High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan

Aging Cell

Volumn 12, Issue 3, 2013, Pages 446-458

  Dellago, Hanna ^a   Preschitz Kammerhofer, Barbara ^a   Terlecki Zaniewicz, Lucia ^a   Schreiner, Carina ^a   Fortschegger, Klaus ^b   Chang, Martina W F ^a   Hackl, Matthias ^a   Monteforte, Rossella ^a   Kühnel, Harald ^c   Schosserer, Markus ^a   Gruber, Florian ^d   Tschachler, Erwin ^d,e   Scheideler, Marcel ^f   Grillari Voglauer, Regina ^a,g,h   Grillari, Johannes ^a,g   Wieser, Matthias ^a,h  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^c UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^d Universitatsklinik fur Dermatologie   (Austria)

^e CERIES Centre de Recherches et d'Investigations Epidermiques et Sensorielles   (France)

^f GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^g Evercyte GmbH   (Austria)

^h AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

Author keywords

CDC25A; CDK2; Cellular senescence; Hyperoncogenic signal; MicroRNA; MiR 21; NFIB; P21

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; MICRORNA 100; MICRORNA 193A; MICRORNA 221; MICRORNA 222; MICRORNA 23A; MICRORNA 27A; MICRORNA 29A; MICRORNA 31; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL SURVIVAL; GENETIC TRANSFECTION; GROWTH DISORDER; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PUVA; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

APOPTOSIS; CDC25 PHOSPHATASES; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; NFI TRANSCRIPTION FACTORS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; UP-REGULATION;

EID: 84877798880     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12069     Document Type: Article

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