, K.; Stewart, R.A. Effects of high and low fat dairy food on cardio-metabolic risk factors: A meta-analysis of randomized studies. PLoS ONE 2013, 8, e76480
    • (2013) Plos ONE , vol.8
    • Benatar, J.R.1    Sidhu, K.2    Stewart, R.A.3
  • 201
    • 34548487258 scopus 로고    scopus 로고
    • The link between the epidemics of obesity and allergic diseases: Does obesity induce decreased immune tolerance?
    • Hersoug, L.G.; Linneberg, A. The link between the epidemics of obesity and allergic diseases: Does obesity induce decreased immune tolerance? Allergy 2007, 62, 1205–1213
    • (2007) Allergy , vol.62 , pp. 1205-1213
    • Hersoug, L.G.1    Linneberg, A.2
  • 203
    • 18144391936 scopus 로고    scopus 로고
    • The epidemiology of obesity and asthma
    • Ford, E.S. The epidemiology of obesity and asthma. J. Allergy Clin. Immunol. 2005, 115, 897–909
    • (2005) J. Allergy Clin. Immunol , vol.115 , pp. 897-909
    • Ford, E.S.1
  • 207
    • 84866159758 scopus 로고    scopus 로고
    • Excessive leucine-mTORC1-signalling of cow milk-based infant formula: The missing link to understand early childhood obesity
    • Melnik, B.C. Excessive leucine-mTORC1-signalling of cow milk-based infant formula: The missing link to understand early childhood obesity. J. Obes. 2012, 2012, doi:10.1155/2012/197653
    • (2012) J. Obes , vol.2012
    • Melnik, B.C.1
  • 209
    • 84900814107 scopus 로고    scopus 로고
    • Subsets of regulatory T cells and their roles in allergy
    • Zhang, H.; Kong, H.; Zeng, X.; Guo, L.; Sun, X.; He, S. Subsets of regulatory T cells and their roles in allergy. J. Transl. Med. 2014, 12, doi:10.1186/1479-5876-12-125
    • (2014) J. Transl. Med , vol.12
    • Zhang, H.1    Kong, H.2    Zeng, X.3    Guo, L.4    Sun, X.5    He, S.6
  • 210
    • 77957054466 scopus 로고    scopus 로고
    • The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
    • Powell, J.D.; Delgoffe, G.M. The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism. Immunity 2010, 33, 301–311
    • (2010) Immunity , vol.33 , pp. 301-311
    • Powell, J.D.1    Delgoffe, G.M.2
  • 213
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo differentiation of CD4+FoxP3+ cells
    • Haxhinasto, S.; Mathis, D.; Benoist, C. The AKT-mTOR axis regulates de novo differentiation of CD4+FoxP3+ cells. J. Exp. Med. 2008, 205, 565–574
    • (2008) J. Exp. Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 216
    • 65649132344 scopus 로고    scopus 로고
    • Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps
    • Xu, G.; Xia, J.; Hua, X.; Zhou, H.; Yu, C.; Liu, Z.; Cai, K.; Shi, J.; Li, H. Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps. Respir. Res. 2009, 10, doi:10.1186/1465-9921-10-13
    • (2009) Respir. Res
    • Xu, G.1    Xia, J.2    Hua, X.3    Zhou, H.4    Yu, C.5    Liu, Z.6    Cai, K.7    Shi, J.8    Li, H.9
  • 217
    • 84904527116 scopus 로고    scopus 로고
    • The potential mechanistic link between allergy and obesity development and infant formula feeding
    • Melnik, B.C. The potential mechanistic link between allergy and obesity development and infant formula feeding. Allergy Asthma Clin. Immunol. 2014, 10, doi:10.1186/1710-1492-10-37
    • (2014) Allergy Asthma Clin. Immunol
    • Melnik, B.C.1
  • 219
    • 79952096291 scopus 로고    scopus 로고
    • Evidence for acne-promoting effects of milk and other insulinotropic dairy products
    • Melnik, B.C. Evidence for acne-promoting effects of milk and other insulinotropic dairy products. Nestle Nutr. Workshop Ser. Pediatr. Program 2011, 67, 131–145
    • (2011) Nestle Nutr. Workshop Ser. Pediatr. Program , vol.67 , pp. 131-145
    • Melnik, B.C.1
  • 220
    • 84938056795 scopus 로고    scopus 로고
    • Linking diet to acne metabolomics, inflammation, and comedogenesis: An update
    • Melnik, B.C. Linking diet to acne metabolomics, inflammation, and comedogenesis: An update. Clin. Cosmet. Investig. Dermatol. 2015, 8, 371–388
    • (2015) Clin. Cosmet. Investig. Dermatol , vol.8 , pp. 371-388
    • Melnik, B.C.1
  • 221
    • 84886410712 scopus 로고    scopus 로고
    • Acne: Risk indicator for increased body mass index and insulin resistance
    • Melnik, B.C.; John, S.M.; Plewig G. Acne: Risk indicator for increased body mass index and insulin resistance. Acta Derm. Venereol. 2013, 93, 644–649
    • (2013) Acta Derm. Venereol , vol.93 , pp. 644-649
    • Melnik, B.C.1    John, S.M.2    Plewig, G.3
  • 222
    • 84887842393 scopus 로고    scopus 로고
    • The role of mTORC1 in acne pathogenesis and treatment
    • Melnik, B.C. The role of mTORC1 in acne pathogenesis and treatment. Exp. Rev. Dermatol. 2013, 8, 617–622
    • (2013) Exp. Rev. Dermatol , vol.8 , pp. 617-622
    • Melnik, B.C.1
  • 225
    • 84894048655 scopus 로고    scopus 로고
    • Relationships of self-reported dietary factors and perceived acne severity in a cohort of New York young adults
    • Burris, J.; Rietkerk, W.; Woolf, K. Relationships of self-reported dietary factors and perceived acne severity in a cohort of New York young adults. J. Acad. Nutr. Diet. 2014, 114, 384–392
    • (2014) J. Acad. Nutr. Diet , vol.114 , pp. 384-392
    • Burris, J.1    Rietkerk, W.2    Woolf, K.3
  • 227
    • 79952025848 scopus 로고    scopus 로고
    • Milk intake and total dairy consumption: Associations with early menarche in NHANES 1999–2004
    • Wiley, A.S. Milk intake and total dairy consumption: Associations with early menarche in NHANES 1999–2004. PLoS ONE 2011, 6, e14685
    • (2011) Plos ONE , vol.6
    • Wiley, A.S.1
  • 228
    • 84922919186 scopus 로고    scopus 로고
    • Brazilian Type 1 Diabetes Study Group (BrazDiab1SG). Early age at menarche: A risk factor for overweight or obesity in patients with type 1 diabetes living in urban areas?
    • Gomes, M.B.; Negrato, C.A.; Calliari, L.E.; Brazilian Type 1 Diabetes Study Group (BrazDiab1SG). Early age at menarche: a risk factor for overweight or obesity in patients with type 1 diabetes living in urban areas? Diabetes Res. Clin. Pract. 2015, 107, 23–30
    • (2015) Diabetes Res. Clin. Pract , vol.107 , pp. 23-30
    • Gomes, M.B.1    Negrato, C.A.2    Calliari, L.E.3
  • 229
    • 84905856492 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of age at menarche and risk of type 2 diabetes
    • Janghorbani, M.; Mansourian, M.; Hosseini, E. Systematic review and meta-analysis of age at menarche and risk of type 2 diabetes. Acta Diabetol. 2014, 51, 519–528
    • (2014) Acta Diabetol , vol.51 , pp. 519-528
    • Janghorbani, M.1    Mansourian, M.2    Hosseini, E.3
  • 230
    • 84924725797 scopus 로고    scopus 로고
    • Early menarche increases the risk of type 2 diabetes in young and middle-aged Korean women
    • Lim, J.S.; Lee, H.S.; Kim, E.Y.; Yi, K.H.; Hwang, J.S. Early menarche increases the risk of type 2 diabetes in young and middle-aged Korean women. Diabet. Med.2015, 32, 521–525
    • (2015) Diabet. Med , vol.32 , pp. 521-525
    • Lim, J.S.1    Lee, H.S.2    Kim, E.Y.3    Yi, K.H.4    Hwang, J.S.5
  • 232
    • 84894101658 scopus 로고    scopus 로고
    • Role of the mammalian target of rapamycin (MTOR) complexes in pancreatic β-cell mass regulation
    • Bartolome, A.; Guillén, C. Role of the mammalian target of rapamycin (mTOR) complexes in pancreatic β-cell mass regulation. Vitam. Horm.2014, 95, 425–469
    • (2014) Vitam. Horm , vol.95 , pp. 425-469
    • Bartolome, A.1    Guillén, C.2
  • 233
    • 81555221602 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in the β-cell cell pathogenesis of type 2 diabetes
    • Back, S.H.; Kang, S.W.; Han, J.; Chung, H.A.T. Endoplasmic reticulum stress in the β-cell cell pathogenesis of type 2 diabetes. Exp. Diabetes Res. 2012, 2012, doi:10.1155/2012/618396
    • (2012) Exp. Diabetes Res
    • Back, S.H.1    Kang, S.W.2    Han, J.3    Chung, H.4
  • 234
    • 84861905329 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and type 2 diabetes
    • Back, S.H.; Kaufman, R.J. Endoplasmic reticulum stress and type 2 diabetes. Annu. Rev. Biochem. 2012, 81, 767–793
    • (2012) Annu. Rev. Biochem , vol.81 , pp. 767-793
    • Back, S.H.1    Kaufman, R.J.2
  • 235
    • 40649120732 scopus 로고    scopus 로고
    • Increased mTORC1 singaling UPRegulates stress
    • Reiling, J.H.; Sabatini, D.M. Increased mTORC1 singaling UPRegulates stress. Mol. Cell 2008, 29, 533–535
    • (2008) Mol. Cell , vol.29 , pp. 533-535
    • Reiling, J.H.1    Sabatini, D.M.2
  • 236
    • 84855696465 scopus 로고    scopus 로고
    • MTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE-JNK pathway
    • Kato, H.; Nakajima, S.; Saito, Y.; Takahashi, S.; Katoh, R.; Kitamura, M. mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE-JNK pathway. Cell Death Differ. 2012, 19, 310–320
    • (2012) Cell Death Differ , vol.19 , pp. 310-320
    • Kato, H.1    Nakajima, S.2    Saito, Y.3    Takahashi, S.4    Katoh, R.5    Kitamura, M.6
  • 237
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin singaling and apoptosis
    • Ozcan, U.; Ozcan, L.; Yilmaz, E.; Duvel, K.; Sahin, M.; Manning, B.D.; Hotamisligil, G.S. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin singaling and apoptosis. Mol. Cell 2008, 29, 541–551
    • (2008) Mol. Cell , vol.29 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Duvel, K.4    Sahin, M.5    Manning, B.D.6    Hotamisligil, G.S.7
  • 238
    • 84860468095 scopus 로고    scopus 로고
    • Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
    • Appenzeller-Herzog, C.; Hall, M.N. Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol. 2012, 22, 274–282
    • (2012) Trends Cell Biol , vol.22 , pp. 274-282
    • Appenzeller-Herzog, C.1    Hall, M.N.2
  • 239
    • 84899714318 scopus 로고    scopus 로고
    • Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α
    • Guan, B.J.; Krokowski, D.; Majumder, M.; Schmotzer, C.L.; Kimball, S.R.; Merrick, W.C.; Koromilas, A.E.; Hatzolou, M. Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α. J. Biol. Chem. 2014, 289, 12593–12611
    • (2014) J. Biol. Chem , vol.289 , pp. 12593-12611
    • Guan, B.J.1    Krokowski, D.2    Majumder, M.3    Schmotzer, C.L.4    Kimball, S.R.5    Merrick, W.C.6    Koromilas, A.E.7    Hatzolou, M.8
  • 243
    • 84879037139 scopus 로고    scopus 로고
    • A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux
    • Krokowski, D.; Han, J.; Saikia, M.; Majumder, M.; Yuan, C.L.; Guan, B.J.; Bevilacqua, E.; Bussolati, O.; Bröer, S.; Arvan, P.; et al. A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. J. Biol. Chem. 2013, 288, 17202–17213
    • (2013) J. Biol. Chem , vol.288 , pp. 17202-17213
    • Krokowski, D.1    Han, J.2    Saikia, M.3    Majumder, M.4    Yuan, C.L.5    Guan, B.J.6    Bevilacqua, E.7    Bussolati, O.8    Bröer, S.9    Arvan, P.10
  • 246
    • 84864914359 scopus 로고    scopus 로고
    • The impact of cow’s milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer
    • Melnik, B.C.; John, S.M.; Carrera-Bastos, P.; Cordain, L. The impact of cow’s milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer. Nutr. Metab. 2012, 9, doi:10.1186/1743-7075-9-74
    • (2012) Nutr. Metab
    • Melnik, B.C.1    John, S.M.2    Carrera-Bastos, P.3    Cordain, L.4
  • 247
    • 84900471149 scopus 로고    scopus 로고
    • PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance
    • Edlind, M.P.; Hsieh, A.C. PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance. Asian J. Androl.2014, 16, 378–386
    • (2014) Asian J. Androl , vol.16 , pp. 378-386
    • Edlind, M.P.1    Hsieh, A.C.2
  • 248
    • 84904619768 scopus 로고    scopus 로고
    • Expression of phosphorylated-mTOR during the development of prostate cancer
    • Sutherland, S.I.; Pe Benito, R.; Henshall, S.M.; Horvath, L.G.; Kench, J.G. Expression of phosphorylated-mTOR during the development of prostate cancer. Prostate 2014, 74, 1231–1239
    • (2014) Prostate , vol.74 , pp. 1231-1239
    • Sutherland, S.I.1    Pe Benito, R.2    Henshall, S.M.3    Horvath, L.G.4    Kench, J.G.5
  • 255
    • 77953530401 scopus 로고    scopus 로고
    • The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer
    • Ribas, J.; Lupold, S.E. The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer. Cell Cycle 2010, 9, 923–929
    • (2010) Cell Cycle , vol.9 , pp. 923-929
    • Ribas, J.1    Lupold, S.E.2
  • 256
    • 84907420516 scopus 로고    scopus 로고
    • MicroRNA-21 inhibits p57Kip2 expression in prostate cancer
    • Mishra, S.; Lin, C.L.; Huang, T.H.; Bouamar, H.; Sun, L.Z. MicroRNA-21 inhibits p57Kip2 expression in prostate cancer. Mol. Cancer 2014, 13, 212
    • (2014) Mol. Cancer , vol.13 , pp. 212
    • Mishra, S.1    Lin, C.L.2    Huang, T.H.3    Bouamar, H.4    Sun, L.Z.5
  • 257
    • 84923686674 scopus 로고    scopus 로고
    • Controlling RECK miR21 promotes tumor cell invasion and is related to biochemical recurrence in prostate cancer
    • Leite, K.R.; Reis, S.T.; Viana, N.; Morais D.R.; Moura, C.M.; Silva, I.A.; Pontes, J., Jr.; Katz, B.; Srougi, M. Controlling RECK miR21 promotes tumor cell invasion and is related to biochemical recurrence in prostate cancer. J. Cancer 2015, 6, 292–301
    • (2015) J. Cancer , vol.6 , pp. 292-301
    • Leite, K.R.1    Reis, S.T.2    Viana, N.3    Morais, D.R.4    Moura, C.M.5    Silva, I.A.6    Pontes, J.7    Katz, B.8    Srougi, M.9
  • 258
    • 84905379640 scopus 로고    scopus 로고
    • Androgen receptor and microRNA-21 axis downregulates transforming growth factor β receptor II (TGFBR2) expression in prostate cancer
    • Mishra, S.; Deng, J.J.; Gowda, P.S.; Rao, M.K.; Lin, C.L.; Chen, C.L.; Huang, T.; Sun, L.Z. Androgen receptor and microRNA-21 axis downregulates transforming growth factor β receptor II (TGFBR2) expression in prostate cancer. Oncogene 2014, 33, 4097–4106
    • (2014) Oncogene , vol.33 , pp. 4097-4106
    • Mishra, S.1    Deng, J.J.2    Gowda, P.S.3    Rao, M.K.4    Lin, C.L.5    Chen, C.L.6    Huang, T.7    Sun, L.Z.8
  • 259
    • 84857338212 scopus 로고    scopus 로고
    • Milk stimulates growth of prostate cancer cells in culture
    • Tate, P.L.; Bibb, R.; Larcom, L.L. Milk stimulates growth of prostate cancer cells in culture. Nutr. Cancer 2011, 63, 1361–1366
    • (2011) Nutr. Cancer , vol.63 , pp. 1361-1366
    • Tate, P.L.1    Bibb, R.2    Larcom, L.L.3
  • 261
    • 0028851961 scopus 로고
    • Dietary fat and the risk of breast cancer; A prospective study of 25,892 Norwegian women
    • Gaard, M.; Tretli, S.; Løken, E.B. Dietary fat and the risk of breast cancer; A prospective study of 25,892 Norwegian women. Int. J. Cancer 1995, 63, 13–17
    • (1995) Int. J. Cancer , vol.63 , pp. 13-17
    • Gaard, M.1    Tretli, S.2    Løken, E.B.3
  • 262
    • 35248855633 scopus 로고    scopus 로고
    • Consumption of commercial whole and non-fat milk increases the incidence of 7,12-dimethylbenz(α)anthracene-induced mammary tumors in rats
    • Qin, L.Q.; Xu, J.Y.; Tezuka, H.; Li, J.; Arita, J.; Hoshi, K.; Sato, A. Consumption of commercial whole and non-fat milk increases the incidence of 7,12-dimethylbenz(α)anthracene-induced mammary tumors in rats. Cancer Detect. Prev. 2007, 31, 339–343
    • (2007) Cancer Detect. Prev , vol.31 , pp. 339-343
    • Qin, L.Q.1    Xu, J.Y.2    Tezuka, H.3    Li, J.4    Arita, J.5    Hoshi, K.6    Sato, A.7
  • 263
    • 46349088663 scopus 로고    scopus 로고
    • Milk inhibits the regression of 7,12-dimethylbenz(α)anthracene-induced mammary tumors in ovariectomized rats
    • Qin, L.Q.; Xu, J.Y.; Tezuka, H.; Wang, P.Y.; Hoshi, K. Milk inhibits the regression of 7,12-dimethylbenz(α)anthracene-induced mammary tumors in ovariectomized rats. Nutr. Cancer 2008, 60, 505–510
    • (2008) Nutr. Cancer , vol.60 , pp. 505-510
    • Qin, L.Q.1    Xu, J.Y.2    Tezuka, H.3    Wang, P.Y.4    Hoshi, K.5
  • 265
    • 43149112727 scopus 로고    scopus 로고
    • Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: Hypotheses based on epidemiological evidence
    • Martin, L.J.; Boyd, N.F. Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: Hypotheses based on epidemiological evidence. Breast Cancer Res. 2008, 10, doi:10.1186/bcr1831
    • (2008) Breast Cancer Res
    • Martin, L.J.1    Boyd, N.F.2
  • 267
    • 84929119583 scopus 로고    scopus 로고
    • Induction of anterior gradient 2 (AGR2) plays a key role in insulin-like growth factor-1 (IGF-1)-induced breast cancer cell proliferation and migration
    • Li, Z.; Wu, Z.; Chen, H.; Zhu, Q.; Gao, G.; Hu, L.; Negi, H.; Kamle, S.; Li, D. Induction of anterior gradient 2 (AGR2) plays a key role in insulin-like growth factor-1 (IGF-1)-induced breast cancer cell proliferation and migration. Med. Oncol. 2015, 32, 577
    • (2015) Med. Oncol , vol.32 , pp. 577
    • Li, Z.1    Wu, Z.2    Chen, H.3    Zhu, Q.4    Gao, G.5    Hu, L.6    Negi, H.7    Kamle, S.8    Li, D.9
  • 268
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and meta-regression analysis
    • Renehan, A.G.; Zwahlen, M.; Minder, C.; O’Dwyer, S.T.; Shalet, S.M.; Egger, M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and meta-regression analysis. Lancet 2004, 363, 1346–1353
    • (2004) Lancet , vol.363 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3    O’Dwyer, S.T.4    Shalet, S.M.5    Egger, M.6
  • 270
    • 33745115859 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: Eight years on
    • Renehan, A.G.; Harvie, M.; Howell, A. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: Eight years on. Endocr. Relat. Cancer 2006, 13, 273–278
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 273-278
    • Renehan, A.G.1    Harvie, M.2    Howell, A.3
  • 271
    • 84924236911 scopus 로고    scopus 로고
    • The role of the insulin-like growth factor-1 system in breast cancer
    • Christopoulos, P.F.; Msaouel, P.; Koutsilieris, M. The role of the insulin-like growth factor-1 system in breast cancer. Mol. Cancer2015, 14, doi:10.1186/s12943-015-0291-7
    • (2015) Mol. Cancer , vol.14
    • Christopoulos, P.F.1    Msaouel, P.2    Koutsilieris, M.3
  • 272
    • 84857945379 scopus 로고    scopus 로고
    • Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2
    • Worster, D.T.; Schmelzle, T.; Solimini, N.L.; Lightcap, E.S.; Millard, B.; Mills, G.B.; Brugge, J.S.; Albeck, J.G. Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Sci. Signal.2012, 5, ra19
    • (2012) Sci. Signal , vol.5
    • Worster, D.T.1    Schmelzle, T.2    Solimini, N.L.3    Lightcap, E.S.4    Millard, B.5    Mills, G.B.6    Brugge, J.S.7    Albeck, J.G.8
  • 273
    • 84957954240 scopus 로고    scopus 로고
    • Serum microRNA-21 as a potential diagnostic biomarker for breast cancer: A systematic review and meta-analysis
    • Li, S.; Yang, X.; Yang, J.; Zhen, J.; Zhang, D. Serum microRNA-21 as a potential diagnostic biomarker for breast cancer: A systematic review and meta-analysis. Clin. Exp. Med.2014, doi:10.1007/s10238-014-0332-3
    • (2014) Clin. Exp. Med
    • Li, S.1    Yang, X.2    Yang, J.3    Zhen, J.4    Zhang, D.5
  • 274
    • 84923651749 scopus 로고    scopus 로고
    • Quantitative measurement of serum microRNA-21 expression in relation to breast cancer metastasis in Chinese females
    • Wang, G.; Wang, L.; Sun, S.; Wu, J.; Wang, Q. Quantitative measurement of serum microRNA-21 expression in relation to breast cancer metastasis in Chinese females. Ann. Lab. Med.2015, 35, 226–232
    • (2015) Ann. Lab. Med , vol.35 , pp. 226-232
    • Wang, G.1    Wang, L.2    Sun, S.3    Wu, J.4    Wang, Q.5
  • 275
    • 84911495931 scopus 로고    scopus 로고
    • Prognostic and clinicopathological significance of microRNA-21 overexpression in breast cancer: A meta-analysis
    • Pan, F.; Mao, H.; Deng, L.; Li, G.; Geng, P. Prognostic and clinicopathological significance of microRNA-21 overexpression in breast cancer: A meta-analysis. Int. J. Clin. Exp. Pathol. 2014, 7, 5622–5633
    • (2014) Int. J. Clin. Exp. Pathol , vol.7 , pp. 5622-5633
    • Pan, F.1    Mao, H.2    Deng, L.3    Li, G.4    Geng, P.5
  • 276
    • 84896723630 scopus 로고    scopus 로고
    • MicroRNA-21 in breast cancer: Diagnostic and prognostic potential
    • Chen, J.; Wang, X. MicroRNA-21 in breast cancer: Diagnostic and prognostic potential. Clin. Transl. Oncol. 2014, 16, 225–233
    • (2014) Clin. Transl. Oncol , vol.16 , pp. 225-233
    • Chen, J.1    Wang, X.2
  • 278
    • 84876231995 scopus 로고    scopus 로고
    • Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancer
    • Wazir, U.; Newbold, R.F.; Jiang, W.G.; Sharma, A.K. Mokbel, K. Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancer. Oncol. Rep. 2013, 29, 1969–1974
    • (2013) Oncol. Rep , vol.29 , pp. 1969-1974
    • Wazir, U.1    Newbold, R.F.2    Jiang, W.G.3    Sharma, A.K.4    Mokbel, K.5
  • 279
    • 84937638607 scopus 로고    scopus 로고
    • Associations between diabetes medication use and risk of second breast cancer events and mortality
    • Calip, G.S.; Yu, O.; Hoskins, K.F.; Boudreau, D.M. Associations between diabetes medication use and risk of second breast cancer events and mortality. Cancer Causes Control 2015, 26, 1065–1077
    • (2015) Cancer Causes Control , vol.26 , pp. 1065-1077
    • Calip, G.S.1    Yu, O.2    Hoskins, K.F.3    Boudreau, D.M.4
  • 280
    • 84927127799 scopus 로고    scopus 로고
    • Attenuating tumour angiogenesis: A preventive role of metformin against breast cancer
    • Gao, S.; Jiang, J.; Li, P.; Song, H.; Wang, W.; Li, C.; Kong, D. Attenuating tumour angiogenesis: A preventive role of metformin against breast cancer. Biomed. Res. Int. 2015, 2015, doi:10.1155/2015/592523
    • (2015) Biomed. Res. Int , vol.2015
    • Gao, S.1    Jiang, J.2    Li, P.3    Song, H.4    Wang, W.5    Li, C.6    Kong, D.7
  • 281
    • 84926500195 scopus 로고    scopus 로고
    • Recent advances in the use of metformin: Can treating diabetes prevent breast cancer?
    • Hatoum, D.; McGowan, E.M. Recent advances in the use of metformin: Can treating diabetes prevent breast cancer? Biomed. Res. Int. 2015, 2015, doi:10.1155/2015/548436
    • (2015) Biomed. Res. Int , vol.2015
    • Hatoum, D.1    McGowan, E.M.2
  • 283
    • 84922460867 scopus 로고    scopus 로고
    • Parkinson disease and Alzheimer disease: Environmental risk factors
    • Campdelacreu, J. Parkinson disease and Alzheimer disease: Environmental risk factors. Neurologia 2014, 29, 541–549
    • (2014) Neurologia , vol.29 , pp. 541-549
    • Campdelacreu, J.1
  • 284
    • 84908472846 scopus 로고    scopus 로고
    • Dairy foods intake and risk of Parkinson’s disease: A dose-response meta-analysis of prospective cohort studies
    • Jiang, W.; Ju, C.; Jiang, H.; Zhang, D. Dairy foods intake and risk of Parkinson’s disease: A dose-response meta-analysis of prospective cohort studies. Eur. J. Epidemiol. 2014, 29, 613–619
    • (2014) Eur. J. Epidemiol , vol.29 , pp. 613-619
    • Jiang, W.1    Ju, C.2    Jiang, H.3    Zhang, D.4
  • 286
    • 84925436842 scopus 로고    scopus 로고
    • MTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy
    • Perluigi, M.; di domenico, F.; Butterfield, D.A. mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy. Neurobiol. Dis. 2015, in press.
    • (2015) Neurobiol
    • Perluigi, M.1    Di Domenico, F.2    Butterfield, D.A.3
  • 287
    • 84901364520 scopus 로고    scopus 로고
    • Protein phosphorylation in neurodegeneration: Friend or foe? Front
    • Tenreiro, S.; Eckermann, K.; Outeiro, T.F. Protein phosphorylation in neurodegeneration: Friend or foe? Front. Mol. Neurosci. 2014, 7, doi:10.3389/fnmol.2014.00042
    • (2014) Mol. Neurosci , vol.7
    • Tenreiro, S.1    Eckermann, K.2    Outeiro, T.F.3
  • 288
    • 84877803859 scopus 로고    scopus 로고
    • MTOR regulates tau phosphorylation and degradation: Implications for Alzheimer’s disease and other tauopathies
    • Caccamo, A.; Magrì, A.; Medina, D.X.; Wisely, E.V.; López-Aranda, M.F.; Silva, A.J.; Oddo, S. mTOR regulates tau phosphorylation and degradation: Implications for Alzheimer’s disease and other tauopathies. Aging Cell 2013, 12, 370–380
    • (2013) Aging Cell , vol.12 , pp. 370-380
    • Caccamo, A.1    Magrì, A.2    Medina, D.X.3    Wisely, E.V.4    López-Aranda, M.F.5    Silva, A.J.6    Oddo, S.7
  • 289
  • 290
    • 84938061050 scopus 로고    scopus 로고
    • How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story
    • Richardson, A.; Galvan, V.; Lin, A.L.; Oddo, S. How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story. Exp. Gerontol.2015, 68, 51–58
    • (2015) Exp. Gerontol , vol.68 , pp. 51-58
    • Richardson, A.1    Galvan, V.2    Lin, A.L.3    Oddo, S.4
  • 292
    • 84938096122 scopus 로고    scopus 로고
    • Formula feeding promotes adipogenic, diabetogenic, hypertonic and allergic mTORC1-programming
    • 1st ed.; Preedy, V.R., Watson, R.R., Zibadi, S., Eds.; Wagenigen Academic Publishers: Wageningen, The Netherlands
    • Melnik, B.C. Formula feeding promotes adipogenic, diabetogenic, hypertonic and allergic mTORC1-programming. In Handbook of Dietary and Nutritional Aspects of Bottle Feeding, 1st ed.; Preedy, V.R., Watson, R.R., Zibadi, S., Eds.; Wagenigen Academic Publishers: Wageningen, The Netherlands, 2014; pp. 545–568
    • (2014) Handbook of Dietary and Nutritional Aspects of Bottle Feeding , pp. 545-568
    • Melnik, B.C.1
  • 294
    • 84924331365 scopus 로고    scopus 로고
    • Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)
    • Modepalli, V.; Kumar, A.; Hinds, L.A.; Sharp, J.A.; Nicholas, K.R.; Lefevre, C. Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii). BMC Genomics 2014, 15, 1012
    • (2014) BMC Genomics , vol.15 , pp. 1012
    • Modepalli, V.1    Kumar, A.2    Hinds, L.A.3    Sharp, J.A.4    Nicholas, K.R.5    Lefevre, C.6
  • 295
    • 0006460431 scopus 로고
    • An experimental study of the use of unsweetened evaporated milk for the preparation of infant feeding formulas
    • Marriott, M.; Schoenthal, J. An experimental study of the use of unsweetened evaporated milk for the preparation of infant feeding formulas. Arch. Pediatr. 1929, 46, 135–148
    • (1929) Arch. Pediatr , vol.46 , pp. 135-148
    • Marriott, M.1    Schoenthal, J.2
  • 296
    • 67349194955 scopus 로고    scopus 로고
    • From breast to bottle: A history of modern infant feeding
    • Bryder, L. From breast to bottle: A history of modern infant feeding. Endeavour 2009, 54–59
    • (2009) Endeavour , pp. 54-59
    • Bryder, L.1
  • 297
    • 0011164979 scopus 로고
    • Prolonging the life span
    • McCay, C.M.; Crowell, M.F. Prolonging the life span. Sci. Mon. 1934, 39, 405–414
    • (1934) Sci. Mon , vol.39 , pp. 405-414
    • McCay, C.M.1    Crowell, M.F.2
  • 298
    • 57349100793 scopus 로고    scopus 로고
    • Hypothesis: Is lactose a dietary risk factor for ischaemic heart disease?
    • Segall, J.J. Hypothesis: Is lactose a dietary risk factor for ischaemic heart disease? Int. J. Epidemiol. 2008, 37, 1204–1208
    • (2008) Int. J. Epidemiol , vol.37 , pp. 1204-1208
    • Segall, J.J.1
  • 299
    • 84920658497 scopus 로고    scopus 로고
    • Lactose intolerance and risk of lung, breast and ovarian cancers: Aetiological clues from a population-based study in Sweden
    • Ji, J.; Sundquist, J.; Sundquist, K. Lactose intolerance and risk of lung, breast and ovarian cancers: Aetiological clues from a population-based study in Sweden. Br. J. Cancer 2015, 112, 149–152
    • (2015) Br. J. Cancer , vol.112 , pp. 149-152
    • Ji, J.1    Sundquist, J.2    Sundquist, K.3
  • 300
    • 84914165449 scopus 로고    scopus 로고
    • Can people with type 2 diabetes life longer than those without? A comparison of mortality in people initiatd with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
    • Bannister, C.A.; Holden, S.E.; Jenkins-Jones, S.; Morgan, C.L.; Halcox, J.P.; Schernthaner, G.; Mukherjee, J.; Currie, C.J. Can people with type 2 diabetes life longer than those without? A comparison of mortality in people initiatd with metformin or sulphonylurea monotherapy and matched, non-diabetic controls. Diabetes Obes. Metab. 2014, 16, 1165–1173
    • (2014) Diabetes Obes. Metab , vol.16 , pp. 1165-1173
    • Bannister, C.A.1    Holden, S.E.2    Jenkins-Jones, S.3    Morgan, C.L.4    Halcox, J.P.5    Schernthaner, G.6    Mukherjee, J.7    Currie, C.J.8
  • 301
    • 77955722198 scopus 로고    scopus 로고
    • Revisiting the antagonistic peiotropy theory of aging. TOR-driven program and quasi-program
    • Blagosklonny, M.V. Revisiting the antagonistic peiotropy theory of aging. TOR-driven program and quasi-program. Cell Cycle 2010, 9, 3151–3156
    • (2010) Cell Cycle , vol.9 , pp. 3151-3156
    • Blagosklonny, M.V.1
  • 302
    • 84908409210 scopus 로고    scopus 로고
    • Milk and mortality
    • Schooling, C.M. Milk and mortality. BMJ 2014, 349, g6205
    • (2014) BMJ , vol.349
    • Schooling, C.M.1
  • 306
    • 77955661579 scopus 로고    scopus 로고
    • MicroRNA-21 in cardiovascular disease
    • Cheng, Y.; Zhang, C. MicroRNA-21 in cardiovascular disease. J. Cardiovasc. Transl. Res. 2010, 3, 251–255
    • (2010) J. Cardiovasc. Transl. Res , vol.3 , pp. 251-255
    • Cheng, Y.1    Zhang, C.2
  • 307
    • 84880906480 scopus 로고    scopus 로고
    • MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic diesease
    • Hulsmans, M.; Holvoet, P. MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic diesease. Cardiovasc. Res.2013, 100, 7–18
    • (2013) Cardiovasc. Res , vol.100 , pp. 7-18
    • Hulsmans, M.1    Holvoet, P.2
  • 308
    • 84881129444 scopus 로고    scopus 로고
    • Role of microRNA-21 in regulating 3T3-L1 adipocyte differentiation and adiponectin expression
    • Kang, M.; Yan, L.M.; Zhang, W.Y.; Li, Y.M.; Tang, A.Z.; Ou, H.S. Role of microRNA-21 in regulating 3T3-L1 adipocyte differentiation and adiponectin expression. Mol. Biol. Rep. 2013, 40, 5027–5034
    • (2013) Mol. Biol. Rep , vol.40 , pp. 5027-5034
    • Kang, M.1    Yan, L.M.2    Zhang, W.Y.3    Li, Y.M.4    Tang, A.Z.5    Ou, H.S.6
  • 312
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection and the evolution of senescence
    • Williams, G.C. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957, 11, 398–411
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1
  • 313
    • 84891887779 scopus 로고    scopus 로고
    • Aging is not programmed: Genetic pseudo-program is a shadow of developmental growth
    • Blagosklonny, M.V. Aging is not programmed: Genetic pseudo-program is a shadow of developmental growth. Cell Cycle 2013, 12, 3736–3742
    • (2013) Cell Cycle , vol.12 , pp. 3736-3742
    • Blagosklonny, M.V.1
  • 316
    • 62949152092 scopus 로고    scopus 로고
    • Milk-the promoter of chronic Western diseases
    • Melnik, B.C. Milk-the promoter of chronic Western diseases. Med. Hypotheses 2009, 72, 631–639.
    • (2009) Med. Hypotheses , vol.72 , pp. 631-639
    • Melnik, B.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.