Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body

RNA

Volumn 11, Issue 12, 2005, Pages 1795-1802

  Jiang, Hong Yu ^a   Yang, Wei Hong ^a   Gulick, Tod ^b   Bloch, Kenneth D ^b   Bloch, Donald B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Autoantigen; mRNA decay; mRNA processing body

Indexed keywords

AMINO ACID; ANTIBODY; AUTOANTIGEN; COMPLEMENTARY DNA; CYTOPLASM PROTEIN; GE 1 PROTEIN; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOIMMUNE DISEASE; BILIARY CIRRHOSIS; CARBOXY TERMINAL SEQUENCE; CELL STRUCTURE; CYTOPLASM; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN TARGETING; RNA PROCESSING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIBODIES; AUTOANTIGENS; CELL LINE, TUMOR; CYTOPLASMIC STRUCTURES; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORESCENT DYES; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; LIVER CIRRHOSIS, BILIARY; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROTEIN STRUCTURE, TERTIARY; RNA CAPS; RNA, MESSENGER; RNA, SMALL INTERFERING; SERINE;

MAMMALIA;

EID: 28344456221     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2142405     Document Type: Article

References (25)

1. Andrei, M.A., Ingelfinger, D., Heintzmann, R., Achsel, T., Rivera-Pomar, R., and Luhrmann, R. 2005. A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. RNA 11: 717-727.
2. Bloch, D.B., Rabkina, D., Quertermous, T., and Bloch, K.D. 1994. The immunoreactive region in a novel autoantigen contains a nuclear localization sequence. Clin. Immunol. Immunopathol. 72: 380-389.
3. Bloch, D.B., Yu, J.H., Yang, W.H., Graeme-Cook, F., Lindor, K.D., Viswanathan, A., Bloch, K.D., and Nakajima, A. 2005. The cytoplasmic dot staining pattern is detected in a subgroup of patients with primary biliary cirrhosis. J. Rheumatol. 32: 477-483.
4. Bornberg-Bauer, E., Rivals, E., and Vingron, M. 1998. Computational approaches to identify leucine zippers. Nucleic Acids Res. 26: 2740-2746.
5. Bouveret, E., Rigaut, G., Shevchenko, A., Wilm, M., and Seraphin, B. 2000. A Sm-like protein complex that participates in mRNA degradation. EMBO J. 19: 1661-1671.
6. Cheng, Z., Liu, Y., Wang, C., Parker, R., and Song, H. 2004. Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination. Protein Sci. 13: 2673-2684.
7. Coller, J. and Parker, R. 2004. Eukaryotic mRNA decapping. Annu. Rev. Biochem. 73: 861-890.
8. Coller, J.M., Tucker, M., Sheth, U., Valencia-Sanchez, M.A., and Parker, R. 2001. The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA 7: 1717-1727.
9. Cougot, N., Babajko, S., and Seraphin, B. 2004. Cytoplasmic foci are sites of mRNA decay in human cells. J. Cell Biol. 165: 31-40.
10. Eystathioy, T., Chan, E.K., Takeuchi, K., Mahler, M., Luft, L.M., Zochodne, D.W., and Fritzler, M.J. 2003a. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. J. Mol. Med. 81: 811-818.
11. Eystathioy, T., Jakymiw, A., Chan, E.K., Seraphin, B., Cougot, N., and Fritzler, M.J. 2003b. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. RNA 9: 1171-1173.
12. Garcia-Lozano, J.R., Gonzalez-Escribano, M.F., Wichmann, I., and Nunez-Roldan, A. 1997. Cytoplasmic detection of a novel protein containing a nuclear localization sequence by human autoantibodies. Clin. Exp. Immunol. 107: 501-506.
13. Kaplan, M.M. 1996. Primary biliary cirrhosis. N. Engl. J. Med. 335: 1570-1580.
14. Kedersha, N. and Anderson, P. 2002. Stress granules: Sites of mRNA triage that regulate mRNA stability and translatability. Biochem. Soc. Trans. 30: 963-969.
15. Kedersha, N., Stoecklin, G., Ayodele, M., Yacono, P., Lykke-Andersen, J., Fitzler, M.J., Scheuner, D., Kaufman, R.J., Golan, D.E., and Anderson, P. 2005. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J. Cell Biol. 169: 871-884.
16. Kobe, B. and Kajava, A.V. 2001. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 11: 725-732.
17. Madrona, A.Y. and Wilson, D.K. 2004. The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure. Protein Sci. 13: 1557-1565.
18. Parker, R. and Song, H. 2004. The enzymes and control of eukaryotic mRNA turnover. Nat. Struct. Mol. Biol. 11: 121-127.
19. Sheth, U. and Parker, R. 2003. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300: 805-808.
20. Smith, D.B. and Johnson, K.S. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67: 31-40.
21. Smith, T.F., Gaitatzes, C., Saxena, K., and Neer, E.J. 1999. The WD repeat: A common architecture for diverse functions. Trends Biochem. Sci. 24: 181-185.
22. Wilczynska, A., Aigueperse, C., Kress, M., Dautry, F., and Weil, D. 2005. The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules. J. Cell Sci. 118: 981-992.
23. Yang, W.H., Yu, J.H., Nakajima, A., Neuberg, D., Lindor, K., and Bloch, D.B. 2004a. Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure? Clin. Gastroenterol. Hepatol. 2: 1116-1122.
24. Yang, Z., Jakymiw, A., Wood, M.R., Eystathioy, T., Rubin, R.L., Fritzler, M.J., and Chan, E.K. 2004b. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. J. Cell Sci. 117: 5567-5578.
25. Young, R.A. and Davis, R.W. 1983. Efficient isolation of genes by using antibody probes. Proc. Natl. Acad. Sci. 80: 1194-1198.