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Volumn 68, Issue 5, 2010, Pages 270-279

Leucine metabolism in regulation of insulin secretion from pancreatic beta cells

Author keywords

ATP synthase; Glutamate dehydrogenase; Leucine; MTOR

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); GLUTAMATE DEHYDROGENASE; INSULIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RAPAMYCIN;

EID: 77955890920     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2010.00282.x     Document Type: Review
Times cited : (172)

References (115)
  • 1
    • 1642465556 scopus 로고    scopus 로고
    • Hyperinsulinism/hyperammonemia syndrome: Insights into the regulatory role of glutamate dehydrogenase in ammonia metabolism
    • Stanley CA. Hyperinsulinism/hyperammonemia syndrome: Insights into the regulatory role of glutamate dehydrogenase in ammonia metabolism. Mol Genet Metab. 2004;81(Suppl 1):45-51.
    • (2004) Mol Genet Metab. , vol.81 , Issue.SUPPL. 1 , pp. 45-51
    • Stanley, C.A.1
  • 2
    • 0019133275 scopus 로고
    • L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
    • Sener A, Malaisse WJ. l-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature. 1980;288:187-189.
    • (1980) Nature. , vol.288 , pp. 187-189
    • Sener, A.1    Malaisse, W.J.2
  • 4
    • 0032486283 scopus 로고    scopus 로고
    • Direct inhibition of the pancreatic beta-cell ATP-regulated potassium channel by alpha-ketoisocaproate
    • Branstrom R, Efendic S, Berggren PO, Larsson O. Direct inhibition of the pancreatic beta-cell ATP-regulated potassium channel by alpha-ketoisocaproate. J Biol Chem. 1998;273: 14113-14118.
    • (1998) J Biol Chem. , vol.273 , pp. 14113-14118
    • Branstrom, R.1    Efendic, S.2    Berggren, P.O.3    Larsson, O.4
  • 5
    • 0036787462 scopus 로고    scopus 로고
    • Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells
    • McDaniel ML, Marshall CA, Pappan KL, Kwon G. Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes. 2002;51:2877-2885.
    • (2002) Diabetes. , vol.51 , pp. 2877-2885
    • McDaniel, M.L.1    Marshall, C.A.2    Pappan, K.L.3    Kwon, G.4
  • 6
    • 31544454965 scopus 로고    scopus 로고
    • Branchedchain amino acids activate key enzymes in protein synthesis after physical exercise
    • Blomstrand E, Eliasson J, Karlsson HK, Kohnke R. Branchedchain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr. 2006;136(Suppl 1):S269-S273.
    • (2006) J Nutr. , vol.136 , Issue.SUPPL. 1
    • Blomstrand, E.1    Eliasson, J.2    Karlsson, H.K.3    Kohnke, R.4
  • 7
    • 34247573364 scopus 로고    scopus 로고
    • Leucine and protein synthesis: MTOR and beyond
    • Stipanuk MH. Leucine and protein synthesis: MTOR and beyond. Nutr Rev. 2007;65:122-129.
    • (2007) Nutr Rev. , vol.65 , pp. 122-129
    • Stipanuk, M.H.1
  • 8
    • 0347627142 scopus 로고    scopus 로고
    • Regulation of protein synthesis by branchedchain amino acids in vivo
    • Yoshizawa F. Regulation of protein synthesis by branchedchain amino acids in vivo. Biochem Biophys Res Commun. 2004;313:417-422.
    • (2004) Biochem Biophys Res Commun. , vol.313 , pp. 417-422
    • Yoshizawa, F.1
  • 9
    • 9444234587 scopus 로고    scopus 로고
    • Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
    • Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML. Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes. 2004;53(Suppl 3):S225-S232.
    • (2004) Diabetes. , vol.53 , Issue.SUPPL. 3
    • Kwon, G.1    Marshall, C.A.2    Pappan, K.L.3    Remedi, M.S.4    McDaniel, M.L.5
  • 10
    • 19944426266 scopus 로고    scopus 로고
    • Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic betacells
    • Yang J, Wong RK, Wang X, et al. Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic betacells. J Biol Chem. 2004;279:53915-53923.
    • (2004) J Biol Chem. , vol.279 , pp. 53915-53923
    • Yang, J.1    Wong, R.K.2    Wang, X.3
  • 11
    • 33644753928 scopus 로고    scopus 로고
    • Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells
    • Yang J, Wong RK, Park M, et al. Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2006;55: 193-201.
    • (2006) Diabetes. , vol.55 , pp. 193-201
    • Yang, J.1    Wong, R.K.2    Park, M.3
  • 12
    • 34249680883 scopus 로고    scopus 로고
    • Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    • Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes. 2007;56:1647-1654.
    • (2007) Diabetes. , vol.56 , pp. 1647-1654
    • Zhang, Y.1    Guo, K.2    LeBlanc, R.E.3    Loh, D.4    Schwartz, G.J.5    Yu, Y.H.6
  • 13
    • 34147133191 scopus 로고    scopus 로고
    • Metabolic effects of amino acid mixtures and whey protein in healthy subjects: Studies using glucose-equivalent drinks
    • Nilsson M, Holst JJ, Bjorck IM. Metabolic effects of amino acid mixtures and whey protein in healthy subjects: Studies using glucose-equivalent drinks. Am J Clin Nutr. 2007; 85:996-1004.
    • (2007) Am J Clin Nutr. , vol.85 , pp. 996-1004
    • Nilsson, M.1    Holst, J.J.2    Bjorck, I.M.3
  • 14
    • 33745814724 scopus 로고    scopus 로고
    • Decreased nutrientstimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect
    • Rozance PJ, Limesand SW, Hay WW Jr. Decreased nutrientstimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2006;291:404-411.
    • (2006) Am J Physiol Endocrinol Metab. , vol.291 , pp. 404-411
    • Rozance, P.J.1    Limesand, S.W.2    Hay Jr., W.W.3
  • 15
    • 55649124531 scopus 로고    scopus 로고
    • Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose
    • Kalogeropoulou D, Lafave L, Schweim K, Gannon MC, Nuttall FQ. Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose. Metabolism. 2008;57:1747-1752.
    • (2008) Metabolism. , vol.57 , pp. 1747-1752
    • Kalogeropoulou, D.1    Lafave, L.2    Schweim, K.3    Gannon, M.C.4    Nuttall, F.Q.5
  • 16
    • 0036517376 scopus 로고    scopus 로고
    • Effect of a highprotein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes
    • Parker B, Noakes M, Luscombe N, Clifton P. Effect of a highprotein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes. Diabetes Care. 2002;25:425-430.
    • (2002) Diabetes Care. , vol.25 , pp. 425-430
    • Parker, B.1    Noakes, M.2    Luscombe, N.3    Clifton, P.4
  • 17
    • 33745654536 scopus 로고    scopus 로고
    • A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats
    • Baum JI, Layman DK, Freund GG, Rahn KA, Nakamura MT, Yudell BE. A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats. J Nutr. 2006;136:1855-1861.
    • (2006) J Nutr. , vol.136 , pp. 1855-1861
    • Baum, J.I.1    Layman, D.K.2    Freund, G.G.3    Rahn, K.A.4    Nakamura, M.T.5    Yudell, B.E.6
  • 18
    • 31544440119 scopus 로고    scopus 로고
    • Potential importance of leucine in treatment of obesity and the metabolic syndrome
    • Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr. 2006;136(Suppl 1):S319-S323.
    • (2006) J Nutr. , vol.136 , Issue.SUPPL. 1
    • Layman, D.K.1    Walker, D.A.2
  • 19
    • 29244439931 scopus 로고    scopus 로고
    • A leucinesupplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle
    • Combaret L, Dardevet D, Rieu I, et al. A leucinesupplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle. J Physiol. 2005;569:489-499.
    • (2005) J Physiol. , vol.569 , pp. 489-499
    • Combaret, L.1    Dardevet, D.2    Rieu, I.3
  • 20
    • 0038071524 scopus 로고    scopus 로고
    • Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells
    • Gao Z, Young RA, Li G, et al. Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells. Endocrinology. 2003;144:1949-1957.
    • (2003) Endocrinology. , vol.144 , pp. 1949-1957
    • Gao, Z.1    Young, R.A.2    Li, G.3
  • 21
    • 54249092318 scopus 로고    scopus 로고
    • Untangling the glutamate dehydrogenase allosteric nightmare
    • Smith TJ, Stanley CA. Untangling the glutamate dehydrogenase allosteric nightmare. Trends Biochem Sci. 2008;33: 557-564.
    • (2008) Trends Biochem Sci. , vol.33 , pp. 557-564
    • Smith, T.J.1    Stanley, C.A.2
  • 23
    • 33847211465 scopus 로고    scopus 로고
    • Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism
    • Straub SG, Sharp GW. Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism. Diabetes Metab Res Rev. 2007;23:146-151.
    • (2007) Diabetes Metab Res Rev. , vol.23 , pp. 146-151
    • Straub, S.G.1    Sharp, G.W.2
  • 24
    • 44649195062 scopus 로고    scopus 로고
    • Studies with leucine, beta-hydroxybutyrate and ATP citrate lyasedeficient beta cells support the acetoacetate pathway of insulin secretion
    • Macdonald MJ, Hasan NM, Longacre MJ. Studies with leucine, beta-hydroxybutyrate and ATP citrate lyasedeficient beta cells support the acetoacetate pathway of insulin secretion. Biochim Biophys Acta. 2008;1780:966-972.
    • (2008) Biochim Biophys Acta. , vol.1780 , pp. 966-972
    • Macdonald, M.J.1    Hasan, N.M.2    Longacre, M.J.3
  • 25
    • 33846954392 scopus 로고    scopus 로고
    • Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion
    • Pongratz RL, Kibbey RG, Shulman GI, Cline GW. Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. J Biol Chem. 2007;282:200-207.
    • (2007) J Biol Chem. , vol.282 , pp. 200-207
    • Pongratz, R.L.1    Kibbey, R.G.2    Shulman, G.I.3    Cline, G.W.4
  • 26
    • 0020317782 scopus 로고
    • The stimulus-secretion coupling of amino acidinduced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets
    • Malaisse-Lagae F, Sener A, Garcia-Morales P, Valverde I, MalaisseWJ. The stimulus-secretion coupling of amino acidinduced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets. J Biol Chem. 1982;257:3754-3758.
    • (1982) J Biol Chem. , vol.257 , pp. 3754-3758
    • Malaisse-Lagae, F.1    Sener, A.2    Garcia-Morales, P.3    Valverde, I.4    Malaisse, W.J.5
  • 27
    • 0020319986 scopus 로고
    • Signal function of metabolism of neutral amino acids and 2-keto acids for initiation of insulin secretion
    • Lenzen S, Formanek H, Panten U. Signal function of metabolism of neutral amino acids and 2-keto acids for initiation of insulin secretion. J Biol Chem. 1982;257:6631-6633.
    • (1982) J Biol Chem. , vol.257 , pp. 6631-6633
    • Lenzen, S.1    Formanek, H.2    Panten, U.3
  • 28
    • 4544344374 scopus 로고    scopus 로고
    • Familial leucinesensitive hypoglycemia of infancy due to a dominant mutation of the beta-cell sulfonylurea receptor
    • Magge SN, Shyng SL, MacMullen C, et al. Familial leucinesensitive hypoglycemia of infancy due to a dominant mutation of the beta-cell sulfonylurea receptor. J Clin Endocrinol Metab. 2004;89:4450-4456.
    • (2004) J Clin Endocrinol Metab. , vol.89 , pp. 4450-4456
    • Magge, S.N.1    Shyng, S.L.2    MacMullen, C.3
  • 29
    • 0034886416 scopus 로고    scopus 로고
    • Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome
    • Kelly A, Ng D, Ferry RJ Jr, et al. Acute insulin responses to leucine in children with the hyperinsulinism/ hyperammonemia syndrome. J Clin Endocrinol Metab. 2001;86:3724-3728.
    • (2001) J Clin Endocrinol Metab. , vol.86 , pp. 3724-3728
    • Kelly, A.1    Ng, D.2    Ferry Jr., R.J.3
  • 30
    • 47749151440 scopus 로고    scopus 로고
    • Elimination of KATP channels in mouse islets results in elevated [U-13C] glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt
    • Li C, Nissim I, Chen P, et al. Elimination of KATP channels in mouse islets results in elevated [U-13C] glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt. J Biol Chem. 2008;283: 17238-17249.
    • (2008) J Biol Chem. , vol.283 , pp. 17238-17249
    • Li, C.1    Nissim, I.2    Chen, P.3
  • 31
    • 2942520864 scopus 로고    scopus 로고
    • Acute and long-term effects of nateglinide on insulin secretory pathways
    • Ball AJ, Flatt PR, McClenaghan NH. Acute and long-term effects of nateglinide on insulin secretory pathways. Br J Pharmacol. 2004;142:367-373.
    • (2004) Br J Pharmacol. , vol.142 , pp. 367-373
    • Ball, A.J.1    Flatt, P.R.2    McClenaghan, N.H.3
  • 33
    • 0027457452 scopus 로고
    • Fuel secretagogue stimulation of arachidonic acid accumulation in fresh and cultured pancreatic islets
    • Konrad RJ, Jolly YC, Major C, Wolf BA. Fuel secretagogue stimulation of arachidonic acid accumulation in fresh and cultured pancreatic islets. Mol Cell Endocrinol. 1993;92:135-140.
    • (1993) Mol Cell Endocrinol. , vol.92 , pp. 135-140
    • Konrad, R.J.1    Jolly, Y.C.2    Major, C.3    Wolf, B.A.4
  • 34
    • 0032787470 scopus 로고    scopus 로고
    • Decreased pancreatic islet response to l-leucine in the spontaneously diabetic GK rat: Enzymatic, metabolic and secretory data
    • Giroix MH, Saulnier C, Portha B. Decreased pancreatic islet response to l-leucine in the spontaneously diabetic GK rat: Enzymatic, metabolic and secretory data. Diabetologia. 1999;42:965-977.
    • (1999) Diabetologia. , vol.42 , pp. 965-977
    • Giroix, M.H.1    Saulnier, C.2    Portha, B.3
  • 35
    • 34250310891 scopus 로고    scopus 로고
    • Synergistic potent insulin release by combinations ofweak secretagogues in pancreatic islets and INS-1 cells
    • MacDonald MJ. Synergistic potent insulin release by combinations ofweak secretagogues in pancreatic islets and INS-1 cells. J Biol Chem. 2007;282:6043-6052.
    • (2007) J Biol Chem. , vol.282 , pp. 6043-6052
    • MacDonald, M.J.1
  • 36
    • 44449124999 scopus 로고    scopus 로고
    • Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria
    • MacDonald MJ, Stoker SW, Hasan NM. Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria. Mol Cell Biochem. 2008;313:195-202.
    • (2008) Mol Cell Biochem. , vol.313 , pp. 195-202
    • MacDonald, M.J.1    Stoker, S.W.2    Hasan, N.M.3
  • 37
    • 0033788590 scopus 로고    scopus 로고
    • Nerve tissuespecific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: Implications for biologic function
    • Plaitakis A, Metaxari M, Shashidharan P. Nerve tissuespecific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: Implications for biologic function. J Neurochem. 2000;75:1862-1869.
    • (2000) J Neurochem. , vol.75 , pp. 1862-1869
    • Plaitakis, A.1    Metaxari, M.2    Shashidharan, P.3
  • 38
    • 33845725307 scopus 로고    scopus 로고
    • Mechanisms of disease: Advances in diagnosis and treatment of hyperinsulinism in neonates
    • De Leon DD, Stanley CA. Mechanisms of disease: Advances in diagnosis and treatment of hyperinsulinism in neonates. Nat Clin Pract Endocrinol Metab. 2007;3:57-68.
    • (2007) Nat Clin Pract Endocrinol Metab. , vol.3 , pp. 57-68
    • De Leon, D.D.1    Stanley, C.A.2
  • 39
    • 0032493123 scopus 로고    scopus 로고
    • Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
    • Stanley CA, Lieu YK, Hsu BY, et al. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med. 1998;338:1352-1357.
    • (1998) N Engl J Med. , vol.338 , pp. 1352-1357
    • Stanley, C.A.1    Lieu, Y.K.2    Hsu, B.Y.3
  • 40
    • 0017144760 scopus 로고
    • Comparison of the effects of leucines, nonmetabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase
    • Gylfe E. Comparison of the effects of leucines, nonmetabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase. Acta Diabetol Lat. 1976;13:20-24.
    • (1976) Acta Diabetol Lat. , vol.13 , pp. 20-24
    • Gylfe, E.1
  • 41
    • 33744527647 scopus 로고    scopus 로고
    • Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase
    • Li C, Allen A, Kwagh J, et al. Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. J Biol Chem. 2006;281:10214-10221.
    • (2006) J Biol Chem. , vol.281 , pp. 10214-10221
    • Li, C.1    Allen, A.2    Kwagh, J.3
  • 42
    • 0038422184 scopus 로고    scopus 로고
    • Regulatory effects of 5'-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets
    • Yang SJ, Huh JW, Kim MJ, et al. Regulatory effects of 5'-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets. Biochimie. 2003;85:581-586.
    • (2003) Biochimie. , vol.85 , pp. 581-586
    • Yang, S.J.1    Huh, J.W.2    Kim, M.J.3
  • 44
    • 0032806183 scopus 로고    scopus 로고
    • Glucose regulation of glutaminolysis and its role in insulin secretion
    • Gao ZY, Li G, Najafi H, Wolf BA, Matschinsky FM. Glucose regulation of glutaminolysis and its role in insulin secretion. Diabetes. 1999;48:1535-1542.
    • (1999) Diabetes. , vol.48 , pp. 1535-1542
    • Gao, Z.Y.1    Li, G.2    Najafi, H.3    Wolf, B.A.4    Matschinsky, F.M.5
  • 46
    • 59449108595 scopus 로고    scopus 로고
    • Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis
    • Carobbio S, Frigerio F, Rubi B, et al. Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis. J Biol Chem. 2008;284:921-929.
    • (2008) J Biol Chem. , vol.284 , pp. 921-929
    • Carobbio, S.1    Frigerio, F.2    Rubi, B.3
  • 47
    • 2642556203 scopus 로고    scopus 로고
    • Hyperinsulinemic hypoglycemia of infancy: The challenge continues
    • Dekelbab BH, Sperling MA. Hyperinsulinemic hypoglycemia of infancy: The challenge continues. Diabetes Metab Res Rev. 2004;20:189-195.
    • (2004) Diabetes Metab Res Rev. , vol.20 , pp. 189-195
    • Dekelbab, B.H.1    Sperling, M.A.2
  • 48
    • 33748778496 scopus 로고    scopus 로고
    • Hypoglycemia in newborns and infants
    • Dekelbab BH, Sperling MA. Hypoglycemia in newborns and infants. Adv Pediatr. 2006;53:5-22.
    • (2006) Adv Pediatr. , vol.53 , pp. 5-22
    • Dekelbab, B.H.1    Sperling, M.A.2
  • 49
    • 33748877830 scopus 로고    scopus 로고
    • Recent advances in hyperinsulinemic hypoglycemia of infancy
    • Dekelbab BH, Sperling MA. Recent advances in hyperinsulinemic hypoglycemia of infancy. Acta Paediatr. 2006;95:1157-1164.
    • (2006) Acta Paediatr. , vol.95 , pp. 1157-1164
    • Dekelbab, B.H.1    Sperling, M.A.2
  • 50
    • 0035091975 scopus 로고    scopus 로고
    • Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome
    • Hsu BY, Kelly A, Thornton PS, Greenberg CR, Dilling LA, Stanley CA. Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome. J Pediatr. 2001;138:383-389.
    • (2001) J Pediatr. , vol.138 , pp. 383-389
    • Hsu, B.Y.1    Kelly, A.2    Thornton, P.S.3    Greenberg, C.R.4    Dilling, L.A.5    Stanley, C.A.6
  • 51
    • 0035030231 scopus 로고    scopus 로고
    • Hyperinsulinism/ hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphatebinding domain of glutamate dehydrogenase
    • MacMullen C, Fang J, Hsu BY, et al. Hyperinsulinism/ hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphatebinding domain of glutamate dehydrogenase. J Clin Endocrinol Metab. 2001;86:1782-1787.
    • (2001) J Clin Endocrinol Metab. , vol.86 , pp. 1782-1787
    • MacMullen, C.1    Fang, J.2    Hsu, B.Y.3
  • 52
    • 33744951873 scopus 로고    scopus 로고
    • Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice
    • Li C, Matter A, Kelly A, et al. Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice. J Biol Chem. 2006;281:15064-15072.
    • (2006) J Biol Chem. , vol.281 , pp. 15064-15072
    • Li, C.1    Matter, A.2    Kelly, A.3
  • 53
    • 0037195942 scopus 로고    scopus 로고
    • Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and l-leucine
    • Zaganas I, Spanaki C, Karpusas M, Plaitakis A. Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and l-leucine. J Biol Chem. 2002; 277:46552-46558.
    • (2002) J Biol Chem. , vol.277 , pp. 46552-46558
    • Zaganas, I.1    Spanaki, C.2    Karpusas, M.3    Plaitakis, A.4
  • 54
    • 70449706000 scopus 로고    scopus 로고
    • Hyperinsulinismhyperammonaemia (HI/HA) syndrome: Novel mutations in the GLUD1 gene and genotype-phenotype correlations
    • Kapoor R, Flanagan S, Fulton P, et al. Hyperinsulinismhyperammonaemia (HI/HA) syndrome: Novel mutations in the GLUD1 gene and genotype-phenotype correlations. Eur J Endocrinol. 2009;161:731-735.
    • (2009) Eur J Endocrinol. , vol.161 , pp. 731-735
    • Kapoor, R.1    Flanagan, S.2    Fulton, P.3
  • 55
    • 37349039359 scopus 로고    scopus 로고
    • High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors
    • Li M, Allen A, Smith TJ. High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors. Biochem. 2007;46:15089-15102.
    • (2007) Biochem. , vol.46 , pp. 15089-15102
    • Li, M.1    Allen, A.2    Smith, T.J.3
  • 56
    • 25844456577 scopus 로고    scopus 로고
    • Pancreatic beta cells from db/db mice show cell-specific [Ca2+]i and NADH responses to glucose but not to alpha-ketoisocaproic acid
    • Gustavsson N, Larsson-Nyren G, Lindstrom P. Pancreatic beta cells from db/db mice show cell-specific [Ca2+]i and NADH responses to glucose but not to alpha-ketoisocaproic acid. Pancreas. 2005;31:242-250.
    • (2005) Pancreas. , vol.31 , pp. 242-250
    • Gustavsson, N.1    Larsson-Nyren, G.2    Lindstrom, P.3
  • 57
    • 0024363195 scopus 로고
    • L-leucine or its keto acid potentiate but do not initiate insulin release in chicken
    • Rideau N, Simon J. l-leucine or its keto acid potentiate but do not initiate insulin release in chicken. Am J Physiol. 1989;257:15-19.
    • (1989) Am J Physiol. , vol.257 , pp. 15-19
    • Rideau, N.1    Simon, J.2
  • 58
    • 0035145602 scopus 로고    scopus 로고
    • Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells
    • Xu G, Kwon G, Cruz WS, Marshall CA, McDaniel ML. Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. Diabetes. 2001;50:353-360.
    • (2001) Diabetes. , vol.50 , pp. 353-360
    • Xu, G.1    Kwon, G.2    Cruz, W.S.3    Marshall, C.A.4    McDaniel, M.L.5
  • 59
    • 0032561348 scopus 로고    scopus 로고
    • Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling
    • Xu G, Kwon G, Marshall CA, Lin TA, Lawrence JC Jr, McDaniel ML. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J Biol Chem. 1998;273:28178-28184.
    • (1998) J Biol Chem. , vol.273 , pp. 28178-28184
    • Xu, G.1    Kwon, G.2    Marshall, C.A.3    Lin, T.A.4    Lawrence Jr., J.C.5    McDaniel, M.L.6
  • 60
    • 0026515343 scopus 로고
    • Pancreatic beta-cell growth and diabetes mellitus
    • Swenne I. Pancreatic beta-cell growth and diabetes mellitus. Diabetologia. 1992;35:193-201.
    • (1992) Diabetologia. , vol.35 , pp. 193-201
    • Swenne, I.1
  • 61
    • 0026709588 scopus 로고
    • Persistent reduction of pancreatic beta-cell mass after a limited period of protein-energy malnutrition in the young rat
    • Swenne I, Borg LA, Crace CJ, Schnell Landstrom A. Persistent reduction of pancreatic beta-cell mass after a limited period of protein-energy malnutrition in the young rat. Diabetologia. 1992;35:939-945.
    • (1992) Diabetologia. , vol.35 , pp. 939-945
    • Swenne, I.1    Borg, L.A.2    Crace, C.J.3    Schnell Landstrom, A.4
  • 62
  • 63
    • 54749088342 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by 5-aminoimidazole- 4-carboxamide-1-beta-D-ribonucleoside prevents leucinestimulated protein synthesis in rat skeletal muscle
    • Pruznak AM, Kazi AA, Frost RA, Vary TC, Lang CH. Activation of AMP-activated protein kinase by 5-aminoimidazole- 4-carboxamide-1-beta-D- ribonucleoside prevents leucinestimulated protein synthesis in rat skeletal muscle. J Nutr. 2008;138:1887-1894.
    • (2008) J Nutr. , vol.138 , pp. 1887-1894
    • Pruznak, A.M.1    Kazi, A.A.2    Frost, R.A.3    Vary, T.C.4    Lang, C.H.5
  • 64
    • 0031887111 scopus 로고    scopus 로고
    • Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters
    • Fox HL, Kimball SR, Jefferson LS, Lynch CJ. Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. Am J Physiol. 1998;274:206-213.
    • (1998) Am J Physiol. , vol.274 , pp. 206-213
    • Fox, H.L.1    Kimball, S.R.2    Jefferson, L.S.3    Lynch, C.J.4
  • 65
    • 0032553411 scopus 로고    scopus 로고
    • Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts
    • Kimball SR, Horetsky RL, Jefferson LS. Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts. J Biol Chem. 1998; 273:30945-30953.
    • (1998) J Biol Chem. , vol.273 , pp. 30945-30953
    • Kimball, S.R.1    Horetsky, R.L.2    Jefferson, L.S.3
  • 66
    • 0034073638 scopus 로고    scopus 로고
    • Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes
    • Lynch CJ, Fox HL, Vary TC, Jefferson LS, Kimball SR. Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes. J Cell Biochem. 2000;77:234-251.
    • (2000) J Cell Biochem. , vol.77 , pp. 234-251
    • Lynch, C.J.1    Fox, H.L.2    Vary, T.C.3    Jefferson, L.S.4    Kimball, S.R.5
  • 67
    • 0034618364 scopus 로고    scopus 로고
    • Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
    • Pham PT, Heydrick SJ, Fox HL, Kimball SR, Jefferson LS Jr, Lynch CJ. Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. J Cell Biochem. 2000;79:427-441.
    • (2000) J Cell Biochem. , vol.79 , pp. 427-441
    • Pham, P.T.1    Heydrick, S.J.2    Fox, H.L.3    Kimball, S.R.4    Jefferson Jr., L.S.5    Lynch, C.J.6
  • 69
    • 34248140159 scopus 로고    scopus 로고
    • Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells
    • Evans K, Nasim Z, Brown J, et al. Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells. J Am Soc Nephrol. 2007;18:1426-1436.
    • (2007) J Am Soc Nephrol. , vol.18 , pp. 1426-1436
    • Evans, K.1    Nasim, Z.2    Brown, J.3
  • 70
    • 34247241597 scopus 로고    scopus 로고
    • Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphateactivated protein kinase
    • Du M, Shen QW, Zhu MJ, Ford SP. Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphateactivated protein kinase. J Anim Sci. 2007;85:919-927.
    • (2007) J Anim Sci. , vol.85 , pp. 919-927
    • Du, M.1    Shen, Q.W.2    Zhu, M.J.3    Ford, S.P.4
  • 71
    • 53849096018 scopus 로고    scopus 로고
    • Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs
    • Dardevet D, Kimball SR, Jefferson LS, et al. Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. Am J Clin Nutr. 2008;88:986-996.
    • (2008) Am J Clin Nutr. , vol.88 , pp. 986-996
    • Dardevet, D.1    Kimball, S.R.2    Jefferson, L.S.3
  • 72
    • 10744228630 scopus 로고    scopus 로고
    • Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets
    • Bell E, Cao X, Moibi JA, et al. Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets. Diabetes. 2003;52:2731-2739.
    • (2003) Diabetes. , vol.52 , pp. 2731-2739
    • Bell, E.1    Cao, X.2    Moibi, J.A.3
  • 73
    • 33646785781 scopus 로고    scopus 로고
    • Regulation of protein synthesis by leucine starvation involves distinct mechanisms in mouse C2C12 myoblasts and myotubes
    • Talvas J, Obled A, Fafournoux P, Mordier S. Regulation of protein synthesis by leucine starvation involves distinct mechanisms in mouse C2C12 myoblasts and myotubes. J Nutr. 2006;136:1466-1471.
    • (2006) J Nutr. , vol.136 , pp. 1466-1471
    • Talvas, J.1    Obled, A.2    Fafournoux, P.3    Mordier, S.4
  • 74
    • 57349114142 scopus 로고    scopus 로고
    • L-leucine increases [3H]-thymidine incorporation in chicken hepatocytes: Involvement of the PKC, PI3K/Akt, ERK1/2, andmTOR signaling pathways
    • Lee MY, Jo SD, Lee JH, Han HJ. l-leucine increases [3H]-thymidine incorporation in chicken hepatocytes: Involvement of the PKC, PI3K/Akt, ERK1/2, andmTOR signaling pathways. J Cell Biochem. 2008;105:1410-1419.
    • (2008) J Cell Biochem. , vol.105 , pp. 1410-1419
    • Lee, M.Y.1    Jo, S.D.2    Lee, J.H.3    Han, H.J.4
  • 76
    • 39149094602 scopus 로고    scopus 로고
    • Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats
    • Filiputti E, Ferreira F, Souza KL, et al. Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats. Life Sci. 2008;82:542-548.
    • (2008) Life Sci. , vol.82 , pp. 542-548
    • Filiputti, E.1    Ferreira, F.2    Souza, K.L.3
  • 77
    • 0030771909 scopus 로고    scopus 로고
    • Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase
    • Wang H, Iynedjian PB. Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase. J Biol Chem. 1997;272:25731-25736.
    • (1997) J Biol Chem. , vol.272 , pp. 25731-25736
    • Wang, H.1    Iynedjian, P.B.2
  • 78
    • 0030956626 scopus 로고    scopus 로고
    • Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase
    • Wang H, Iynedjian PB. Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. Proc Natl Acad Sci U S A. 1997;94:4372-4377.
    • (1997) Proc Natl Acad Sci U S A. , vol.94 , pp. 4372-4377
    • Wang, H.1    Iynedjian, P.B.2
  • 79
    • 0037023692 scopus 로고    scopus 로고
    • Mitochondrial metabolism sets the maximal limit of fuelstimulated insulin secretion in a model pancreatic beta cell: A survey of four fuel secretagogues
    • Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB. Mitochondrial metabolism sets the maximal limit of fuelstimulated insulin secretion in a model pancreatic beta cell: A survey of four fuel secretagogues. J Biol Chem. 2002;277:11746-11755.
    • (2002) J Biol Chem. , vol.277 , pp. 11746-11755
    • Antinozzi, P.A.1    Ishihara, H.2    Newgard, C.B.3    Wollheim, C.B.4
  • 80
    • 0035202886 scopus 로고    scopus 로고
    • Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio
    • Anello M, Ucciardello V, Piro S, et al. Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio. Am J Physiol Endocrinol Metab. 2001;281:1082-1087.
    • (2001) Am J Physiol Endocrinol Metab. , vol.281 , pp. 1082-1087
    • Anello, M.1    Ucciardello, V.2    Piro, S.3
  • 81
    • 65249085779 scopus 로고    scopus 로고
    • AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells
    • Zhang X, Sun N,Wang L, et al. AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells. J Cell Mol Med. 2009;13:758-770.
    • (2009) J Cell Mol Med. , vol.13 , pp. 758-770
    • Zhang, X.1    Sun, N.2    Wang, L.3
  • 82
    • 20144364947 scopus 로고    scopus 로고
    • Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells
    • Martens GA, Cai Y, Hinke S, Stange G, Van de Casteele M, Pipeleers D. Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J Biol Chem. 2005;280:20389-20396.
    • (2005) J Biol Chem. , vol.280 , pp. 20389-20396
    • Martens, G.A.1    Cai, Y.2    Hinke, S.3    Stange, G.4    Van De Casteele, M.5    Pipeleers, D.6
  • 83
    • 0024354291 scopus 로고
    • ATP synthase (H+-ATPase): Results by combined biochemical and molecular biological approaches
    • Futai M, Noumi T, Maeda M. ATP synthase (H+-ATPase): Results by combined biochemical and molecular biological approaches. Annu Rev Biochem. 1989;58:111-136.
    • (1989) Annu Rev Biochem. , vol.58 , pp. 111-136
    • Futai, M.1    Noumi, T.2    Maeda, M.3
  • 84
    • 0025819697 scopus 로고
    • Nucleotide binding to the isolated beta subunit of the chloroplast ATP synthase
    • Mills DA, RichterML. Nucleotide binding to the isolated beta subunit of the chloroplast ATP synthase. J Biol Chem. 1991;266:7440-7444.
    • (1991) J Biol Chem. , vol.266 , pp. 7440-7444
    • Mills, D.A.1    Richter, M.L.2
  • 85
    • 34548848059 scopus 로고    scopus 로고
    • Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    • Boudina S, Sena S, Theobald H, et al.Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes. 2007;56:2457-2466.
    • (2007) Diabetes. , vol.56 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3
  • 86
    • 0038576291 scopus 로고    scopus 로고
    • Proteome analysis reveals phosphorylation of ATP synthase beta-subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes
    • Hojlund K, Wrzesinski K, Larsen PM, et al. Proteome analysis reveals phosphorylation of ATP synthase beta-subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes. J Biol Chem. 2003;278:10436-10442.
    • (2003) J Biol Chem. , vol.278 , pp. 10436-10442
    • Hojlund, K.1    Wrzesinski, K.2    Larsen, P.M.3
  • 87
    • 9644301151 scopus 로고    scopus 로고
    • The F1-ATPase beta-subunit is the putative enterostatin receptor
    • Park M, Lin L, Thomas S, et al. The F1-ATPase beta-subunit is the putative enterostatin receptor. Peptides. 2004;25:2127-2133.
    • (2004) Peptides. , vol.25 , pp. 2127-2133
    • Park, M.1    Lin, L.2    Thomas, S.3
  • 88
    • 33646856216 scopus 로고    scopus 로고
    • Procolipase gene expression in the rat brain: Source of endogenous enterostatin production in the brain
    • York DA, Lin L, Thomas SR, Braymer HD, Park M. Procolipase gene expression in the rat brain: Source of endogenous enterostatin production in the brain. Brain Res. 2006; 1087:52-59.
    • (2006) Brain Res. , vol.1087 , pp. 52-59
    • York, D.A.1    Lin, L.2    Thomas, S.R.3    Braymer, H.D.4    Park, M.5
  • 89
    • 50449094038 scopus 로고    scopus 로고
    • Enterostatin up-regulates the expression of the beta-subunit of F(1)F(o)- ATPase in the plasma membrane of INS-1 cells
    • Lindqvist A, Berger K, Erlanson-Albertsson C. Enterostatin up-regulates the expression of the beta-subunit of F(1)F(o)- ATPase in the plasma membrane of INS-1 cells. Nutr Neurosci. 2008;11:55-60.
    • (2008) Nutr Neurosci. , vol.11 , pp. 55-60
    • Lindqvist, A.1    Berger, K.2    Erlanson-Albertsson, C.3
  • 90
    • 0029816608 scopus 로고    scopus 로고
    • Effect of enterostatin on insulin, glucagon, and somatostatin secretion in the perfused rat pancreas
    • Silvestre RA, Rodriguez-Gallardo J, Marco J. Effect of enterostatin on insulin, glucagon, and somatostatin secretion in the perfused rat pancreas. Diabetes. 1996;45:1157-1160.
    • (1996) Diabetes. , vol.45 , pp. 1157-1160
    • Silvestre, R.A.1    Rodriguez-Gallardo, J.2    Marco, J.3
  • 91
  • 92
    • 0030794045 scopus 로고    scopus 로고
    • Inhibition of insulin release by intraduodenally infused enterostatin-VPDPR in rats
    • Mei J, Bouras M, Erlanson-Albertsson C. Inhibition of insulin release by intraduodenally infused enterostatin-VPDPR in rats. Peptides. 1997;18:651-655.
    • (1997) Peptides. , vol.18 , pp. 651-655
    • Mei, J.1    Bouras, M.2    Erlanson-Albertsson, C.3
  • 93
    • 0033779714 scopus 로고    scopus 로고
    • Free fatty acids and pathogenesis of type 2 diabetes mellitus
    • Bergman RN, Ader M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab. 2000;11:351-356.
    • (2000) Trends Endocrinol Metab. , vol.11 , pp. 351-356
    • Bergman, R.N.1    Ader, M.2
  • 95
    • 52949094588 scopus 로고    scopus 로고
    • Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells
    • Azzu V, Affourtit C, Breen EP, Parker N, Brand MD. Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Biochim Biophys Acta. 2008;1777:1378-1383.
    • (2008) Biochim Biophys Acta. , vol.1777 , pp. 1378-1383
    • Azzu, V.1    Affourtit, C.2    Breen, E.P.3    Parker, N.4    Brand, M.D.5
  • 96
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    • Zhang CY, Baffy G, Perret P, et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001;105:745-755.
    • (2001) Cell. , vol.105 , pp. 745-755
    • Zhang, C.Y.1    Baffy, G.2    Perret, P.3
  • 97
    • 33744548069 scopus 로고    scopus 로고
    • Genipin inhibits UCP2- mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets
    • Zhang CY, Parton LE, Ye CP, et al. Genipin inhibits UCP2- mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab. 2006;3:417-427.
    • (2006) Cell Metab. , vol.3 , pp. 417-427
    • Zhang, C.Y.1    Parton, L.E.2    Ye, C.P.3
  • 98
    • 37849046731 scopus 로고    scopus 로고
    • Fatty acids and glucose in high concentration downregulates ATP synthase beta-subunit protein expression in INS-1 cells
    • Kohnke R, Mei J, Park M, York DA, Erlanson-Albertsson C. Fatty acids and glucose in high concentration downregulates ATP synthase beta-subunit protein expression in INS-1 cells. Nutr Neurosci. 2007;10:273-278.
    • (2007) Nutr Neurosci. , vol.10 , pp. 273-278
    • Kohnke, R.1    Mei, J.2    Park, M.3    York, D.A.4    Erlanson-Albertsson, C.5
  • 100
    • 36649027086 scopus 로고    scopus 로고
    • Free fatty acidinduced reduction in glucose-stimulated insulin secretion: Evidence for a role of oxidative stress in vitro and in vivo
    • Oprescu AI, Bikopoulos G, Naassan A, et al. Free fatty acidinduced reduction in glucose-stimulated insulin secretion: Evidence for a role of oxidative stress in vitro and in vivo. Diabetes. 2007;56:2927-2937.
    • (2007) Diabetes , vol.56 , pp. 2927-2937
    • Oprescu, A.I.1    Bikopoulos, G.2    Naassan, A.3
  • 101
    • 42349110538 scopus 로고    scopus 로고
    • Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL
    • Holohan C, Szegezdi E, Ritter T, O'Brien T, Samali A. Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL. J Cell Mol Med. 2008;12:591-606.
    • (2008) J Cell Mol Med. , vol.12 , pp. 591-606
    • Holohan, C.1    Szegezdi, E.2    Ritter, T.3    O'Brien, T.4    Samali, A.5
  • 102
    • 58149337392 scopus 로고    scopus 로고
    • Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling
    • Akerfeldt MC, Howes J, Chan JY, et al. Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes. 2008;57:3034-3044.
    • (2008) Diabetes. , vol.57 , pp. 3034-3044
    • Akerfeldt, M.C.1    Howes, J.2    Chan, J.Y.3
  • 103
    • 23844433186 scopus 로고    scopus 로고
    • Glucokinase, glucose homeostasis, and diabetes mellitus
    • Matschinsky FM. Glucokinase, glucose homeostasis, and diabetes mellitus. Curr Diab Rep. 2005;5:171-176.
    • (2005) Curr Diab Rep. , vol.5 , pp. 171-176
    • Matschinsky, F.M.1
  • 104
    • 14644394924 scopus 로고    scopus 로고
    • Glucokinase and glucose homeostasis: Proven concepts and new ideas
    • Zelent D, Najafi H, Odili S, et al. Glucokinase and glucose homeostasis: Proven concepts and new ideas. Biochem Soc Trans. 2005;33:306-310.
    • (2005) Biochem Soc Trans. , vol.33 , pp. 306-310
    • Zelent, D.1    Najafi, H.2    Odili, S.3
  • 105
    • 3242789423 scopus 로고    scopus 로고
    • Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?
    • Fridlyand LE, Philipson LH. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes. 2004;53:1942-1948.
    • (2004) Diabetes. , vol.53 , pp. 1942-1948
    • Fridlyand, L.E.1    Philipson, L.H.2
  • 106
    • 33845949078 scopus 로고    scopus 로고
    • Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species
    • Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, et al. Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species. Diabetologia. 2007;50:84-93.
    • (2007) Diabetologia. , vol.50 , pp. 84-93
    • Produit-Zengaffinen, N.1    Davis-Lameloise, N.2    Perreten, H.3
  • 107
    • 1842582779 scopus 로고    scopus 로고
    • Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines
    • Wu L, Nicholson W, Knobel SM, et al. Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines. J Biol Chem. 2004;279:12126-12134.
    • (2004) J Biol Chem. , vol.279 , pp. 12126-12134
    • Wu, L.1    Nicholson, W.2    Knobel, S.M.3
  • 108
    • 45449118936 scopus 로고    scopus 로고
    • Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells
    • Saitoh Y, Chun-ping C, Noma K, Ueno H, Mizuta M, Nakazato M. Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells. Diabetes Obes Metab. 2008;10:564-573.
    • (2008) Diabetes Obes Metab. , vol.10 , pp. 564-573
    • Saitoh, Y.1    Chun-ping, C.2    Noma, K.3    Ueno, H.4    Mizuta, M.5    Nakazato, M.6
  • 109
    • 0347477364 scopus 로고    scopus 로고
    • Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance
    • Ferre T, Riu E, Franckhauser S, Agudo J, Bosch F. Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance. Diabetologia. 2003;46:1662-1668.
    • (2003) Diabetologia. , vol.46 , pp. 1662-1668
    • Ferre, T.1    Riu, E.2    Franckhauser, S.3    Agudo, J.4    Bosch, F.5
  • 110
    • 41549084644 scopus 로고    scopus 로고
    • AMPactivated protein kinase activation by 5-aminoimidazole-4- carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression
    • Kim JE, Kim YW, Lee IK, Kim JY, Kang YJ, Park SY. AMPactivated protein kinase activation by 5-aminoimidazole-4- carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. J Pharmacol Sci. 2008;106:394-403.
    • (2008) J Pharmacol Sci. , vol.106 , pp. 394-403
    • Kim, J.E.1    Kim, Y.W.2    Lee, I.K.3    Kim, J.Y.4    Kang, Y.J.5    Park, S.Y.6
  • 111
    • 33847065108 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptorgamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells
    • Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL. Peroxisome proliferator-activated receptorgamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells. Diabetes. 2007;56:88-95.
    • (2007) Diabetes. , vol.56 , pp. 88-95
    • Moibi, J.A.1    Gupta, D.2    Jetton, T.L.3    Peshavaria, M.4    Desai, R.5    Leahy, J.L.6
  • 112
    • 9444296497 scopus 로고    scopus 로고
    • Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells
    • Efanov AM, Sewing S, Bokvist K, Gromada J. Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells. Diabetes. 2004;53(Suppl 3):S75-S78.
    • (2004) Diabetes. , vol.53 , Issue.SUPPL. 3
    • Efanov, A.M.1    Sewing, S.2    Bokvist, K.3    Gromada, J.4
  • 113
    • 0842307302 scopus 로고    scopus 로고
    • Liver glucokinase can be activated by peroxisome proliferator-activated receptorgamma
    • Kim SY, Kim HI, Park SK, et al. Liver glucokinase can be activated by peroxisome proliferator-activated receptorgamma. Diabetes. 2004;53(Suppl 1):S66-S70.
    • (2004) Diabetes. , vol.53 , Issue.SUPPL. 1
    • Kim, S.Y.1    Kim, H.I.2    Park, S.K.3
  • 114
    • 0842263985 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells
    • Kim HI, Ahn YH. Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells. Diabetes. 2004;53(Suppl 1):S60-S65.
    • (2004) Diabetes. , vol.53 , Issue.SUPPL. 1
    • Kim, H.I.1    Ahn, Y.H.2
  • 115
    • 33644821858 scopus 로고    scopus 로고
    • Mitochondria are impaired in the adipocytes of type 2 diabetic mice
    • Choo HJ, Kim JH, Kwon OB, et al. Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia. 2006;49:784-791.
    • (2006) Diabetologia. , vol.49 , pp. 784-791
    • Choo, H.J.1    Kim, J.H.2    Kwon, O.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.