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Volumn 2012, Issue , 2012, Pages

Excessive leucine-mTORC1-signalling of cow milk-based infant formula: The missing link to understand early childhood obesity

Author keywords

[No Author keywords available]

Indexed keywords

INCRETIN; INSULIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MILK PROTEIN; S6 KINASE; SOMATOMEDIN C;

EID: 84866159758     PISSN: 20900708     EISSN: 20900716     Source Type: Journal    
DOI: 10.1155/2012/197653     Document Type: Review
Times cited : (45)

References (140)
  • 1
    • 0031934790 scopus 로고    scopus 로고
    • Overweight children and adolescents: Description, epidemiology, and demographics
    • Troiano R. P., Flegal K. M., Overweight children and adolescents: description, epidemiology, and demographics. Pediatrics 1998 101 3, supplement 2 497 504 2-s2.0-0031934790 (Pubitemid 28119985)
    • (1998) Pediatrics , vol.101 , Issue.3 II SUPPL. , pp. 497-504
    • Troiano, R.P.1    Flegal, K.M.2
  • 2
    • 84866259024 scopus 로고    scopus 로고
    • Genetics of childhood obesity
    • 845148 10.1155/2011/845148
    • Zhao J., Grant S. F. A., Genetics of Childhood Obesity. Journal of Obesity 2011 2011 9 845148 10.1155/2011/845148
    • (2011) Journal of Obesity , vol.2011 , pp. 9
    • Zhao, J.1    Grant, S.F.A.2
  • 3
    • 84866249021 scopus 로고    scopus 로고
    • Obesity and type 2 diabetes
    • 10.4236/jdm.2011.14012
    • Yaturu S., Obesity and type 2 diabetes. Journal of Diabetes Mellitus 2011 1 4 79 95 10.4236/jdm.2011.14012
    • (2011) Journal of Diabetes Mellitus , vol.1 , Issue.4 , pp. 79-95
    • Yaturu, S.1
  • 4
    • 84896943451 scopus 로고    scopus 로고
    • Overweight among four-year-old children in relation to early growth characteristics and socioeconomic factors
    • 580642 10.1155/2010/580642
    • Thorn J., Waller M., Johansson M., Marild S., Overweight among four-year-old children in relation to early growth characteristics and socioeconomic factors. Journal of Obesity 2010 2010 6 580642 10.1155/2010/580642
    • (2010) Journal of Obesity , vol.2010 , pp. 6
    • Thorn, J.1    Waller, M.2    Johansson, M.3    Marild, S.4
  • 5
    • 19444378231 scopus 로고    scopus 로고
    • Experimental models of developmental programming: Consequences of exposure to an energy rich diet during development
    • DOI 10.1113/jphysiol.2004.079756
    • Armitage J. A., Taylor P. D., Poston L., Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. The Journal of Physiology 2005 565 1 3 8 2-s2.0-19444378231 10.1113/jphysiol.2004.079756 (Pubitemid 40723685)
    • (2005) Journal of Physiology , vol.565 , Issue.1 , pp. 3-8
    • Armitage, J.A.1    Taylor, P.D.2    Poston, L.3
  • 6
    • 0019461514 scopus 로고
    • Do breast-feeding and delayed introduction of solid foods protect against subsequent obesity
    • DOI 10.1016/S0022-3476(81)80579-3
    • Kramer M. S., Do breast-feeding and delayed introduction of solid foods protect against subsequent obesity? The Journal of Pediatrics 1981 98 6 883 887 2-s2.0-0019461514 (Pubitemid 11093043)
    • (1981) Journal of Pediatrics , vol.98 , Issue.6 , pp. 883-887
    • Kramer, M.S.1
  • 12
    • 33645520651 scopus 로고    scopus 로고
    • Higher versus lower protein intake in formula-fed low birth weight infants
    • 2-s2.0-33645520651 CD003959
    • Premji S. S., Fenton T. R., Sauve R. S., Higher versus lower protein intake in formula-fed low birth weight infants. Cochrane Database of Systematic Reviews 2006 1 2-s2.0-33645520651 CD003959
    • (2006) Cochrane Database of Systematic Reviews , Issue.1
    • Premji, S.S.1    Fenton, T.R.2    Sauve, R.S.3
  • 13
    • 82355165135 scopus 로고    scopus 로고
    • Perinatal programming of body weight control by leptin: Putative roles of AMP kinase and muscle thermogenesis
    • 10.3945/ajcn.110.000752
    • Pico C., Jilkova Z. M., Kus V., Palou A., Kopecky J., kopecky@biomed.cas.cz Perinatal programming of body weight control by leptin: putative roles of AMP kinase and muscle thermogenesis. The American Journal of Clinical Nutrition 2011 94 6 1830S 1837S 10.3945/ajcn.110.000752
    • (2011) The American Journal of Clinical Nutrition , vol.94 , Issue.6
    • Pico, C.1    Jilkova, Z.M.2    Kus, V.3    Palou, A.4    Kopecky, J.5
  • 14
    • 33645953010 scopus 로고    scopus 로고
    • Fetal programming: Causes and consequences as revealed by studies of dietary manipulation in ratsa review
    • 10.1016/j.placenta.2006.01.014
    • McArdle H. J., h.mcardle@rowett.ac.uk Andersen H. S., Jones H., Gambling L., Fetal programming: causes and consequences as revealed by studies of dietary manipulation in ratsa review. Placenta 2006 27 supplement 56 60 10.1016/j.placenta.2006.01.014
    • (2006) Placenta , vol.27 , Issue.SUPPL. , pp. 56-60
    • McArdle, H.J.1    Andersen, H.S.2    Jones, H.3    Gambling, L.4
  • 15
    • 59649115412 scopus 로고    scopus 로고
    • Changes in satiety hormones and expression of genes involved in glucose and lipid metabolism in rats weaned onto diets high in fibre or protein reflect susceptibility to increased fat mass in adulthood
    • 2-s2.0-59649115412 10.1113/jphysiol.2008.161844
    • Maurer A. D., Chen Q., McPherson C., Reimer R. A., Changes in satiety hormones and expression of genes involved in glucose and lipid metabolism in rats weaned onto diets high in fibre or protein reflect susceptibility to increased fat mass in adulthood. The Journal of Physiology 2009 587 3 679 691 2-s2.0-59649115412 10.1113/jphysiol.2008.161844
    • (2009) The Journal of Physiology , vol.587 , Issue.3 , pp. 679-691
    • Maurer, A.D.1    Chen, Q.2    McPherson, C.3    Reimer, R.A.4
  • 16
    • 79951677393 scopus 로고    scopus 로고
    • Maternal consumption of high-prebiotic fibre or -protein diets during pregnancy and lactation differentially influences satiety hormones and expression of genes involved in glucose and lipid metabolism in offspring in rats
    • 2-s2.0-78649601967 10.1017/S0007114510003533
    • Maurer A. D., Reimer R. A., Maternal consumption of high-prebiotic fibre or -protein diets during pregnancy and lactation differentially influences satiety hormones and expression of genes involved in glucose and lipid metabolism in offspring in rats. British Journal of Nutrition 2011 105 3 329 338 2-s2.0-78649601967 10.1017/S0007114510003533
    • (2011) British Journal of Nutrition , vol.105 , Issue.3 , pp. 329-338
    • Maurer, A.D.1    Reimer, R.A.2
  • 17
    • 77957141387 scopus 로고    scopus 로고
    • Consumption of diets high in prebiotic fiber or protein during growth influences the response to a high fat and sucrose diet in adulthood in rats
    • 2-s2.0-77957141387 10.1186/1743-7075-7-77
    • Maurer A. D., Eller L. K., Hallam M. C., Taylor K., Reimer R. A., Consumption of diets high in prebiotic fiber or protein during growth influences the response to a high fat and sucrose diet in adulthood in rats. Nutrition & Metabolism 2010 7, article 77 2-s2.0-77957141387 10.1186/1743-7075-7-77
    • (2010) Nutrition & Metabolism , vol.777
    • Maurer, A.D.1    Eller, L.K.2    Hallam, M.C.3    Taylor, K.4    Reimer, R.A.5
  • 18
    • 79960258500 scopus 로고    scopus 로고
    • Maternal over-nutrition and offspring obesity predisposition: Targets for preventative interventions
    • 10.1038/ijo.2011.96
    • Rooney K., Ozanne S. E., Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions. International Journal of Obesity 2011 35 7 883 890 10.1038/ijo.2011.96
    • (2011) International Journal of Obesity , vol.35 , Issue.7 , pp. 883-890
    • Rooney, K.1    Ozanne, S.E.2
  • 19
    • 68549125477 scopus 로고    scopus 로고
    • The effects of whole milk and infant formula on growth and IGF-I in late infancy
    • 2-s2.0-68549125477 10.1038/ejcn.2008.80
    • Larnkjær A., Hoppe C., Molgaard C., Michaelsen K. F., The effects of whole milk and infant formula on growth and IGF-I in late infancy. European Journal of Clinical Nutrition 2009 63 8 956 963 2-s2.0-68549125477 10.1038/ejcn.2008.80
    • (2009) European Journal of Clinical Nutrition , vol.63 , Issue.8 , pp. 956-963
    • Larnkjær, A.1    Hoppe, C.2    Molgaard, C.3    Michaelsen, K.F.4
  • 20
    • 4344685478 scopus 로고    scopus 로고
    • Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children
    • 2-s2.0-4344685478
    • Hoppe C., Udam T. R., Lauritzen L., Molgaard C., Juul A., Michaelsen K. F., Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children. The American Journal of Clinical Nutrition 2004 80 2 447 452 2-s2.0-4344685478
    • (2004) The American Journal of Clinical Nutrition , vol.80 , Issue.2 , pp. 447-452
    • Hoppe, C.1    Udam, T.R.2    Lauritzen, L.3    Molgaard, C.4    Juul, A.5    Michaelsen, K.F.6
  • 21
    • 4644297300 scopus 로고    scopus 로고
    • High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys
    • DOI 10.1038/sj.ejcn.1601948
    • Hoppe C., Molgaard C., Juul A., Michaelsen K. F., High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. European Journal of Clinical Nutrition 2004 58 9 1211 1216 2-s2.0-4644297300 10.1038/sj.ejcn.1601948 (Pubitemid 39264017)
    • (2004) European Journal of Clinical Nutrition , vol.58 , Issue.9 , pp. 1211-1216
    • Hoppe, C.1    Molgaard, C.2    Juul, A.3    Michaelsen, K.F.4
  • 22
    • 15544362097 scopus 로고    scopus 로고
    • High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys
    • DOI 10.1038/sj.ejcn.1602086
    • Hoppe C., Molgaard C., Vaag A., Barkholt V., Michaelsen K. F., High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys. European Journal of Clinical Nutrition 2005 59 3 393 398 2-s2.0-15544362097 10.1038/sj.ejcn.1602086 (Pubitemid 40403293)
    • (2005) European Journal of Clinical Nutrition , vol.59 , Issue.3 , pp. 393-398
    • Hoppe, C.1    Molgaard, C.2    Vaag, A.3    Barkholt, V.4    Michaelsen, K.F.5
  • 23
    • 70249098802 scopus 로고    scopus 로고
    • Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: Results from a randomized 7-day supplementation study in prepubertal boys
    • 2-s2.0-70249098802 10.1038/ejcn.2009.34
    • Hoppe C., Molgaard C., Dalum C., Vaag A., Michaelsen K. F., Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. European Journal of Clinical Nutrition 2009 63 9 1076 1083 2-s2.0-70249098802 10.1038/ejcn.2009.34
    • (2009) European Journal of Clinical Nutrition , vol.63 , Issue.9 , pp. 1076-1083
    • Hoppe, C.1    Molgaard, C.2    Dalum, C.3    Vaag, A.4    Michaelsen, K.F.5
  • 27
    • 0023919926 scopus 로고
    • Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes
    • 2-s2.0-0023919926
    • Smith P. J., Wise L. S., Berkowitz R., Wan C., Rubin C. S., Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. The Journal of Biological Chemistry 1988 263 19 9402 9408 2-s2.0-0023919926
    • (1988) The Journal of Biological Chemistry , vol.263 , Issue.19 , pp. 9402-9408
    • Smith, P.J.1    Wise, L.S.2    Berkowitz, R.3    Wan, C.4    Rubin, C.S.5
  • 28
    • 29244491445 scopus 로고    scopus 로고
    • Insulin-like growth factor I, growth hormone and insulin in white adipose tissue
    • DOI 10.1016/j.beem.2005.07.011, PII S1521690X05000539, Adipose Tissue as an Endocrine Organ
    • Blüher S., Kratzsch J., Kiess W., Insulin-like growth factor I, growth hormone and insulin in white adipose tissue. Best Practice & Research Clinical Endocrinology & Metabolism 2005 19 4 577 587 2-s2.0-29244491445 10.1016/j.beem.2005.07.011 (Pubitemid 41819219)
    • (2005) Best Practice and Research: Clinical Endocrinology and Metabolism , vol.19 , Issue.4 , pp. 577-587
    • Bluher, S.1    Kratzsch, J.2    Kiess, W.3
  • 29
    • 9444234587 scopus 로고    scopus 로고
    • Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
    • DOI 10.2337/diabetes.53.suppl-3.S225
    • Kwon G., Marshall C. A., Pappan K. L., Remedi M. S., McDaniel M. L., Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes 2004 53 supplement 3 S225 S232 2-s2.0-9444234587 10.2337/diabetes.53.suppl3.S225 (Pubitemid 39564548)
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Kwon, G.1    Marshall, C.A.2    Pappan, K.L.3    Remedi, M.S.4    McDaniel, M.L.5
  • 30
    • 0036787462 scopus 로고    scopus 로고
    • Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic β -cells
    • 2-s2.0-0036787462
    • McDaniel M. L., Marshall C. A., Pappan K. L., Kwon G., Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic β -cells. Diabetes 2002 51 10 2877 2885 2-s2.0-0036787462
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 2877-2885
    • McDaniel, M.L.1    Marshall, C.A.2    Pappan, K.L.3    Kwon, G.4
  • 32
    • 79952313197 scopus 로고    scopus 로고
    • Milk signalling in the pathogenesis of type 2 diabetes
    • 10.1016/j.mehy.2010.12.017
    • Melnik B. C., melnik@t-online.de Milk signalling in the pathogenesis of type 2 diabetes. Medical Hypotheses 2011 76 4 553 559 10.1016/j.mehy.2010.12.017
    • (2011) Medical Hypotheses , vol.76 , Issue.4 , pp. 553-559
    • Melnik, B.C.1
  • 34
    • 0025822463 scopus 로고
    • Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 mo of lactation: The DARLING Study
    • Nommsen L. A., Lovelady C. A., Heinig M. J., Lonnerdal B., Dewey K. G., Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 mo of lactation: the DARLING Study. The American Journal of Clinical Nutrition 1991 53 2 457 465 2-s2.0-0025822463 (Pubitemid 121000854)
    • (1991) American Journal of Clinical Nutrition , vol.53 , Issue.2 , pp. 457-465
    • Nommsen, L.A.1    Lovelady, C.A.2    Heinig, M.J.3    Lonnerdal, B.4    Dewey, K.G.5
  • 35
    • 79957942368 scopus 로고    scopus 로고
    • Nitrogen and protein content analysis of human milk, diurnality vs nocturnality
    • 10.3305/nh.2011.26.3.4582
    • Sánchez López C. L., crissanchez@unex.es Hernández A., Rodríguez A. B., Rivero M., Barriga C., Cubero J., Nitrogen and protein content analysis of human milk, diurnality vs nocturnality. Nutricion Hospitalaria 2011 26 3 511 514 10.3305/nh.2011.26.3.4582
    • (2011) Nutricion Hospitalaria , vol.26 , Issue.3 , pp. 511-514
    • Sánchez López, C.L.1    Hernández, A.2    Rodríguez, A.B.3    Rivero, M.4    Barriga, C.5    Cubero, J.6
  • 36
    • 0023805814 scopus 로고
    • Evolutionary traits in human milk proteins
    • 2-s2.0-0023805814
    • Bounous G., Kongshavn P. A. L., Taveroff A., Gold P., Evolutionary traits in human milk proteins. Medical Hypotheses 1988 27 2 133 140 2-s2.0-0023805814
    • (1988) Medical Hypotheses , vol.27 , Issue.2 , pp. 133-140
    • Bounous, G.1    Kongshavn, P.A.L.2    Taveroff, A.3    Gold, P.4
  • 40
    • 43549114054 scopus 로고    scopus 로고
    • Protein quality assessment: Impact of expanding understanding of protein and amino acid needs for optimal health
    • Millward D. J., Layman D. K., Tomé D., Schaafsma G., Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal health. The American Journal of Clinical Nutrition 2008 87 5 1576S 1581S 2-s2.0-43549114054 (Pubitemid 351679814)
    • (2008) American Journal of Clinical Nutrition , vol.87 , Issue.5
    • Millward, D.J.1    Layman, D.K.2    Tome, D.3    Schaafsma, G.4
  • 41
    • 0141992791 scopus 로고    scopus 로고
    • Nutritional and physiologic significance of α-lactalbumin in infants
    • DOI 10.1301/nr.2003.sept.295-305
    • Lönnerdal B., Lien E. L., Nutritional and physiologic significance of α -lactalbumin in infants. Nutrition Reviews 2003 61 9 295 305 2-s2.0-0141992791 10.1301/nr.2003.sept.295-305 (Pubitemid 37259920)
    • (2003) Nutrition Reviews , vol.61 , Issue.9 , pp. 295-305
    • Lonnerdal, B.1    Lien, E.L.2
  • 42
    • 34147133191 scopus 로고    scopus 로고
    • Metabolic effects of amino acid mixtures and whey protein in healthy subjects: Studies using glucose-equivalent drinks
    • Nilsson M., Holst J. J., Björck I. M. E., Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks. The American Journal of Clinical Nutrition 2007 85 4 996 1004 2-s2.0-34147133191 (Pubitemid 46557914)
    • (2007) American Journal of Clinical Nutrition , vol.85 , Issue.4 , pp. 996-1004
    • Nilsson, M.1    Holst, J.J.2    Bjorck, I.M.E.3
  • 43
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • DOI 10.1074/jbc.273.23.14484
    • Hara K., Yonezawa K., Weng Q. P., Kozlowski M. T., Belham C., Avruch J., Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. The Journal of Biological Chemistry 1998 273 23 14484 14494 2-s2.0-0032486268 10.1074/jbc.273.23.14484 (Pubitemid 28319170)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.23 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.-P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 44
    • 14844363721 scopus 로고    scopus 로고
    • Signaling by target of rapamycin proteins in cell growth control
    • DOI 10.1128/MMBR.69.1.79-100.2005
    • Inoki K., Ouyang H., Li Y., Guan K. L., Signaling by target of rapamycin proteins in cell growth control. Microbiology and Molecular Biology Reviews 2005 69 1 79 100 2-s2.0-14844363721 10.1128/MMBR.69.1.79-100.2005 (Pubitemid 40358068)
    • (2005) Microbiology and Molecular Biology Reviews , vol.69 , Issue.1 , pp. 79-100
    • Inoki, K.1    Ouyang, H.2    Li, Y.3    Guan, K.-L.4
  • 46
    • 80052188788 scopus 로고    scopus 로고
    • Spatial regulation of the mTORC1 system in amino acids sensing pathway
    • 10.1093/abbs/gmr066
    • Suzuki T., Inoki K., inokik@umich.edu Spatial regulation of the mTORC1 system in amino acids sensing pathway. Acta Biochimica et Biophysica Sinica 2011 43 9 671 679 10.1093/abbs/gmr066
    • (2011) Acta Biochimica et Biophysica Sinica , vol.43 , Issue.9 , pp. 671-679
    • Suzuki, T.1    Inoki, K.2
  • 47
    • 80051637832 scopus 로고    scopus 로고
    • MTORC1 signaling: What we still don't know
    • 10.1093/jmcb/mjq038
    • Wang X., Proud C. G., mTORC1 signaling: what we still don't know. Journal of Molecular Cell Biology 2011 3 4 206 220 10.1093/jmcb/mjq038
    • (2011) Journal of Molecular Cell Biology , vol.3 , Issue.4 , pp. 206-220
    • Wang, X.1    Proud, C.G.2
  • 48
    • 80053613846 scopus 로고    scopus 로고
    • A New Link in the Chain from Amino Acids to mTORC1 Activation
    • 10.1016/j.molcel.2011.09.004
    • Proud C. G., c.g.proud@soton.ac.uk A New Link in the Chain from Amino Acids to mTORC1 Activation. Molecular Cell 2011 44 1 7 8 10.1016/j.molcel.2011. 09.004
    • (2011) Molecular Cell , vol.44 , Issue.1 , pp. 7-8
    • Proud, C.G.1
  • 49
    • 79959409830 scopus 로고    scopus 로고
    • Amino acid signaling in TOR activation
    • 10.1146/annurev-biochem-062209-094414
    • Kim J., Guan K.-L., kuguan@ucsd.edu Amino acid signaling in TOR activation. Annual Review of Biochemistry 2011 80 1001 1032 10.1146/annurev- biochem-062209-094414
    • (2011) Annual Review of Biochemistry , vol.80 , pp. 1001-1032
    • Kim, J.1    Guan, K.-L.2
  • 50
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • 2-s2.0-78650510609 10.1038/nrm3025
    • Zoncu R., Efeyan A., Sabatini D. M., mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Reviews Molecular Cell Biology 2011 12 1 21 35 2-s2.0-78650510609 10.1038/nrm3025
    • (2011) Nature Reviews Molecular Cell Biology , vol.12 , Issue.1 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 51
    • 66349138676 scopus 로고    scopus 로고
    • Nutrient control of TORC1, a cell-cycle regulator
    • 2-s2.0-66349138676 10.1016/j.tcb.2009.03.005
    • Wang X., Proud C. G., Nutrient control of TORC1, a cell-cycle regulator. Trends in Cell Biology 2009 19 6 260 267 2-s2.0-66349138676 10.1016/j.tcb.2009. 03.005
    • (2009) Trends in Cell Biology , vol.19 , Issue.6 , pp. 260-267
    • Wang, X.1    Proud, C.G.2
  • 52
    • 63849149937 scopus 로고    scopus 로고
    • LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    • 2-s2.0-63849149937 10.1111/j.1748-1716.2009.01972.x
    • Shaw R. J., LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiologica 2009 196 1 65 80 2-s2.0-63849149937 10.1111/j.1748-1716.2009.01972.x
    • (2009) Acta Physiologica , vol.196 , Issue.1 , pp. 65-80
    • Shaw, R.J.1
  • 53
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • DOI 10.1038/ncb839
    • Inoki K., Li Y., Zhu T., Wu J., Guan K. L., TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nature Cell Biology 2002 4 9 648 657 2-s2.0-0036713778 10.1038/ncb839 (Pubitemid 34993700)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.-L.5
  • 54
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
    • DOI 10.1016/S1097-2765(02)00568-3
    • Manning B. D., Tee A. R., Logsdon M. N., Blenis J., Cantley L. C., Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway. Molecular Cell 2002 10 1 151 162 2-s2.0-0036342294 10.1016/S1097-2765(02)00568-3 (Pubitemid 34876569)
    • (2002) Molecular Cell , vol.10 , Issue.1 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon M.Nicole3    Blenis, J.4    Cantley, L.C.5
  • 55
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • DOI 10.1073/pnas.202476899
    • Tee A. R., Fingar D. C., Manning B. D., Kwiatkowski D. J., Cantley L. C., Blenis J., Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences of the United States of America 2002 99 21 13571 13576 2-s2.0-0037108750 10.1073/pnas.202476899 (Pubitemid 35215423)
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , Issue.21 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 56
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • Inoki K., Zhu T., Guan K. L., TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003 115 5 577 590 2-s2.0-0345167800 10.1016/S0092-8674(03)00929-2 (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 57
    • 42949139481 scopus 로고    scopus 로고
    • AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
    • DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
    • Gwinn D. M., Shackelford D. B., Egan D. F., Mihaylova M. M., Mery A., Vasquez D. S., Turk B. E., Shaw R. J., AMPK phosphorylation of raptor mediates a metabolic checkpoint. Molecular Cell 2008 30 2 214 226 2-s2.0-42949139481 10.1016/j.molcel.2008.03.003 (Pubitemid 351626684)
    • (2008) Molecular Cell , vol.30 , Issue.2 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3    Mihaylova, M.M.4    Mery, A.5    Vasquez, D.S.6    Turk, B.E.7    Shaw, R.J.8
  • 58
    • 45849105156 scopus 로고    scopus 로고
    • The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • DOI 10.1126/science.1157535
    • Sancak Y., Peterson T. R., Shaul Y. D., Lindquist R. A., Thoreen C. C., Bar-Peled L., Sabatini D. M., The rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008 320 5882 1496 1501 2-s2.0-45849105156 10.1126/science.1157535 (Pubitemid 351929429)
    • (2008) Science , vol.320 , Issue.5882 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3    Lindquist, R.A.4    Thoreen, C.C.5    Bar-Peled, L.6    Sabatini, D.M.7
  • 59
    • 48649085816 scopus 로고    scopus 로고
    • Regulation of TORC1 by Rag GTPases in nutrient response
    • 2-s2.0-48649085816 10.1038/ncb1753
    • Kim E., Goraksha-Hicks P., Li L., Neufeld T. P., Guan K. L., Regulation of TORC1 by Rag GTPases in nutrient response. Nature Cell Biology 2008 10 8 935 945 2-s2.0-48649085816 10.1038/ncb1753
    • (2008) Nature Cell Biology , vol.10 , Issue.8 , pp. 935-945
    • Kim, E.1    Goraksha-Hicks, P.2    Li, L.3    Neufeld, T.P.4    Guan, K.L.5
  • 60
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • 2-s2.0-77951768486 10.1016/j.cell.2010.02.024
    • Sancak Y., Bar-Peled L., Zoncu R., Markhard A. L., Nada S., Sabatini D. M., Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010 141 2 290 303 2-s2.0-77951768486 10.1016/j.cell.2010.02.024
    • (2010) Cell , vol.141 , Issue.2 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 61
    • 79952774855 scopus 로고    scopus 로고
    • Intracellular amino acid sensing and mTORC1-regulated growth: New ways to block an old target?
    • Goberdhan D. C.I., deborah.goberdhan@dpag.ox.ac.uk Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target? Current Opinion in Investigational Drugs 2010 11 12 1360 1367
    • (2010) Current Opinion in Investigational Drugs , vol.11 , Issue.12 , pp. 1360-1367
    • Goberdhan, D.C.I.1
  • 63
    • 80053613846 scopus 로고    scopus 로고
    • A New Link in the Chain from Amino Acids to mTORC1 Activation
    • 10.1016/j.molcel.2011.09.004
    • Proud C. G., c.g.proud@soton.ac.uk A New Link in the Chain from Amino Acids to mTORC1 Activation. Molecular Cell 2011 44 1 7 8 10.1016/j.molcel.2011. 09.004
    • (2011) Molecular Cell , vol.44 , Issue.1 , pp. 7-8
    • Proud, C.G.1
  • 66
    • 1242317638 scopus 로고    scopus 로고
    • Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
    • DOI 10.1007/s00424-003-1117-9, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Mackenzie B., Erickson J. D., Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Archiv European Journal of Physiology 2004 447 5 784 795 2-s2.0-1242317638 10.1007/s00424-003-1117-9 (Pubitemid 38241468)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 784-795
    • Mackenzie, B.1    Erickson, J.D.2
  • 67
    • 3342931591 scopus 로고    scopus 로고
    • An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival
    • DOI 10.1038/sj.onc.1207738
    • Edinger A. L., Thompson C. B., An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival. Oncogene 2004 23 33 5654 5663 2-s2.0-3342931591 10.1038/sj.onc.1207738 (Pubitemid 39093043)
    • (2004) Oncogene , vol.23 , Issue.33 , pp. 5654-5663
    • Edinger, A.L.1    Thompson, C.B.2
  • 68
    • 0034283186 scopus 로고    scopus 로고
    • L-leucine availability regulates phosphatidylinositol 3-kinase, p70 s6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: Evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of System A amino acid transport
    • 2-s2.0-0034283186 10.1042/0264-6021:3500361
    • Peyrollier K., Hajduch E., Blair A. S., Hyde R., Hundal H. S., L-leucine availability regulates phosphatidylinositol 3-kinase, p70 s6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of System A amino acid transport. Biochemical Journal 2000 350 2 361 368 2-s2.0-0034283186 10.1042/0264-6021:3500361
    • (2000) Biochemical Journal , vol.350 , Issue.2 , pp. 361-368
    • Peyrollier, K.1    Hajduch, E.2    Blair, A.S.3    Hyde, R.4    Hundal, H.S.5
  • 69
    • 0038645859 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine
    • DOI 10.1074/jbc.M208500200
    • Xia Y., Wen H. Y., Young M. E., Guthrie P. H., Taegtmeyer H., Kellems R. E., Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine. The Journal of Biological Chemistry 2003 278 15 13143 13150 2-s2.0-0038645859 10.1074/jbc.M208500200 (Pubitemid 36800082)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.15 , pp. 13143-13150
    • Xia, Y.1    Wen, H.Y.2    Young, M.E.3    Guthrie, P.H.4    Taegtmeyer, H.5    Kellems, R.E.6
  • 70
    • 20144371132 scopus 로고    scopus 로고
    • Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: Role of glutamine and of cell shrinkage
    • DOI 10.1002/jcp.20272
    • Fumarola C., La Monica S., Guidotti G. G., Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: role of glutamine and of cell shrinkage. Journal of Cellular Physiology 2005 204 1 155 165 2-s2.0-20144371132 10.1002/jcp.20272 (Pubitemid 40776818)
    • (2005) Journal of Cellular Physiology , vol.204 , Issue.1 , pp. 155-165
    • Fumarola, C.1    La Monica, S.2    Guidotti, G.G.3
  • 72
    • 23044474905 scopus 로고    scopus 로고
    • Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
    • DOI 10.1016/j.semcancer.2005.04.005, PII S1044579X05000222, Tumor Metabolome
    • Fuchs B. C., Bode B. P., Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Seminars in Cancer Biology 2005 15 4 254 266 2-s2.0-23044474905 10.1016/j.semcancer.2005.04.005 (Pubitemid 41065034)
    • (2005) Seminars in Cancer Biology , vol.15 , Issue.4 , pp. 254-266
    • Fuchs, B.C.1    Bode, B.P.2
  • 74
    • 0020157282 scopus 로고
    • Prediction of plasma amino acid concentration from diet amino acid content
    • 2-s2.0-0020157282
    • Johnson D. J., Anderson G. H., Prediction of plasma amino acid concentration from diet amino acid content. The American Journal of Physiology 1982 243 1 R99 103 2-s2.0-0020157282
    • (1982) The American Journal of Physiology , vol.243 , Issue.1
    • Johnson, D.J.1    Anderson, G.H.2
  • 75
    • 0034978502 scopus 로고    scopus 로고
    • Inconsistency between glycemic and insulinemic responses to regular and fermented milk products
    • Östman E. M., Liljeberg Elmståhl H. G. M., Björck I. M. E., Inconsistency between glycemic and insulinemic responses to regular and fermented milk products. The American Journal of Clinical Nutrition 2001 74 1 96 100 2-s2.0-0034978502 (Pubitemid 32574916)
    • (2001) American Journal of Clinical Nutrition , vol.74 , Issue.1 , pp. 96-100
    • Ostman, E.M.1    Liljeberg Elmstahl, H.G.M.2    Bjorck, I.M.E.3
  • 76
    • 15944404633 scopus 로고    scopus 로고
    • Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk
    • 2-s2.0-15944404633 10.1079/BJN20041304
    • Hoyt G., Hickey M. S., Cordain L., Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk. British Journal of Nutrition 2005 93 2 175 177 2-s2.0-15944404633 10.1079/BJN20041304
    • (2005) British Journal of Nutrition , vol.93 , Issue.2 , pp. 175-177
    • Hoyt, G.1    Hickey, M.S.2    Cordain, L.3
  • 77
    • 77955890920 scopus 로고    scopus 로고
    • Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
    • 2-s2.0-77955890920 10.1111/j.1753-4887.2010.00282.x
    • Yang J., Chi Y., Burkhardt B. R., Guan Y., Wolf B. A., Leucine metabolism in regulation of insulin secretion from pancreatic beta cells. Nutrition Reviews 2010 68 5 270 279 2-s2.0-77955890920 10.1111/j.1753-4887.2010.00282.x
    • (2010) Nutrition Reviews , vol.68 , Issue.5 , pp. 270-279
    • Yang, J.1    Chi, Y.2    Burkhardt, B.R.3    Guan, Y.4    Wolf, B.A.5
  • 79
    • 0035145602 scopus 로고    scopus 로고
    • Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic β-cells
    • Xu G., Kwon G., Cruz W. S., Marshall C. A., McDaniel M. L., Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic β -cells. Diabetes 2001 50 2 353 360 2-s2.0-0035145602 (Pubitemid 32127292)
    • (2001) Diabetes , vol.50 , Issue.2 , pp. 353-360
    • Xu, G.1    Kwon, G.2    Cruz, W.S.3    Marshall, C.A.4    McDaniel, M.L.5
  • 80
    • 0032561348 scopus 로고    scopus 로고
    • Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic β-cells: A possible role in protein translation and mitogenic signaling
    • DOI 10.1074/jbc.273.43.28178
    • Xu G., Kwon G., Marshall C. A., Lin T. A., Lawrence J. C., McDaniel M. L., Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic β -cells: a possible role in protein translation and mitogenic signaling. The Journal of Biological Chemistry 1998 273 43 28178 28184 2-s2.0-0032561348 10.1074/jbc.273.43.28178 (Pubitemid 28496115)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.43 , pp. 28178-28184
    • Xu, G.1    Kwon, G.2    Marshall, C.A.3    Lin, T.-A.4    Lawrence Jr., J.C.5    McDaniel, M.L.6
  • 81
    • 80051835640 scopus 로고    scopus 로고
    • Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1
    • e23238 10.1371/journal.pone.0023238
    • Koyanagi M., Asahara S., Matsuda T., Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. PLoS One 2011 6 8 e23238 10.1371/journal.pone.0023238
    • (2011) PLoS One , vol.6 , Issue.8
    • Koyanagi, M.1    Asahara, S.2    Matsuda, T.3
  • 83
    • 79955773535 scopus 로고    scopus 로고
    • Infant formulas
    • 10.1542/pir.32-5-179
    • Martinez J. A., Ballew M. P., Infant formulas. Pediatrics in Review 2011 32 5 179 189 10.1542/pir.32-5-179
    • (2011) Pediatrics in Review , vol.32 , Issue.5 , pp. 179-189
    • Martinez, J.A.1    Ballew, M.P.2
  • 84
    • 0033035564 scopus 로고    scopus 로고
    • Macronutrient intake of 3- to 36-month-old German infants and children: Results of the DONALD Study
    • DOI 10.1159/000012762
    • Alexy U., alexy@fke-uni-dortmund.de Kersting M., Sichert-Hellert W., Manz F., Schöch G., Macronutrient intake of 3- to 36-month-old German infants and children: results of the DONALD Study. Annals of Nutrition & Metabolism 1999 43 1 14 22 10.1159/000012762 (Pubitemid 29267897)
    • (1999) Annals of Nutrition and Metabolism , vol.43 , Issue.1 , pp. 14-22
    • Alexy, U.1    Kersting, M.2    Sichert-Hellert, W.3    Manz, F.4    Schoch, G.5
  • 85
    • 33244481462 scopus 로고    scopus 로고
    • Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance
    • PE4 2-s2.0-33244481462 10.1126/stke.2682005pe4
    • Zick Y., Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Science's Signal Transduction Knowledge Environment 2005 2005 268, pe4 2-s2.0-33244481462 10.1126/stke.2682005pe4
    • (2005) Science's Signal Transduction Knowledge Environment , vol.2005 , Issue.268
    • Zick, Y.1
  • 86
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • 2-s2.0-65649098029 10.1152/ajpendo.90437.2008
    • Boura-Halfon S., Zick Y., Phosphorylation of IRS proteins, insulin action, and insulin resistance. American Journal of PhysiologyEndocrinology and Metabolism 2009 296 4 E581 E591 2-s2.0-65649098029 10.1152/ajpendo.90437.2008
    • (2009) American Journal of PhysiologyEndocrinology and Metabolism , vol.296 , Issue.4
    • Boura-Halfon, S.1    Zick, Y.2
  • 87
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    • DOI 10.1016/j.cmet.2006.05.003, PII S1550413106001586
    • Um S. H., D'Alessio D., Thomas G., Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metabolism 2006 3 6 393 402 2-s2.0-33744505375 10.1016/j.cmet.2006.05.003 (Pubitemid 43811780)
    • (2006) Cell Metabolism , vol.3 , Issue.6 , pp. 393-402
    • Um, S.H.1    D'Alessio, D.2    Thomas, G.3
  • 90
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • DOI 10.2337/diabetes.54.9.2674
    • Tremblay F., Krebs M., Dombrowski L., Brehm A., Bernroider E., Roth E., Nowotny P., Waldhäusl W., Marette A., Roden M., Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 2005 54 9 2674 2684 2-s2.0-24144446404 10.2337/diabetes.54.9.2674 (Pubitemid 41233590)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2674-2684
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3    Brehm, A.4    Bernroider, E.5    Roth, E.6    Nowotny, P.7    Waldhausl, W.8    Marette, A.9    Roden, M.10
  • 91
    • 77957567397 scopus 로고    scopus 로고
    • Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle
    • 2-s2.0-77957567397 10.2337/db09-1870
    • Saha A. K., Xu X. J., Lawson E., Deoliveira R., Brandon A. E., Kraegen E. W., Ruderman N. B., Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes 2010 59 10 2426 2434 2-s2.0-77957567397 10.2337/db09-1870
    • (2010) Diabetes , vol.59 , Issue.10 , pp. 2426-2434
    • Saha, A.K.1    Xu, X.J.2    Lawson, E.3    Deoliveira, R.4    Brandon, A.E.5    Kraegen, E.W.6    Ruderman, N.B.7
  • 94
    • 0016166002 scopus 로고
    • Metabolic fate of leucine: A significant sterol precursor in adipose tissue and muscle
    • 2-s2.0-0016166002
    • Rosenthal J., Angel A., Farkas J., Metabolic fate of leucine: a significant sterol precursor in adipose tissue and muscle. American Journal of Physiology 1974 226 2 411 418 2-s2.0-0016166002
    • (1974) American Journal of Physiology , vol.226 , Issue.2 , pp. 411-418
    • Rosenthal, J.1    Angel, A.2    Farkas, J.3
  • 95
    • 0034073638 scopus 로고    scopus 로고
    • Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes
    • DOI 10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3.0.CO;2-I
    • Lynch C. J., Fox H. L., Vary T. C., Jefferson L. S., Kimball S. R., Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes. Journal of Cellular Biochemistry 2000 77 2 234 251 2-s2.0-0034073638 10.1002/(SICI)1097-4644(20000501)77:2234::AID-JCB7>3.0.CO;2-I (Pubitemid 30176653)
    • (2000) Journal of Cellular Biochemistry , vol.77 , Issue.2 , pp. 234-251
    • Lynch, C.J.1    Fox, H.L.2    Vary, T.C.3    Jefferson, L.S.4    Kimball, S.R.5
  • 96
    • 0035094978 scopus 로고    scopus 로고
    • Role of leucine in the regulation of mTOR by amino acids: Revelations from structure-activity studies
    • Lynch C. J., Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. Journal of Nutrition 2001 131 3 861S 865S 2-s2.0-0035094978 (Pubitemid 32199160)
    • (2001) Journal of Nutrition , vol.131 , Issue.3
    • Lynch, C.J.1
  • 98
    • 0034618364 scopus 로고    scopus 로고
    • Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
    • 2-s2.0-0034618364 10.1002/1097-4644(20001201)79:3427: AID-JCB80>3.0.CO;2-0
    • Pham P. T. T., Heydrick S. J., Fox H. L., Kimball S. R., Jefferson L. S., Lynch C. J., Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. Journal of Cellular Biochemistry 2000 79 3 427 441 2-s2.0-0034618364 10.1002/1097-4644(20001201)79:3427::AID-JCB80>3.0.CO;2-0
    • (2000) Journal of Cellular Biochemistry , vol.79 , Issue.3 , pp. 427-441
    • Pham, P.T.T.1    Heydrick, S.J.2    Fox, H.L.3    Kimball, S.R.4    Jefferson, L.S.5    Lynch, C.J.6
  • 99
    • 7044234995 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis
    • DOI 10.2337/diabetes.53.11.2748
    • Kim J. E., Chen J., Regulation of peroxisome proliferator-activated receptor- γ activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes 2004 53 11 2748 2756 2-s2.0-7044234995 10.2337/diabetes.53.11.2748 (Pubitemid 39425899)
    • (2004) Diabetes , vol.53 , Issue.11 , pp. 2748-2756
    • Kim, J.E.1    Chen, J.2
  • 100
    • 0031887111 scopus 로고    scopus 로고
    • Amino acids stimulate phosphorylation of p70(S6k) and organization of rat adipocytes into multicellular clusters
    • 2-s2.0-0031887111
    • Fox H. L., Kimball S. R., Jefferson L. S., Lynch C. J., Amino acids stimulate phosphorylation of p70(S6k) and organization of rat adipocytes into multicellular clusters. American Journal of PhysiologyCell Physiology 1998 274 1 C206 C213 2-s2.0-0031887111
    • (1998) American Journal of PhysiologyCell Physiology , vol.274 , Issue.1
    • Fox, H.L.1    Kimball, S.R.2    Jefferson, L.S.3    Lynch, C.J.4
  • 101
    • 0031730304 scopus 로고    scopus 로고
    • Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes
    • 2-s2.0-0031730304
    • Fox H. L., Pham P. T., Kimball S. R., Jefferson L. S., Lynch C. J., Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. American Journal of PhysiologyCell Physiology 1998 275 5 C1232 C1238 2-s2.0-0031730304
    • (1998) American Journal of PhysiologyCell Physiology , vol.275 , Issue.5
    • Fox, H.L.1    Pham, P.T.2    Kimball, S.R.3    Jefferson, L.S.4    Lynch, C.J.5
  • 102
    • 67650523945 scopus 로고    scopus 로고
    • Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway
    • 2-s2.0-67650523945 10.1371/journal.pone.0006189 e6189
    • Zhang H. H., Huang J., Düvel K., Boback B., Wu S., Squillance R. M., Wu C. L., Manning B. D., Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One 2009 4 7 2-s2.0-67650523945 10.1371/journal.pone.0006189 e6189
    • (2009) PLoS One , vol.4 , Issue.7
    • Zhang, H.H.1    Huang, J.2    Düvel, K.3    Boback, B.4    Wu, S.5    Squillance, R.M.6    Wu, C.L.7    Manning, B.D.8
  • 105
    • 76349083837 scopus 로고    scopus 로고
    • The role of dietary protein on lipotoxicity
    • 2-s2.0-76349083837 10.1016/j.bbalip.2009.09.007
    • Tovar A. R., Torres N., The role of dietary protein on lipotoxicity. Biochimica et Biophysica ActaMolecular and Cell Biology of Lipids 2010 1801 3 367 371 2-s2.0-76349083837 10.1016/j.bbalip.2009.09.007
    • (2010) Biochimica et Biophysica ActaMolecular and Cell Biology of Lipids , vol.1801 , Issue.3 , pp. 367-371
    • Tovar, A.R.1    Torres, N.2
  • 106
    • 59749106220 scopus 로고    scopus 로고
    • A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size
    • 2-s2.0-59749106220 10.1042/BST0370278
    • Porstmann T., Santos C. R., Lewis C., Griffiths B., Schulze A., A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. Biochemical Society Transactions 2009 37 1 278 283 2-s2.0-59749106220 10.1042/BST0370278
    • (2009) Biochemical Society Transactions , vol.37 , Issue.1 , pp. 278-283
    • Porstmann, T.1    Santos, C.R.2    Lewis, C.3    Griffiths, B.4    Schulze, A.5
  • 107
    • 33750120099 scopus 로고    scopus 로고
    • Cow's milk and linear growth in industrialized and developing countries
    • 2-s2.0-33750120099 10.1146/annurev.nutr.26.010506.103757
    • Hoppe C., Molgaard C., Michaelsen K. F., Cow's milk and linear growth in industrialized and developing countries. Annual Review of Nutrition 2006 26 131 173 2-s2.0-33750120099 10.1146/annurev.nutr.26.010506.103757
    • (2006) Annual Review of Nutrition , vol.26 , pp. 131-173
    • Hoppe, C.1    Molgaard, C.2    Michaelsen, K.F.3
  • 108
    • 77953555973 scopus 로고    scopus 로고
    • Dairy and milk consumption and child growth: Is BMI involved? An analysis of NHANES 19992004
    • 2-s2.0-77953555973 10.1002/ajhb.21042
    • Wiley A. S., Dairy and milk consumption and child growth: is BMI involved? An analysis of NHANES 19992004. American Journal of Human Biology 2010 22 4 517 525 2-s2.0-77953555973 10.1002/ajhb.21042
    • (2010) American Journal of Human Biology , vol.22 , Issue.4 , pp. 517-525
    • Wiley, A.S.1
  • 109
    • 79960128997 scopus 로고    scopus 로고
    • MTOR and the differentiation of mesenchymal stem cells
    • 10.1093/abbs/gmr041
    • Xiang X., Zhao J., Xu G., Li Y., yinli@bjmu.edu.cn Zhang W., weizhenzhang@bjmu.edu.cn mTOR and the differentiation of mesenchymal stem cells. Acta Biochimica et Biophysica Sinica 2011 43 7 501 510 10.1093/abbs/gmr041
    • (2011) Acta Biochimica et Biophysica Sinica , vol.43 , Issue.7 , pp. 501-510
    • Xiang, X.1    Zhao, J.2    Xu, G.3    Li, Y.4
  • 111
    • 17044370010 scopus 로고    scopus 로고
    • MTOR: A placental growth signaling sensor
    • 2-s2.0-17044370010 10.1016/j.placenta.2005.02.004
    • Wen H. Y., Abbasi S., Kellems R. E., Xia Y., mTOR: a placental growth signaling sensor. Placenta 2005 26 supplement S63 S69 2-s2.0-17044370010 10.1016/j.placenta.2005.02.004
    • (2005) Placenta , vol.26 , Issue.SUPPL.
    • Wen, H.Y.1    Abbasi, S.2    Kellems, R.E.3    Xia, Y.4
  • 112
    • 17044399745 scopus 로고    scopus 로고
    • Signalling pathways regulating the invasive differentiation of human trophoblasts: A review
    • 10.1016/j.placenta.2004.11.013
    • Pollheimer J., Knöfler M., martin.knoefler@meduniwien.ac.at Signalling pathways regulating the invasive differentiation of human trophoblasts: a review. Placenta 2005 26 supplement S21 S30 10.1016/j.placenta. 2004.11.013
    • (2005) Placenta , vol.26 , Issue.SUPPL.
    • Pollheimer, J.1    Knöfler, M.2
  • 113
    • 70349246381 scopus 로고    scopus 로고
    • Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling
    • 2-s2.0-70349246381 10.1152/ajpcell.00191.2009
    • Roos S., Lagerlöf O., Wennergren M., Powell T. L., Jansson T., Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling. American Journal of PhysiologyCell Physiology 2009 297 3 C723 C731 2-s2.0-70349246381 10.1152/ajpcell.00191.2009
    • (2009) American Journal of PhysiologyCell Physiology , vol.297 , Issue.3
    • Roos, S.1    Lagerlöf, O.2    Wennergren, M.3    Powell, T.L.4    Jansson, T.5
  • 114
    • 34347211057 scopus 로고    scopus 로고
    • Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth
    • DOI 10.1113/jphysiol.2007.129676
    • Roos S., Jansson N., Palmberg I., Säljö K., Powell T. L., Jansson T., Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. The Journal of Physiology 2007 582 1 449 459 2-s2.0-34347211057 10.1113/jphysiol.2007.129676 (Pubitemid 46993587)
    • (2007) Journal of Physiology , vol.582 , Issue.1 , pp. 449-459
    • Roos, S.1    Jansson, N.2    Palmberg, I.3    Saljo, K.4    Powell, T.L.5    Jansson, T.6
  • 115
    • 59749101802 scopus 로고    scopus 로고
    • Placental mTOR links maternal nutrient availability to fetal growth
    • 2-s2.0-59749101802 10.1042/BST0370295
    • Roos S., Powell T. L., Jansson T., Placental mTOR links maternal nutrient availability to fetal growth. Biochemical Society Transactions 2009 37 1 295 298 2-s2.0-59749101802 10.1042/BST0370295
    • (2009) Biochemical Society Transactions , vol.37 , Issue.1 , pp. 295-298
    • Roos, S.1    Powell, T.L.2    Jansson, T.3
  • 116
    • 79951938584 scopus 로고    scopus 로고
    • Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters
    • 10.1210/en.2010-1153
    • Rosario F. J., Jansson N., Kanai Y., Prasad P. D., Powell T. L., Jansson T., Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology 2011 152 3 1119 1129 10.1210/en.2010-1153
    • (2011) Endocrinology , vol.152 , Issue.3 , pp. 1119-1129
    • Rosario, F.J.1    Jansson, N.2    Kanai, Y.3    Prasad, P.D.4    Powell, T.L.5    Jansson, T.6
  • 118
    • 3242721268 scopus 로고    scopus 로고
    • MTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
    • DOI 10.1128/MCB.24.15.6710-6718.2004
    • Murakami M., Ichisaka T., Maeda M., Oshiro N., Hara K., Edenhofer F., Kiyama H., Yonezawa K., Yamanaka S., mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Molecular and Cellular Biology 2004 24 15 6710 6718 2-s2.0-3242721268 10.1128/MCB.24.15.6710- 6718.2004 (Pubitemid 38944350)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.15 , pp. 6710-6718
    • Murakami, M.1    Ichisaka, T.2    Maeda, M.3    Oshiro, N.4    Hara, K.5    Edenhofer, F.6    Kiyama, H.7    Yonezawa, K.8    Yamanaka, S.9
  • 119
    • 33947165785 scopus 로고    scopus 로고
    • Non-human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient-responsive pathway
    • DOI 10.1113/jphysiol.2006.122101
    • Nijland M. J., Schlabritz-loutsevitch N. E., Hubbard G. B., Nathanielsz P. W., Cox L. A., Non-human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient-responsive pathway. The Journal of Physiology 2007 579 3 643 656 2-s2.0-33947165785 10.1113/jphysiol.2006.122101 (Pubitemid 46404348)
    • (2007) Journal of Physiology , vol.579 , Issue.3 , pp. 643-656
    • Nijland, M.J.1    Schlabritz-loutsevitch, N.E.2    Hubbard, G.B.3    Nathanielsz, P.W.4    Cox, L.A.5
  • 121
    • 21744457297 scopus 로고    scopus 로고
    • Fetal and perinatal programming of appetite
    • DOI 10.1042/CS20040367
    • Cripps R. L., Martin-Gronert M. S., Ozanne S. E., Fetal and perinatal programming of appetite. Clinical Science 2005 109 1 1 11 2-s2.0-21744457297 10.1042/CS20040367 (Pubitemid 40943028)
    • (2005) Clinical Science , vol.109 , Issue.1 , pp. 1-11
    • Cripps, R.L.1    Martin-Gronert, M.S.2    Ozanne, S.E.3
  • 123
    • 84857910457 scopus 로고    scopus 로고
    • Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: An insulin signaling pathway approach
    • 10.1007/s11357-011-9246-0
    • Zeanandin G., Balage M., Schneider S. M., Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach. Age 34 2 371 387 10.1007/s11357-011-9246-0
    • Age , vol.34 , Issue.2 , pp. 371-387
    • Zeanandin, G.1    Balage, M.2    Schneider, S.M.3
  • 125
    • 85028116707 scopus 로고    scopus 로고
    • MTORC1 signaling in energy balance and metabolic disease
    • 2-s2.0-77957105612 10.1038/ijo.2010.208
    • Catania C., Binder E., Cota D., mTORC1 signaling in energy balance and metabolic disease. International Journal of Obesity 2010 2-s2.0-77957105612 10.1038/ijo.2010.208
    • (2010) International Journal of Obesity
    • Catania, C.1    Binder, E.2    Cota, D.3
  • 127
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • DOI 10.1126/science.1124147
    • Cota D., Proulx K., Blake Smith K. A., Kozma S. C., Thomas G., Woods S. C., Seeley R. J., Hypothalamic mTOR signaling regulates food intake. Science 2006 312 5775 927 930 2-s2.0-33646582664 10.1126/science.1124147 (Pubitemid 43727328)
    • (2006) Science , vol.312 , Issue.5775 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Blake Smith, K.A.3    Kozma, S.C.4    Thomas, G.5    Woods, S.C.6    Seeley, R.J.7
  • 128
    • 70349315117 scopus 로고    scopus 로고
    • Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
    • 2-s2.0-70349315117 10.1210/en.2009-0642
    • Villanueva E. C., Münzberg H., Cota D., Leshan R. L., Kopp K., Ishida-Takahashi R., Jones J. C., Fingar D. C., Seeley R. J., Myers M. G., Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology 2009 150 10 4541 4551 2-s2.0-70349315117 10.1210/en.2009-0642
    • (2009) Endocrinology , vol.150 , Issue.10 , pp. 4541-4551
    • Villanueva, E.C.1    Münzberg, H.2    Cota, D.3    Leshan, R.L.4    Kopp, K.5    Ishida-Takahashi, R.6    Jones, J.C.7    Fingar, D.C.8    Seeley, R.J.9    Myers, M.G.10
  • 129
    • 49049114337 scopus 로고    scopus 로고
    • The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    • 2-s2.0-49049114337 10.1523/JNEUROSCI.1389-08.2008
    • Cota D., Matter E. K., Woods S. C., Seeley R. J., The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. Journal of Neuroscience 2008 28 28 7202 7208 2-s2.0-49049114337 10.1523/JNEUROSCI.1389-08.2008
    • (2008) Journal of Neuroscience , vol.28 , Issue.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 131
  • 132
    • 42249100527 scopus 로고    scopus 로고
    • Effects of α-lactalbumin-enriched formula containing different concentrations of glycomacropeptide on infant nutrition
    • Sandström O., Lönnerdal B., Graverholt G., Hernell O., Effects of α -lactalbumin-enriched formula containing different concentrations of glycomacropeptide on infant nutrition. The American Journal of Clinical Nutrition 2008 87 4 921 928 2-s2.0-42249100527 (Pubitemid 351549237)
    • (2008) American Journal of Clinical Nutrition , vol.87 , Issue.4 , pp. 921-928
    • Sandstrom, O.1    Lonnerdal, B.2    Graverholt, G.3    Hernell, O.4
  • 133
    • 0037563682 scopus 로고    scopus 로고
    • Infant formulas with increased concentrations of alpha-lactalbumin
    • 2-s2.0-0037563682
    • Lien E. L., Infant formulas with increased concentrations of alpha-lactalbumin. The American Journal of Clinical Nutrition 2003 77 6 2-s2.0-0037563682
    • (2003) The American Journal of Clinical Nutrition , vol.77 , Issue.6
    • Lien, E.L.1
  • 134
    • 0025756737 scopus 로고
    • The importance of α -lactalbumin in infant nutrition
    • 2-s2.0-0025756737
    • Heine W. E., Klein P. D., Reeds P. J., The importance of α -lactalbumin in infant nutrition. Journal of Nutrition 1991 121 3 277 283 2-s2.0-0025756737
    • (1991) Journal of Nutrition , vol.121 , Issue.3 , pp. 277-283
    • Heine, W.E.1    Klein, P.D.2    Reeds, P.J.3
  • 135
    • 79953166481 scopus 로고    scopus 로고
    • MTOR signalling in health and disease
    • 10.1042/BST0390431
    • Proud C. G., C.G.Proud@soton.ac.uk mTOR signalling in health and disease. Biochemical Society Transactions 2011 39 2 431 436 10.1042/BST0390431
    • (2011) Biochemical Society Transactions , vol.39 , Issue.2 , pp. 431-436
    • Proud, C.G.1
  • 136
    • 77954383345 scopus 로고    scopus 로고
    • Tuberous sclerosis complex: Linking cancer to metabolism
    • 2-s2.0-77954383345 10.1016/j.molmed.2010.05.001
    • Mieulet V., Lamb R. F., Tuberous sclerosis complex: linking cancer to metabolism. Trends in Molecular Medicine 2010 16 7 329 335 2-s2.0-77954383345 10.1016/j.molmed.2010.05.001
    • (2010) Trends in Molecular Medicine , vol.16 , Issue.7 , pp. 329-335
    • Mieulet, V.1    Lamb, R.F.2
  • 137
    • 34249679614 scopus 로고    scopus 로고
    • MTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer
    • DOI 10.1016/j.molmed.2007.04.002, PII S1471491407000664
    • Dann S. G., Selvaraj A., Thomas G., mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends in Molecular Medicine 2007 13 6 252 259 2-s2.0-34249679614 10.1016/j.molmed.2007.04.002 (Pubitemid 46836871)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.6 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 139
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • DOI 10.1038/nature04869, PII NATURE04869
    • Shaw R. J., Cantley L. C., Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006 441 7092 424 430 2-s2.0-33745307617 10.1038/nature04869 (Pubitemid 44050136)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 140
    • 79953684026 scopus 로고    scopus 로고
    • Secreted proteins from adipose tissue and skeletal muscleAdipokines, myokines and adipose/muscle cross-talk
    • 10.3109/13813455.2010.535835
    • Trayhurn P., p.trayhurn@liverpool.ac.uk Drevon C. A., Eckel J., Secreted proteins from adipose tissue and skeletal muscleAdipokines, myokines and adipose/muscle cross-talk. Archives of Physiology and Biochemistry 2011 117 2 47 56 10.3109/13813455.2010.535835
    • (2011) Archives of Physiology and Biochemistry , vol.117 , Issue.2 , pp. 47-56
    • Trayhurn, P.1    Drevon, C.A.2    Eckel, J.3


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