Mir-21 modulates htert through a stat3-dependent manner on glioblastoma cell growth

CNS Neuroscience and Therapeutics

Volumn 18, Issue 9, 2012, Pages 722-728

  Wang, Ying Yi ^a   Sun, Guan ^b   Luo, Hui ^a   Wang, Xie Feng ^a   Lan, Feng Ming ^c   Yue, Xiao ^c   Fu, Lin Shan ^b   Pu, Pei Yu ^c   Kang, Chun Sheng ^c   Liu, Ning ^a   You, Yong Ping ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANTONG UNIVERSITY   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Glioblastoma; HTERT; MiR 21; STAT3

Indexed keywords

LUCIFERASE; MESSENGER RNA; MICRORNA 21; SMALL INTERFERING RNA; STAT3 PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MICRORNAS; STAT3 TRANSCRIPTION FACTOR; TELOMERASE;

EID: 84865737617     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2012.00349.x     Document Type: Article

References (24)

1. Calin GA, Croce CM MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-866.
2. Hatley ME, Patrick DM, Garcia MR, Richardson JA, Bassel-Duby R, van Rooij E, Olson EN Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell 2010;18:282-293.
3. Terao M, Fratelli M, Kurosaki M, et al. Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: Biological correlates and molecular targets. J Biol Chem 2011;286:4027-4042.
4. Wang P, Zou F, Zhang X, et al. microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res 2009;69:8157-8165.
5. Chan JA, Krichevsky AM, Kosik KS MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005;65:6029-6033.
6. Zhou X, Ren Y, Moore L, et al. Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest 2010;90:144-155.
7. Chen Y, Liu W, Chao T, et al. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. Cancer Lett 2008;272:197-205.
8. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol 2008;28:5369-5380.
9. Iwamaru A, Szymanski S, Iwado E, et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 2007;26:2435-2444.
10. Lederle W, Depner S, Schnur S, et al. Mueller MMIL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines. Int J Cancer 2011;128:2803-2814.
11. Zhang CZ, Zhang JX, Zhang AL, et al. MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma. Mol Cancer 2010;9:229.
12. Liu JP, Chen W, Schwarer AP, Li H Telomerase in cancer immunotherapy. Biochim Biophys Acta 2010;1805:35-42.
13. Chen H, Li Y, Tollefsbol TO Strategies targeting telomerase inhibition. Mol Biotechnol 2009;41:194-199.
14. Shay JW, Bacchetti S A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-791.
15. You Y, Pu P, Peng Q, Xia Z, Huang Q, Wang C, Wang G Telomerase activity and regulation in human neuroepithelial tumors. Zhonghua Wai Ke Za Zhi 2002;40:90-93.
16. Boldrini L, Pistolesi S, Gisfredi S, et al. Telomerase activity and hTERT mRNA expression in glial tumors. Int J Oncol 2006;28:1555-1560.
17. You Y, Geng X, Zhao P, et al. Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts. Cell Mol Life Sci 2007;64:621-631.
18. George J, Banik NL, Ray SK Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma. Clin Cancer Res 2009;15:7186-7195.
19. Mitomo S, Maesawa C, Ogasawara S, et al. Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines. Cancer Sci 2008;99:280-286.
20. Strati A, Papoutsi Z, Lianidou E, Moutsatsou P Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem 2009;42:1358-1362.
21. Kumari A, Srinivasan R, Wig JD Effect of c-MYC and E2F1 gene silencing and of 5-azacytidine treatment on telomerase activity in pancreatic cancer-derived cell lines. Pancreatology 2009;9:360-368.
22. Li W, Li L, Liu Z, et al. Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues. Cancer Lett 2008;260:28-36.
23. Aravindan N, Veeraraghavan J, Madhusoodhanan R, Herman TS, Natarajan M Curcumin regulates low-linear energy transfer gamma-radiation-induced NFkappaB-dependent telomerase activity in human neuroblastoma cells. Int J Radiat Oncol Biol Phys 2011;79:1206-1215.
24. Konnikova L, Simeone MC, Kruger MM, Kotecki M, Cochran BH Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells. Cancer Res 2005;65:6516-6520.